This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorders of puberty, all
E4_DISPUB_ALL
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
707 |
4. Check minimum number of eventsNone |
707 |
5. Include endpoints |
707 |
6. Filter based on genotype QC (FinnGen only) |
657 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Disorders of puberty, all
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 657 | 427 | 230 |
| Unadjusted period prevalence (%) | 0.14 | 0.15 | 0.11 |
| Median age at first event (years) | 12.09 | 10.56 | 14.93 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 707
- Matched controls
- 7070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
2573.1
197.5
182
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
13.5
190.2
207
211
E30.09
ICD-10 Finland
Delayed puberty NOS
2334.2
184.8
171
*
E30.00
ICD-10 Finland
Familial delayed puberty
2313.2
183.7
170
*
L02AE02
ATC
leuprorelin; implant, parenteral
43.6
145.4
88
23
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
26.9
138.8
98
42
E22.80
ICD-10 Finland
Central precocious puberty
1160.9
105.1
100
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
85.2
80
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
291.7
78.2
78
*
E34.35
ICD-10 Finland
Abnormal growth retardation
9.0
54.8
71
87
101
Kela drug reimbursment
Anterior pituitary hypofunction
11.4
48.5
52
49
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
500.1
47.9
47
*
H01AC01
ATC
somatropin; parenteral
7.3
34.8
53
78
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
8.7
29.4
38
46
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
10.8
25.5
28
27
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.0
21
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
7.8
21.4
30
40
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
20.9
20
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
G03FB08
ATC
dydrogesterone and estrogen; systemic
8.6
19.4
25
30
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
18.3
98
379
H03AA01
ATC
levothyroxine sodium; systemic
2.5
17.7
122
535
H02AB09
ATC
hydrocortisone; systemic
3.8
16.8
53
148
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
5.5
14.8
29
55
Z3231
NOMESCO Finland
Registered nurse
2.0
14.6
231
1405
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
14.4
198
1146
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.8
14.3
45
125
E27.0
ICD-10 Finland
Other adrenocortical overactivity
11.2
14.1
26
24
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
14.0
86
355
E23.00
ICD-10 Finland
Panhypopituitarism
30.7
13.9
18
6
N91.0
ICD-10 Finland
Primary amenorrhoea
11.7
13.9
25
22
L02AE04
ATC
