No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
585 |
4. Check minimum number of eventsNone |
585 |
5. Include endpoints |
621 |
6. Filter based on genotype QC (FinnGen only) |
621 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Perturbationes pubertatis non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders of puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13514 | 6222 | 7284 |
| Only index persons | 12248 | 5115 | 7133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.18 | 0.20 |
| Only index persons | 0.24 | 0.19 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 12.30 | 9.31 | 14.85 |
| Only index persons | 12.72 | 9.74 | 14.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 621 | 394 | 227 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 12.18 | 10.60 | 14.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 560
- Matched controls
- 5601
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
+∞
173.1
157
*
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
170.8
155
*
E30.00
ICD-10 Finland
Familial delayed puberty
2024.3
161.7
149
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
23.8
106.8
157
90
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
79.1
74
*
E30.8
ICD-10 Finland
Other disorders of puberty
731.2
67.4
65
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
36.2
63.0
81
26
E34.35
ICD-10 Finland
Abnormal growth retardation
+∞
55.1
52
*
E22.80
ICD-10 Finland
Central precocious puberty
426.7
40.6
40
*
L02AE02
ATC
leuprorelin; implant, parenteral
34.2
38.6
50
16
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
35.8
34
*
H01AC01
ATC
somatropin; parenteral
330.4
31.1
31
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
30.5
29
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
114.3
20.7
22
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
17.8
17
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
17.8
17
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
43.5
17.4
21
5
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
153.8
14.5
15
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
28.0
14.4
19
7
H03AA01
ATC
levothyroxine sodium; systemic
2.9
13.2
87
338
N91.0
ICD-10 Finland
Primary amenorrhoea
29.1
13.0
17
6
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
12.5
12
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
12.5
12
*
301
Kela drug reimbursment
Growth hormone
+∞
12.5
12
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
12.0
12.4
22
19
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
12.2
10.9
19
16
G03DB01
ATC
dydrogesterone; oral
3.5
10.6
49
148
104
Kela drug reimbursment
Thyroid insufficiency
5.5
10.4
30
57
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
10.3
10.1
19
19
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.4
10.0
36
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
