Acromegaly and pituitary gigantism

E4_ACROMEG

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E22.0
  • Hospital discharge: ICD-9 2530
  • Hospital discharge: ICD-8 2530
  • Hospital discharge: excluded ICD-8 25301
  • Cause of death: ICD-10 E22.0
  • Cause of death: ICD-9 2530
  • Cause of death: ICD-8 2530
  • Cause of death: excluded ICD-8 25301

2 out of 7 registries used, show all original rules.

245

4. Check minimum number of events

None

245

5. Include endpoints

None

245

6. Filter based on genotype QC (FinnGen only)

245

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E22
Name in latin
Acromegalia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1586 866 703
Only index persons 1180 661 519
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 48.81 49.54 47.84
Only index persons 45.67 45.99 45.26

-FinnGen-

Key figures

All Female Male
Number of individuals 245 149 96
Unadjusted period prevalence (%) 0.05 0.05 0.04
Median age at first event (years) 45.16 43.33 47.99

-FinRegistry-

Age distribution of first events

01020304050607080050100150200250300AgeIndividuals

-FinnGen-

Age distribution of first events

0102030405060700510152025303540455055AgeIndividuals

-FinRegistry-

Year distribution of first events

19751980198519901995200020052010201520202022020406080100120140160180200220YearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230510152025303540YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
222
Matched controls
2219
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
263.0
197
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
1541.3
152.4
131
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
125.2
108
*
H02AB09
ATC
hydrocortisone; systemic
262.0
105.8
101
7
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
1210.8
86.7
79
*
H01CB02
ATC
octreotide; parenteral
+∞
46.5
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
42.0
39
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
39.8
37
*
H01CB03
ATC
lanreotide; parenteral
220.7
37.0
37
*
ZXC86
NOMESCO Finland
Use of endoscopic device
137.7
33.7
35
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
192.7
32.7
33
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
32.1
30
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
27.7
26
*
UJF32
NOMESCO Finland
Coloscopy
5.0
25.1
102
321
G02CB01
ATC
bromocriptine; systemic
32.5
23.9
31
11
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
22.3
21
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
21.2
20
*
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
21.2
20
*
H03AA01
ATC
levothyroxine sodium; systemic
4.2
19.2
92
322
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.8
18.0
68
187
102
Kela drug reimbursment
Diabetes insipidus
+∞
16.9
16
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
26.9
16.4
22
9
2542
FHL
Transasal hypophysectomy
+∞
14.7
14
