This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorders of puberty, all
E4_DISPUB_ALL
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
695 |
4. Check minimum number of eventsNone |
695 |
5. Include endpoints |
695 |
6. Filter based on genotype QC (FinnGen only) |
695 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Disorders of puberty, all
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 695 | 453 | 242 |
| Unadjusted period prevalence (%) | 0.14 | 0.15 | 0.11 |
| Median age at first event (years) | 11.93 | 10.36 | 14.85 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 628
- Matched controls
- 6282
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
2119.3
169.8
157
*
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
169.7
155
*
E30.00
ICD-10 Finland
Familial delayed puberty
+∞
162.8
149
*
E22.80
ICD-10 Finland
Central precocious puberty
+∞
98.6
92
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
12.4
94.3
183
201
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
835.0
77.0
74
*
E30.8
ICD-10 Finland
Other disorders of puberty
733.7
68.3
66
*
L02AE02
ATC
leuprorelin; implant, parenteral
36.5
62.3
80
25
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
26.8
60.3
84
36
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
457.9
43.8
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
15.9
30.6
50
34
E34.35
ICD-10 Finland
Abnormal growth retardation
10.4
30.1
60
63
H01AC01
ATC
somatropin; parenteral
8.0
20.5
47
63
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
19.9
19
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
13.3
16.3
28
22
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
8.6
14.9
32
39
121
Kela drug reimbursment
Severe hypofunction of sexual glands
14.9
14.1
23
16
H03AA01
ATC
levothyroxine sodium; systemic
2.7
14.0
106
445
L02AE04
ATC
triptorelin; parenteral
+∞
13.6
13
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
9.4
13.3
27
30
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
19.5
13.0
19
10
E23.00
ICD-10 Finland
Panhypopituitarism
24.9
12.5
17
7
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
12.1
75
279
H02AB09
ATC
hydrocortisone; systemic
4.1
11.7
45
115
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
11.6
70
255
104
Kela drug reimbursment
Thyroid insufficiency
5.2
10.6
32
64
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
6.7
10.6
26
40
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.7
10.5
45
127
G03DB01
