hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
245 |
4. Check minimum number of eventsNone |
245 |
5. Include endpointsNone |
245 |
6. Filter based on genotype QC (FinnGen only) |
245 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E22
- Name in latin
- Acromegalia
Similar endpoints
↥List of similar endpoints to
Acromegaly and pituitary gigantism
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 866 | 703 |
| Only index persons | 1180 | 661 | 519 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.81 | 49.54 | 47.84 |
| Only index persons | 45.67 | 45.99 | 45.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 245 | 149 | 96 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 45.16 | 43.33 | 47.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 222
- Matched controls
- 2219
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
263.0
197
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
1541.3
152.4
131
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
125.2
108
*
H02AB09
ATC
hydrocortisone; systemic
262.0
105.8
101
7
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
1210.8
86.7
79
*
H01CB02
ATC
octreotide; parenteral
+∞
46.5
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
42.0
39
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
39.8
37
*
H01CB03
ATC
lanreotide; parenteral
220.7
37.0
37
*
ZXC86
NOMESCO Finland
Use of endoscopic device
137.7
33.7
35
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
192.7
32.7
33
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
32.1
30
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
27.7
26
*
UJF32
NOMESCO Finland
Coloscopy
5.0
25.1
102
321
G02CB01
ATC
bromocriptine; systemic
32.5
23.9
31
11
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
22.3
21
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
21.2
20
*
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
21.2
20
*
H03AA01
ATC
levothyroxine sodium; systemic
4.2
19.2
92
322
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.8
18.0
68
187
102
Kela drug reimbursment
Diabetes insipidus
+∞
16.9
16
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
26.9
16.4
22
9
2542
FHL
Transasal hypophysectomy
+∞
14.7
14
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
8.5
14.6
32
43
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
12.6
14.2
25
22
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
13.7
13
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
13.7
13
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
148.7
13.6
14
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
148.7
13.6
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
13.4
89
382
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.0
13.0
37
72
G47.3
ICD-10 Finland
Sleep apnoea
3.4
13.0
73
276
ZXC95
NOMESCO Finland
Use of surgical navigator
20.3
11.8
17
9
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
11.6
11
*
N04BC01
ATC
bromocriptine; oral
115.2
10.5
11
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
115.2
10.5
11
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
10.5
10
*
T99
ICPC
Endocr/metab/nutrit disease other
16.5
9.2
14
9
H01AX01
ATC
pegvisomant; parenteral
+∞
8.4
8
*
D352, E220
ICD-10 Finland
NA
+∞
8.4
8
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.5
8.3
39
126
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.7
8.1
18
25
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.0
8.1
49
190
XCK00
NOMESCO Finland
Perimetry
4.4
7.9
28
70
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
7.2
7.8
18
27
T73
ICPC
Neoplasm endocrine other/unspecified
82.7
7.5
8
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
7.3
7
*
AA1AD
NOMESCO Finland
CT of head and brain
2.5
7.0
63
305
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
6.9
49
208
121
Kela drug reimbursment
Severe hypofunction of sexual glands
11.5
6.9
12
11
WX402
NOMESCO Finland
General anaesthesia
2.6
6.6
53
243
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
6.5
69
364
R06.5
ICD-10 Finland
Mouth breathing
3.5
6.5
30
96
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
71.8
6.5
7
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
71.8
6.5
7
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.3
6.3
31
104
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.7
6.3
17
32
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
6.3
6
