No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
177 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E30
- Name in latin
- Pubertas praecox
Similar endpoints
↥List of similar endpoints to
Precocious puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3614 | 2856 | 755 |
| Only index persons | 3025 | 2327 | 698 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.48 | 8.97 | 11.38 |
| Only index persons | 9.57 | 9.01 | 11.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 177 | 148 | 29 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 9.62 | 9.03 | 12.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
+∞
243.1
180
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
17.3
52.0
47
35
L02AE02
ATC
leuprorelin; implant, parenteral
80.1
40.0
44
7
E22.80
ICD-10 Finland
Central precocious puberty
412.6
35.1
34
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.3
21
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
20.1
19
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
184.9
16.8
17
*
E34.45
ICD-10 Finland
Abnormal growth increase
93.9
8.5
9
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
8.4
8
*
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
20.9
7.2
10
5
Z3231
NOMESCO Finland
Registered nurse
2.3
7.0
72
392
XLA10, ,
NOMESCO Finland
72.1
6.5
7
*
H01AC01
ATC
somatropin; parenteral
+∞
6.3
6
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
92
5.53
19.02
3.4
1.7
7.26
9.36
iu/l
0.37
33
62
45
111
4.95
17.72
3.4
1.6
4.91
6.88
u/l
1.63
33
78
13
11
12.55
7.69
2.0
3.5
5.55
2.95
nmol/l
0.78
13
11
82
548
1.85
4.17
12.0
7.8
1.21
1.22
mmol/l
0.54
74
492
79
552
1.72
3.29
3.7
2.7
75.15
66.68
nmol/l
1.56
74
507
161
1375
1.91
3.19
11.8
7.9
139.25
139.42
mmol/l
0.38
154
1317
160
1370
1.87
3.06
11.7
7.9
3.86
3.86
mmol/l
0.04
153
1305
18
79
2.41
2.77
1.7
1.5
—
—
—
0
0
14
55
2.66
2.68
2.6
1.6
—
—
—
0
0
8
20
4.12
2.59
1.0
1.1
—
—
—
0
0
10
31
3.34
2.55
1.3
1.1
—
—
—
0
0
10
31
3.34
2.55
1.3
1.1
—
—
—
0
0
18
83
2.29
2.50
10.9
7.1
62.83
47.87
ng/l
0.85
18
78
70
504
1.60
2.47
6.0
4.5
8.44
10.97
umol/l
1.81
65
454
30
171
1.89
2.42
10.6
4.8
0.70
1.01
mmol/l
0.26
19
121
34
202
1.82
2.41
12.2
7.8
24.79
24.88
mmol/l
0.06
34
202
30
172
1.88
2.38
10.8
4.9
5.10
5.02
kpa
0.29
30
164
11
40
2.85
2.31
1.7
1.1
—
—
—
0
0
62
442
1.59
2.25
5.6
3.4
—
—
—
0
0
11
41
2.78
2.24
1.7
1.1
—
—
—
0
0
32
192
1.80
2.20
13.7
8.9
1.24
1.24
mmol/l
0.01
32
185
48
323
1.64
2.20
4.6
2.2
—
—
—
0
0
26
147
1.88
2.15
3.1
2.2
413.19
403.75
nmol/l
0.08
26
137
17
84
2.12
2.02
6.6
10.7
106.18
106.17
mmol/l
0.00
17
84
47
322
1.60
2.00
3.8
4.3
1.03
1.05
inr
0.14
17
113
105
856
1.48
2.00
8.0
4.6
94.65
86.91
u/l
0.45
97
797
14
64
2.28
