No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
597 |
4. Check minimum number of eventsNone |
597 |
5. Include endpoints |
633 |
6. Filter based on genotype QC (FinnGen only) |
594 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Perturbationes pubertatis non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders of puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13514 | 6222 | 7284 |
| Only index persons | 12248 | 5115 | 7133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.18 | 0.20 |
| Only index persons | 0.24 | 0.19 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 12.30 | 9.31 | 14.85 |
| Only index persons | 12.72 | 9.74 | 14.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 594 | 373 | 221 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 12.38 | 10.87 | 14.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 633
- Matched controls
- 6330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
24.3
230.6
179
101
E30.1
ICD-10 Finland
Precocious puberty
2674.8
198.8
182
*
E30.09
ICD-10 Finland
Delayed puberty NOS
2417.3
186.0
171
*
E30.00
ICD-10 Finland
Familial delayed puberty
2394.8
184.8
170
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
39.3
150.4
94
28
L02AE02
ATC
leuprorelin; implant, parenteral
36.0
88.2
56
17
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
84.3
79
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
440.0
79.8
78
*
E34.35
ICD-10 Finland
Abnormal growth retardation
171.5
60.1
62
*
E22.80
ICD-10 Finland
Central precocious puberty
457.7
43.8
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
36.8
35
*
H01AC01
ATC
somatropin; parenteral
377.9
36.4
36
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
34.7
33
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
97.5
25.9
28
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
124.5
22.7
24
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.0
21
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
19.9
19
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
7.6
17.5
25
34
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
65.2
16.8
19
*
H03AA01
ATC
levothyroxine sodium; systemic
2.6
15.4
102
440
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
15.3
78
293
121
Kela drug reimbursment
Severe hypofunction of sexual glands
20.7
15.2
22
11
N91.0
ICD-10 Finland
Primary amenorrhoea
17.0
14.9
23
14
301
Kela drug reimbursment
Growth hormone
153.4
14.5
15
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.2
14.2
59
197
104
Kela drug reimbursment
Thyroid insufficiency
4.7
14.2
33