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
6.3
6
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3036481) Cortisol [Moles/volume] in Serum or Plasma
163
173
26.16
157.08
6.0
1.7
nmol/l
358.3
401.2
1.40
155
160
(3035637) Corticotropin [Mass/volume] in Plasma
42
14
36.00
64.85
1.7
1.4
—
—
—
0
0
(3009214) Lutropin [Units/volume] in Serum or Plasma
61
52
15.29
62.55
2.5
1.1
u/l
7.8
7.8
0.01
49
43
(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood
29
16
20.42
36.59
1.2
1.9
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
26
13
22.26
34.14
1.0
1.6
mu/l
6.6
16.9
1.85
26
13
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
29
23
14.17
30.28
2.7
1.3
—
—
—
0
0
(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma
27
23
13.07
26.95
2.0
1.3
nmol/l
0.4
0.3
0.03
15
18
(3023323) Follitropin [Units/volume] in Serum or Plasma
47
88
6.37
25.13
2.1
1.3
iu/l
20.8
24.5
0.28
35
77
(3018418) pH of Serum or Plasma
123
563
3.38
19.65
5.4
3.4
ph
7.4
7.4
0.48
30
98
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
166
920
3.49
19.13
8.2
5.8
mmol/l
1.2
1.2
0.36
136
778
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
154
841
3.24
17.69
7.4
5.0
mmol/l
1.2
1.2
0.46
146
754
(3013826) Glucose [Moles/volume] in Serum or Plasma
177
1145
2.97
13.36
7.7
4.0
mmol/l
6.5
6.7
0.64
167
1058
(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation
25
47
5.81
13.07
3.3
1.4
pmol/l
173.3
248.5
1.79
25
42
(4035726)
50
170
3.44
12.28
1.3
1.3
—
—
—
0
0
(3027801) Oxygen [Partial pressure] in Arterial blood
54
195
3.27
12.03
5.4
7.0
kpa
15.6
12.3
2.00
49
186
(3003396) Base excess in Arterial blood by calculation
54
198
3.22
11.72
5.3
6.9
mmol/l
0.3
1.2
1.03
42
155
(3046904) Somatotropin [Units/volume] in Serum or Plasma
9
0
+∞
9.43
8.4
0.0
mu/l
2.2
—
—
9
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
13
20
6.81
8.15
1.4
1.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
102
610
2.15
7.64
2.3
2.1
—
—
—
0
0
(43055514) Macroprolactin [Presence] in Serum or Plasma
10
6
17.28
6.80
2.2
1.0
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
111
716
2.01
6.54
6.3
7.5
inr
1.1
1.2
2.09
35
212
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
89
533
2.05
6.43
1.7
1.6
mmol/l
1.2
1.3
0.52
79
453
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
132
913
1.97
6.29
4.1
3.8
—
—
—
0
0
(3026782) Osmolality of Urine
65
353
2.15
6.03
3.4
2.6
mosm/kgh2o
506.1
561.6
1.43
55
302
(3014576) Chloride [Moles/volume] in Serum or Plasma
46
218
2.37
5.90
6.6
6.1
mmol/l
104.3
104.1
0.13
46
212
(3022145) Colonoscopy Study observation
47
228
2.31
5.71
1.2
1.3
—
—
—
0
0
(3000991) Gas panel - Venous blood
32
130
2.68
5.65
9.5
7.2
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
91
579
1.91
5.35
2.8
3.0
mmol/l
9.1
7.7
1.48
84
484
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
76
459
1.95
5.19
2.4
2.1
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
35
164
2.32
4.58
4.4
3.7
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
38
187
2.22
4.44
3.1
3.0
—
—
—
0
0
(1616796) Gas panel - Central venous blood
12
31
4.02
4.31
1.8
3.1
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
16
51
3.29
4.29
2.1
1.5
—
—
—
0
0
(3012501) Base excess in Blood by calculation
13
36
3.76
4.26
1.9
2.8
mmol/l
2.7
3.2
—
7
24
(3033658) Prothrombin time (PT) actual/Normal
74
480
1.78
3.90
4.5
3.3
%
89.2
93.5
0.73
74
470
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
11
29
3.92
3.85
2.4
2.8
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
185
1546
1.80
3.83
9.0
6.9
u/l
76.8
77.5
0.11
178
1433
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
212
1864
2.02
3.54
7.1
4.6
mu/l
1.3
1.9
12.86
202
1698
(3022806) Fractional oxyhemoglobin in Capillary blood
9
18
5.15
3.40
1.4
1.4
%
86.7
90.2
—
9
18
(3044889) 12 lead EKG panel
167
1391
1.63
3.13
3.9
3.5
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
117
899
1.58
3.07
12.8
8.7
e9/l
0.0
0.0
0.56
100
734
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
101
750
1.59
3.07
1.9
1.9
pmol/l
97.4
97.7
0.02
55
356
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
20
88
2.39
3.03
8.3
8.1
—
—
—
0
0
(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum
5
5
10.17
2.99
1.2
1.2
ug/l
131.4
82.9
—
5
5
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
129
1019
1.56
2.97
6.6
5.6
umol/l
10.4
10.8
0.37
124
961
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
8
17
4.83
2.94
1.1
1.2