triptorelin; parenteral
+∞
13.6
13
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.9
13.6
66
241
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
14.1
13.3
22
16
121
Kela drug reimbursment
Severe hypofunction of sexual glands
9.9
12.8
25
26
G03DB01
ATC
dydrogesterone; oral
2.9
12.7
64
238
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
6.1
12.7
22
37
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
12.5
225
1414
R1260
NOMESCO Finland
Evaluation of communicative skills
5.9
12.3
22
38
XW000
NOMESCO Finland
Bone marrow biopsy
4.6
12.2
29
65
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
12.1
80
342
104
Kela drug reimbursment
Thyroid insufficiency
3.8
11.5
35
95
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.8
11.5
35
95
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
11.5
71
294
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.2
11.4
30
73
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.6
143
814
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
10.5
130
718
602
Kela drug reimbursment
Children's severe malnutrition
3.6
10.1
34
99
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
9.9
96
483
F83
ICD-10 Finland
Mixed specific developmental disorders
3.4
9.8
36
111
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
5.2
9.4
19
37
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
Z2446
NOMESCO Finland
Social worker
2.1
9.3
97
503
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
9.1
129
743
E34.45
ICD-10 Finland
Abnormal growth increase
10.2
9.1
17
17
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
8.9
118
665
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.9
192
1256
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
8.9
59
253
Z2445
NOMESCO Finland
Psychologist
2.1
8.9
85
426
ZY010
NOMESCO Finland
Hospital outpatient
2.1
8.8
82
407
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
8.8
173
1103
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.5
8.7
30
89
C08CA02
ATC
felodipine; oral
4.3
8.7
22
52
T99
ICPC
Endocr/metab/nutrit disease other
10.2
8.6
16
16
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
8.5
114
644
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
8.5
51
208
P85
ICPC
Mental retardation
7.5
8.5
19
26
NK6NA
NOMESCO Finland
Other bone age measurement with X-ray
91.1
8.4
9
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
8.4
51
209
301
Kela drug reimbursment
Growth hormone
6.8
8.4
20
30
BF10A, ,
NOMESCO Finland
+∞
8.3
8
*
ZXE00
NOMESCO Finland
One hour or less
1.6
8.2
249
1772
L04AA01
ATC
[U] ciclosporin
7.7
8.2
18
24
E29.1
ICD-10 Finland
Testicular hypofunction
10.2
8.1
15
15
