No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6354 |
4. Check minimum number of eventsNone |
6354 |
5. Include endpointsNone |
6354 |
6. Filter based on genotype QC (FinnGen only) |
6354 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H33
- Name in latin
- Ruptura retinae sine ablatione
Similar endpoints
↥List of similar endpoints to
Retinal breaks without detachment
based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 37057 | 20151 | 16809 |
| Only index persons | 36278 | 19857 | 16421 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.53 | 0.58 | 0.47 |
| Only index persons | 0.68 | 0.73 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 60.88 | 60.16 | 61.81 |
| Only index persons | 60.82 | 60.09 | 61.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6354 | 3558 | 2796 |
| Unadjusted period prevalence (%) | 1.22 | 1.21 | 1.23 |
| Median age at first event (years) | 61.24 | 59.65 | 63.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 5622
- Matched controls
- 56219
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.5
323.0
604
190
H33.3
ICD-10 Finland
Retinal breaks without detachment
4503599627370496.0
323.0
5592
9
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
498.0
323.0
330
7
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2400.3
323.0
1048
5
WX140
NOMESCO Finland
Parabulbar anesthesy
17.6
323.0
624
396
CKC10
NOMESCO Finland
Local photocoagulation of retina
402.3
323.0
711
20
H43.8
ICD-10 Finland
Other disorders of vitreous body
8.0
323.0
1566
2576
CKC12
NOMESCO Finland
Photocoagulation of retina
1565.0
323.0
3336
51
CKD40
NOMESCO Finland
Endophotocoagulation of retina
300.6
307.8
311
11
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
61.2
289.1
340
59
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
90.5
283.8
316
37
H35.4
ICD-10 Finland
Peripheral retinal degeneration
518.5
251.8
249
5
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
225.8
231.6
238
11
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.5
227.6
899
2276
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
104.2
209.9
230
23
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
113.4
200.7
218
20
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.8
196.7
930
2754
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.4
192.7
2217
11811
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.9
175.9
626
1402
CKC60
NOMESCO Finland
Local buckling of sclera using implant
1744.1
168.5
163
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.4
167.0
1810
9178
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
59.9
138.3
163
28
CKC30
NOMESCO Finland
Cryopexy of detached retina
1344.6
134.9
131
*
H26.4
ICD-10 Finland
After-cataract
3.7
134.0
645
1900
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
126.7
2521
16249
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
260.0
124.5
127
5
H33.5
ICD-10 Finland
Other retinal detachments
28.3
122.0
168
61
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
119.6
566
1636
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
90.1
118.6
132
15
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
77.7
113.8
129
17
CKD20
NOMESCO Finland
Removal of vitreous body substitute
527.6
105.0
104
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
254.6
98.0
100
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
13.7
97.4
172
129
H25.1
ICD-10 Finland
Senile nuclear cataract
2.1
95.1
1368
7539
S01ED51
ATC
timolol, combinations; ophthalmic
3.4
94.9
511
1626
H35.37
ICD-10 Finland
Macular holes
315.4
93.1
94
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
92.8
387
995
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
88.8
85
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
98.7
88.2
97
10
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
226.0
86.6
89
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
223.4
85.6
88