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
14
52
2.79
2.94
2.1
3.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
80
573
1.59
2.79
3.3
2.7
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
57
377
1.67
2.72
2.9
2.4
e6/l
6.4
4.3
0.78
51
329
(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma
7
15
4.77
2.61
1.3
1.3
u/l
54.3
66.9
—
7
9
(3042936) Bacteria identified in Isolate by Culture
43
269
1.73
2.51
2.2
1.8
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
86
639
1.53
2.51
6.0
2.9
mmol/l
2.4
2.3
1.02
78
561
(3002582) Erythrocytes [#/volume] in Urine
78
569
1.54
2.47
3.6
2.8
e6/l
35.9
162.2
0.55
62
423
(42870588) Differential panel, method unspecified - Blood
87
651
1.52
2.45
5.3
5.0
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
159
1352
1.50
2.36
5.0
4.0
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
70
506
1.54
2.29
3.7
2.6
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
207
1872
1.68
2.28
7.5
5.3
mmol/mol
40.1
39.5
0.41
202
1757
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
7
18
3.97
2.27
1.0
1.2
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
116
934
1.46
2.23
5.8
5.7
%
8.8
8.4
0.75
106
878
(3030467) Casts [#/volume] in Urine by Automated count
71
519
1.52
2.20
3.7
2.7
e6/l
0.8
0.3
0.63
55
374
(40768797) Stomach Pathology biopsy report
42
271
1.66
2.20
1.3
1.3
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
115
927
1.45
2.19
5.7
5.4
%
2.7
2.8
0.33
105
863
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
215
1972
1.74
2.14
5.3
4.3
mmol/l
5.8
5.9
0.53
210
1804
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
87
667
1.47
2.13
3.5
2.8
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
43
282
1.64
2.11
2.9
2.1
umol/l
11.7
14.2
2.16
43
262
(3013650) Neutrophils [#/volume] in Blood by Automated count
138
1157
1.44
2.10
9.4
9.2
e9/l
3.8
4.0
0.27
121
1014
(3041096) Erythrocytes [Presence] in Urine by Automated
74
551
1.49
2.09
3.7
3.0
—
—
—
0
0
(3035947) Staphylolysin Ab [Units/volume] in Serum
5
10
5.08
2.08
1.0
1.0
iu/ml
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
6
15
4.07
2.05
1.0
1.1
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
21
112
1.96
2.03
1.4
1.4
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
65
474
1.51
2.03
5.1
3.9
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
9
32
2.88
2.02
4.6
2.5
—
—
—
0
0
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
7
21
3.40
1.98
1.0
1.2
nmol/l
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
111
902
1.42
1.96
5.8
5.4
%
0.7
0.7
0.14
102
841
(40768804) Tissue Pathology biopsy report
99
793
1.42
1.88
2.1
2.0
—
—
—
0
0
(3002030) Lymphocytes/100 leukocytes in Blood
116
957
1.40
1.85
5.8
5.5
%
28.8
28.4
0.14
106
894
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
6
17
3.59
1.85
2.2
1.9
nmol/l
1.8
3.1
—
6
17
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
59
430
1.49
1.84
2.1
2.0
mg/l
3.1
3.3
0.34
52
371
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
8
29
2.82
1.81
1.3
1.4
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
119
992
1.39
1.76
5.5
5.4
e9/l
0.5
0.6
0.35
106
867
(3018010) Neutrophils/100 leukocytes in Blood
114
944
1.39
1.76
5.7
5.3
%
56.4
56.8
0.12
104
889
(3006315) Basophils [#/volume] in Blood
119
998
1.37
1.68
5.5
5.4
e9/l
0.0
0.0
0.25
106
871
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
8
31
2.63
1.67
2.1
1.5
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
122
1029
1.37
1.65
5.6
5.6
e9/l
0.2
0.2
0.68
112
913
(3003327) Ova and parasites identified in Stool by Light microscopy
14
70
2.06
1.62
1.2
1.6
—
—
—
0
0
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
5
14
3.62
1.62
1.2
1.1
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
7
26
2.74
1.59
1.1
1.7
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
7
26
2.74
1.59
2.4
1.5
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
46
328
1.50
1.59
3.4
2.8
mmol/l
2.4
2.4
0.25
39
290
(3037121) Protein [Mass/volume] in Urine
13
64
2.09
1.57
2.8
3.3
g/l
0.1
0.1
—
7
22
(3019198) Lymphocytes [#/volume] in Blood
120
1021
1.34
1.49
5.6
5.4
e9/l
1.7
2.0
1.43
109
911
(3021601) Nitrite [Presence] in Urine by Test strip
116
984
1.34
1.46
5.2
4.6
estimate
0.0
0.0
0.00
33
174
(3035350) Ketones [Presence] in Urine by Test strip
115
975
1.34
1.45
3.5
3.4
estimate
0.0
0.0
0.00
35
174
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
6
22
2.77
1.44
1.5
1.1