73
G03FB08
ATC
dydrogesterone and estrogen; systemic
16.2
14.0
22
14
Z3231
NOMESCO Finland
Registered nurse
2.0
13.8
202
1201
E34.30
ICD-10 Finland
Short stature NOS
142.9
13.5
14
*
E34.45
ICD-10 Finland
Abnormal growth increase
142.9
13.5
14
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
29.0
13.0
17
6
G03DB01
ATC
dydrogesterone; oral
3.1
12.4
53
180
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.9
12.0
36
97
H02AB09
ATC
hydrocortisone; systemic
3.8
11.9
37
102
602
Kela drug reimbursment
Children's severe malnutrition
4.7
11.5
27
60
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
11.5
11
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
11.4
70
289
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
11.4
11.1
20
18
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
10.9
192
1200
XW000
NOMESCO Finland
Bone marrow biopsy
4.6
10.6
25
56
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
10.4
161
962
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.9
115
622
E29.1
ICD-10 Finland
Testicular hypofunction
17.9
9.4
14
8
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
9.4
9
*
E28.3
ICD-10 Finland
Primary ovarian failure
+∞
9.4
9
*
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
9.4
9
*
Z3226
NOMESCO Finland
Physiotherapist
1.9
9.0
120
680
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.3
8.7
22
52
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.8
8.7
26
70
ZY010
NOMESCO Finland
Hospital outpatient
2.3
8.7
72
341
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
8.6
110
614
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.3
8.6
66
303
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
8.5
56
239
L02AE04
ATC
triptorelin; parenteral
+∞
8.3
8
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.1
8.3
35
118
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
8.3
59
261
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.2
99
541
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
8.2
77
384
Z2445
NOMESCO Finland
Psychologist
2.2
8.2
72
350
Z2446
NOMESCO Finland
Social worker
2.1
8.1
82
420
T10
ICPC
Growth delay
11.9
8.1
14
12
T99
ICPC
Endocr/metab/nutrit disease other
11.9
8.1
14
12
ZX120
NOMESCO Finland
Intravenous
2.6
8.0
48
196
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.0
7.8
22
57
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
7.7
42
164
XA800
NOMESCO Finland
Neuropsychological investigation
2.7
7.5
41
160
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
7.5
42
166
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
6.6