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
8.5
14.6
32
43
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
12.6
14.2
25
22
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
13.7
13
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
13.7
13
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
148.7
13.6
14
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
148.7
13.6
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
13.4
89
382
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.0
13.0
37
72
G47.3
ICD-10 Finland
Sleep apnoea
3.4
13.0
73
276
ZXC95
NOMESCO Finland
Use of surgical navigator
20.3
11.8
17
9
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
11.6
11
*
N04BC01
ATC
bromocriptine; oral
115.2
10.5
11
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
115.2
10.5
11
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
10.5
10
*
T99
ICPC
Endocr/metab/nutrit disease other
16.5
9.2
14
9
H01AX01
ATC
pegvisomant; parenteral
+∞
8.4
8
*
D352, E220
ICD-10 Finland
NA
+∞
8.4
8
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.5
8.3
39
126
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.7
8.1
18
25
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.0
8.1
49
190
XCK00
NOMESCO Finland
Perimetry
4.4
7.9
28
70
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
7.2
7.8
18
27
T73
ICPC
Neoplasm endocrine other/unspecified
82.7
7.5
8
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
7.3
7
*
AA1AD
NOMESCO Finland
CT of head and brain
2.5
7.0
63
305
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
6.9
49
208
121
Kela drug reimbursment
Severe hypofunction of sexual glands
11.5
6.9
12
11
WX402
NOMESCO Finland
General anaesthesia
2.6
6.6
53
243
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
6.5
69
364
R06.5
ICD-10 Finland
Mouth breathing
3.5
6.5
30
96
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
71.8
6.5
7
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
71.8
6.5
7
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.3
6.3
31
104
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.7
6.3
17
32
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
6.3
6
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
6.3
6
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
163
173
26.16
157.08
6.0
1.7
358.3
401.2
nmol/l
1.40
155
160
42
14
36.00
64.85
1.7
1.4
—
—
—
0
0
61
52
15.29
62.55
2.5
1.1
7.8
7.8
u/l
0.01
49
43
26
13
22.26
34.14
1.0
1.6
6.6
16.9
mu/l
1.85
26
13
29
23
14.17
30.28
2.7
1.3
—
—
—
0
0
27
23
13.07
26.95
2.0
1.3
0.4
0.3
nmol/l
0.03
15
18
47
88
6.37
25.13
2.1
1.3
20.8
24.5
iu/l
0.28
35
77
123
563
3.38
19.65
5.4
3.4
7.4
7.4
ph
0.48
30
98
166
920
3.49
19.13
8.2
5.8
1.2
1.2
mmol/l
0.36
136
778
154
841
3.24
17.69
7.4
5.0
1.2
1.2
mmol/l
0.46
146
754
177
1145
2.97
13.36
7.7
4.0
6.5
6.7
mmol/l
0.64
167
1058
25
47
5.81
13.07
3.3
1.4
173.3
248.5
pmol/l
1.79
25
42
50
170
3.44
12.28
1.3
1.3
—
—
—
0
0
54
195