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
117
996
1.33
1.43
3.8
3.5
estimate
0.0
0.0
0.00
33
166
(3001122) Ferritin [Mass/volume] in Serum or Plasma
106
890
1.34
1.42
3.2
2.5
ug/l
96.5
108.4
0.46
98
816
(3018095) Leukocytes [#/volume] in Urine
84
683
1.35
1.39
4.3
3.3
e6/l
73.2
55.4
0.26
65
464
(3022217) INR in Platelet poor plasma by Coagulation assay
32
218
1.54
1.37
27.3
19.6
inr
1.3
1.3
—
6
34
(3029937) Albumin [Presence] in Urine by Test strip
69
545
1.37
1.37
3.7
3.7
estimate
0.1
0.0
0.49
33
169
(3045142) Bone marrow Pathology biopsy report
5
17
2.98
1.36
1.4
1.3
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
40
287
1.47
1.35
3.1
2.5
e6/l
1.8
3.0
0.63
23
145
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
13
69
1.93
1.31
6.9
3.5
mmol/l
25.1
24.3
0.44
13
61
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
23
346
0.63
1.30
1.7
1.4
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
5
18
2.81
1.29
1.0
1.0
—
—
—
0
0
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
5
18
2.81
1.29
1.0
1.0
—
—
—
0
0
(3002179) Metamyelocytes/100 leukocytes in Blood
23
148
1.61
1.25
3.1
4.9
%
1.1
0.4
—
7
36
(21494755) Public health laboratory ask at order entry panel
14
236
0.57
1.24
1.1
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
93
780
1.31
1.22
3.8
3.5
—
—
—
0
0
(3021440) Promyelocytes/100 leukocytes in Blood
24
158
1.58
1.20
3.0
4.9
%
0.0
0.2
—
10
49
(3044290) Cell count panel - Cerebral spinal fluid
8
38
2.14
1.19
1.0
1.3
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
18
110
1.69
1.19
1.0
1.2
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
167
1520
1.31
1.16
4.3
3.9
mm/h
12.9
10.9
1.05
160
1388
(3002256) Pathology report gross observation
32
227
1.47
1.15
1.3
1.2
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
75
618
1.31
1.11
2.5
2.4
u/l
62.3
55.3
0.33
70
565
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
12
204
0.57
1.11
2.0
1.7
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
22
145
1.57
1.10
2.8
2.5
e9/l
74.5
69.9
0.19
15
110
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
5
21
2.41
1.09
1.2
1.0
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
55
436
1.34
1.06
1.6
1.5
nmol/l
21.9
21.0
0.17
47
369
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
28
198
1.47
1.03
1.8
4.7
u/l
243.4
244.2
0.01
28
192
(3013512) EKG study
69
569
1.30
1.01
3.6
3.5
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
23
157
1.51
1.00
1.2
1.2
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
14
84
1.71
1.00
1.1
1.1
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
16
100
1.64
0.99
1.7
2.6
e6/l
0.3
0.2
0.11
16
95
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
87
742
1.27
0.98
3.6
3.4
ng/l
40.0
36.3
0.09
68
481
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
16
243
0.63
0.96
2.1
2.0
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
59
480
1.30
0.95
2.9
5.1
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
22
151
1.50
0.94
3.1
5.0
%
0.1
0.2
—
8
41
(3044941) Cell count panel - Synovial fluid
6
27
2.25
0.94
1.8
1.4
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
6
27
2.25
0.94
4.8
1.8
%
66.4
60.5
—
6
27
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
13
206
0.61
0.94
1.2
1.4
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
202
1909
1.33
0.93
19.6
11.4
ml/min/173m2
85.0
83.0
0.68
195
1558
(3037522) Nuclear Ab [Titer] in Serum
35
265
1.37
0.91
1.2
1.4
titre
453.3
492.9
—
6
65
(3017181) Myelocytes/100 leukocytes in Blood
24
170
1.46
0.89
3.0
4.8
%
1.3
0.9
—
10
57
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
8
44
1.85
0.86
1.3
1.2
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
8
45
1.80
0.85
2.3
1.2
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
210
2003
1.34
0.84
5.0
4.3
mmol/l
1.4
1.5
0.56
210
1844
(3003694) ABO and Rh group [Type] in Blood
65
545
1.26
0.83
1.4
1.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
36
279
1.34
0.82
1.6
1.8
—
—
—
0
0
(3012544) pH of Venous blood
23
165
1.43
0.81
7.0
3.2
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
24
0.00
0.79
0.0
2.7
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
9
53
1.72
0.76
1.1
1.9
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
42
338
1.29
0.74
5.1
3.8
ng/l
48.4
344.7
1.66
30
250
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
7
39
1.82
0.73
1.0
1.2
nmol/l
0.4
0.9
—
7
33
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