9.8
141
799
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
9.7
60
223
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
9.7
48
154
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
9.4
9
*
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
9.7
9.3
18
19
602
Kela drug reimbursment
Children's severe malnutrition
5.4
8.7
25
48
E29.1
ICD-10 Finland
Testicular hypofunction
28.0
8.5
11
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
91.4
8.4
9
*
R1260
NOMESCO Finland
Evaluation of communicative skills
8.0
8.4
18
23
E28.3
ICD-10 Finland
Primary ovarian failure
+∞
8.4
8
*
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
H02AB09
ATC
hydrocortisone; systemic
4.1
8.3
31
79
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.7
8.2
55
216
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
8.2
61
253
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
22.4
8.0
11
5
RD210
NOMESCO Finland
NA
3.4
7.9
37
115
T10
ICPC
Growth delay
18.7
7.6
11
6
T99
ICPC
Endocr/metab/nutrit disease other
12.1
7.6
13
11
XA800
NOMESCO Finland
Neuropsychological investigation
3.2
7.6
38
124
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
7.5
68
315
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.4
93
495
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
7.3
7
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
7.1
50
204
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.7
7.0
22
48
N91.1
ICD-10 Finland
Secondary amenorrhoea
4.0
6.9
26
68
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.8
83
435
L04AA01
ATC
[U] ciclosporin; systemic
11.1
6.8
12
11
R62.0
ICD-10 Finland
Delayed milestone
4.0
6.8
25
64
F83
ICD-10 Finland
Mixed specific developmental disorders
4.0
6.7
25
65
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.6
133
839
KAC00
NOMESCO Finland
Nephrectomy
70.6
6.4
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
6.2
81
441
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
6.2
100
586
R4110
NOMESCO Finland
Physiotherapy
1.8
6.1
106
639
RK220
NOMESCO Finland
NA
10.2
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
151
280
6.80
82.01
3.3
1.6
5.0
5.9
u/l
0.71
119
206
144
267
6.72
78.00
3.2
1.6
8.3
9.9
iu/l
0.40
118
195
58
54
11.74
54.70
2.6
1.7
0.1
0.2
nmol/l
1.03
50
41
115
284
4.74
44.05
3.5
1.7
6.9
12.6
nmol/l
8.62
102
258
29
19
15.96
33.30
2.1
2.0
4.7
3.5
nmol/l
0.70
29
19
183
994
2.19
16.40
2.6
2.4
2.4
2.4
mmol/l
0.15
170
891
454
3594
1.98
12.62
4.7
3.6
14.4
14.4
pmol/l
0.15
426
3251
41
119
3.62
12.29
1.9
1.4
0.3
0.4
nmol/l
0.24
34
98
91
413
2.41
12.20
2.8
2.1
368.5
389.6
nmol/l
0.49
86
386
243
1635
1.80
10.88
9.6
7.2
1.2
1.2
mmol/l
0.55
209
1434
246
1712
1.72
9.48
3.3
2.6
69.6
67.3
nmol/l
0.68
231
1603
221
1509
1.72
9.03
9.7
7.3
1.2
1.2
mmol/l
0.16
208
1405
46
176
2.74
8.73
1.6
1.4
8.4
3.5
ug/l
1.33
40
169
78
384
2.18
8.57