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.7
8.0
42
160
H47.2
ICD-10 Finland
Optic atrophy
13.2
7.9
13
10
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.9
135
824
ZX120
NOMESCO Finland
Intravenous
2.4
7.8
55
242
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
7.7
103
582
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
7.6
37
136
A50
ICPC
General and Unspecified, Medication/prescr/renewal
3.8
7.4
22
59
R62.0
ICD-10 Finland
Delayed milestone
2.9
7.3
33
116
ZXA00
NOMESCO Finland
Right side
1.9
7.2
89
488
T10
ICPC
Growth delay
8.0
7.1
15
19
127
Kela drug reimbursment
Transplant complication
3.7
7.1
22
61
E34.30
ICD-10 Finland
Short stature NOS
6.4
7.0
17
27
C09CA01
ATC
losartan; oral
2.4
6.9
45
192
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.2
6.8
27
88
205
Kela drug reimbursment
Chronic hypertension
2.6
6.8
38
150
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
6.8
72
375
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
6.7
40
163
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.0
6.7
74
391
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
12.4
6.6
11
9
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.6
106
633
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
6.6
48
215
H50.30
ICD-10 Finland
Intermittent esotropy
3.9
6.6
19
50
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
6.5
68
352
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
6.5
64
324
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.0
6.4
27
91
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
6.4
25
81
U04
ICPC
Incontinence urine
3.6
6.4
20
56
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.9
6.3
18
47
102
Kela drug reimbursment
Diabetes insipidus
26.9
6.2
8
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.3
6.2
23
72
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.0
6.2
63
323
RS220, ,
NOMESCO Finland
3.5
6.2
21
62
RD210, ,
NOMESCO Finland
2.3
6.1
46
209
Z2221
NOMESCO Finland
Medical doctor
1.6
6.1
167
1149
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.1
6.1
54
263
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
5.3
6.0
17
33
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
2.4
6.0
41
178
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
187
418
5.72
82.82
3.5
1.7
5.23
6.86
u/l
1.75
149
299
172
397
5.40
72.83
3.4
1.7
8.28
9.44
iu/l
0.33
140
284
71
92
8.47
52.33
2.7
1.8
0.10
0.15
nmol/l
0.97
60
72
140
391
4.22
45.45
3.5
1.9
7.06
10.78
nmol/l
5.11
131
358
35
45
8.13
25.73
2.0
2.2
4.09
5.56
nmol/l
0.81
35
45
213
1207
2.09
16.78
2.7
2.5
2.38
2.37
mmol/l
0.26
197
1095
119
562
2.34
14.54
3.3
2.2
357.57
376.46
nmol/l
0.53
113
526
530
4233
2.01
14.25