39
312
1.30
0.72
3.1
2.3
e6/l
2.6
1.0
0.39
23
168
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
9
143
0.62
0.72
1.3
1.5
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
7
118
0.58
0.70
1.3
1.8
—
—
—
0
0
(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma
5
93
0.53
0.68
3.0
2.5
u/l
37.2
42.7
—
5
82
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
16
224
0.69
0.68
2.0
1.9
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
5
28
1.80
0.66
1.2
1.3
—
—
—
0
0
(3019225) pH of Specimen
23
174
1.36
0.62
3.5
3.7
—
—
—
0
0
(4094501)
8
49
1.65
0.62
1.3
1.1
—
—
—
0
0
(40758558) Short blood count panel - Blood
57
487
1.22
0.62
8.5
6.4
—
—
—
0
0
(4306422)
5
30
1.68
0.62
1.0
1.4
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
8
51
1.59
0.61
1.3
1.3
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
23
0.00
0.58
0.0
2.0
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
6
35
1.73
0.58
1.5
3.6
e9/l
4.6
4.9
—
6
35
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
6
36
1.68
0.57
1.5
1.4
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
6
36
1.68
0.57
1.5
4.1
%
61.2
59.0
—
6
36
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
202
1942
1.23
0.56
4.3
3.8
mmol/l
1.3
1.3
0.12
202
1785
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
18
237
0.74
0.55
7.9
6.4
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
25
197
1.30
0.53
1.5
1.7
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
61
533
1.19
0.53
3.7
3.2
mg/l
66.7
63.8
0.04
46
335
(3013139) Helicobacter pylori Ag [Presence] in Stool
9
136
0.65
0.53
1.1
1.3
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
11
75
1.49
0.51
1.5
1.4
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
14
102
1.40
0.48
1.5
1.3
—
—
—
0
0
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
18
138
1.33
0.47
1.2
1.3
iu/ml
135.2
157.9
—
8
56
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
211
2048
1.22
0.46
18.5
12.2
mg/l
24.5
21.6
0.66
171
1572
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
51
446
1.18
0.45
1.5
1.3
u/ml
1.8
1.4
0.11
14
119
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
51
446
1.18
0.45
1.9
1.7
mg/l
1.3
1.0
0.37
43
344
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
24
194
1.26
0.44
1.5
1.7
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
219
2137
1.23
0.42
18.4
11.7
—
—
—
0
0
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
15
0.00
0.41
0.0
10.9
—
0.6
—
0
15
(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
5
34
1.48
0.40
2.2
1.4
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
7
103
0.67
0.40
1.0
1.3
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
7
104
0.66
0.40
1.0
1.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
19
236
0.79
0.40
1.4
1.4
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
(4062490)
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
19
0.00
0.39
0.0
4.1
—
74.8
—
0
19
(3037756) Immunofixation for Serum or Plasma
5
36
1.40
0.38
1.0
1.6
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
8
114
0.69
0.38
1.0
1.1
—
—
—
0
0
(3019060) Gas panel - Arterial blood
15
116
1.31
0.38
3.2
4.7
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
9
70
1.30
0.37
1.4
1.4
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
11
81
1.37
0.37
1.5
1.4
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
9
123
0.72
0.36
1.2
1.9
—
—
—
0
0
(40768443) Skin Pathology biopsy report
5
80
0.62
0.36
1.0
1.2
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
42
1.44
0.36
1.2
1.6
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
11
82
1.36
0.34
1.5
1.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
11
82
1.36
0.34
1.5
1.4
—
—
—
0
0
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
21
173
1.23
0.34
2.1
2.2
g/l
0.2
0.2
0.84
21
159
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
6
45
1.34
0.34
1.2
1.6
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
34
388
0.86
0.32
1.4
1.7
pmol/l
443.6
465.1
0.25
29
332
(3019309) Folate [Moles/volume] in Red Blood Cells
38
335
1.16
0.31
1.6
1.7
nmol/l
1086.9
1189.4
0.29
31
242
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
7
97
0.71
0.31
2.1
2.3
—
—
—
0
0
(3008898) HLA-B27 [Presence]
7
99
0.70
0.31
1.3
1.1
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
7
53
1.33
0.31
1.1
1.2
—
—
—
0
0
(3035941) MCH [Entitic mass]
231
2276
1.26
0.30
28.6
18.3
pg
30.2
30.3
0.29
231
2235
