No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
196 |
4. Check minimum number of eventsNone |
196 |
5. Include endpointsNone |
196 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E30
- Name in latin
- Pubertas praecox
Similar endpoints
↥List of similar endpoints to
Precocious puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3614 | 2856 | 755 |
| Only index persons | 3025 | 2327 | 698 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.48 | 8.97 | 11.38 |
| Only index persons | 9.57 | 9.01 | 11.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | 164 | 32 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 9.50 | 8.95 | 12.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 172
- Matched controls
- 1720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
+∞
208.3
155
*
L02AE02
ATC
leuprorelin; implant, parenteral
86.0
36.8
40
6
E22.80
ICD-10 Finland
Central precocious puberty
377.9
32.0
31
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
24.5
30.2
43
23
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
20.2
19
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
19.1
18
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
64.1
10.8
12
*
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
E34.45
ICD-10 Finland
Abnormal growth increase
83.5
7.5
8
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
7.3
7
*
P05.1
ICD-10 Finland
Small for gestational age
18.9
6.3
9
5
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
6.3
6
*
H01AC01
ATC
somatropin; parenteral
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
90
5.50
18.51
3.3
1.7
7.0
9.4
iu/l
0.43
32
62
44
109
4.92
17.23
3.4
1.6
4.6
6.9
u/l
2.11
32
78
13
8
17.28
8.68
2.0
1.4
5.6
3.9
nmol/l
—
13
8
81
540
1.85
4.16
12.0
7.8
1.2
1.2
mmol/l
0.68
73
481
55
323
1.98
4.14
3.2
2.1
2.4
2.4
mmol/l
0.05
50
290
79
551
1.73
3.33
3.7
2.6
75.1
66.8
nmol/l
1.52
74
506
159
1364
1.88
3.01
11.9
7.9
139.3
139.4
mmol/l
0.28
152
1305
158
1359
1.84
2.88
11.7
7.9
3.9
3.9
mmol/l
0.11
151
1293
18
79
2.41
2.77
1.7
1.5
—
—
—
0
0
14
55
2.66
2.68
2.6
1.7
—
—
—
0
0
8
20
4.12
2.59
1.0
1.1
—
—
—
0
0
70
501
1.62
2.55
6.0
4.5
8.4
9.9
umol/l
1.28
65
451
11
39
2.93
2.52
1.7
1.1
—
—
—
0
0
18
83
2.29
2.50
10.9
6.8
62.8
48.8
ng/l
0.77
18
78
29
163
1.91
2.44
10.6
4.5
0.6
1.1
mmol/l
0.38
18
116
11
40
2.85
2.41
1.7
1.1
—
—
—
0
0
29
164
1.90
2.39
10.8
4.5
5.1
5.1
kpa
0.05
29
155
33
195
1.83
2.38
12.5
7.3
24.8
24.9
mmol/l
0.01
33
195
48
318
1.67
2.34
4.6
2.3
—
—
—
0
0
61
433
1.59
2.26
5.7
3.3
—
—
—
0
0
31
184
1.81
2.21
14.0
9.4
1.2