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
84.1
961
4754
H52.1
ICD-10 Finland
Myopia
5.2
78.8
256
509
CKD15
NOMESCO Finland
Injection of vitreous substitute
382.5
75.9
76
*
Z2221
NOMESCO Finland
Medical doctor
1.8
72.0
1595
10118
XCH00
NOMESCO Finland
Eye pressure measurement
4.1
70.1
292
747
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
65.6
429
1552
CKC20
NOMESCO Finland
Cryopexy of undetached retina
225.9
65.3
67
*
H33
ICD-10 Finland
Retinal detachments and breaks
47.1
64.7
79
17
XCK10
NOMESCO Finland
Photography of fundus of eye
2.5
63.1
538
2274
ZXA05
NOMESCO Finland
Left side
1.7
60.6
1454
9365
ZXA00
NOMESCO Finland
Right side
1.7
56.4
1539
10255
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
53.9
640
3173
H43.9
ICD-10 Finland
Disorder of vitreous body, unspecified
10.0
52.5
107
109
H26.2
ICD-10 Finland
Complicated cataract
8.1
51.8
119
149
WX002
NOMESCO Finland
Sedation and analgesia
1.7
48.2
1115
7022
S01EA03
ATC
apraclonidine; ophthalmic
10.7
47.5
93
88
H25.8
ICD-10 Finland
Other senile cataract
2.1
45.1
545
2712
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.3
45.0
242
763
H43.3
ICD-10 Finland
Other vitreous opacities
5.9
42.7
122
209
H26.02
ICD-10 Finland
Presenil cataract
3.5
41.3
203
598
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
39.6
38
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
11.3
39.0
74
66
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.4
38.9
198
600
H35.7
ICD-10 Finland
Separation of retinal layers
201.3
38.9
40
*
S01BC05
ATC
ketorolac; ophthalmic
3.2
38.0
206
654
XCD20
NOMESCO Finland
Photoangiography of eye
14.9
37.0
62
42
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
36.5
35
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
34.4
33
*
3613A
ICD-9 Finland
Retinal detachments and defects, Retinal defects without detachment
+∞
34.4
33
*
ZXA10
NOMESCO Finland
Bilateral
1.6
34.1
929
6060
H35.6
ICD-10 Finland
Retinal haemorrhage
65.4
34.0
39
6
S01ED01
ATC
timolol; ophthalmic
3.1
33.9
197
658
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
17.2
33.6
53
31
S01EE01
ATC
latanoprost; ophthalmic
2.4
33.2
308
1351
H35.36
ICD-10 Finland
Macular cyst
329.0
32.9
33
*
H33.2
ICD-10 Finland
Serous retinal detachment
117.4
32.7
35
*
S01EC01
ATC
acetazolamide; systemic
4.3
32.5
125
299
H3601, E113
ICD-10 Finland
NA
+∞
32.3
31
*
H3600, E113
ICD-10 Finland
NA
+∞
31.3
30
*
A98
ICPC
Health maint/preventive medicine
1.9
29.7
5322
50754
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.6
29.4
137
388
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.6
29.1
76
117
H43
ICD-10 Finland
Disorders of vitreous body
7.6
27.9
66
88
H25.0
ICD-10 Finland
Senile incipient cataract
2.2
27.3
301
1432
H3603, E103
ICD-10 Finland
NA
+∞
27.1
26
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
75.5
26.8
30
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
13.7
26.2
45
33
H3603, E113
ICD-10 Finland
NA
+∞
26.1
25
*
H3600, E103
ICD-10 Finland
NA
+∞
26.1
25
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
73.0
25.8
29
*
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
25.3
496
2926
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.3
25.0
131
408
114
Kela drug reimbursment
Glaucoma
1.9
24.1
401
2239
H40.0
ICD-10 Finland
Glaucoma suspect
1.9
23.8
379
2085
F05
ICPC
Visual disturbance other
2.9
23.7
150
533
H30.2
ICD-10 Finland
Posterior cyclitis
240.9
23.7
24
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
65.2
22.8
26
*
H35.8
ICD-10 Finland
Other specified retinal disorders
62.7
21.8
25
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
21.8
1814
14681
CKD50
NOMESCO Finland
Endodiathermy of retina
220.8
21.6
22
*
XCK00
NOMESCO Finland
Perimetry
1.9
21.6
309
1637
F29
ICPC
Eye symptom/complaint other
1.8
21.5
397
2296
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
11.9
21.4
39
33
ZXE00
NOMESCO Finland
One hour or less
