This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorders of puberty, all
E4_DISPUB_ALL
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
695 |
4. Check minimum number of eventsNone |
695 |
5. Include endpoints |
695 |
6. Filter based on genotype QC (FinnGen only) |
695 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Disorders of puberty, all
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 695 | 453 | 242 |
| Unadjusted period prevalence (%) | 0.14 | 0.15 | 0.11 |
| Median age at first event (years) | 11.93 | 10.36 | 14.85 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 628
- Matched controls
- 6282
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
2119.3
169.8
157
*
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
169.7
155
*
E30.00
ICD-10 Finland
Familial delayed puberty
+∞
162.8
149
*
E22.80
ICD-10 Finland
Central precocious puberty
+∞
98.6
92
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
12.4
94.3
183
201
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
835.0
77.0
74
*
E30.8
ICD-10 Finland
Other disorders of puberty
733.7
68.3
66
*
L02AE02
ATC
leuprorelin; implant, parenteral
36.5
62.3
80
25
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
26.8
60.3
84
36
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
457.9
43.8
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
15.9
30.6
50
34
E34.35
ICD-10 Finland
Abnormal growth retardation
10.4
30.1
60
63
H01AC01
ATC
somatropin; parenteral
8.0
20.5
47
63
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
19.9
19
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
13.3
16.3
28
22
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
8.6
14.9
32
39
121
Kela drug reimbursment
Severe hypofunction of sexual glands
14.9
14.1
23
16
H03AA01
ATC
levothyroxine sodium; systemic
2.7
14.0
106
445
L02AE04
ATC
triptorelin; parenteral
+∞
13.6
13
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
9.4
13.3
27
30
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
13.1
187
1066
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
19.5
13.0
19
10
E23.00
ICD-10 Finland
Panhypopituitarism
24.9
12.5
17
7
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
12.1
75
279
H02AB09
ATC
hydrocortisone; systemic
4.1
11.7
45
115
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
11.6
70
255
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
10.9
208
1309
Z3231
NOMESCO Finland
Registered nurse
1.9
10.8
203
1272
104
Kela drug reimbursment
Thyroid insufficiency
5.2
10.6
32
64
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
6.7
10.6
26
40
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.7
10.5
45
127
G03DB01
ATC
dydrogesterone; oral
3.0
10.5
60
211
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
8.1
10.2
22
28
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.0
10.1
59
211
E27.0
ICD-10 Finland
Other adrenocortical overactivity
10.3
10.1
19
19
N91.0
ICD-10 Finland
Primary amenorrhoea
10.9
9.8
18
17
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
9.8
81
357
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.1
9.6
54
187
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
7.3
9.6
22
31
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
R1260
NOMESCO Finland
Evaluation of communicative skills
7.1
9.4
22
32
E34.45
ICD-10 Finland
Abnormal growth increase
13.9
9.2
15
11
Z3226
NOMESCO Finland
Physiotherapist
2.0
9.1
134
761
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
8.8
163
1004
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.4
8.6
30
71
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.6
8.4
63
262
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
8.2
83
403
602
Kela drug reimbursment
Children's severe malnutrition
3.9
8.2
32
85
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
8.1
110
602
T99
ICPC
Endocr/metab/nutrit disease other
10.2
8.1
15
15
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.2
8.0
29
72
F83
ICD-10 Finland
Mixed specific developmental disorders
3.5
7.5
33
97
E34.30
ICD-10 Finland
Short stature NOS
8.5
7.3
15
18
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.3
106
596
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.3
104
581
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.2
124
739
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.4
7.0
32
98
H47.2
ICD-10 Finland
Optic atrophy
14.0
6.9
11
8
H50.31
ICD-10 Finland
Intermittent exotropia
4.5
6.7
22
50
P05.1
ICD-10 Finland
Small for gestational age
7.9
6.6
14
18
ZXE00
NOMESCO Finland
One hour or less
1.6
6.5
230
1682
L04AA01
ATC
[U] ciclosporin; systemic
6.3
6.5
16
26
P85
ICPC
Mental retardation
7.5
6.4
14
19
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.3
93
524
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
11.2
6.3
11
10
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
6.3
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.3
101
587
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.2
89
497
Z2446
NOMESCO Finland
Social worker
1.9
6.2
87
481
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.1
160
1079
T10
ICPC
Growth delay
8.7
6.1
12
14
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.0
6.0
22
56
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
5.6
6.0
16
29
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: E4_DISPUB_ALL – Disorders of puberty, all
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).