1.2
mmol/l
0.16
31
178
9
30
3.09
2.17
1.3
1.1
—
—
—
0
0
9
30
3.09
2.17
1.3
1.1
—
—
—
0
0
17
82
2.18
2.14
6.6
9.5
106.1
106.2
mmol/l
0.02
17
82
25
143
1.86
2.00
3.2
2.2
416.9
404.8
nmol/l
0.11
25
133
5
11
4.63
1.95
1.0
1.1
23.0
166.6
pmol/l
—
5
11
14
65
2.24
1.93
2.2
1.6
—
—
—
0
0
104
851
1.47
1.93
8.0
4.6
93.0
85.8
u/l
0.42
96
791
26
154
1.79
1.87
5.7
4.4
6.3
7.3
umol/l
0.12
20
116
17
89
2.00
1.76
1.5
1.7
189.2
183.9
u/ml
—
10
46
52
376
1.52
1.74
4.6
2.8
0.3
0.3
e6/l
0.18
41
268
7
24
2.99
1.74
1.1
1.2
—
—
—
0
0
124
1063
1.45
1.72
8.0
5.7
111.5
109.9
ml/min/173m2
0.29
95
733
25
151
1.75
1.70
1.6
1.7
—
—
—
0
0
19
105
1.90
1.70
1.2
1.6
—
—
—
0
0
115
979
1.42
1.62
5.1
3.6
7.5
7.4
mm/h
0.03
110
909
17
92
1.93
1.62
1.5
1.6
—
—
—
0
0
108
911
1.41
1.59
10.3
7.6
4.1
3.8
e9/l
0.48
97
771
12
57
2.18
1.58
1.8
1.6
—
—
—
0
0
126
1102
1.40
1.44
3.3
2.3
5.5
5.4
mmol/l
0.28
119
993
15
81
1.92
1.44
1.6
1.4
2.4
3.1
ug/l
0.64
15
76
6
22
2.78
1.44
1.0
1.7
—
—
—
0
0
152
1376
1.47
1.42
5.1
4.2
2.4
1.8
mu/l
0.77
144
1296
15
83
1.87
1.35
2.5
5.7
4.3
3.1
g/l
0.98
15
77
167
1547
1.54
1.32
12.5
8.6
19.3
21.6
mg/l
0.40
123
1104
22
139
1.66
1.30
10.8
4.0
10.3
9.8
kpa
0.78
22
131
162
1497
1.47
1.24
10.0
6.7
27.6
23.5
u/l
0.83
156
1434
136
1220
1.37
1.24
4.8
3.7
14.2
14.3
pmol/l
0.26
128
1106
26
174
1.57
1.23
1.4
1.3
27.7
148.3
iu/ml
—
8
60
11
57
1.99
1.19
2.0
1.9
—
—
—
0
0
5
22
2.30
1.04
1.2
1.2
—
—
—
0
0
17
107
1.64
1.03
1.2
1.6
—
—
—
0
0
17
108
1.63
1.00
3.4
2.7
5.3
4.9
pmol/l
1.28
17
96
17
112
1.57
0.88
1.4
1.5
—
—
—
0
0
29
217
1.39
0.83
4.8
2.4
3.4
3.9
e6/l
0.14
15
102
75
646
1.26
0.81
1.5
1.7
3.9
3.1
u/ml
0.10
15
137
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
5
100
0.49
0.79
1.2
1.2
1.0
2.1
u/ml
—
5
49
35
275
1.33
0.75
2.2
2.8
0.8
1.4
mg/l
0.77
24
180
7
39
1.82
0.73
1.9
3.2
0.8
0.5
nmol/l
—
7
33
5
25
2.03
0.73
2.0
1.4
—
—
—
0
0
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
7
40
1.78
0.72
2.1
2.0
—
—
—
0
0
48
397
1.28
0.72
3.0
3.0
0.0
0.0
estimate
0.50
20
160
76
664
1.24
0.71
5.6
4.4
—
—
—
0
0
18
128
1.45
0.68
1.2
1.3
208.5
496.8
u/ml
0.68
18
120
30
234
1.33
0.68
1.7
2.1
25.7
11.3
ng/l
0.43
11
58
7
44
1.61
0.66
1.0
1.5
—
—
—
0
0
23
173
1.37
0.65
1.5
1.2
—
—
—
0
0
10
152
0.64
0.64
1.2
1.2
—
—
—
0
0
6
36
1.69
0.57
1.0
1.0
—
—
—
0
0
83
748
1.19
0.55
3.6
3.0
0.0
0.0
estimate
0.00
21
161
82
739
1.19
0.54
3.7
2.9
0.0
0.0
estimate
0.00
19
155
14
190
0.72
0.52
1.2
1.6
—
—
—
0
0
33
273
1.25
0.50
3.0
2.4
5683.9
4898.2
u/l
0.08
17
114
7
50
1.41
0.45
1.4
1.1
—
—
—
0
0
27
222
1.25
0.44
4.2
2.4
0.5
1.0