7.5
18
28
E34.31
ICD-10 Finland
Short stature, prenatal disorder
81.0
7.4
8
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.1
7.3
31
105
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.9
7.3
21
55
BF10A, ,
NOMESCO Finland
+∞
7.3
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.7
7.1
22
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.0
163
1084
ZXE00
NOMESCO Finland
One hour or less
1.6
7.0
213
1517
R1260
NOMESCO Finland
Evaluation of communicative skills
5.9
7.0
18
31
R62.0
ICD-10 Finland
Delayed milestone
3.2
6.9
27
87
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.4
6.9
49
217
L04AA01
ATC
[U] ciclosporin
9.5
6.8
13
14
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.7
110
664
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.6
93
534
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
12.4
6.6
11
9
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.6
144
942
205
Kela drug reimbursment
Chronic hypertension
2.8
6.5
32
118
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
6.5
61
304
SPAT1139
SPAT
Nutrition survey
3.6
6.5
21
60
RD210, ,
NOMESCO Finland
2.5
6.5
39
160
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.4
87
495
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.2
6.4
56
272
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.2
6.2
24
77
U04
ICPC
Incontinence urine
3.8
6.1
18
48
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
6.0
95
565
ZXA00
NOMESCO Finland
Right side
1.9
6.0
75
414
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
6.0
59
299
WX702
NOMESCO Finland
Supraglottic ventilation device
2.9
6.0
27
95
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
159
281
7.22
90.92
3.3
1.6
5.01
5.87
u/l
0.70
123
207
152
268
7.15
86.89
3.1
1.6
8.31
9.87
iu/l
0.39
122
196
62
52
13.11
62.60
2.5
1.7
0.11
0.17
nmol/l
0.96
52
41
121
289
4.94
48.44
3.4
1.8
6.91
12.50
nmol/l
8.82
114
266
31
20
16.23
19.45
2.1
3.2
4.47
3.24
nmol/l
0.73
31
20
188
1012
2.22
17.31
2.8
2.3
2.38
2.37
mmol/l
0.29
176
912
464
3648
2.02
13.54
4.6
3.6
14.42
14.40
pmol/l
0.08
434
3303
95
424
2.46
13.23
2.8
2.1
367.59
386.65
nmol/l
0.43
90
396
41
116
3.71
12.75
1.9
1.4
0.32
0.38
nmol/l
0.25
34
96
48
170
2.97
10.46
1.6
1.4
8.60
3.39
ug/l
1.47
41
164
249
1703
1.76
10.37
10.0
7.5
1.21
1.22
mmol/l
0.41
215
1508
251
1744
1.73
9.74
3.3
2.7
69.38
67.31
nmol/l
0.61
236
1634
499
4241
1.83
8.82
5.3
4.0
2.08
2.06
mu/l
0.02
477
3978
227
1578
1.68
8.54
10.1
7.7
1.22
1.22
mmol/l
0.02
214
1482
78
385
2.17
8.50
1.7
1.4
349.92
329.33
mu/l
0.19
73
337
199
1337
1.71
8.49
6.2
5.6
37.83
38.14
g/l