ATC
dydrogesterone; oral
3.0
10.5
60
211
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
8.1
10.2
22
28
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.0
10.1
59
211
E27.0
ICD-10 Finland
Other adrenocortical overactivity
10.3
10.1
19
19
N91.0
ICD-10 Finland
Primary amenorrhoea
10.9
9.8
18
17
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
9.8
81
357
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.1
9.6
54
187
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
7.3
9.6
22
31
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
R1260
NOMESCO Finland
Evaluation of communicative skills
7.1
9.4
22
32
E34.45
ICD-10 Finland
Abnormal growth increase
13.9
9.2
15
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
8.8
163
1004
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.4
8.6
30
71
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.6
8.4
63
262
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
8.2
83
403
602
Kela drug reimbursment
Children's severe malnutrition
3.9
8.2
32
85
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
8.1
110
602
T99
ICPC
Endocr/metab/nutrit disease other
10.2
8.1
15
15
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.2
8.0
29
72
F83
ICD-10 Finland
Mixed specific developmental disorders
3.5
7.5
33
97
E34.30
ICD-10 Finland
Short stature NOS
8.5
7.3
15
18
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.3
106
596
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.3
104
581
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.2
124
739
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.4
7.0
32
98
H47.2
ICD-10 Finland
Optic atrophy
14.0
6.9
11
8
H50.31
ICD-10 Finland
Intermittent exotropia
4.5
6.7
22
50
P05.1
ICD-10 Finland
Small for gestational age
7.9
6.6
14
18
L04AA01
ATC
[U] ciclosporin; systemic
6.3
6.5
16
26
P85
ICPC
Mental retardation
7.5
6.4
14
19
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.3
93
524
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
11.2
6.3
11
10
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
6.3
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.3
101
587
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.2
89
497
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.1
160
1079
T10
ICPC
Growth delay
8.7
6.1
12
14
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.0
6.0
22
56
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
179
410
5.53
76.84
3.5
1.7
5.3
6.9
u/l
1.59
145
298
165
388