1.99
2.2
1.6
—
—
—
0
0
5
11
4.63
1.95
1.0
1.1
23.00
166.64
pmol/l
—
5
11
26
154
1.79
1.87
5.7
4.3
6.33
7.30
umol/l
0.12
20
116
53
383
1.52
1.78
4.5
3.0
0.61
0.25
e6/l
0.55
42
275
7
24
2.98
1.74
1.1
1.2
—
—
—
0
0
17
90
1.97
1.71
1.5
1.7
189.20
184.20
u/ml
—
10
45
19
105
1.90
1.70
1.2
1.5
—
—
—
0
0
25
151
1.75
1.70
1.6
1.7
—
—
—
0
0
124
1069
1.43
1.62
8.0
5.7
111.56
109.93
ml/min/173m2
0.30
95
738
17
93
1.91
1.57
1.5
1.6
—
—
—
0
0
154
1387
1.50
1.55
5.0
4.2
2.41
1.76
mu/l
0.75
145
1307
109
924
1.40
1.53
10.2
7.3
4.09
3.82
e9/l
0.60
98
784
12
58
2.14
1.52
1.8
1.6
—
—
—
0
0
127
1106
1.41
1.52
3.3
2.3
5.47
5.39
mmol/l
0.29
119
997
6
22
2.78
1.44
1.0
1.8
—
—
—
0
0
169
1560
1.57
1.43
12.5
8.5
19.35
21.71
mg/l
0.42
125
1109
115
991
1.38
1.43
5.1
3.6
7.45
7.32
mm/h
0.08
110
920
15
82
1.90
1.40
2.5
6.2
4.31
3.11
g/l
0.98
15
76
138
1231
1.40
1.35
4.7
3.6
14.21
14.36
pmol/l
0.37
129
1116
23
146
1.65
1.33
10.8
4.5
10.10
9.84
kpa
0.33
23
139
26
174
1.57
1.23
1.4
1.3
27.71
148.34
iu/ml
—
8
60
163
1507
1.46
1.22
10.0
6.7
27.67
23.51
u/l
0.83
157
1443
11
57
1.98
1.19
2.0
1.9
—
—
—
0
0
26
176
1.55
1.18
9.2
6.4
23.84
23.45
mmol/l
0.34
26
176
15
89
1.74
1.11
2.4
6.6
102.53
92.44
%
1.40
15
89
5
21
2.42
1.09
1.2
1.2
—
—
—
0
0
18
114
1.64
1.07
1.4
1.5
—
—
—
0
0
99
859
1.31
1.06
4.0
2.8
36.40
35.90
mmol/mol
0.16
94
812
17
107
1.64
1.03
1.2
1.5
—
—
—
0
0
17
108
1.63
1.00
3.4
2.7
5.34
4.88
pmol/l
1.28
17
96
5
103
0.47
0.92
1.2
1.2
0.99
4.93
u/ml
—
5
65
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
35
275
1.33
0.75
2.2
3.0
0.79
1.40
mg/l
0.78
24
179
5
24
2.11
0.75
2.6
2.2
—
—
—
0
0
5
25
2.03
0.73
2.0
1.4
—
—
—
0
0
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
7
40
1.78
0.72
2.1
2.0
—
—
—
0
0
75
654
1.24
0.71
1.5
1.7
3.89
3.12
u/ml
0.10
15
137
7
41
1.73
0.70
1.9
3.0
0.81
0.44
nmol/l
—
7
35
29
224
1.35
0.70
4.8
2.6
3.39
3.66
e6/l
0.07
15
106
48
399
1.27
0.69
3.0
3.0
0.00
0.01
estimate
0.50
20
161
30
234
1.33
0.68
1.7
2.2
25.68
11.20
ng/l
0.43
11
59
7
43
1.65
0.67
1.0
1.5
—
—
—
0
0
76
668
1.22
0.66
4.4
2.8
—
—
—
0
0
23
174
1.36
0.63
1.5
1.2
—
—
—
0
0
10
151
0.64
0.62
1.2
1.2
—
—
—
0
0
18
132
1.40
0.59
1.2
1.3
208.54
488.85
u/ml
0.67
18
123
6
35
1.74
0.58
3.5
3.6
50.67
51.83
%
—
6
35
6
37
1.64
0.56
1.0
1.0
—
—
—
0
0
14
190
0.72
0.52
1.2
1.6
—
—
—
0
0
33
274
1.25
0.49
3.0
2.5
5683.90
4898.21
u/l
0.08
17
114
83
755
1.17
0.48
3.6
3.0
0.00
0.00
estimate
-0.00
21
161
27
222
1.25
0.44
3.6
1.9
—
—
—
0
0
82
750
1.16
0.43
3.7
2.9
0.00
0.00
estimate
-0.00
20
165
5
31
1.63
0.43
1.4
5.1
3.60
9.55
u/ml
—
5
31
41
354
1.20
0.43
1.5
1.5
—
—
—
0
0
41
354
1.20
0.43
1.7
1.4
92.44
96.39
pmol/l
0.27
23
191
185
1808
1.35
0.43
18.3
12.7
278.39
267.56
e9/l