0.37
188
1246
355
2775
1.64
8.34
7.3
5.4
96.36
86.76
u/l
1.89
335
2592
251
1834
1.61
7.54
1.5
1.6
1.82
2.37
u/ml
0.25
54
399
226
1628
1.60
7.11
1.6
1.5
1.88
1.89
g/l
0.02
117
928
10
6
16.91
6.76
2.2
2.5
—
—
—
0
0
540
4819
1.82
6.65
9.7
7.3
27.46
26.15
u/l
0.45
525
4627
497
4352
1.66
6.35
13.0
8.6
3.90
3.88
mmol/l
0.63
478
4168
496
4349
1.65
6.21
13.2
8.6
139.52
139.50
mmol/l
0.06
479
4182
132
858
1.68
6.14
3.8
2.5
5.05
8.12
e6/l
2.30
117
747
519
4613
1.69
6.06
16.3
11.6
13.70
13.44
%
0.83
511
4526
221
1663
1.51
5.41
5.9
5.4
10.15
10.91
umol/l
0.67
208
1527
168
1192
1.56
5.40
4.0
3.2
0.37
0.22
e6/l
0.63
127
881
82
483
1.80
5.38
9.3
5.0
1.66
0.95
mmol/l
1.00
58
347
191
1408
1.51
5.11
4.5
3.3
—
—
—
0
0
339
2799
1.45
5.09
11.0
8.9
3.72
3.75
e9/l
0.09
296
2395
606
5718
2.40
5.00
18.2
13.1
264.86
262.70
e9/l
0.33
586
5528
24
88
2.80
4.99
1.8
1.5
113.58
217.02
pmol/l
3.04
24
83
75
441
1.79
4.95
3.9
2.5
25.23
24.26
%
0.18
69
399
606
5721
2.39
4.94
18.3
13.3
40.16
41.35
%
0.80
578
5433
116
773
1.61
4.83
2.8
2.3
185.82
222.41
u/l
0.37
110
735
606
5727
2.36
4.82
18.2
13.1
4.60
4.64
e12/l
1.02
584
5524
314
2573
1.44
4.81
9.4
7.0
32.54
32.37
%
0.10
304
2447
606
5733
2.34
4.70
18.4
13.2
134.86
136.34
g/l
1.90
599
5647
366
3099
1.43
4.59
5.0
3.7
8.41
7.36
mm/h
1.07
341
2859
307
2523
1.42
4.53
9.1
6.9
52.70
53.36
%
0.43
296
2403
174
1291
1.48
4.43
4.5
3.1
17.93
115.00
e6/l
1.07
130
961
281
2288
1.41
4.30
5.6
4.9
6.42
6.16
mmol/l
0.60
259
2032
27
114
2.43
4.29
5.8
7.3
—
508.00
—
0
14
153
1113
1.49
4.28
6.2
5.5
1.04
1.08
inr
1.03
59
387
26
110
2.42
4.12
1.3
1.3
—
—
—
0
0
26
110
2.42
4.12
1.3
1.3
—
—
—
0
0
84
539
1.64
4.06
11.8
9.9
25.35
24.78
mmol/l
0.83
84
539
536
4935
1.56
3.97
12.6
9.0
18.36
21.57
mg/l
1.75
407
3499
19
71
2.73
3.85
1.2
1.3
—
—
—
0
0
14
44
3.23
3.79
3.5
3.0
168.33
79.02
u/ml
—
6
12
400
3503
1.39
3.76
3.1
2.4
5.47
5.43
mmol/l
0.31
376
3222
147
1090
1.45
3.69
4.1
4.1
9.43
9.09
mmol/l
0.27
138
998
18
67
2.74
3.68
2.7
2.6
18.00
17.89
%
0.04
13
37
21
85
2.52
3.66
1.4
1.3
300.55
363.37
ug/g
—
8
36
77
498
1.62
3.61
3.7
2.4
2.53
2.56
g/l
0.24
71
453
338
2893
1.36
3.60
4.1
3.1
37.21
36.65
mmol/mol
0.40
319
2720
83
548
1.59
3.58
3.7
2.4
15.21
14.97
umol/l
0.09
77
514
402
3548
1.36
3.44
9.1
6.4
109.07
106.90
ml/min/173m2
1.09
307
2549
57
346
1.71
3.41
1.9
1.6
—
—
—
0
0
178
1390
1.39
3.31
4.1
3.3
32.95
29.87
u/l
0.54
173
1315
91
625
1.53
3.31
1.5
1.3
19.28
18.05
nmol/l
0.39
80
547
87
592
1.54
3.30
7.1
7.5
1.69
1.41
mmol/l
0.46
79
476
57
350
1.69
3.28
1.9
1.7
—
—
—
0
0
13
39
3.38
3.24
1.3
1.1
—
—
—
0
0
63
401
1.63
3.17
3.3
4.6