3.27
12.03
5.4
7.0
15.6
12.3
kpa
2.00
49
186
54
198
3.22
11.72
5.3
6.9
0.3
1.2
mmol/l
1.03
42
155
9
0
+∞
9.43
8.4
0.0
2.2
—
mu/l
—
9
0
102
610
2.15
7.64
2.3
2.1
—
—
—
0
0
10
6
17.28
6.80
2.2
1.0
—
—
—
0
0
111
716
2.01
6.54
6.3
7.5
1.1
1.2
inr
2.09
35
212
89
533
2.05
6.43
1.7
1.6
1.2
1.3
mmol/l
0.52
79
453
65
353
2.15
6.03
3.4
2.6
506.1
561.6
mosm/kgh2o
1.43
55
302
46
218
2.37
5.90
6.6
6.1
104.3
104.1
mmol/l
0.13
46
212
47
228
2.31
5.71
1.2
1.3
—
—
—
0
0
32
130
2.68
5.65
9.5
7.2
—
—
—
0
0
91
579
1.91
5.35
2.8
3.0
9.1
7.7
mmol/l
1.48
84
484
35
164
2.32
4.58
4.4
3.7
—
—
—
0
0
12
31
4.02
4.31
1.8
3.1
—
—
—
0
0
13
36
3.76
4.26
1.9
2.8
2.7
3.2
mmol/l
—
7
24
74
480
1.78
3.90
4.5
3.3
89.2
93.5
%
0.73
74
470
11
29
3.92
3.85
2.4
2.8
—
—
—
0
0
185
1546
1.80
3.83
9.0
6.9
76.8
77.5
u/l
0.11
178
1433
212
1864
2.02
3.54
7.1
4.6
1.3
1.9
mu/l
12.86
202
1698
9
18
5.15
3.40
1.4
1.4
86.7
90.2
%
—
9
18
167
1391
1.63
3.13
3.9
3.5
—
—
—
0
0
117
899
1.58
3.07
12.8
8.7
0.0
0.0
e9/l
0.56
100
734
101
750
1.59
3.07
1.9
1.9
97.4
97.7
pmol/l
0.02
55
356
20
88
2.39
3.03
8.3
8.1
—
—
—
0
0
129
1019
1.56
2.97
6.6
5.6
10.4
10.8
umol/l
0.37
124
961
8
17
4.83
2.94
1.1
1.2
—
—
—
0
0
14
52
2.79
2.94
2.1
3.0
—
—
—
0
0
80
573
1.59
2.79
3.3
2.7
—
—
—
0
0
57
377
1.67
2.72
2.9
2.4
6.4
4.3
e6/l
0.78
51
329
43
269
1.73
2.51
2.2
1.8
—
—
—
0
0
86
639
1.53
2.51
6.0
2.9
2.4
2.3
mmol/l
1.02
78
561
78
569
1.54
2.47
3.6
2.8
35.9
162.2
e6/l
0.55
62
423
87
651
1.52
2.45
5.3
5.0
—
—
—
0
0
159
1352
1.50
2.36
5.0
4.0
—
—
—
0
0
70
506
1.54
2.29
3.7
2.6
—
—
—
0
0
207
1872
1.68
2.28
7.5
5.3
40.1
39.5
mmol/mol
0.41
202
1757
7
18
3.97
2.27
1.0
1.2
—
—
—
0
0
116
934
1.46
2.23
5.8
5.7
8.8
8.4
%
0.75
106
878
71
519
1.52
2.20
3.7
2.7
0.8
0.3
e6/l
0.63
55
374
42
271
1.66
2.20
1.3
1.3
—
—
—
0
0
115
927
1.45
2.19
5.7
5.4
2.7
2.8
%
0.33
105
863
215
1972
1.74
2.14
5.3
4.3
5.8
5.9
mmol/l
0.53
210
1804
43
282
1.64
2.11
2.9
2.1
11.7
14.2
umol/l
2.16
43
262
138
1157
1.44
2.10
9.4
9.2
3.8
4.0
e9/l
0.27
121
1014
74
551
1.49
2.09
3.7
3.0
—
—
—
0
0
5
10
5.08
2.08
1.0
1.0
—
—
iu/ml
—
0
0
6
15
4.07
2.05
1.0
1.1
—
—
—
0
0
65
474
1.51
2.03
5.1
3.9
—
—
—
0
0
9
32
2.88
2.02
4.6
2.5
—
—
—
0
0
7
21
3.40
1.98
1.0
1.2
—
—
nmol/l
—
0
0
111
902
1.42
1.96
5.8
5.4
0.7
0.7
%
0.14
102
841
99
793
1.42
1.88
2.1
2.0
—
—
—
0
0
116
957
1.40
1.85
5.8
5.5
28.8
28.4
%
0.14
106
894
6
17
3.59
1.85
2.2
1.9
1.8
3.1
nmol/l
—
6
17
59
430
1.49
1.84
2.1
2.0
3.1
3.3
mg/l
0.34
52
371
119
992
1.39
1.76
5.5
5.4
0.5
0.6
e9/l
0.35
106
867
114
944
1.39
1.76
5.7
5.3
56.4
56.8
%
0.12
104
889
119
998
1.37
1.68
5.5
5.4
0.0
0.0
e9/l
0.25
106
871
122
1029
1.37
1.65
5.6
5.6
0.2
0.2
e9/l
0.68
112
913
5
14
3.62
1.62
1.2
1.1
—
—
—
0
0
7
26
2.74
1.59
2.4
1.5
—
—
—
0
0
46
328
1.50
1.59
3.4
2.8
2.4
2.4
mmol/l
0.25
39
290
13
64
2.09
1.57
2.8
3.3
0.1
0.1
g/l
—
7
22
120
1021
1.34
1.49
5.6
5.4
1.7
2.0
e9/l
1.43
109
911
116
984
1.34
1.46
5.2
4.6
0.0
0.0
estimate
0.00
33
174
115
975
