No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
77 |
4. Check minimum number of eventsNone |
77 |
5. Include endpointsNone |
77 |
6. Filter based on genotype QC (FinnGen only) |
77 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H34
- Name in latin
- Occlusio arteriae retinalis transitoria
Similar endpoints
↥List of similar endpoints to
Transient retinal artery occlusion
based on the number of shared cases.
Similar with more cases:
- Retinal vascular occlusion
- Retinal vascular disorders
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 494 | 232 | 259 |
| Only index persons | 457 | 219 | 238 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.25 | 71.14 | 67.63 |
| Only index persons | 68.72 | 70.55 | 67.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 77 | 39 | 38 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 64.91 | 63.60 | 66.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H34.0
ICD-10 Finland
Transient retinal artery occlusion
+∞
102.0
71
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
18.5
17
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
+∞
18.5
17
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
15.1
14
*
CKC12
NOMESCO Finland
Photocoagulation of retina
+∞
11.8
11
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
15.5
10.5
17
14
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
9.6
9
*
XCK10
NOMESCO Finland
Photography of fundus of eye
7.8
9.5
23
41
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
18.9
9.5
14
9
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
101.5
8.6
9
*
AA1AD
NOMESCO Finland
CT of head and brain
4.8
8.2
33
109
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
7.0
25
71
XCK00
NOMESCO Finland
Perimetry
7.9
6.8
15
23
C10AA05
ATC
atorvastatin; oral
3.7
6.6
44
217
H53.1
ICD-10 Finland
Subjective visual disturbances
9.1
6.5
13
17
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETARTOCCTRANS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETARTOCCTRANS | 1.193 [0.88, 1.61] | 0.248 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 215 females with H7_RETARTOCCTRANS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETARTOCCTRANS | 1.48 [1.11, 1.98] | 0.008 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 228 males with H7_RETARTOCCTRANS died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETARTOCCTRANS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.28% |
| 5 | 0.736% | 1.675% |
| 10 | 1.684% | 4.116% |
| 15 | 3.186% | 7.73% |
| 20 | 5.643% | 12.837% |
Relationships between endpoints
↥Index endpoint: H7_RETARTOCCTRANS – Transient retinal artery occlusion
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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