5.27
68.17
3.4
1.7
8.3
9.6
iu/l
0.35
137
279
68
87
8.56
50.63
2.7
1.8
0.1
0.2
nmol/l
1.11
59
69
134
383
4.10
42.02
3.5
1.9
7.0
11.0
nmol/l
5.56
120
345
33
44
7.82
23.52
2.0
2.0
4.3
5.7
nmol/l
0.76
33
44
208
1183
2.08
16.19
2.6
2.6
2.4
2.4
mmol/l
0.24
191
1067
116
540
2.38
14.68
3.4
2.2
357.6
382.2
nmol/l
0.76
110
506
520
4166
1.99
13.65
4.9
3.7
14.4
14.4
pmol/l
0.10
488
3779
50
161
3.27
12.74
2.0
1.6
0.3
0.3
nmol/l
0.05
41
136
283
1917
1.80
12.38
10.0
7.7
1.2
1.2
mmol/l
1.01
246
1688
262
1769
1.77
11.36
9.9
7.8
1.2
1.2
mmol/l
0.53
248
1651
283
1998
1.70
10.19
3.5
2.8
69.7
67.3
nmol/l
0.79
266
1876
57
230
2.61
9.71
1.6
1.4
7.5
4.0
ug/l
1.14
51
217
94
485
2.08
9.10
1.8
1.5
427.6
324.5
mu/l
1.07
88
427
12
15
8.12
8.88
2.3
2.2
—
—
—
0
0
556
4788
1.81
8.82
5.5
4.1
2.1
2.0
mu/l
0.04
533
4505
32
101
3.27
8.45
2.3
1.4
8.8
11.0
u/l
0.34
27
92
393
3143
1.58
7.84
7.5
5.5
94.5
87.2
u/l
1.42
371
2939
219
1530
1.63
7.76
6.3
5.6
37.7
38.2
g/l
0.72
206
1419
554
4824
1.73
7.73
13.2
8.9
3.9
3.9
mmol/l
0.58
533
4626
553
4817
1.72
7.66
13.3
9.0
139.6
139.5
mmol/l
0.20
534
4640
220
1576
1.58
6.88
4.6
3.4
—
—
—
0
0
272
2050
1.54
6.76
1.5
1.6
1.8
2.3
u/ml
0.26
58
450
597
5367
1.80
6.74
9.9
7.4
28.0
25.9
u/l
0.99
581
5160
191
1331
1.60
6.69
4.1
3.2
0.3
0.2
e6/l
0.52
145
987
98
591
1.77
5.89
10.8
9.8
25.3
24.9
mmol/l
0.56
98
591
249
1886
1.50
5.85
5.8
5.6
9.8
10.7
umol/l
1.04
234
1739
86
507
1.79
5.58
9.3
6.1
1.5
1.0
mmol/l
0.55
61
367
378
3134
1.45
5.48
11.0
9.0
3.9
3.7
e9/l
0.54
334
2690
559
5037
1.56
5.11
16.2
11.9
13.2
13.1
%
1.62
550
4936
667
6319
2.38
5.07
18.5
13.6
134.9
136.1
g/l
1.64
660
6227
21
71
3.02
5.02
3.3
3.1
18.2
17.7
%
0.22
15
38
314
2568
1.41
4.63
5.7
4.8
6.4
6.1
mmol/l
0.76
287
2275
127
873
1.56
4.57
2.7
2.3
173.6
284.9
u/l
0.74
121
831
100
652
1.62
4.50
6.1
7.7
1.7
1.4
mmol/l
0.50
90
526
28
118
2.43
4.45
1.3
1.3
—
—
—
0
0
28
118
2.43
4.45
1.3
1.3
—
—
—
0
0
27
114
2.42
4.28
2.0
1.6
118.5
196.5
pmol/l
2.37
27
107
450
3944
1.40
4.25
3.1
2.5
5.5
5.4
mmol/l
0.23
427
3632
452
3970
1.40
4.18
9.3
6.5
109.2
106.6
ml/min/173m2
1.56
341
2867
590
5457
1.54
4.00
12.7
9.3
18.5
21.1
mg/l
1.28
454
3876
43
228
1.94
3.92
3.3
2.5
90.9
91.9
ml/min/173m2
0.04
14
77
72
449
1.67
3.86
3.2
4.4
247.0
954.5
ng/l
1.27
55
346
45
246
1.89
3.76
10.1
10.9
0.4
0.4
mmol/l
0.01
33
193
81
525
1.61
3.74
3.9
2.7
25.3
23.6
%
0.37
75
476
39
205
1.96
3.65
1.6
1.6
—
—
—
0
0
399
3481
1.34
3.57
5.0
3.8
8.5
7.4
mm/h
1.25
373
3207
63
390
1.68
3.48
1.8
1.7
—
—
—
0
0
161