1.34
1.45
3.5
3.4
0.0
0.0
estimate
0.00
35
174
117
996
1.33
1.43
3.8
3.5
0.0
0.0
estimate
0.00
33
166
106
890
1.34
1.42
3.2
2.5
96.5
108.4
ug/l
0.46
98
816
84
683
1.35
1.39
4.3
3.3
73.2
55.4
e6/l
0.26
65
464
32
218
1.54
1.37
27.3
19.6
1.3
1.3
inr
—
6
34
69
545
1.37
1.37
3.7
3.7
0.1
0.0
estimate
0.49
33
169
5
17
2.98
1.36
1.4
1.3
—
—
—
0
0
13
69
1.93
1.31
6.9
3.5
25.1
24.3
mmol/l
0.44
13
61
23
148
1.61
1.25
3.1
4.9
1.1
0.4
%
—
7
36
14
236
0.57
1.24
1.1
1.3
—
—
—
0
0
24
158
1.58
1.20
3.0
4.9
0.0
0.2
%
—
10
49
8
38
2.14
1.19
1.0
1.3
—
—
—
0
0
18
110
1.69
1.19
1.0
1.2
—
—
—
0
0
167
1520
1.31
1.16
4.3
3.9
12.9
10.9
mm/h
1.05
160
1388
32
227
1.47
1.15
1.3
1.2
—
—
—
0
0
75
618
1.31
1.11
2.5
2.4
62.3
55.3
u/l
0.33
70
565
22
145
1.57
1.10
2.8
2.5
74.5
69.9
e9/l
0.19
15
110
55
436
1.34
1.06
1.6
1.5
21.9
21.0
nmol/l
0.17
47
369
69
569
1.30
1.01
3.6
3.5
—
—
—
0
0
23
157
1.51
1.00
1.2
1.2
—
—
—
0
0
16
100
1.64
0.99
1.7
2.6
0.3
0.2
e6/l
0.11
16
95
87
742
1.27
0.98
3.6
3.4
40.0
36.3
ng/l
0.09
68
481
59
480
1.30
0.95
2.9
5.1
—
—
—
0
0
22
151
1.50
0.94
3.1
5.0
0.1
0.2
%
—
8
41
6
27
2.25
0.94
1.8
1.4
—
—
—
0
0
6
27
2.25
0.94
4.8
1.8
66.4
60.5
%
—
6
27
13
206
0.61
0.94
1.2
1.4
—
—
—
0
0
35
265
1.37
0.91
1.2
1.4
453.3
492.9
titre
—
6
65
24
170
1.46
0.89
3.0
4.8
1.3
0.9
%
—
10
57
210
2003
1.34
0.84
5.0
4.3
1.4
1.5
mmol/l
0.56
210
1844
65
545
1.26
0.83
1.4
1.4
—
—
—
0
0
23
165
1.43
0.81
7.0
3.2
—
—
—
0
0
42
338
1.29
0.74
5.1
3.8
48.4
344.7
ng/l
1.66
30
250
7
39
1.82
0.73
1.0
1.2
0.4
0.9
nmol/l
—
7
33
9
143
0.62
0.72
1.3
1.5
—
—
—
0
0
7
118
0.58
0.70
1.3
1.8
—
—
—
0
0
23
174
1.36
0.62
3.5
3.7
—
—
—
0
0
8
49
1.65
0.62
1.3
1.1
—
—
—
0
0
57
487
1.22
0.62
8.5
6.4
—
—
—
0
0
5
30
1.68
0.62
1.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
2.0
—
—
—
0
0
6
35
1.73
0.58
1.5
3.6
4.6
4.9
e9/l
—
6
35
6
36
1.68
0.57
1.5
4.1
61.2
59.0
%
—
6
36
202
1942
1.23
0.56
4.3
3.8
1.3
1.3
mmol/l
0.12
202
1785
61
533
1.19
0.53
3.7
3.2
66.7
63.8
mg/l
0.04
46
335
9
136
0.65
0.53
1.1
1.3
—
—
—
0
0
11
75
1.49
0.51
1.5
1.4
—
—
—
0
0
18
138
1.33
0.47
1.2
1.3
135.2
157.9
iu/ml
—
8
56
211
2048
1.22
0.46
18.5
12.2
24.5
21.6
mg/l
0.66
171
1572
51
446
1.18
0.45
1.5
1.3
1.8
1.4
u/ml
0.11
14
119
51
446
1.18
0.45
1.9
1.7
1.3
1.0
mg/l
0.37
43
344
219
2137
1.23
0.42
18.4
11.7
—
—
—
0
0
0
15
0.00
0.41
0.0
10.9
—
0.6
—
0
15
5
34
1.48
0.40
2.2
1.4
—
—
—
0
0
19
236
0.79
0.40
1.4
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
5
36
1.40
0.38
1.0
1.6
—
—
—
0
0
15
116
1.31
0.38
3.2
4.7
—
—
—
0
0
11
81
1.37
0.37
1.5
1.4
—
—
—
0
0
5
80
0.62
0.36
1.0
1.2
—
—
—
0
0
11
82
1.36
0.34
1.5
1.4
—
—
—
0
0
11
82
1.36
0.34
1.5
1.4
—
—
—
0
0
21
173
1.23
0.34
2.1
2.2
0.2
0.2
g/l
0.84
21
159
34
388
0.86
0.32
1.4
1.7
443.6
465.1
pmol/l
0.25
29
332
38
335
1.16
0.31
1.6
1.7
1086.9
1189.4
nmol/l
0.29
31
242
7
97
0.71
0.31
2.1
2.3
—
—
—
0
0
7
99
0.70
0.31
1.3
1.1
—
—
—
0
0
7
53
1.33
0.31
1.1
1.2
—
—
—
0
0
231
2276
1.26
0.30
28.6