1.3
21.2
1909
15620
S01EC04
ATC
brinzolamide; ophthalmic
2.4
20.1
180
777
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
19.9
876
6316
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
19.8
19
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
+∞
19.8
19
*
R01AD09
ATC
mometasone; nasal
1.3
19.7
2119
17746
S01BC03
ATC
diclofenac; ophthalmic
3.0
19.6
114
385
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
21.6
19.5
28
13
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.4
18.4
66
150
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.8
18.3
61
129
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
52.7
17.9
21
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
17.7
17
*
F04
ICPC
Visual floaters/spots
5.9
17.3
48
82
R01AD08
ATC
fluticasone; nasal
1.3
17.3
1320
10460
H3601, E103
ICD-10 Finland
NA
+∞
16.7
16
*
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
35.1
16.6
21
6
H53.8
ICD-10 Finland
Other visual disturbances
3.9
16.5
68
177
H34.1
ICD-10 Finland
Central retinal artery occlusion
170.4
16.5
17
*
H27.1
ICD-10 Finland
Dislocation of lens
9.5
16.4
33
35
H36.01
ICD-10 Finland
Diabetic maculopathy
47.6
16.0
19
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
15.7
1871
15742
H34.2
ICD-10 Finland
Other retinal artery occlusions
85.3
15.6
17
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
8.2
14.7
32
39
CKD25
NOMESCO Finland
External drainage of subretinal fluid
+∞
14.6
14
*
1LA05
NOMESCO Finland
NA
+∞
14.6
14
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
1.9
13.7
193
1021
H57.1
ICD-10 Finland
Ocular pain
2.2
13.6
141
655
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
5.9
13.6
37
63
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
34.1
13.5
17
5
J01FA10
ATC
azithromycin; systemic
1.2
13.2
2703
24087
CS494
NOMESCO Finland
Other visual field testing
2.4
13.2
108
450
ZXD20
NOMESCO Finland
Day surgery
1.4
13.2
590
4248
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
13.0
1285
10497
H53
ICD-10 Finland
Visual disturbances
4.4
13.0
46
105
A02BC05
ATC
esomeprazole; systemic
1.2
12.7
2008
17360
S01EE05
ATC
tafluprost; ophthalmic
2.1
12.7
149
733
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
12.7
1486
12404
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
12.5
12
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
+∞
12.5
12
*
S01FA04
ATC
cyclopentolate; ophthalmic
3.5
12.5
58
169
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.1
12.4
142
692
A02BC02
ATC
pantoprazole; systemic
1.2
12.3
3273
29890
H44.2
ICD-10 Finland
Degenerative myopia
12.4
12.1
21
17
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
12.1
1136
9209
A10AA01
ATC
NA
3.3
12.0
60
185
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
12.0
947
7493
Z3231
NOMESCO Finland
Registered nurse
1.3
11.9
1233
10122
CKD30
NOMESCO Finland
Internal drainage of subretinal fluid
+∞
11.5
11
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
6.1
11.0
29
48
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
28.1
10.7
14
5
J01CA04
ATC
amoxicillin; systemic
1.2
10.7
3983
37360
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
2.6
10.6
75
290
J01AA02
ATC
doxycycline; systemic
1.2
10.6
4014
37695
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
10.4
2347
20925
CKC75
NOMESCO Finland
Removal of cerclage from sclera
+∞
10.4
10
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
2.5
10.3
80
325
R01AD01
ATC
beclometasone; nasal
1.3
10.3
674
5176
M01AE02
ATC
naproxen; oral, rectal
1.2
10.2
2681
24242
A10BA02
ATC
metformin; oral
0.8
10.2
873
10692
G47.3
ICD-10 Finland
Sleep apnoea
1.3
10.2
984
7989
H36.00
ICD-10 Finland
Diabetic background retinopathy
7.9
10.1
22
28
S01EC54
ATC
brinzolamide, combinations; ophthalmic
3.1
10.0
54
178
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
10.0
1021
8342
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
9.9
1034
8476