1223
1.41
3.47
4.1
3.8
9.5
9.0
mmol/l
0.49
148
1104
198
1560
1.38
3.43
3.9
3.4
39.0
29.2
u/l
0.84
192
1478
63
394
1.66
3.36
1.8
1.7
—
—
—
0
0
167
1296
1.38
3.15
1.6
1.5
91.2
97.2
pmol/l
1.04
83
723
19
80
2.41
3.08
3.1
3.7
11.1
9.2
%
—
10
71
8
16
5.04
3.05
1.0
1.4
—
—
—
0
0
19
81
2.38
3.01
1.2
1.2
—
—
—
0
0
65
425
1.58
2.92
3.9
3.9
0.2
0.2
g/l
0.62
65
406
18
77
2.37
2.84
3.3
3.8
—
—
—
0
0
14
53
2.68
2.81
3.5
2.8
198.6
97.0
u/ml
—
5
17
376
3318
1.29
2.80
4.3
3.2
37.2
36.5
mmol/mol
0.58
358
3123
41
242
1.74
2.73
2.3
1.6
—
—
—
0
0
35
197
1.82
2.73
11.8
10.3
123.9
125.7
g/l
0.17
35
185
72
492
1.52
2.68
2.3
2.1
2.4
2.4
mmol/l
1.05
60
406
10
32
3.16
2.65
1.4
1.1
—
—
—
0
0
24
120
2.04
2.63
5.1
3.6
3.3
3.6
e9/l
0.26
24
120
13
49
2.68
2.63
1.3
1.1
—
—
—
0
0
105
777
1.41
2.61
2.8
2.8
0.7
1.0
e6/l
0.85
49
422
7
15
4.70
2.60
10.9
11.7
—
—
—
0
0
40
239
1.71
2.57
3.5
7.0
3.9
3.0
g/l
1.95
40
230
153
1209
1.34
2.54
2.5
2.5
54.0
55.0
u/l
0.15
141
1114
24
123
1.99
2.48
5.3
3.8
50.3
53.0
%
0.44
24
123
82
586
1.45
2.46
3.8
2.6
2.5
2.6
g/l
0.17
76
534
88
640
1.43
2.41
3.7
2.6
15.1
14.8
umol/l
0.10
82
596
79
564
1.45
2.39
2.0
1.8
—
—
—
0
0
92
677
1.41
2.37
3.8
3.3
312.7
2359.2
umol/l
1.34
87
625
97
721
1.40
2.36
1.5
1.4
19.0
18.3
nmol/l
0.21
85
632
138
1087
1.34
2.34
3.0
2.4
—
—
—
0
0
594
5630
1.38
2.33
14.2
10.5
39.6
40.5
%
2.82
504
4805
20
100
2.03
2.22
1.5
1.2
1.7
5.6
u/ml
—
10
49
135
1069
1.33
2.21
3.0
2.8
127.2
105.5
ug/g
0.32
104
836
76
548
1.43
2.20
1.3
1.5
469.1
28571853.6
pmol/l
0.80
68
476
78
568
1.42
2.14
2.6
1.9
—
—
—
0
0
22
116
1.93
2.13
4.0
11.8
24.9
23.5
mmol/l
0.91
22
104
19
97
1.99
2.02
1.4
1.2
3.0
4.2
u/ml
—
9
50
8
26
3.10
2.02
4.3
6.4
—
—
—
0
0
8
26
3.10
2.02
4.3
6.2
—
—
—
0
0
76
558
1.41
2.00
1.3
1.2
118.5
149.3
iu/ml
0.31
24
203
99
761
1.35
1.98
3.1
2.8
7.9
4.0
e6/l
0.52
45
407
74
543
1.41
1.96
4.8
5.1
5.0
7.0
umol/l
1.03
65
437
370
3344
1.23
1.95
5.6
3.8
15.0
418.3
e6/l
—
6
30
6
16
3.77
1.94
3.8
1.6
—
—
—
0
0
9
33
2.75
1.93
10.1
8.9
—
—
—
0
0
8
28
2.88
1.86
1.4
1.0
190.4
147.4
u/l
—
8
20
36
230
1.60
1.85
1.4
1.3
—
—
—
0
0
6
17
3.55
1.84
4.0
3.9
—
—
—
0
0
11
47
2.36
1.78
3.4
1.4
—
—
—
0
0
44
299
1.50
1.75
3.6
2.2
—
—
—
0
0
9
36
2.52
1.74
3.9
1.5
—
—
—
0
0
7
24
2.94
1.72
5.1
6.9
—
—
—
0
0
7
25
2.82
1.65
3.3
5.1
162.7
152.4
ug/l
—
7
25
11
49
2.26
1.64
1.5
1.5
329.3
387.8
pmol/l
—
6
42
157
1319
1.25
1.61
2.7
2.6
2.7
2.5
mg/l
0.51
130
1142
6
20
3.02
1.58
4.5
5.8
14.1
22.3
ug/l
—
6
20
7
26
2.71
1.58
2.1
1.6
24.5
1.1
nmol/l
—