4.9
3.7
14.36
14.40
pmol/l
0.15
496
3842
51
164
3.27
13.02
2.0
1.6
0.33
0.33
nmol/l
0.03
42
138
290
1987
1.78
12.07
10.4
8.0
1.21
1.22
mmol/l
0.86
253
1766
269
1837
1.75
11.10
10.3
8.1
1.22
1.22
mmol/l
0.39
255
1730
59
231
2.70
10.65
1.6
1.4
7.66
3.95
ug/l
1.25
52
219
288
2044
1.69
10.09
3.5
2.8
69.47
67.46
nmol/l
0.63
271
1921
567
4859
1.84
9.50
5.5
4.1
2.05
2.03
mu/l
0.03
542
4571
33
101
3.38
9.14
2.3
1.4
8.71
11.02
u/l
0.37
28
92
94
493
2.05
8.69
1.8
1.5
427.58
328.10
mu/l
1.01
88
435
399
3195
1.57
7.87
7.4
5.5
97.00
89.62
u/l
1.36
377
2992
224
1572
1.62
7.76
6.6
5.8
37.72
38.21
g/l
0.77
211
1463
563
4915
1.71
7.61
13.6
9.1
3.90
3.88
mmol/l
0.64
542
4717
562
4909
1.71
7.52
13.8
9.1
139.55
139.50
mmol/l
0.19
543
4733
155
1005
1.69
7.25
4.2
2.7
5.41
8.28
e6/l
2.41
138
880
606
5442
1.79
6.89
10.1
7.5
27.96
25.87
u/l
0.97
590
5232
197
1375
1.60
6.85
4.3
3.3
0.40
0.21
e6/l
0.82
149
1029
226
1629
1.57
6.85
4.8
3.5
—
—
—
0
0
13
14
9.44
6.81
2.3
2.2
—
—
—
0
0
277
2116
1.51
6.33
1.5
1.6
1.73
2.43
u/ml
0.37
59
460
251
1882
1.52
6.25
1.6
1.6
1.86
1.87
g/l
0.03
127
1061
93
558
1.77
5.68
9.0
6.3
1.54
0.97
mmol/l
0.84
66
403
578
5198
1.61
5.65
16.9
12.0
13.72
13.46
%
0.88
569
5103
251
1914
1.48
5.64
6.2
5.6
9.78
10.94
umol/l
1.44
236
1764
387
3212
1.45
5.57
11.8
9.0
3.85
3.73
e9/l
0.49
339
2752
104
648
1.71
5.56
10.8
10.4
25.29
24.90
mmol/l
0.59
104
648
679
6417
2.47
5.50
18.8
13.6
265.02
263.99
e9/l
0.15
656
6210
679
6419
2.46
5.46
19.1
13.7
40.11
41.18
%
0.81
651
6112
679
6426
2.43
5.32
18.8
13.5
4.60
4.63
e12/l
0.88
654
6206
202
1489
1.50
5.31
4.8
3.3
27.62
100.66
e6/l
0.87
151
1123
679
6432
2.41
5.20
19.0
13.7
134.64
136.01
g/l
1.86
672
6339
324
2633
1.43
5.05
5.8
5.0
6.39
6.14
mmol/l
0.68
297
2338
21
72
2.98
4.91
3.3
3.1
18.19
17.76
%
0.20
15
39
30
125
2.46
4.86
1.3
1.3
—
—
—
0
0
30
125
2.46
4.86
1.3
1.3
—
—
—
0
0
355
2955
1.40
4.72
10.0
7.2
32.30
32.45
%
0.10
344
2818
456
3974
1.42
4.58
3.1
2.5
5.47
5.44
mmol/l
0.23
430
3661
10
15
6.74
4.48
1.2
1.2
69.00
71.93
nmol/24h
—
10
15
128
890
1.54
4.36
2.7
2.3
175.36
287.25
u/l
0.76
122
848
346
2897
1.38
4.30
9.6
7.1
52.89
53.23
%
0.21
334
2767
601
5550
1.55
4.21
13.0
9.3
18.62
21.25
mg/l
1.32
462
3935
27
115
2.40
4.21
2.0
1.6
118.52
196.54
pmol/l
2.37
27
107
171
1271
1.46
4.20
6.0
5.9
1.05
1.08
inr
0.97
63
430
104
700
1.57
4.09
7.0
8.1
1.67
1.35
mmol/l
0.63
94
571
21
81
2.64
4.00
3.1
3.8
—
—
—
0
0
84
542
1.62
3.94
3.9
2.7
25.28
23.58
%
0.39
78
493
43
229
1.93
3.87
3.3
2.5
90.93
91.86
ml/min/173m2
0.04
14
77
452
3991
1.37
3.83
9.3
6.5
109.09
106.57
ml/min/173m2
1.51
342
2886
24
102
2.40
3.78
1.4
1.3
290.54
367.40
ug/g
—
10
46
73
461
1.65
3.73
3.2
4.6
249.62
933.39
ng/l