1.7
1.4
349.9
325.5
mu/l
0.23
73
336
349
2736
1.63
8.06
7.3
5.5
93.6
84.8
u/l
1.76
329
2551
194
1312
1.70
8.04
5.9
5.4
37.9
38.2
g/l
0.42
183
1219
488
4177
1.79
8.01
5.4
4.0
2.1
2.1
mu/l
0.03
468
3917
246
1777
1.64
7.86
1.5
1.6
1.8
2.2
u/ml
0.15
53
389
488
4261
1.68
6.47
12.5
8.5
3.9
3.9
mmol/l
0.53
469
4076
531
4751
1.81
6.37
9.5
7.2
27.5
26.2
u/l
0.46
516
4561
487
4257
1.67
6.35
12.7
8.5
139.5
139.5
mmol/l
0.07
470
4088
76
427
1.89
5.79
9.6
4.8
1.6
1.0
mmol/l
0.75
54
303
9
7
13.02
5.59
2.2
2.3
—
—
—
0
0
219
1638
1.52
5.58
5.4
5.4
10.2
10.6
umol/l
0.36
206
1506
501
4461
1.64
5.51
15.5
11.4
13.2
13.1
%
1.37
493
4368
162
1148
1.56
5.24
3.7
3.1
0.3
0.2
e6/l
0.30
123
842
185
1356
1.52
5.11
4.3
3.3
—
—
—
0
0
24
87
2.83
5.09
1.7
1.5
113.6
212.2
pmol/l
2.86
24
82
115
759
1.63
5.00
2.8
2.3
184.0
217.9
u/l
0.33
109
719
330
2727
1.45
4.90
10.2
8.8
3.7
3.8
e9/l
0.11
291
2342
79
481
1.74
4.64
11.8
9.2
25.4
24.8
mmol/l
0.83
79
481
594
5619
2.31
4.59
17.8
13.1
135.1
136.5
g/l
1.75
587
5534
72
431
1.76
4.48
3.8
2.5
25.3
24.2
%
0.19
66
389
358
3035
1.42
4.44
4.9
3.7
8.4
7.4
mm/h
0.97
334
2801
13
37
3.57
4.07
1.3
1.1
—
—
—
0
0
14
42
3.39
4.06
3.5
3.1
198.6
79.0
u/ml
—
5
12
272
2225
1.40
4.00
5.4
4.7
6.4
6.2
mmol/l
0.68
250
1971
525
4837
1.55
3.83
12.3
9.0
18.2
21.2
mg/l
1.57
399
3439
26
114
2.34
3.83
5.9
7.4
—
494.9
—
0
14
402
3534
1.39
3.70
9.0
6.4
109.1
106.9
ml/min/173m2
1.16
306
2537
18
67
2.74
3.68
2.7
2.7
18.0
17.7
%
0.10
13
37
83
547
1.60
3.61
6.0
7.2
1.7
1.4
mmol/l
0.42
75
438
18
69
2.66
3.50
1.2
1.3
—
—
—
0
0
24
107
2.29
3.43
1.3
1.3
—
—
—
0
0
24
107
2.29
3.43
1.3
1.3
—
—
—
0
0
394
3474
1.37
3.42
3.1
2.4
5.5
5.4
mmol/l
0.31
373
3196
176
1370
1.40
3.36
3.8
3.2
32.9
29.7
u/l
0.56
171
1296
57
348
1.70
3.34
3.7
3.7
0.2
0.2
g/l
0.15
57
332
80
533
1.58
3.33
3.6
2.4
15.3
15.0
umol/l
0.10
74
496
62
389
1.66
3.29
3.4
4.6
282.3
1051.2
ng/l
1.17
46
301
55
335
1.70
3.26
1.9
1.6
—
—
—
0
0
332
2865
1.34
3.25
4.1
3.1
37.2
36.6
mmol/mol
0.44
315
2694
149
1133
1.41
3.24
1.7
1.5
90.2
97.3
pmol/l
1.26
77
626
74
488
1.59
3.22
3.7
2.4
2.5
2.6
g/l
0.14
68
443
10
28
3.61
3.20
1.3
1.3
—
—
nmol/l
—
0
0
55
339
1.68
3.13
1.9
1.7
—
—
—
0
0
11
35
3.18
2.94
1.5
1.2
329.3
339.8
pmol/l
—
6
30
89
626
1.49
2.91
1.6
1.3
19.1
18.0
nmol/l
0.34
78
547
63
415
1.58
2.78
2.2
2.1
2.4
2.4
mmol/l
1.57
54
342
33
182
1.86
2.75
1.5
1.6
—
—
—
0
0
37
212
1.79
2.73
8.7
11.7
-0.1
0.3
mmol/l
0.17
26
168
70
480
1.52
2.59
1.3
1.2
123.6
142.7
iu/ml
0.17
23
174
81
578
1.46
2.48
3.6
3.4
316.6
2731.1
umol/l
1.34
76
529
35
204
1.76
2.46
3.6
6.8
4.0
3.1
g/l
1.81
35
197
136
1065
1.35
2.44
2.5
2.4
54.9
54.3
u/l
0.08
127
980
6
12
5.04
2.40
1.0
1.5
—
—
—
0
0
36
214
1.72
2.38
2.2
1.6
—
—
—
0
0
15
65
2.34
2.33
2.3
2.7
12.7
9.3
%
—
7
57
140
1110
1.34
2.31
2.4
2.5
2.8
2.6
mg/l
0.70
114
959
6
13
4.65
2.27
6.0
11.4
—
—
—
0
0
67
469
1.48
2.27
4.3
4.6
5.1
7.2
umol/l