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
9.8
2111
18701
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
9.7
503
3715
R01AD12
ATC
fluticasone furoate; nasal
1.2
9.7
1233
10342
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
6.8
9.6
23
34
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.5
9.6
330
2254
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
6.3
9.5
24
38
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.4
9.5
75
311
H31.0
ICD-10 Finland
Chorioretinal scars
100.2
9.4
10
*
F82
ICPC
Detached retina
100.2
9.4
10
*
Z3229
NOMESCO Finland
Other healthcare associate professional
1.5
9.4
328
2246
G04CA01
ATC
alfuzosin; oral
1.4
9.4
514
3835
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
9.4
9
*
H3602, E103
ICD-10 Finland
NA
+∞
9.4
9
*
3759
FHL
Other measure in this category
+∞
9.4
9
*
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
9.4
9
*
WX110
NOMESCO Finland
Local anesthesy
1.2
9.3
3285
30414
WX408
NOMESCO Finland
General anesthesy, balanced
1.2
9.2
1229
10354
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.7
9.2
181
1075
J01FA09
ATC
clarithromycin; systemic
1.2
9.0
1417
12144
J31.0
ICD-10 Finland
Chronic rhinitis
1.5
9.0
315
2159
J02AC01
ATC
fluconazole; systemic
1.2
9.0
1751
15337
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.4
8.8
40
117
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
2.4
8.8
70
291
DFF00
NOMESCO Finland
Pure tone audiometry
1.4
8.7
388
2791
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
8.7
2066
18421
A10AA02
ATC
NA
2.5
8.7
66
267
M01AH05
ATC
etoricoxib; oral
1.2
8.6
2896
26609
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
8.5
1883
16661
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
16.3
8.5
13
8
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
1.6
8.5
198
1233
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
2.7
8.4
54
199
Q14.10
ICD-10 Finland
Congenital retinoschis
90.2
8.4
9
*
R05
ICD-10 Finland
Cough
1.3
8.4
848
6913
CKD75
NOMESCO Finland
Retinotomy
+∞
8.3
8
*
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
8.3
8
*
H02AB07
ATC
prednisone; oral
1.3
8.2
611
4779
S01KA02
ATC
hypromellose; ophthalmic
2.1
8.2
88
424
Z01.2
ICD-10 Finland
Dental examination
1.2
8.2
1784
15759
J01MA02
ATC
ciprofloxacin; systemic
1.2
8.1
1783
15761
H04AA01
ATC
glucagon; nasal, parenteral
2.8
8.1
49
177
M01AX05
ATC
glucosamine; oral
1.2
8.0
958
7967
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.4
8.0
423
3141
D07AC13
ATC
mometasone; topical
1.2
7.9
1269
10883
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
13.0
7.9
13
10
S01EE03
ATC
bimatoprost; ophthalmic
2.0
7.8
90
444
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
1.8
7.8
121
666
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
6.9
7.8
18
26
L15
ICPC
Knee symptom/complaint
1.2
7.7
929
7720
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
1.7
7.7
151
897
ZX198
NOMESCO Finland
Other local administration
4.1
7.6
28
69
WX320
NOMESCO Finland
Spinalanesthesy
1.2
7.6
1004
8427
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
7.6
1971
17646
J01DB01
ATC
cefalexin; oral
1.2
7.6
4094
38928
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.2
7.6
1509
13202
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
7.5
463
3520
M79.1
ICD-10 Finland
Myalgia
1.3
7.5
500
3851
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
80.2
7.4
8
*
S83.2
ICD-10 Finland
Tear of meniscus, current
1.5
7.3
275
1915
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
7.3
7
*
H30.8
ICD-10 Finland
Other chorioretinal inflammations
+∞
7.3
7
*
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
7.3
7
*
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.2
7.2
1598
14100
H53.4
ICD-10 Finland
Visual field defects
2.0
7.2
83
411
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
30.0
7.1
9
*
R74
ICPC
Upper respiratory infection acute
1.2
7.0
1018