1.27
56
358
165
1246
1.42
3.68
4.3
4.0
9.48
8.95
mmol/l
0.49
154
1150
407
3550
1.35
3.65
5.1
3.8
8.52
7.40
mm/h
1.33
380
3272
39
206
1.95
3.61
1.6
1.6
—
—
—
0
0
65
403
1.67
3.57
1.8
1.7
—
—
—
0
0
65
407
1.66
3.44
1.9
1.7
—
—
—
0
0
20
82
2.48
3.41
1.2
1.2
—
—
—
0
0
45
256
1.81
3.34
10.1
11.1
0.44
0.43
mmol/l
0.00
33
204
200
1586
1.36
3.30
4.2
3.5
38.99
29.47
u/l
0.82
194
1503
21
91
2.35
3.20
5.8
4.1
5.26
4.83
kpa
2.20
21
91
8
16
5.04
3.05
1.0
1.4
—
—
—
0
0
87
602
1.51
3.03
4.9
4.5
7.28
13.45
mg/mmol
1.26
77
453
382
3353
1.30
3.03
4.3
3.2
37.20
36.52
mmol/mol
0.56
362
3156
167
1306
1.36
2.99
1.6
1.5
91.24
97.22
pmol/l
1.04
83
723
42
246
1.75
2.86
2.3
1.6
—
—
—
0
0
110
808
1.43
2.84
3.1
2.9
0.68
1.02
e6/l
0.92
52
442
73
498
1.52
2.73
2.3
2.1
2.42
2.41
mmol/l
0.96
61
410
85
603
1.47
2.64
3.8
2.6
2.52
2.57
g/l
0.32
79
551
24
120
2.04
2.63
5.1
3.6
3.32
3.59
e9/l
0.26
24
120
99
724
1.43
2.62
1.5
1.4
19.13
18.27
nmol/l
0.27
87
634
154
1216
1.34
2.57
2.5
2.5
53.82
55.45
u/l
0.26
142
1121
91
658
1.44
2.56
3.7
2.6
15.00
14.77
umol/l
0.09
85
618
14
56
2.53
2.54
3.5
2.8
168.33
97.01
u/ml
—
6
17
13
50
2.63
2.54
1.3
1.1
—
—
—
0
0
78
550
1.47
2.50
1.3
1.5
466.64
28511955.35
pmol/l
0.80
70
477
24
123
1.98
2.48
5.3
3.8
50.29
52.99
%
0.44
24
123
7
16
4.41
2.48
10.9
12.4
—
—
—
0
0
66
451
1.51
2.47
3.9
4.1
0.24
0.22
g/l
0.98
66
431
8
21
3.84
2.47
11.0
3.9
15.71
22.49
ug/l
—
8
21
41
250
1.68
2.45
3.6
6.9
3.91
3.04
g/l
2.01
41
241
10
32
3.15
2.44
1.4
1.1
—
—
—
0
0
81
579
1.45
2.43
2.0
1.8
—
—
—
0
0
35
205
1.74
2.42
11.8
10.6
123.94
125.25
g/l
0.12
35
195
93
683
1.42
2.41
3.8
3.3
311.09
2326.81
umol/l
1.34
88
635
21
104
2.05
2.38
1.4
1.2
1.64
5.52
u/ml
1.20
11
52
10
33
3.06
2.36
9.2
9.1
—
—
—
0
0
57
385
1.52
2.26
9.6
8.2
106.23
105.08
mmol/l
0.64
57
385
141
1123
1.32
2.21
3.3
2.3
—
—
—
0
0
12
48
2.53
2.19
3.2
1.4
—
—
—
0
0
20
101
2.01
2.17
1.4
1.2
3.00
4.40
u/ml
—
10
53
10
36
2.80
2.14
4.7
10.1
2.45
2.32
mg/l
—
5
30
17
81
2.13
2.14
1.6
2.5
—
—
—
0
0
78
568
1.42
2.14
2.6
1.9
—
—
—
0
0
22
116
1.93
2.13
4.0
11.8
24.93
23.45
mmol/l
0.94
22
105
104
797
1.36
2.11
3.4
3.0
7.44
3.77
e6/l
0.51
48
432
137
1094
1.31
2.10
2.9
2.9
125.54
105.12
ug/g
0.31
106
858
8
25
3.22
2.10
2.3
1.6
22.14
0.86
nmol/l
—
8
19
77
562
1.42
2.09
1.3
1.2
118.52
149.26
iu/ml
0.31
24
203
10
37
2.73
2.07
3.6
1.5
—
—
—
0
0
377
3399
1.23
2.06
5.6
3.8
15.00
418.33
e6/l
—
6
30
8
27
2.98
1.94
4.3
6.2
—
—
—
0
0
8
27
2.98
1.94
4.3
6.3
—
—
—
0
0
6
16
3.77
1.94
3.8
1.6
—
—
—
0
0
6
17
3.55
1.84
2.5
3.9
—
—
—
0
0
75
559
1.38
1.82
6.0
5.0
4.98
6.94
umol/l
1.02
66
451
36
232
1.58
1.79
1.4
1.3
—
—
—
0
0
44
302
1.49
1.67
3.6
2.2
—
—
—
0
0
8
31
2.60
1.66
2.0
1.8
—
1224630.00
—
0
5
7