0.87
59
374
529
4999
1.39
2.27
13.6
10.1
39.6
40.6
%
2.79
446
4258
68
480
1.47
2.21
1.3
1.5
452.5
32692737.0
pmol/l
0.80
60
416
8
24
3.36
2.18
1.5
1.1
—
—
—
0
0
6
14
4.32
2.15
4.5
7.5
14.1
24.1
ug/l
—
6
14
69
494
1.45
2.09
2.0
1.8
—
—
—
0
0
14
62
2.29
2.09
2.6
2.7
—
—
—
0
0
7
20
3.53
2.06
2.1
1.6
24.5
1.2
nmol/l
—
7
15
29
171
1.73
2.00
9.7
11.1
123.5
126.6
g/l
0.31
29
161
20
105
1.93
1.97
5.0
3.7
3.5
3.6
e9/l
0.12
20
105
69
500
1.43
1.97
2.7
1.9
—
—
—
0
0
326
2928
1.24
1.91
5.4
3.7
17.0
403.1
e6/l
—
5
23
22
121
1.85
1.90
1.2
3.0
490.1
447.0
mg/l
0.13
22
113
14
65
2.18
1.89
1.5
2.5
—
—
—
0
0
7
22
3.21
1.88
3.3
4.8
162.7
157.7
ug/l
—
7
22
25
144
1.77
1.88
6.3
2.7
201.5
119.9
ng/l
0.37
20
126
17
86
2.00
1.86
1.5
1.2
1.8
4.7
u/ml
—
8
44
20
108
1.88
1.83
5.1
3.9
51.8
53.6
%
0.22
20
108
32
200
1.63
1.81
3.7
2.4
88.7
93.9
ml/min/173m2
0.25
12
66
87
667
1.35
1.80
2.8
2.7
0.6
1.0
e6/l
1.21
39
358
10
41
2.46
1.76
3.6
1.5
—
—
—
0
0
101
797
1.32
1.73
1.5
1.6
1.4
1.4
%
0.64
91
735
85
654
1.35
1.72
3.0
2.8
7.0
4.1
e6/l
0.30
38
345
32
203
1.61
1.72
1.3
1.3
—
—
—
0
0
8
32
2.52
1.60
4.3
1.6
—
—
—
0
0
7
26
2.71
1.58
1.0
1.0
206.6
118.3
u/l
—
7
17
18
100
1.82
1.54
3.9
11.9
25.0
23.5
mmol/l
0.76
18
90
5
15
3.35
1.52
4.4
1.7
—
—
—
0
0
27
171
1.61
1.48
4.5
4.9
133.4
133.5
g/l
0.01
27
165
25
157
1.62
1.42
1.4
1.1
—
—
—
0
0
15
81
1.87
1.41
1.4
1.2
3.2
4.4
u/ml
—
6
45
115
950
1.26
1.40
3.2
2.3
—
—
—
0
0
5
17
2.96
1.36
5.6
5.9
—
—
—
0
0
6
24
2.51
1.30
11.3
7.9
—
—
—
0
0
5
18
2.79
1.28
4.2
6.3
—
—
—
0
0
5
18
2.79
1.28
4.2
6.5
—
—
—
0
0
41
295
1.42
1.28
8.8
8.6
1.6
1.3
mmol/l
0.91
34
279
25
162
1.57
1.28
1.4
1.1
—
—
—
0
0
8
35
2.30
1.27
1.1
1.2
—
—
—
0
0
282
2570
1.18
1.24
3.9
2.9
61.5
56.2
ug/l
0.29
258
2412
22
140
1.59
1.21
1.1
1.6
—
—
—
0
0
8
38
2.12
1.18
1.4
1.0
—
—
—
0
0
66
523
1.29
1.14
3.2
2.9
177.9
1133.6
ng/l
1.87
29
239
18
111
1.64
1.13
1.3
3.0
3.9
3.5
mmol/l
0.74
18
104
5
21
2.39
1.09
3.4
1.3
—
23.3
—
0
7
103
866
1.23
1.09
2.9
2.3
47.2
44.3
ng/l
0.03
46
323
38
280
1.38
1.06
1.6
1.4
—
—
—
0
0
28
195
1.46
1.06
2.0
1.7
90.2
104.0
u/ml
—
5
22
36
264
1.39
1.04
3.7
2.3
—
—
—
0
0
9
49
1.85
0.99
1.0
1.1
—
—
—
0
0
356
3343
1.15
0.98
3.0
2.4
1.2
1.1
mmol/l
1.19
339
3160
37
278
1.35
0.94
1.8
1.5
—
—
—
0
0
9
52
1.74
0.92
3.9
1.4
—
—
—
0
0
36
274
1.33
0.86
1.8
1.5
180.2
187.7
u/ml
0.10
22
145
15
96
1.58
0.85
3.1
1.7
—
—
—
0
0
6
31
1.94
0.84
1.3
3.5
—
—
—
0
0
6
31
1.94
0.84
1.3
3.5
—
—
—
0
0
12
73
1.66
0.82
1.5
1.7
5.2
6.8
mmol/l
—
6
45
8
47
1.71
0.81
2.6
2.1
—
—
—
0
0
8
47
1.71
0.81
9.8
25.4
2120.5
1369.6
nmol/l
—
8
47
29
217
1.35
0.78
1.3
1.2
—
—
—
0
0
6
34
1.77
0.76
3.8
1.5
—
—
—
0
0
209
1925
1.13
0.73
4.4
4.1
—
—
—
0
0
10
60
1.68
0.72
1.1
2.1
—
—
—
0
0
10
60
1.68
0.72
1.9
1.3
57.9
36.2
nmol/l
—
10
55
9
57
1.59
0.71
3.0
1.8
—
—
—
0
0
95
829
1.17
0.71
2.5
2.9
1.0
1.0
mg/l
0.11
63
539
374
3568
1.12
0.71
3.3
2.6
2.7