1.33
177
1749
12
88
1.39
0.41
1.8
1.4
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
5
35
1.44
0.39
1.4
3.3
200.40
222.47
e6/l
—
5
30
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
24
198
1.24
0.38
1.1
1.1
—
—
—
0
0
5
36
1.40
0.38
1.2
3.2
4.42
3.43
mmol/l
—
5
36
5
36
1.40
0.38
1.0
1.8
6.46
6.48
mmol/l
—
5
36
81
747
1.14
0.37
5.5
4.2
0.00
0.00
estimate
-0.00
20
163
185
1812
1.32
0.37
18.0
12.8
39.85
39.77
%
0.10
177
1736
161
1659
0.84
0.37
4.8
4.2
—
—
—
0
0
27
227
1.22
0.37
4.2
2.7
0.45
1.01
e6/l
0.81
14
110
185
1813
1.31
0.36
18.2
12.6
4.53
4.55
e12/l
0.23
176
1752
47
421
1.15
0.33
3.1
2.6
2.55
2.44
mg/l
0.17
38
362
7
52
1.36
0.31
1.4
1.1
—
—
—
0
0
12
151
0.78
0.29
1.5
1.5
—
—
—
0
0
86
807
1.12
0.29
2.3
2.1
—
—
—
0
0
56
514
1.12
0.27
2.0
2.1
—
—
—
0
0
47
427
1.13
0.27
1.7
1.9
—
—
—
0
0
20
169
1.20
0.27
1.9
2.3
218.00
693.50
ng/l
—
6
68
21
244
0.84
0.26
1.3
1.4
—
—
—
0
0
60
557
1.11
0.24
3.0
2.8
—
—
—
0
0
5
38
1.32
0.23
3.4
2.2
—
—
—
0
0
5
38
1.32
0.23
3.6
2.1
—
—
—
0
0
5
39
1.29
0.23
1.2
3.4
751.80
334.28
mg/l
—
5
39
10
79
1.28
0.22
3.2
1.7
—
—
—
0
0
5
40
1.26
0.22
1.8
1.5
—
—
—
0
0
33
365
0.88
0.22
1.5
1.5
—
—
—
0
0
20
173
1.17
0.22
1.6
1.4
—
—
—
0
0
20
173
1.17
0.22
1.6
1.4
—
—
—
0
0
20
173
1.17
0.22
1.6
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
164.69
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
20
174
1.17
0.20
1.6
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
94
904
1.08
0.17
4.7
3.0
29.22
25.36
u/l
0.55
89
868
7
85
0.82
0.15
2.0
2.7
—
—
—
0
0
63
659
0.94
0.13
2.3
2.4
—
—
—
0
0
9
110
0.81
0.13
1.4
1.5
765.22
991.87
nmol/l
—
9
86
15
169
0.88
0.13
1.7
1.7
—
—
—
0
0
5
47
1.07
0.09
1.2
1.7
—
—
—
0
0
69
709
0.96
0.07
2.7
2.6
—
—
—
0
0
22
206
1.08
0.07
1.1
1.2
11.29
13.58
iu/ml
—
7
44
9
84
1.07
0.07
1.6
2.1
—
—
—
0
0
105
1066
0.97
0.05
3.3
2.3
1.34
1.45
mmol/l
2.14
100
1011
10
110
0.90
0.05
1.4
4.1
653.20
600.02
ng/l
—
5
86
21
199
1.06
0.04
1.7
1.5
—
—
—
0
0
11
101
1.09
0.04
3.0
3.1
3.23
7.27
umol/l
—
6
81
94
927
1.03
0.04
5.4
2.8
48.35
48.34
ug/l
0.00
83
864
19
191
0.99
0.00
1.1
1.2
1.14
6.61
u/ml
—
8
71
10
105
0.95
0.00
2.2
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.3
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.06
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
2.72
—
0
6
8
88
0.91
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
824.67
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PREPUB and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PREPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PREPUB – Precocious puberty
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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