25
2.82
1.65
5.1
6.9
—
—
—
0
0
160
1349
1.24
1.58
2.7
2.7
2.69
2.53
mg/l
0.43
132
1172
7
26
2.71
1.58
3.3
5.2
162.71
163.96
ug/l
—
7
26
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
412
3815
1.19
1.51
3.2
2.5
1.22
1.13
mmol/l
1.79
393
3603
9
39
2.32
1.43
1.4
1.2
—
—
—
0
0
114
937
1.26
1.42
1.8
1.6
1.46
1.28
mmol/l
1.39
104
847
14
75
1.88
1.35
1.1
2.1
8.54
8.66
mg/l
0.03
14
69
13
68
1.93
1.34
2.5
2.2
—
—
—
0
0
45
326
1.41
1.34
1.5
1.4
—
—
—
0
0
117
976
1.24
1.29
2.8
2.3
42.37
41.74
ng/l
0.01
53
358
434
4067
1.17
1.28
3.5
2.7
2.73
2.74
mmol/l
0.07
412
3827
249
2233
1.18
1.28
3.3
2.7
—
—
—
0
0
430
4029
1.17
1.27
3.4
2.7
1.43
1.42
mmol/l
0.26
408
3815
108
895
1.24
1.26
1.6
1.6
1.50
1.37
%
1.05
97
821
116
969
1.24
1.26
2.4
3.0
2.41
1.07
mg/l
0.54
77
635
20
124
1.63
1.22
3.0
1.7
—
—
—
0
0
24
157
1.55
1.19
1.4
3.0
471.54
425.86
mg/l
0.16
24
148
433
4071
1.16
1.18
3.5
2.7
4.51
4.50
mmol/l
0.06
412
3864
32
447
0.70
1.16
1.6
1.5
—
—
—
0
0
27
184
1.49
1.12
6.0
3.2
194.27
131.12
ng/l
0.30
22
166
7
31
2.27
1.10
3.7
7.1
—
—
—
0
0
32
227
1.43
1.10
2.1
1.8
90.20
97.19
u/ml
—
5
25
5
21
2.39
1.09
1.8
1.4
0.92
0.94
g/l
—
5
21
29
202
1.45
1.09
4.2
7.8
132.93
130.86
g/l
0.23
29
194
8
41
1.96
1.09
1.0
1.1
111.18
211.82
pmol/l
—
8
41
14
82
1.72
1.05
2.5
1.7
—
—
—
0
0
5
22
2.28
1.03
3.4
1.3
—
23.33
—
0
7
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
13
76
1.72
0.99
2.6
1.7
—
—
—
0
0
19
124
1.55
0.97
2.6
1.7
—
—
—
0
0
17
108
1.59
0.97
1.4
1.1
—
—
—
0
0
27
191
1.43
0.96
1.4
1.1
—
—
—
0
0
38
496
0.75
0.93
1.4
1.6
—
—
—
0
0
6
28
2.15
0.91
4.0
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
86
1.64
0.91
6.7
13.4
0.29
0.35
u/ml
—
9
53
8
43
1.87
0.87
1.4
1.0
—
—
—
0
0
27
196
1.39
0.85
1.4
1.1
—
—
—
0
0
25
179
1.41
0.85
1.2
1.7
—
—
—
0
0
41
319
1.30
0.84
1.8
1.6
—
—
—
0
0
123
1078
1.17
0.84
1.5
1.5
—
—
—
0
0
6
32
1.88
0.82
2.2
3.1
585.83
807.47
u/ml
—
6
32
320
2999
1.12
0.81
3.9
3.0
70.28
55.67
ug/l
0.85
292
2816
73
613
1.21
0.80
3.0
2.9
206.00
1010.24
ng/l
1.89
35
289
6
33
1.82
0.79
1.7
1.3
—
—
—
0
0
40
314
1.29
0.78
1.8
1.6
194.39
199.18
u/ml
0.05
24
164
11
67
1.65
0.75
1.4
2.0
—
—
—
0
0
87
1002
0.85
0.72
1.5
1.5
—
—
—
0
0
11
68
1.63
0.72
3.4
1.4
—
—
—
0
0
7
41
1.71
0.70
1.3
3.3
—
—
—
0
0
7
41
1.71
0.70
1.3
3.3
—
—
—
0
0
45
550
0.81
0.69
1.4
1.3
—
—
—
0
0
14
94
1.50
0.67
2.5
1.7
—
—
—
0
0
13
86
1.52
0.66
1.0
1.4
—
—
—
0
0
5
28
1.79
0.66
1.8
1.4
—
—
—
0
0
20
270
0.73
0.65
1.3
1.6
3.74
3.99
mg/l
0.08
12
177
31
242
1.29
0.65
1.3
1.2
—
—
—
0
0
41
333
1.25
0.64
4.8
4.1
—
—
—
0
0
272
2555
1.10
0.63
4.3
3.1
0.00
0.00
estimate
-0.00
60
517
54
639
0.83
0.62
1.4
1.4
—
—
—
0
0
270
2538
1.10
0.62
4.3
3.0
0.00
0.00
estimate