7
20
11
50
2.22
1.57
4.8
3.5
0.7
1.8
%
0.93
11
39
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
15
79
1.92
1.50
1.7
2.5
—
—
—
0
0
45
319
1.44
1.48
1.5
1.4
—
—
—
0
0
9
37
2.45
1.48
1.4
1.1
—
—
—
0
0
408
3784
1.19
1.46
3.2
2.5
1.2
1.1
mmol/l
1.78
390
3573
24
150
1.62
1.39
1.4
3.0
471.5
436.1
mg/l
0.12
24
141
117
971
1.25
1.35
2.8
2.3
42.4
42.3
ng/l
0.00
53
352
115
956
1.24
1.31
2.4
2.9
2.4
1.0
mg/l
0.58
76
625
245
2195
1.18
1.28
4.5
4.1
—
—
—
0
0
108
895
1.24
1.26
1.6
1.6
1.5
1.4
%
1.05
97
821
46
339
1.38
1.25
10.5
8.2
1.6
1.3
mmol/l
0.61
39
321
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
79
1.79
1.17
6.7
13.8
0.3
0.3
u/ml
—
9
50
27
182
1.50
1.17
1.4
1.1
—
—
—
0
0
26
174
1.51
1.17
6.2
3.0
196.3
132.7
ng/l
0.29
21
156
5
20
2.51
1.15
1.8
1.4
0.9
1.0
g/l
—
5
20
32
446
0.70
1.14
1.6
1.5
—
—
—
0
0
17
103
1.67
1.13
1.4
1.1
—
—
—
0
0
428
4035
1.16
1.10
3.5
2.7
2.7
2.7
mmol/l
0.09
408
3781
7
31
2.27
1.10
2.0
1.8
—
1224630.0
—
0
5
28
194
1.46
1.08
4.4
5.9
132.8
131.6
g/l
0.12
28
187
424
3998
1.16
1.08
3.4
2.7
1.4
1.4
mmol/l
0.24
404
3773
31
220
1.43
1.06
2.1
1.8
90.2
100.5
u/ml
—
5
24
109
923
1.21
1.06
1.8
1.6
1.5
1.3
mmol/l
1.26
100
835
25
170
1.49
1.06
1.2
1.6
—
—
—
0
0
27
187
1.46
1.05
1.4
1.1
—
—
—
0
0
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
5
22
2.28
1.03
3.4
1.3
—
23.3
—
0
7
427
4038
1.15
1.02
3.5
2.7
4.5
4.5
mmol/l
0.01
407
3819
38
495
0.75
0.92
1.4
1.6
—
—
—
0
0
6
28
2.15
0.91
4.0
1.5
—
—
—
0
0
18
119
1.53
0.89
3.1
1.8
—
—
—
0
0
8
43
1.87
0.87
1.4
1.0
—
—
—
0
0
123
1076
1.17
0.85
1.5
1.5
—
—
—
0
0
13
80
1.64
0.85
2.4
1.8
—
—
—
0
0
6
31
1.94
0.84
4.2
6.9
—
—
—
0
0
40
310
1.31
0.84
1.7
1.6
—
—
—
0
0
6
32
1.88
0.82
2.2
3.1
585.8
807.5
u/ml
—
6
32
270
2506
1.13
0.81
4.2
3.0
0.0
0.0
estimate
0.00
60
515
316
2961
1.12
0.80
3.8
3.0
66.0
55.8
ug/l
0.59
288
2780
39
304
1.30
0.80
1.8
1.6
200.6
200.7
u/ml
0.00
23
161
22
156
1.42
0.79
17.1
11.7
93.9
95.2
%
0.23
22
156
6
33
1.83
0.79
1.7
1.3
—
—
—
0
0
11
66
1.68
0.79
1.4
2.0
—
—
—
0
0
71
599
1.21
0.75
3.1
2.9
191.5
1003.6
ng/l
1.80
33
276
22
158
1.41
0.75
17.1
11.6
0.6
0.7
%
1.03
22
158
12
75
1.61
0.75
2.5
1.8
—
—
—
0
0
267
2486
1.12
0.75
4.3
3.0
0.0
0.0
estimate
0.00
59
504
13
84
1.56
0.72
1.0
1.4
—
—
—
0
0
7
40
1.76
0.71
1.3
3.2
—
—
—
0
0
7
40
1.76
0.71
1.3
3.2
—
—
—
0
0
45
551
0.80
0.70
1.4
1.3
—
—
—
0
0
147
1328
1.14
0.68
4.7
3.1
0.0
0.0
estimate
0.80
59
517
5
28
1.79
0.66
1.8
1.4
—
—
—
0
0
88
1004
0.86
0.66
1.5
1.5
—
—
—
0
0
31
242
1.29
0.65
1.3