284.66
1030.68
ng/l
1.17
47
311
58
362
1.66
3.14
3.7
3.8
0.23
0.23
g/l
0.33
58
345
149
1139
1.40
3.13
1.7
1.5
90.20
97.42
pmol/l
1.30
77
625
17
69
2.50
2.98
2.4
2.6
—
—
—
0
0
77
525
1.53
2.91
4.9
4.6
7.78
14.34
mg/mmol
1.18
70
403
64
419
1.59
2.88
2.2
2.1
2.43
2.40
mmol/l
1.54
55
345
126
949
1.41
2.87
2.8
2.9
127.23
112.41
ug/g
0.19
98
741
8
18
4.49
2.80
11.0
4.9
15.70
24.07
ug/l
—
8
18
71
483
1.53
2.72
1.3
1.2
123.65
144.12
iu/ml
0.19
23
172
33
183
1.85
2.70
1.5
1.6
—
—
—
0
0
10
29
3.49
2.70
1.3
1.2
—
—
nmol/l
—
0
0
82
578
1.48
2.65
3.6
3.4
314.73
2717.15
umol/l
1.34
77
532
8
20
4.04
2.57
2.3
1.5
22.14
0.82
nmol/l
—
8
14
18
81
2.26
2.56
4.2
3.8
5.31
4.80
kpa
2.37
18
81
37
217
1.75
2.54
2.2
1.6
—
—
—
0
0
137
1068
1.36
2.53
2.5
2.4
54.66
54.81
u/l
0.02
128
984
70
483
1.51
2.52
1.3
1.5
450.31
32458663.87
pmol/l
0.80
62
419
16
70
2.32
2.43
1.4
2.5
—
—
—
0
0
6
12
5.04
2.40
1.0
1.5
—
—
—
0
0
143
1133
1.34
2.37
2.4
2.6
2.78
2.55
mg/l
0.63
116
980
37
223
1.70
2.33
8.7
11.9
-0.10
0.30
mmol/l
0.16
26
179
6
13
4.65
2.27
6.0
11.4
—
—
—
0
0
36
218
1.69
2.24
3.7
6.8
4.02
3.07
g/l
1.90
36
211
71
505
1.46
2.22
2.1
1.8
—
—
—
0
0
11
41
2.71
2.21
3.4
1.5
—
—
—
0
0
68
481
1.46
2.19
5.6
4.5
5.11
7.12
umol/l
0.87
60
382
8
24
3.36
2.18
1.5
1.1
—
—
—
0
0
18
90
2.03
2.02
1.4
1.3
1.67
5.15
u/ml
—
9
48
92
698
1.37
2.01
3.2
2.9
0.57
1.02
e6/l
1.33
42
376
9
32
2.84
2.00
3.9
1.6
—
—
—
0
0
333
2987
1.24
1.98
5.4
3.6
17.00
403.13
e6/l
—
5
23
20
105
1.93
1.97
5.0
3.7
3.48
3.61
e9/l
0.10
20
105
69
501
1.42
1.95
2.7
1.9
—
—
—
0
0
7
22
3.21
1.88
9.9
8.2
—
—
—
0
0
90
690
1.35
1.85
3.4
2.9
6.53
3.85
e6/l
0.30
41
368
49
337
1.49
1.84
8.2
8.3
106.45
105.09
mmol/l
0.66
49
337
20
108
1.88
1.83
5.1
3.9
51.75
53.53
%
0.22
20
108
101
793
1.33
1.78
1.5
1.6
1.45
1.38
%
0.65
91
731
32
201
1.62
1.78
3.7
2.4
88.67
93.96
ml/min/173m2
0.26
12
67
22
125
1.79
1.74
1.2
3.0
490.14
438.05
mg/l
0.16
22
117
29
179
1.65
1.72
9.7
11.4
123.48
125.90
g/l
0.23
29
171
32
205
1.59
1.66
1.3
1.3
—
—
—
0
0
7
25
2.82
1.65
3.3
5.5
162.71
175.44
ug/l
—
7
25
28
176
1.62
1.57
4.4
6.9
133.50
132.88
g/l
0.06
28
169
16
85
1.91
1.56
1.4
1.3
3.14
4.63
u/ml
—
7
48
25
153
1.66
1.55
6.3
2.9
201.50
125.53
ng/l
0.34
20
134
18
100
1.82
1.54
3.9
11.9
24.98
23.46
mmol/l
0.80
18
91
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
5
16
3.14
1.44
5.6
6.0
—
—
—
0
0
5
17
2.96
1.36
4.2
6.3
—
—
—
0
0
5
17
2.96
1.36
4.2
6.5
—
—
—
0
0
25
162
1.57
1.27
1.4
1.1
—
—
—
0
0
8
35
2.30
1.27
1.1
1.2
—
—
—
0
0
286
2604
1.18
1.27
4.0
2.9
66.33
56.22
ug/l
0.55
262
2442
17
101
1.70
1.21
3.0
1.6
—
—
—
0
0
8
38
2.12