18.3
30.2
30.3
pg
0.29
231
2235
231
2276
1.26
0.30
28.6
18.3
91.0
90.9
fl
0.17
231
2236
7
57
1.23
0.29
2.6
4.1
—
—
—
0
0
8
62
1.30
0.28
1.8
1.3
—
—
—
0
0
9
116
0.77
0.28
1.1
1.3
108.3
366.4
u/ml
—
9
109
231
2279
1.24
0.27
28.9
18.4
133.9
136.3
g/l
1.66
231
2236
16
132
1.23
0.26
1.3
1.4
—
—
—
0
0
61
565
1.11
0.25
4.5
4.0
9.7
10.4
mg/mmol
0.06
46
353
5
39
1.29
0.23
1.2
1.7
—
—
—
0
0
10
79
1.28
0.22
5.1
9.1
—
—
—
0
0
5
40
1.26
0.22
1.8
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
168.0
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
13
155
0.83
0.21
2.2
3.3
—
—
—
0
0
34
374
0.89
0.20
1.1
1.3
43.0
35.7
iu/ml
—
9
128
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
184
1876
0.92
0.18
23.0
12.9
39.3
40.3
%
1.00
133
1407
44
408
1.10
0.18
1.4
1.4
2.2
2.5
g/l
0.46
27
247
7
61
1.15
0.17
1.4
2.6
—
—
—
0
0
10
82
1.23
0.17
1.6
1.4
—
—
—
0
0
11
93
1.19
0.15
3.1
3.3
—
—
—
0
0
36
334
1.09
0.14
2.1
1.9
—
—
—
0
0
42
446
0.93
0.13
3.4
3.5
—
—
—
0
0
22
201
1.10
0.12
2.2
1.7
—
—
—
0
0
15
166
0.90
0.10
1.8
1.8
—
—
—
0
0
20
184
1.09
0.09
1.3
1.3
—
—
—
0
0
6
57
1.05
0.08
3.3
3.9
3.9
3.9
mmol/l
—
6
51
5
64
0.78
0.08
1.0
1.3
—
—
—
0
0
7
66
1.06
0.08
2.0
1.6
—
—
—
0
0
19
204
0.93
0.07
1.6
1.7
—
—
—
0
0
173
1746
0.97
0.05
26.4
15.9
331.9
332.6
g/l
0.49
173
1738
12
129
0.93
0.03
2.2
2.0
—
—
—
0
0
36
371
0.97
0.03
1.1
1.3
1.3
10.2
u/ml
2.76
17
149
28
270
1.04
0.03
2.4
1.6
—
—
—
0
0
10
92
1.09
0.03
3.7
3.3
—
—
—
0
0
13
124
1.05
0.00
1.2
1.3
—
31.0
—
0
5
12
122
0.98
0.00
3.6
2.6
—
—
—
0
0
12
119
1.01
0.00
1.2
1.6
0.9
1.4
g/l
1.20
12
109
22
217
1.02
0.00
2.2
1.6
—
—
—
0
0
15
147
1.02
0.00
1.3
1.4
—
—
—
0
0
10
96
1.04
0.00
1.0
1.1
—
—
—
0
0
10
96
1.04
0.00
5.4
2.4
0.9
1.3
%
—
10
96
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
79
1.01
0.00
1.1
1.5
—
—
—
0
0
32
320
1.00
0.00
2.2
2.6
0.5
0.7
ug/l
2.04
22
187
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
77
770
1.00
0.00
3.2
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
7
71
0.99
0.00
5.7
4.7
—
—
—
0
0
5
54
0.92
0.00
2.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.9
—
0
6
5
53
0.94
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
3.8
—
0
5
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_ACROMEG and mortality.

Females

Parameter HR [95% CI] p-value
E4_ACROMEG 1.68 [1.25, 2.25] < 0.001
Birth year 0.996 [0.99, 1.0] 0.335

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 432 females with E4_ACROMEG died.

Males

Parameter HR [95% CI] p-value
E4_ACROMEG 1.62 [1.24, 2.12] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 350 males with E4_ACROMEG died.

Mortality risk

Mortality risk for people of age

years, who have E4_ACROMEG.

N-year risk Females Males
1 0.147% 0.274%
5 0.885% 2.148%
10 2.427% 5.483%
15 4.67% 9.864%
20 8.7% 16.301%

Relationships between endpoints

Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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