e6/l
0.78
14
108
81
740
1.16
0.44
5.5
4.1
0.0
0.0
estimate
0.00
20
163
41
354
1.20
0.43
1.7
1.4
92.4
96.4
pmol/l
0.27
23
191
27
223
1.24
0.42
3.6
1.9
—
—
—
0
0
41
356
1.19
0.40
1.5
1.5
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
5
34
1.48
0.40
1.2
3.3
4.4
3.5
mmol/l
—
5
34
5
34
1.48
0.40
1.4
3.3
200.4
230.1
e6/l
—
5
29
24
197
1.25
0.40
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
12
89
1.37
0.39
1.8
1.4
—
—
—
0
0
47
418
1.16
0.36
3.1
2.6
2.6
2.4
mg/l
0.22
38
359
160
1645
0.85
0.33
4.8
4.2
—
—
—
0
0
20
166
1.23
0.31
1.9
2.3
218.0
542.8
ng/l
—
6
66
12
152
0.78
0.30
1.5
1.5
—
—
—
0
0
10
76
1.33
0.28
3.2
1.7
—
—
—
0
0
60
552
1.13
0.28
3.0
2.8
—
—
—
0
0
56
515
1.12
0.27
2.0
2.1
—
—
—
0
0
47
428
1.13
0.26
1.7
1.9
—
—
—
0
0
21
243
0.85
0.25
1.3
1.4
—
—
—
0
0
5
37
1.36
0.23
1.2
3.2
751.8
337.0
mg/l
—
5
37
5
38
1.32
0.23
3.6
2.1
—
—
—
0
0
5
38
1.32
0.23
3.4
2.2
—
—
—
0
0
20
172
1.18
0.23
1.6
1.4
—
—
—
0
0
20
172
1.18
0.23
1.6
1.4
—
—
—
0
0
20
172
1.18
0.23
1.6
1.4
—
—
—
0
0
33
366
0.88
0.23
1.5
1.5
—
—
—
0
0
5
40
1.26
0.22
1.8
1.6
—
—
—
0
0
20
173
1.17
0.22
1.6
1.4
—
—
—
0
0
84
798
1.09
0.21
2.3
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
94
904
1.08
0.17
4.7
2.9
29.2
25.4
u/l
0.54
89
868
63
661
0.93
0.15
2.3
2.4
—
—
—
0
0
15
170
0.87
0.14
1.7
1.7
—
—
—
0
0
9
109
0.82
0.13
1.4
1.5
765.2
991.9
nmol/l
—
9
86
22
203
1.09
0.10
1.1
1.2
11.3
13.7
iu/ml
—
7
43
5
47
1.07
0.09
1.2
1.8
—
—
—
0
0
69
711
0.95
0.08
2.7
2.6
—
—
—
0
0
7
84
0.83
0.07
2.0
2.6
—
—
—
0
0
9
85
1.06
0.07
1.6
2.1
—
—
—
0
0
21
198
1.07
0.05
1.7
1.5
—
—
—
0
0
11
101
1.09
0.04
3.0
2.7
3.2
5.2
umol/l
—
6
80
94
927
1.03
0.04
5.4
2.8
48.3
49.9
ug/l
0.06
83
865
163
1622
1.03
0.02
14.3
10.2
38.7
39.9
%
1.21
140
1415
10
107
0.93
0.02
1.4
4.1
653.2
604.0
ng/l
—
5
83
10
105
0.95
0.00
2.2
2.2
—
—
—
0
0
19
188
1.01
0.00
1.1
1.2
1.1
6.6
u/ml
—
8
71
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
5.6
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
5.1
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
824.7
—
0
9
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
8
86
0.93
0.00
1.1
1.2
—
—
—
0
0
8
82
0.97
0.00
1.1
1.4
—
—
—
0
0
6
60
1.00
0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.1
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PREPUB and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PREPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PREPUB – Precocious puberty
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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