1.2
—
—
—
0
0
41
332
1.25
0.65
4.8
4.1
—
—
—
0
0
10
62
1.62
0.65
1.0
1.1
—
—
—
0
0
17
120
1.43
0.65
2.6
1.7
—
—
—
0
0
20
268
0.74
0.63
1.3
1.6
3.7
4.0
mg/l
0.08
12
172
265
2488
1.11
0.62
5.8
4.2
0.0
0.0
estimate
0.00
60
531
54
638
0.83
0.61
1.4
1.4
—
—
—
0
0
8
50
1.61
0.61
1.0
1.6
—
—
—
0
0
19
139
1.38
0.61
1.3
3.0
4.0
3.5
mmol/l
1.08
19
130
51
428
1.21
0.60
1.6
1.6
1018.5
1100.4
nmol/l
0.32
45
331
10
64
1.57
0.59
3.6
1.5
—
—
—
0
0
11
73
1.52
0.56
1.8
1.4
60.5
38.3
nmol/l
0.72
11
67
12
82
1.47
0.54
1.5
1.6
5.2
6.9
mmol/l
—
6
51
6
38
1.58
0.54
1.2
2.0
3.0
3.1
g/l
—
6
33
350
3348
1.09
0.54
4.2
3.2
34.1
28.5
u/l
1.11
335
3211
38
457
0.82
0.53
1.8
1.7
—
—
—
0
0
13
91
1.44
0.53
2.4
1.7
—
—
—
0
0
6
39
1.54
0.53
1.2
1.9
7.2
7.2
g/l
—
6
33
6
39
1.54
0.53
1.2
1.9
4.1
3.5
g/l
—
6
33
6
39
1.54
0.53
1.2
1.9
—
—
—
0
0
131
1196
1.12
0.52
2.1
2.0
—
—
—
0
0
7
45
1.56
0.49
3.4
1.4
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
96.6
87.2
%
—
7
45
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
11
153
0.71
0.46
1.1
1.1
—
—
—
0
0
5
85
0.59
0.45
1.0
1.9
—
—
—
0
0
15
112
1.35
0.45
1.8
1.6
—
—
—
0
0
70
623
1.14
0.43
1.1
1.1
—
—
—
0
0
52
453
1.16
0.43
3.1
2.3
29.6
141.0
u/l
0.52
43
375
8
56
1.43
0.42
2.6
2.3
—
—
—
0
0
12
87
1.39
0.42
2.0
1.2
—
—
—
0
0
13
96
1.36
0.41
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
127
1175
1.10
0.41
3.8
2.9
1.0
1.0
kg/l
1.82
22
168
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
23
282
0.81
0.41
1.4
1.4
—
—
—
0
0
15
114
1.32
0.41
1.8
1.5
0.3
0.5
ug/l
—
8
38
0
18
0.00
0.40
0.0
1.8
—
5.5
—
0
13
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
12
89
1.35
0.38
1.3
1.1
—
—
—
0
0
5
37
1.35
0.37
1.2
1.2
—
—
—
0
0
24
286
0.83
0.34
1.3
1.2
—
—
—
0
0
18
145
1.25
0.34
3.8
1.8
—
—
—
0
0
17
136
1.26
0.34
1.5
1.7
7.3
7.1
mmol/l
0.10
11
75
6
45
1.34
0.34
1.0
1.1
257.0
306.6
mg/l
—
6
39
11
144
0.76
0.33
2.4
2.0
—
—
—
0
0
7
52
1.35
0.31
1.6
1.2
—
—
—
0
0
34
389
0.87
0.31
1.9
2.0
—
—
—
0
0
68
744
0.90
0.31
1.2
1.2
13.0
17.3
iu/ml
0.65
17
185
7
53
1.32
0.31
1.6
1.2
—
—
—
0
0
7
54
1.30
0.30
3.0
4.1
21.1
25.5
umol/l
—
7
54
151
1429
1.07
0.30
2.5
2.2
—
—
—
0
0
35
308
1.14
0.28
1.7
1.4
—
—
—
0
0
11
85
1.30
0.28
2.1
2.0
—
—
—
0
0
8
62
1.29
0.28
1.3
1.0
—
—
—
0
0
44
394
1.12
0.28
1.3
1.3
204.0
253.5
miu/ml
0.42
24
197
8
63
1.27
0.28
1.3
1.1
—
—
—
0
0
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
26
225
1.16
0.26
1.3
1.3
—
—
—
0
0
195
1875
1.06
0.24
4.3
2.9
—
—
—
0
0
19
222
0.85
0.23
1.1
1.1
7.7
5.7