-0.00
62
524
5
30
1.67
0.61
2.2
2.3
107.80
106.37
mmol/l
—
5
30
8
50
1.61
0.61
1.0
1.6
—
—
—
0
0
12
80
1.51
0.60
2.1
1.8
—
—
—
0
0
12
80
1.51
0.60
2.1
1.8
—
—
—
0
0
51
428
1.21
0.60
1.6
1.6
1018.53
1100.38
nmol/l
0.32
45
331
22
166
1.34
0.59
17.1
12.0
93.88
95.10
%
0.22
22
166
10
64
1.57
0.59
1.0
1.1
—
—
—
0
0
147
1342
1.12
0.58
4.7
3.1
0.00
0.00
estimate
0.80
59
519
14
98
1.44
0.57
1.6
1.3
—
—
—
0
0
22
168
1.32
0.55
17.1
11.9
0.57
0.71
%
1.00
22
168
38
458
0.82
0.54
1.8
1.7
—
—
—
0
0
11
74
1.49
0.53
1.5
3.3
640.18
726.28
e6/l
0.29
11
74
11
74
1.49
0.53
1.8
1.4
60.49
37.75
nmol/l
0.74
11
68
6
39
1.54
0.53
1.2
1.9
—
—
—
0
0
131
1197
1.12
0.51
2.1
2.0
—
—
—
0
0
13
92
1.42
0.51
2.1
1.2
—
—
—
0
0
7
46
1.53
0.48
3.4
1.4
—
—
—
0
0
19
146
1.31
0.47
1.3
3.0
3.97
3.47
mmol/l
1.07
19
137
267
2537
1.08
0.47
6.0
4.2
0.00
0.00
estimate
-0.00
60
533
5
85
0.59
0.45
1.0
1.9
—
—
—
0
0
351
3376
1.08
0.45
4.2
3.3
34.23
28.49
u/l
1.18
336
3239
7
50
1.40
0.45
1.0
1.1
96.57
85.84
%
—
7
50
72
642
1.14
0.43
1.1
1.1
—
—
—
0
0
19
149
1.28
0.42
3.9
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
8
59
1.36
0.41
2.6
2.2
—
—
—
0
0
15
114
1.32
0.41
1.8
1.5
0.30
0.47
ug/l
—
8
38
18
141
1.28
0.40
2.1
2.4
0.70
0.62
nmol/l
0.19
18
120
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
15
115
1.31
0.39
1.8
1.5
—
—
—
0
0
13
98
1.33
0.37
2.0
1.7
—
—
—
0
0
13
98
1.33
0.37
1.5
1.3
—
1.41
—
0
8
13
98
1.33
0.37
2.0
1.7
—
—
—
0
0
11
147
0.74
0.37
2.4
2.0
—
—
—
0
0
40
347
1.16
0.36
1.1
1.2
7.81
7.88
u/ml
0.01
25
248
52
461
1.14
0.36
3.1
2.3
29.60
138.69
u/l
0.52
43
382
12
90
1.34
0.36
1.3
1.1
—
—
—
0
0
17
136
1.26
0.34
1.5
1.7
7.45
7.49
mmol/l
0.02
17
130
6
45
1.34
0.34
1.0
1.1
257.00
306.64
mg/l
—
6
39
34
392
0.86
0.33
1.9
2.0
—
—
—
0
0
25
295
0.84
0.32
1.4
1.4
—
—
—
0
0
127
1191
1.08
0.32
3.8
2.9
1.02
1.02
kg/l
1.86
22
173
7
52
1.35
0.31
1.6
1.2
—
—
—
0
0
7
53
1.32
0.31
1.6
1.2
—
—
—
0
0
69
753
0.91
0.30
1.2
1.2
12.98
17.09
iu/ml
0.62
17
188
151
1430
1.07
0.30
2.5
2.1
—
—
—
0
0
7
56
1.25
0.29
3.0
2.5
33724.43
42823.21
ug/l
—
7
56
7
57
1.23
0.29
3.0
4.4
21.14
25.71
umol/l
—
7
57
35
309
1.14
0.27
1.7
1.4
—
—
—
0
0
8
66
1.21
0.26
1.3
1.0
—
—
—
0
0
8
66
1.21
0.26
1.3
1.1
—
—
—
0
0
26
225
1.16
0.26
1.3
1.3
—
—
—
0
0
11
86
1.28
0.26
2.1
2.0
—
—
—
0
0
44
396
1.12
0.26
1.3
1.3
204.01
253.51
miu/ml
0.42
24
197
5
72
0.69
0.26
1.2
1.6
—
—
—
0
0
26
298
0.87
0.25
1.3
1.2
—
—
—
0
0
570
5766
0.94
0.24
4.4
4.0
—
—
—
0
0
219
2268
0.95
0.24
2.9
2.5
—
—
—
0
0
5
38
1.32
0.23
1.2
1.2
—
—
—
0
0
13
157
0.82
0.22
1.1
1.1
—
—
—
0
0
5
41
1.22
0.22
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
506.87
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
17