(3024731) MCV [Entitic volume]
231
2276
1.26
0.30
28.6
18.3
fl
91.0
90.9
0.17
231
2236
(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay
7
57
1.23
0.29
1.3
1.1
—
2.8
—
0
10
(1761482) Bacteria [#/volume] in Urine by Culture
7
57
1.23
0.29
2.6
4.1
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
8
62
1.30
0.28
1.8
1.3
—
—
—
0
0
(3005322) IgE [Units/volume] in Serum or Plasma
9
116
0.77
0.28
1.1
1.3
u/ml
108.3
366.4
—
9
109
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
8
64
1.26
0.27
2.3
1.8
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
231
2279
1.24
0.27
28.9
18.4
g/l
133.9
136.3
1.66
231
2236
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
5
71
0.70
0.26
2.0
1.4
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
16
132
1.23
0.26
1.3
1.4
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
9
74
1.22
0.25
1.3
2.3
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
61
565
1.11
0.25
4.5
4.0
mg/mmol
9.7
10.4
0.06
46
353
(3014051) Protein [Presence] in Urine by Test strip
5
39
1.29
0.23
1.2
1.7
—
—
—
0
0
(4034850)
10
79
1.28
0.22
5.1
9.1
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
5
40
1.26
0.22
1.8
1.6
—
—
—
0
0
(3006462) Nitrate [Presence] in Urine
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
(3017704) Immunofixation for Urine
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
(3006653) Thiamine [Moles/volume] in Blood
0
10
0.00
0.21
0.0
1.6
—
168.0
—
0
10
(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
(44813793)
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
(4211845)
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40761535) Cells panel - Urine sediment
13
155
0.83
0.21
2.2
3.3
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
34
374
0.89
0.20
1.1
1.3
iu/ml
43.0
35.7
—
9
128
(4146454)
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
184
1876
0.92
0.18
23.0
12.9
%
39.3
40.3
1.00
133
1407
(3007164) IgA [Mass/volume] in Serum or Plasma
44
408
1.10
0.18
1.4
1.4
g/l
2.2
2.5
0.46
27
247
(3049717) Cytology report of Urine Cyto stain
7
61
1.15
0.17
1.4
2.6
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
10
82
1.23
0.17
1.6
1.4
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
8
68
1.18
0.17
2.3
2.1
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
6
78
0.76
0.16
1.7
1.9
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
11
93
1.19
0.15
3.1
3.3
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
36
334
1.09
0.14
2.1
1.9
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
41
383
1.08
0.14
1.5
1.5
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
42
446
0.93
0.13
3.4
3.5
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
22
201
1.10
0.12
2.2
1.7
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
15
166
0.90
0.10
1.8
1.8
—
—
—
0
0
(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum
5
44
1.14
0.10
1.4
1.4
—
38.5
—
0
8
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
46
1.09
0.09
1.2
1.4
—
—
—
0
0
(3000492) Spirometry study
20
184
1.09
0.09
1.3
1.3
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
6
57
1.05
0.08
1.3
3.6
—
2.8
—
0
9
(3043409) Potassium [Moles/volume] in Arterial blood
6
57
1.05
0.08
3.3
3.9
mmol/l
3.9
3.9
—
6
51
(3016921) Smith extractable nuclear Ab [Units/volume] in Serum
6
58
1.04
0.08
1.3
1.4
—
2.7
—
0
11
(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum
6
58
1.04
0.08
1.3
1.4
—
2.7
—
0
13
(40768793) Breast Pathology biopsy report
5
64
0.78
0.08
1.0
1.3
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
7
66
1.06
0.08
2.0
1.6
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
74
0.81
0.07
2.3
1.4
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
19
204
0.93
0.07
1.6
1.7
—
—
—
0
0
(3003338) MCHC [Mass/volume]
173
1746
0.97
0.05
26.4
15.9
g/l
331.9
332.6
0.49
173
1738
(3004588) Protein electrophoresis panel - Serum or Plasma
12
129
0.93
0.03
2.2
2.0
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
36
371
0.97
0.03
1.1
1.3
u/ml
1.3
10.2
2.76
17
149
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
28
270
1.04
0.03
2.4
1.6
—
—
—
0
0
(3022313) Gas panel - Capillary blood
10
92
1.09
0.03
3.7
3.3
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
44
430
1.03
0.03
3.6
3.9
%
23.1
21.8
0.19
20
178
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
13
124
1.05
0.00
1.2
1.3
—
31.0
—
0
5
(3022621) pH of Urine by Test strip
12
122
0.98
0.00
3.6