2.7
mmol/l
0.08
354
3341
5
26
1.93
0.70
4.6
1.5
—
—
—
0
0
5
26
1.93
0.70
2.4
2.9
600.4
800.3
u/ml
—
5
26
31
396
0.77
0.69
1.6
1.5
—
—
—
0
0
41
503
0.80
0.67
1.4
1.3
—
—
—
0
0
5
28
1.79
0.66
1.8
1.3
—
—
—
0
0
5
28
1.79
0.66
1.8
1.9
—
1224630.0
—
0
5
12
78
1.55
0.66
1.4
1.3
—
—
—
0
0
11
70
1.58
0.65
1.4
1.2
—
—
—
0
0
370
3537
1.11
0.65
3.2
2.6
1.4
1.4
mmol/l
0.36
350
3343
10
62
1.62
0.65
2.8
1.8
—
—
—
0
0
7
44
1.60
0.65
1.0
1.7
—
—
—
0
0
13
87
1.50
0.63
1.3
1.0
—
—
—
0
0
373
3571
1.11
0.63
3.3
2.6
4.5
4.5
mmol/l
0.03
353
3382
91
800
1.16
0.63
1.7
1.6
1.4
1.3
mmol/l
0.88
83
720
14
97
1.45
0.59
3.0
1.6
—
—
—
0
0
45
374
1.22
0.58
1.6
1.6
1061.3
1094.9
nmol/l
0.10
40
288
6
36
1.67
0.57
1.0
1.1
83.2
89.3
%
—
6
36
6
36
1.67
0.57
1.0
1.1
—
—
—
0
0
63
546
1.17
0.53
1.1
1.1
—
—
—
0
0
234
2205
1.10
0.52
4.1
3.1
0.0
0.0
estimate
0.00
56
463
9
132
0.68
0.52
1.1
1.1
—
—
—
0
0
37
444
0.82
0.51
1.5
1.6
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
257.0
304.0
mg/l
—
6
35
46
390
1.19
0.50
3.2
2.3
29.5
157.1
u/l
0.51
39
326
192
2049
0.91
0.50
2.8
2.5
—
—
—
0
0
10
67
1.50
0.50
2.2
1.9
—
—
—
0
0
16
119
1.35
0.48
4.1
1.9
—
—
—
0
0
18
233
0.77
0.48
1.3
1.5
3.9
3.7
mg/l
0.05
11
143
13
94
1.39
0.46
1.5
1.5
—
—
—
0
0
17
129
1.33
0.46
1.5
1.7
7.3
7.1
mmol/l
0.11
11
72
11
77
1.44
0.45
1.0
1.4
—
—
—
0
0
14
103
1.37
0.45
1.9
1.5
0.3
0.5
ug/l
—
7
35
49
564
0.86
0.44
1.4
1.4
—
—
—
0
0
179
1905
0.92
0.44
2.5
2.4
—
—
—
0
0
102
932
1.11
0.42
1.5
1.5
—
—
—
0
0
81
896
0.89
0.42
1.5
1.5
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
126
1165
1.10
0.42
4.5
3.1
0.0
0.0
estimate
0.80
56
462
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
230
2187
1.08
0.41
4.2
3.0
0.0
0.0
estimate
0.00
55
452
11
79
1.40
0.41
1.3
1.3
—
1.4
—
0
8
20
248
0.80
0.40
1.4
1.4
—
—
—
0
0
31
261
1.20
0.39
2.3
1.7
—
—
—
0
0
309
2980
1.07
0.37
3.9
3.1
33.3
28.4
u/l
0.89
297
2856
10
72
1.40
0.37
2.8
1.8
—
—
—
0
0
9
71
1.27
0.36
7.8
1.4
13.3
12.8
%
—
9
71
229
2188
1.07
0.36
5.8
4.2
0.0
0.0
estimate
0.00
56
476
6
42
1.43
0.35
1.7
1.2
—
—
—
0
0
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
7
52
1.35
0.31
1.3
1.2
—
—
—
0
0
7
52
1.35
0.31
1.3
1.1
—
—
—
0
0
7
52
1.35
0.31
1.0
1.4
—
—
—
0
0
28
240
1.17
0.30
2.6
3.1
3.9
6.4
umol/l
1.48
19
190
7
54
1.30
0.30
1.3
1.1
—
—
—
0
0
109
1019
1.08
0.30
3.6
2.9
1.0
1.0
kg/l
1.48
21
138
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
17
139
1.23
0.29
14.6
12.6
96.3
95.0
%
1.77
17
139
17
139
1.23
0.29
14.6
12.6
0.5
0.7
%
1.13
17
139
15
122
1.24
0.27
1.9
2.5
0.8
0.6
nmol/l
0.72
15
99
17
141
1.21
0.26
1.4
1.8
21.8
48.3
u/ml
1.13
17
136
5
71
0.70
0.26
1.0
2.0
—
—
—
0
0
10
127
0.78
0.25
2.4
2.1
—
—
—
0
0
14
114
1.23
0.25
1.3
1.1
173.0
225.0
iu/ml
—
5
46
32
284
1.13
0.24
4.0
2.4
30.8
32.9
%
0.54
24
205
5
40
1.25
0.22
3.8
3.7
21.4
25.3
umol/l
—
5
40
499
5049
0.94
0.22
4.4
4.0
—
—
—
0
0
10
79
1.27
0.22