145
1.18
0.20
1.2
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
120.62
—
0
14
204
2105
0.96
0.19
2.5
2.3
—
—
—
0
0
66
704
0.93
0.19
1.2
1.2
15.83
7.84
u/ml
0.25
20
250
31
280
1.11
0.18
2.6
3.3
4.43
7.11
umol/l
1.28
22
222
37
338
1.10
0.18
1.1
1.2
2.54
1.19
u/ml
0.65
23
208
7
61
1.15
0.17
1.0
1.4
—
—
—
0
0
20
226
0.88
0.17
1.1
1.1
7.16
5.32
u/ml
0.22
12
136
5
67
0.74
0.17
1.2
1.2
—
—
—
0
0
19
167
1.14
0.17
1.5
1.5
—
—
—
0
0
5
68
0.73
0.17
1.6
1.1
—
—
—
0
0
8
68
1.18
0.16
1.3
1.1
—
—
—
0
0
8
68
1.18
0.16
1.8
1.2
—
—
—
0
0
195
1895
1.04
0.16
4.3
2.9
—
—
—
0
0
11
130
0.84
0.16
2.4
2.0
—
—
—
0
0
9
78
1.16
0.15
7.8
1.4
13.26
12.80
%
—
9
78
22
200
1.10
0.12
3.8
1.6
1.13
1.17
g/l
0.25
22
189
34
317
1.08
0.12
2.1
1.7
—
—
—
0
0
74
771
0.96
0.11
2.9
2.4
6565.57
5864.23
u/l
0.09
29
296
20
182
1.10
0.11
1.2
1.3
—
—
—
0
0
32
342
0.93
0.11
1.3
1.2
—
41.44
—
0
14
35
331
1.06
0.09
4.1
2.4
30.32
32.55
%
0.60
28
250
5
62
0.81
0.08
1.0
1.1
—
—
—
0
0
7
67
1.05
0.08
1.9
1.2
—
—
—
0
0
7
67
1.05
0.08
1.9
1.2
—
—
—
0
0
7
68
1.03
0.08
1.9
1.2
—
—
—
0
0
7
68
1.03
0.08
1.9
1.2
—
—
—
0
0
11
98
1.12
0.07
1.7
1.6
—
—
—
0
0
40
382
1.05
0.07
1.1
1.2
6.28
3.79
u/ml
0.29
25
249
8
78
1.03
0.07
2.8
1.8
0.40
1.58
ug/l
—
8
67
262
2590
1.02
0.07
2.3
1.9
—
—
—
0
0
19
178
1.07
0.05
1.4
2.0
22.95
43.27
u/ml
1.04
19
171
15
139
1.08
0.05
1.3
1.1
173.00
230.10
iu/ml
—
5
54
21
198
1.06
0.05
3.9
1.6
0.21
0.22
g/l
0.17
21
188
20
190
1.05
0.04
1.2
1.1
—
—
—
0
0
59
577
1.02
0.04
1.3
1.3
—
—
—
0
0
19
200
0.95
0.04
1.1
1.1
0.05
0.74
u/ml
—
5
78
34
331
1.03
0.02
1.1
1.1
9.95
2.66
u/ml
1.15
20
219
20
208
0.96
0.02
1.9
1.6
0.10
0.32
iu/ml
—
5
44
48
472
1.02
0.01
1.5
1.4
—
—
—
0
0
48
472
1.02
0.01
1.5
1.5
—
—
—
0
0
48
472
1.02
0.01
1.5
1.5
—
—
—
0
0
21
204
1.03
0.00
1.0
1.1
16.76
8.40
u/ml
—
8
109
17
175
0.97
0.00
7.5
2.6
0.31
0.16
e6/l
0.51
17
165
14
136
1.03
0.00
1.5
1.3
—
64.49
—
0
9
27
266
1.02
0.00
1.9
2.0
—
—
—
0
0
16
157
1.02
0.00
1.6
1.9
3.41
6.15
iu/l
—
5
60
48
475
1.01
0.00
1.5
1.4
—
—
—
0
0
17
167
1.02
0.00
3.9
7.7
0.62
0.66
%
0.19
17
167
52
525
0.99
0.00
1.6
1.5
—
—
—
0
0
11
109
1.01
0.00
1.7
1.5
—
—
—
0
0
12
121
0.99
0.00
1.4
1.3
—
29.13
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
98
0.92
-0.00
1.4
1.3
34.56
44.76
pmol/l
—
9
93
5
50
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
0.80
—
0
5
5
51
0.98
-0.00
1.6
5.4
—
39.33
—
0
6
5
51
0.98
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
15.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.2
—
—
—
0
0
7
70
1.00
-0.00
1.1
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: E4_DISPUB_ALL – Disorders of puberty, all
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).