1.18
1.4
1.0
—
—
—
0
0
117
987
1.23
1.18
3.5
2.3
—
—
—
0
0
29
200
1.47
1.14
2.1
1.7
90.20
104.05
u/ml
—
5
22
25
167
1.52
1.14
1.4
1.1
—
—
—
0
0
5
21
2.39
1.09
3.4
1.3
—
23.33
—
0
7
67
536
1.28
1.08
3.1
2.9
172.10
1165.34
ng/l
2.13
30
251
11
59
1.88
1.08
2.4
2.4
—
—
—
0
0
103
869
1.22
1.05
2.9
2.3
47.21
44.54
ng/l
0.03
46
328
360
3374
1.16
1.03
3.1
2.4
1.20
1.13
mmol/l
1.26
342
3190
36
265
1.38
1.02
3.7
2.2
—
—
—
0
0
39
292
1.36
1.00
1.6
1.4
—
—
—
0
0
18
115
1.58
1.00
1.3
3.0
3.90
3.50
mmol/l
0.74
18
108
7
36
1.95
0.97
1.0
1.1
83.63
225.55
pmol/l
—
7
36
10
54
1.87
0.97
3.6
1.4
—
—
—
0
0
9
50
1.81
0.97
1.0
1.1
—
—
—
0
0
22
149
1.49
0.96
1.1
1.6
—
—
—
0
0
16
101
1.60
0.94
2.9
1.6
—
—
—
0
0
38
287
1.34
0.94
1.8
1.5
—
—
—
0
0
96
815
1.21
0.93
1.7
1.6
1.43
1.27
mmol/l
1.06
87
734
6
28
2.15
0.91
1.8
1.9
—
1224630.00
—
0
5
13
79
1.66
0.88
1.7
1.3
—
—
—
0
0
380
3602
1.14
0.85
3.3
2.6
2.73
2.74
mmol/l
0.04
358
3390
37
284
1.32
0.84
1.9
1.5
174.58
185.53
u/ml
0.15
23
146
11
65
1.70
0.82
2.9
1.7
—
—
—
0
0
8
47
1.71
0.81
9.8
25.4
2127.38
1245.79
nmol/l
—
8
47
10
58
1.74
0.80
3.1
1.7
—
—
—
0
0
376
3571
1.13
0.79
3.2
2.6
1.44
1.42
mmol/l
0.38
354
3388
29
217
1.35
0.78
1.3
1.2
—
—
—
0
0
379
3606
1.13
0.77
3.3
2.6
4.51
4.49
mmol/l
0.11
358
3427
10
59
1.71
0.76
1.9
1.3
57.90
36.80
nmol/l
—
10
53
5
24
2.09
0.74
3.8
6.6
—
—
—
0
0
5
25
2.01
0.73
4.6
1.5
—
—
—
0
0
10
60
1.68
0.72
1.1
2.1
—
—
—
0
0
10
60
1.68
0.72
3.1
3.4
1.75
1.77
umol/l
—
10
60
5
26
1.93
0.70
2.4
2.9
600.40
800.27
u/ml
—
5
26
31
397
0.77
0.70
1.6
1.5
—
—
—
0
0
96
842
1.17
0.67
2.6
3.0
1.01
1.14
mg/l
0.25
64
552
212
1963
1.12
0.67
3.4
2.7
—
—
—
0
0
5
28
1.79
0.66
1.8
1.3
—
—
—
0
0
5
28
1.79
0.66
2.2
2.4
107.80
106.21
mmol/l
—
5
28
11
70
1.58
0.65
1.4
1.2
—
—
—
0
0
7
44
1.60
0.65
1.0
1.7
—
—
—
0
0
12
79
1.53
0.63
1.6
1.4
—
1.47
—
0
7
10
63
1.60
0.62
2.3
1.6
—
—
—
0
0
10
63
1.60
0.62
2.3
1.6
—
—
—
0
0
41
498
0.81
0.62
1.4
1.3
—
—
—
0
0
8
50
1.61
0.61
2.6
2.1
—
—
—
0
0
17
122
1.40
0.60
4.2
1.8
—
—
—
0
0
65
560
1.18
0.58
1.1
1.1
—
—
—
0
0
6
35
1.72
0.58
1.3
3.3
—
—
—
0
0
6
35
1.72
0.58
3.8
1.5
—
—
—
0
0
6
35
1.72
0.58
1.3
3.3
—
—
—
0
0
8
54
1.49
0.57
1.8
1.3
—
—
—
0
0
45
375
1.22
0.57
1.6
1.6
1061.35
1095.71
nmol/l
0.11
40
289
37
447
0.82
0.54
1.5
1.6
—
—
—
0
0
9
60
1.51
0.54
1.2
2.5
737.00
728.63
e6/l
—
9
60
13
91
1.44
0.53
1.3
1.0
—
—
—
0
0
192
2052
0.91
0.52
2.8
2.5
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
257.00
304.00
mg/l
—
6
35
17
127
1.35
0.50
1.9
2.6
0.73
0.53
nmol/l
0.62
17
104
10
67
1.50
0.50
2.2
1.9
—
—
—
0
0
11
76
1.46
0.48
2.9
1.8
—
—
—
0
0
80
894