8627
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.3
7.0
13
451
K03.64
ICD-10 Finland
Dental calculus supragingival
1.2
7.0
1094
9342
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.3
7.0
494
3838
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
2.9
7.0
40
138
R06AX27
ATC
desloratadine; oral
1.2
6.9
1085
9265
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
2.9
6.9
38
130
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
5.1
6.9
20
39
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.0
6.9
83
419
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
6.9
1636
14508
A97
ICPC
No disease
1.3
6.9
584
4648
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.3
6.8
16
494
A06AC51
ATC
ispaghula, combinations; systemic
1.5
6.8
204
1357
F28
ICPC
Limited function/disability (F)
3.4
6.8
30
88
H26.9
ICD-10 Finland
Cataract, unspecified
2.3
6.8
60
265
CA1ME
NOMESCO Finland
Ultrasound oculometry
3.5
6.8
29
83
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.3
6.7
565
4496
M03BX02
ATC
tizanidine; oral
1.2
6.7
2992
27865
N05CF02
ATC
zolpidem; oral
1.2
6.7
746
6145
R5140
NOMESCO Finland
Monitoring the use of the aid
1.3
6.7
444
3418
M01AB05
ATC
diclofenac; systemic, rectal
1.2
6.7
3296
30930
R03BA05
ATC
fluticasone; inhalant
1.2
6.6
720
5916
D01AE16
ATC
amorolfine; topical
1.3
6.6
512
4031
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
4.3
6.5
22
51
C07AA05
ATC
propranolol; systemic
1.2
6.5
785
6520
CKD60
NOMESCO Finland
Anterior vitrectomy
3.1
6.5
32
102
J02AC02
ATC
itraconazole; systemic
1.2
6.5
793
6598
WX199
NOMESCO Finland
Other local analgesia
1.8
6.5
106
600
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.2
6.4
61
281
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.3
6.4
510
4028
F01
ICPC
Eye pain
1.8
6.4
105
593
G04CA02
ATC
tamsulosin; oral
1.2
6.4
953
8093
M02AA07
ATC
piroxicam; topical
1.2
6.4
1690
15104
Z94.0
ICD-10 Finland
Kidney transplant status
2.6
6.4
45
177
H40.8
ICD-10 Finland
Other glaucoma
4.9
6.3
19
39
F45.8
ICD-10 Finland
Other somatoform disorders
1.5
6.3
207
1408
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
6.2
6
*
3742
FHL
Cryocoagulation under general anesthesia
+∞
6.2
6
*
H3602, E113
ICD-10 Finland
NA
+∞
6.2
6
*
CKE40
NOMESCO Finland
Transpupillary photocoagulation of lesion of retina
+∞
6.2
6
*
R06AE07
ATC
cetirizine; oral
1.2
6.2
1897
17133
J05AB01
ATC
aciclovir; systemic
1.2
6.2
869
7332
M79.6
ICD-10 Finland
Pain in limb
1.2
6.2
1579
14061
H21.0
ICD-10 Finland
Hyphaema
4.8
6.2
19
40
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.7
6.2
141
2111
H11.3
ICD-10 Finland
Conjunctival haemorrhage
1.6
6.2
156
1000
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.7
6.2
208
2905
S01EE04
ATC
travoprost; ophthalmic
1.9
6.1
83
441
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
3.0
6.1
31
102
R03BA02
ATC
budesonide; inhalant
1.2
6.1
704
5825
H52.2
ICD-10 Finland
Astigmatism
2.2
6.0
53
237
S18
ICPC
Laceration/cut
1.2
6.0
1953
17720
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINALBREAK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALBREAK | 0.725 [0.65, 0.81] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.329 |
During the follow-up period (1.1.1998 — 31.12.2019), 1190 out of 17611 females with H7_RETINALBREAK died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALBREAK | 0.638 [0.57, 0.71] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 1476 out of 14412 males with H7_RETINALBREAK died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINALBREAK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.134% |
| 5 | 0.415% | 0.759% |
| 10 | 1.058% | 1.968% |
| 15 | 2.039% | 3.615% |
| 20 | 3.557% | 6.424% |
Relationships between endpoints
↥Index endpoint: H7_RETINALBREAK – Retinal breaks without detachment
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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