2.6
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
12
119
1.01
0.00
1.2
1.6
g/l
0.9
1.4
1.20
12
109
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
133
1331
1.00
0.00
2.8
3.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
22
217
1.02
0.00
2.2
1.6
—
—
—
0
0
(4010399)
15
147
1.02
0.00
1.3
1.4
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
10
96
1.04
0.00
1.5
1.7
—
—
—
0
0
(1002224) Polysomnography panel
10
96
1.04
0.00
1.0
1.1
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
10
96
1.04
0.00
5.4
2.4
%
0.9
1.3
—
10
96
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
15
146
1.03
0.00
1.8
2.6
ml/min/173m2
84.8
67.1
—
6
62
(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(36304052) Adalimumab Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
5
58
0.86
0.00
1.0
1.2
—
—
—
0
0
(3005011) Chlamydia sp Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
8
79
1.01
0.00
1.1
1.5
—
—
—
0
0
(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
32
320
1.00
0.00
2.2
2.6
ug/l
0.5
0.7
2.04
22
187
(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
(3011436) Histone Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009871) Measles virus Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3034426) Prothrombin time (PT)
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
(3027300) Silver Birch IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
5
57
0.87
0.00
1.0
1.1
—
—
—
0
0
(3041806) Other cells [#/volume] in Blood by Manual count
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
0.3
—
0
7
(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
77
770
1.00
0.00
3.2
2.8
—
—
—
0
0
(3032057) Clostridioides difficile [Presence] in Stool
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(4015189)
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(3020891) Body temperature
7
71
0.99
0.00
5.7
4.7
—
—
—
0
0
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
5
54
0.92
0.00
2.0
1.7
—
—
—
0
0
(3002619) Bacteria identified in Specimen by Culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000213) Normetanephrine [Moles/time] in 24 hour Urine
0
6
0.00
0.00
0.0
1.3
—
1.9
—
0
6
(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3004446) Plasmodium sp identified in Blood by Light microscopy
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum
6
60
1.00
0.00
1.3
1.4
—
3.3
—
0
5
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
53
0.94
0.00
1.2
1.3
—
—
—
0
0
(3022192) Triglyceride [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3035457) Cefaclor IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003129) Base excess in Capillary blood by calculation
0
5
0.00
0.00
0.0
1.2
—
3.8
—
0
5
(3002222) Hepatitis E virus IgM Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3043410) Blood group antigens tested for on Red Blood Cells
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3008116) Ketones [Moles/volume] in Urine by Test strip
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3037556) Urate [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(40765096) Chromosome analysis panel by Banding
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
56
0.89
0.00
1.0
1.2
—
—
—
0
0
(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010254) Herpes simplex virus identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013293) Extractable nuclear Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(44806071)
0
6
0.00
0.00
0.0
1.2
—
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0
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Mortality – FinRegistry
↥Association
Association between endpoint E4_ACROMEG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACROMEG | 1.68 [1.25, 2.25] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.335 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 432 females with E4_ACROMEG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ACROMEG | 1.62 [1.24, 2.12] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 350 males with E4_ACROMEG died.
Mortality risk
Mortality risk for people of age
years, who have E4_ACROMEG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.274% |
| 5 | 0.885% | 2.148% |
| 10 | 2.427% | 5.483% |
| 15 | 4.67% | 9.864% |
| 20 | 8.7% | 16.301% |
Relationships between endpoints
↥Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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