0.88
0.48
1.5
1.5
—
—
—
0
0
49
567
0.85
0.47
1.4
1.4
—
—
—
0
0
18
232
0.77
0.46
1.3
1.5
3.93
3.76
mg/l
0.05
11
148
17
129
1.33
0.46
1.5
1.7
7.45
7.46
mmol/l
0.01
17
124
14
103
1.37
0.45
1.9
1.5
0.31
0.46
ug/l
—
7
35
7
50
1.40
0.45
3.0
2.8
33724.43
42670.00
ug/l
—
7
50
179
1907
0.91
0.45
2.5
2.4
—
—
—
0
0
11
78
1.42
0.43
1.0
1.4
—
—
—
0
0
11
78
1.42
0.43
2.2
1.6
—
—
—
0
0
11
78
1.42
0.43
2.2
1.6
—
—
—
0
0
236
2243
1.08
0.42
4.2
3.1
0.00
0.00
estimate
-0.00
56
460
46
398
1.17
0.42
3.2
2.3
29.54
154.57
u/l
0.51
39
332
5
33
1.52
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
102
934
1.11
0.41
1.5
1.5
—
—
—
0
0
9
71
1.27
0.36
7.8
1.4
13.26
12.79
%
—
9
71
126
1175
1.09
0.36
4.5
3.1
0.00
0.00
estimate
0.80
56
462
6
42
1.43
0.35
1.7
1.2
—
—
—
0
0
6
42
1.43
0.35
1.0
1.1
83.17
88.29
%
—
6
42
233
2228
1.07
0.35
4.2
3.0
0.00
0.00
estimate
-0.00
58
469
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
32
274
1.18
0.34
2.2
1.7
—
—
—
0
0
507
5152
0.92
0.34
4.4
4.0
—
—
—
0
0
13
100
1.31
0.33
1.5
1.5
—
—
—
0
0
7
53
1.32
0.31
1.9
1.2
—
—
—
0
0
7
53
1.32
0.31
1.9
1.2
—
—
—
0
0
7
53
1.32
0.31
1.0
1.4
—
—
—
0
0
310
3005
1.06
0.30
3.9
3.1
33.54
28.38
u/l
0.97
298
2880
7
54
1.30
0.30
1.9
1.3
—
—
—
0
0
7
54
1.30
0.30
1.9
1.3
—
—
—
0
0
7
54
1.30
0.30
1.3
1.1
—
—
—
0
0
28
241
1.17
0.29
2.6
3.2
3.89
7.25
umol/l
1.68
19
192
7
56
1.25
0.29
1.3
1.1
—
—
—
0
0
7
57
1.23
0.29
1.3
1.1
—
—
—
0
0
22
259
0.84
0.28
1.4
1.4
—
—
—
0
0
231
2226
1.06
0.27
5.9
4.2
0.00
0.00
estimate
-0.00
56
475
5
71
0.70
0.26
1.0
2.0
—
—
—
0
0
11
138
0.79
0.26
1.1
1.1
—
—
—
0
0
9
72
1.25
0.25
2.4
1.2
—
—
—
0
0
10
127
0.78
0.25
2.4
2.1
—
—
—
0
0
109
1031
1.07
0.23
3.6
2.9
1.02
1.02
kg/l
1.59
21
145
5
41
1.22
0.22
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
3.8
4.3
21.40
25.39
umol/l
—
5
43
17
145
1.18
0.20
1.4
2.1
21.76
47.76
u/ml
1.14
17
140
33
364
0.90
0.19
1.9
2.0
—
—
—
0
0
14
118
1.19
0.19
1.3
1.1
173.00
254.28
iu/ml
—
5
48
114
1089
1.06
0.19
2.1
2.0
—
—
—
0
0
54
502
1.08
0.19
1.3
1.3
—
—
—
0
0
10
81
1.24
0.19
1.8
1.7
—
—
—
0
0
31
280
1.11
0.19
4.1
2.4
30.44
32.88
%
0.66
25
209
7
58
1.21
0.18
1.1
1.6
—
—
—
0
0
16
139
1.15
0.16
1.6
1.9
3.41
5.36
iu/l
—
5
56
18
203
0.88
0.15
1.1
1.1
7.16
5.98
u/ml
0.13
12
124
17
150
1.14
0.14
14.6
12.8
0.52
0.71
%
1.19
17
150
17
150
1.14
0.14
14.6
12.9
96.29
95.29
%
1.38
17
150
16
141
1.14
0.14
1.5
1.6
—
—
—
0
0
15
132
1.14
0.13
1.1
2.2
—
—
—
0
0
38
406
0.93
0.12
1.8
1.7
—
—
—
0
0
170
1659
1.03
0.12
4.1
2.9
—
—
—
0
0
18
162
1.11
0.12
1.2
1.1
—
—
—
0
0
24
261
0.92
0.12
1.3
1.2
—
—
—
0
0
30
279
1.08
0.11
1.7
1.4
—
—
—
0