1.8
1.6
—
—
—
0
0
5
41
1.22
0.22
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
54
499
1.09
0.21
1.3
1.3
—
—
—
0
0
17
198
0.85
0.21
1.1
1.1
7.7
6.8
u/ml
0.09
11
98
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
6
52
1.16
0.19
1.2
1.6
—
—
—
0
0
6
52
1.16
0.19
1.3
1.2
—
—
—
0
0
6
52
1.16
0.19
1.3
1.2
—
—
—
0
0
16
137
1.17
0.19
1.6
2.0
3.4
5.4
iu/l
—
5
56
170
1643
1.05
0.18
4.1
2.9
—
—
—
0
0
22
248
0.88
0.18
1.2
1.2
—
—
—
0
0
114
1091
1.06
0.18
2.1
2.0
—
—
—
0
0
33
362
0.91
0.18
1.9
2.0
—
—
—
0
0
8
68
1.18
0.16
2.4
1.2
—
—
—
0
0
15
130
1.16
0.15
1.1
2.0
—
—
—
0
0
16
140
1.15
0.15
1.5
1.6
—
—
—
0
0
38
405
0.93
0.12
1.8
1.7
—
—
—
0
0
30
322
0.93
0.11
1.1
1.2
8.4
3.0
u/ml
0.45
16
169
61
638
0.95
0.11
1.2
1.2
13.6
17.0
iu/ml
0.40
15
155
30
280
1.08
0.10
1.7
1.4
—
—
—
0
0
38
361
1.06
0.08
1.3
1.4
217.6
253.7
miu/ml
0.25
21
187
10
113
0.88
0.08
2.4
2.1
—
—
—
0
0
5
60
0.83
0.08
1.6
1.1
—
—
—
0
0
17
156
1.09
0.08
1.2
1.3
—
—
—
0
0
58
601
0.96
0.08
1.2
1.2
18.1
7.6
u/ml
0.26
16
214
20
186
1.08
0.07
1.2
1.3
—
—
—
0
0
15
138
1.09
0.06
8.3
2.3
0.2
0.2
e6/l
0.18
15
130
9
100
0.90
0.06
1.1
1.3
—
31.8
—
0
8
17
158
1.08
0.06
1.2
1.1
—
—
—
0
0
226
2238
1.02
0.05
2.2
1.9
—
—
—
0
0
17
160
1.06
0.04
3.3
1.6
0.2
0.2
g/l
0.24
17
151
17
161
1.06
0.03
3.3
1.6
1.1
1.2
g/l
0.44
17
151
46
469
0.98
0.02
1.6
1.5
—
—
—
0
0
26
255
1.02
0.00
1.9
2.0
—
—
—
0
0
29
285
1.02
0.00
1.3
1.2
—
46.1
—
0
11
42
425
0.99
0.00
1.5
1.4
—
—
—
0
0
10
102
0.98
0.00
1.7
1.5
—
—
—
0
0
67
666
1.01
0.00
3.0
2.4
6664.5
5789.1
u/l
0.11
28
251
130
1296
1.00
0.00
2.5
2.2
—
—
—
0
0
29
288
1.01
0.00
4.6
4.0
—
—
—
0
0
42
422
0.99
0.00
1.5
1.4
—
—
—
0
0
42
422
0.99
0.00
1.5
1.5
—
—
—
0
0
42
422
0.99
0.00
1.5
1.5
—
—
—
0
0
11
111
0.99
0.00
1.3
1.3
—
35.1
—
0
7
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
491.1
—
0
8
5
56
0.89
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.5
—
142.8
—
0
8
0
5
0.00
0.00
0.0
1.0
—
8.6
—
0
5
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
5
58
0.86
0.00
1.8
2.5
—
—
—
0
0
8
81
0.99
0.00
1.5
1.3
33.4
44.5
pmol/l
—
8
76
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_DISPUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.342 [1.77, 3.1] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 5264 females with E4_DISPUB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.384 [1.66, 3.42] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 6399 males with E4_DISPUB died.
Mortality risk
Mortality risk for people of age
years, who have E4_DISPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.451% |
| 5 | 1.399% | 2.825% |
| 10 | 3.368% | 6.764% |
| 15 | 6.23% | 12.543% |
| 20 | 10.628% | 20.128% |
Relationships between endpoints
↥Index endpoint: E4_DISPUB – Disorders of puberty
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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