u/ml
0.22
11
108
17
143
1.19
0.23
1.2
1.9
—
—
—
0
0
12
97
1.24
0.23
1.2
1.3
—
1.4
—
0
8
219
2264
0.95
0.22
2.9
2.5
—
—
—
0
0
5
41
1.22
0.22
1.6
1.8
—
—
—
0
0
16
135
1.19
0.21
2.0
2.4
0.8
0.6
nmol/l
0.27
16
114
31
277
1.12
0.21
2.6
3.2
4.4
6.4
umol/l
1.01
22
219
0
11
0.00
0.21
0.0
1.2
—
506.9
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
120.6
—
0
14
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
65
695
0.93
0.20
1.2
1.2
15.8
7.8
u/ml
0.25
20
250
204
2102
0.96
0.18
2.5
2.3
—
—
—
0
0
19
166
1.15
0.18
1.5
1.5
—
—
—
0
0
7
61
1.15
0.17
1.0
1.4
—
—
—
0
0
33
301
1.10
0.17
2.2
1.7
—
—
—
0
0
5
66
0.76
0.17
1.6
1.1
—
—
—
0
0
5
70
0.71
0.16
1.2
1.6
—
—
—
0
0
20
177
1.13
0.16
1.2
1.3
—
—
—
0
0
9
78
1.16
0.15
7.8
1.4
13.3
12.8
%
—
9
78
11
93
1.19
0.14
1.7
1.6
—
—
—
0
0
11
128
0.86
0.13
2.4
2.0
—
—
—
0
0
36
335
1.08
0.13
4.1
2.4
30.7
32.6
%
0.49
27
246
21
191
1.10
0.12
3.3
1.5
1.2
1.2
g/l
0.09
21
180
74
768
0.96
0.10
2.9
2.4
6565.6
5883.6
u/l
0.09
29
295
15
135
1.11
0.09
1.3
1.1
173.0
233.4
iu/ml
—
5
53
563
5661
0.97
0.09
4.4
4.0
—
—
—
0
0
59
567
1.04
0.09
1.3
1.3
—
—
—
0
0
19
175
1.09
0.08
1.4
2.0
22.9
43.7
u/ml
1.05
19
168
5
61
0.82
0.08
1.0
1.1
—
—
—
0
0
5
65
0.77
0.08
1.8
2.4
—
—
—
0
0
7
67
1.05
0.08
1.3
1.2
—
—
—
0
0
256
2536
1.01
0.05
2.3
1.9
—
—
—
0
0
38
367
1.04
0.04
1.1
1.2
6.4
2.9
u/ml
0.38
21
197
20
190
1.05
0.04
3.4
1.5
0.2
0.2
g/l
0.05
20
180
32
331
0.97
0.03
1.3
1.2
—
43.3
—
0
13
19
181
1.05
0.03
1.2
1.1
—
—
—
0
0
11
118
0.93
0.03
1.1
1.2
—
29.1
—
0
9
48
472
1.02
0.01
1.5
1.5
—
—
—
0
0
48
472
1.02
0.01
1.5
1.5
—
—
—
0
0
48
472
1.02
0.01
1.5
1.4
—
—
—
0
0
16
154
1.04
0.00
1.6
1.9
3.4
6.1
iu/l
—
5
60
17
166
1.02
0.00
7.5
2.6
0.3
0.2
e6/l
0.47
17
156
20
204
0.98
0.00
1.9
1.6
0.1
0.3
iu/ml
—
5
42
13
133
0.98
0.00
1.2
1.3
—
64.5
—
0
9
27
266
1.02
0.00
1.9
2.0
—
—
—
0
0
48
475
1.01
0.00
1.5
1.4
—
—
—
0
0
52
525
0.99
0.00
1.6
1.5
—
—
—
0
0
11
108
1.02
0.00
1.7
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
0.8
—
0
5
5
51
0.98
0.00
1.2
1.2
—
—
—
0
0
5
50
1.00
0.00
1.2
1.2
—
—
—
0
0
6
66
0.91
0.00
1.3
1.2
—
—
—
0
0
6
67
0.89
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
15.4
—
0
5
6
67
0.89
0.00
1.3
1.2
—
—
—
0
0
6
65
0.92
0.00
1.2
1.5
—
—
—
0
0
5
50
1.00
0.00
1.2
1.2
—
—
—
0
0
9
97
0.93
0.00
1.4
1.3
34.6
44.7
pmol/l
—
9
92
6
66
0.91
0.00
1.3
1.2
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: E4_DISPUB_ALL – Disorders of puberty, all
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).