0
10
114
0.88
0.09
2.4
2.1
—
—
—
0
0
233
2294
1.02
0.09
2.3
1.9
—
—
—
0
0
32
302
1.06
0.08
1.1
1.1
9.18
8.39
u/ml
0.08
20
217
5
61
0.82
0.08
1.2
1.5
—
—
—
0
0
5
60
0.83
0.08
1.2
1.2
—
—
—
0
0
5
62
0.80
0.08
1.6
1.1
—
—
—
0
0
62
642
0.96
0.08
1.2
1.2
13.64
16.79
iu/ml
0.37
15
158
38
362
1.05
0.08
1.3
1.4
217.63
253.52
miu/ml
0.25
21
189
32
337
0.95
0.07
1.2
1.2
7.80
4.04
u/ml
0.38
20
218
20
186
1.08
0.07
1.2
1.3
—
—
—
0
0
59
606
0.97
0.05
1.2
1.2
18.11
7.56
u/ml
0.26
16
216
18
170
1.06
0.04
3.9
1.6
0.20
0.22
g/l
0.36
18
161
28
290
0.96
0.03
1.1
1.1
10.76
2.92
u/ml
0.96
16
193
18
171
1.05
0.03
3.9
1.6
1.09
1.19
g/l
0.69
18
161
12
112
1.07
0.03
1.6
1.3
—
40.73
—
0
6
46
470
0.98
0.02
1.6
1.5
—
—
—
0
0
16
152
1.05
0.02
4.1
7.6
0.62
0.67
%
0.21
16
152
19
182
1.05
0.02
1.1
1.1
16.76
9.22
u/ml
—
8
100
17
163
1.04
0.01
1.2
1.3
—
—
—
0
0
17
177
0.96
0.01
1.1
1.1
0.05
0.45
u/ml
—
5
72
42
427
0.98
0.01
1.5
1.4
—
—
—
0
0
15
145
1.04
0.00
8.3
2.2
0.22
0.16
e6/l
0.20
15
137
29
295
0.98
0.00
1.3
1.2
—
42.74
—
0
13
26
256
1.02
0.00
1.9
2.0
—
—
—
0
0
29
294
0.99
0.00
1.1
1.1
2.78
1.28
u/ml
0.60
19
186
42
424
0.99
0.00
1.5
1.5
—
—
—
0
0
42
424
0.99
0.00
1.5
1.5
—
—
—
0
0
42
424
0.99
0.00
1.5
1.4
—
—
—
0
0
10
102
0.98
0.00
1.7
1.5
—
—
—
0
0
130
1295
1.00
0.00
2.5
2.1
—
—
—
0
0
67
667
1.01
0.00
3.0
2.4
6664.45
5744.56
u/l
0.12
28
252
10
101
0.99
0.00
1.5
1.3
—
36.24
—
0
7
29
291
1.00
0.00
4.6
4.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.5
—
142.84
—
0
8
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
491.09
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
8.60
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
8
82
0.98
-0.00
1.5
1.3
33.38
44.29
pmol/l
—
8
77
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
3.3
1.7
0.47
1.01
ug/l
—
6
55
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_DISPUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.342 [1.77, 3.1] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 5264 females with E4_DISPUB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.384 [1.66, 3.42] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 6399 males with E4_DISPUB died.
Mortality risk
Mortality risk for people of age
years, who have E4_DISPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.451% |
| 5 | 1.399% | 2.825% |
| 10 | 3.368% | 6.764% |
| 15 | 6.23% | 12.543% |
| 20 | 10.628% | 20.128% |
Relationships between endpoints
↥Index endpoint: E4_DISPUB – Disorders of puberty
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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