erythema infectiosum: usually a benign childhood condition characterized by a classic slapped-cheek appearance (see the image below) and lacy exanthem.It results from infection with human parvovirus (PV) B19, an erythrovirus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1130 |
4. Check minimum number of eventsNone |
1130 |
5. Include endpointsNone |
1130 |
6. Filter based on genotype QC (FinnGen only) |
1130 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50-L54
- Name in latin
- Erythema nodosum
Similar endpoints
↥List of similar endpoints to
Erythema nodosum
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9004 | 6843 | 2116 |
| Only index persons | 7799 | 5941 | 1858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.20 | 0.06 |
| Only index persons | 0.18 | 0.22 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 40.55 | 41.91 | 36.01 |
| Only index persons | 37.81 | 38.86 | 34.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1130 | 894 | 236 |
| Unadjusted period prevalence (%) | 0.26 | 0.30 | 0.10 |
| Median age at first event (years) | 38.61 | 38.20 | 40.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1018
- Matched controls
- 10180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L52
ICD-10 Finland
Erythema nodosum
1597.8
323.0
603
9
69520
ICD-8 Finland
Erythematous condition, Erythema nodosum
+∞
257.5
236
*
6952A
ICD-9 Finland
Erythematous conditions, Erythema nodosum[ERYTHEMA NODOSUM ACUTUM]
+∞
100.7
95
*
M148, L529
ICD-10 Finland
NA
+∞
80.3
76
*
H02AB06
ATC
prednisolone; systemic
2.9
55.5
590
3307
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
48.5
178
432
M14.8*L52
ICD-10 Finland
Arthropathy in erythema: nodosum
+∞
36.7
35
*
L04AX01
ATC
azathioprine; systemic
5.9
35.9
105
194
L529
ICD-10 Finland
NA
+∞
35.6
34
*
M79.3
ICD-10 Finland
Panniculitis, unspecified
40.7
34.6
43
11
D86.0
ICD-10 Finland
Sarcoidosis of lung
13.6
33.2
58
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
31.4
465
2789
A46
ICD-10 Finland
Erysipelas
3.1
30.5
187
685
13597
ICD-8 Finland
Sarcoidosis, Suspecta
37.8
26.3
33
9
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
12.0
24.6
45
39
R50.9
ICD-10 Finland
Fever, unspecified
2.7
24.3
180
738
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.6
23.5
85
199
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
15.5
22.1
36
24
A07EC02
ATC
mesalazine; oral, rectal
3.7
19.9
91
265
H02AB07
ATC
prednisone; oral
2.4
18.7
171
781
J01MA02
ATC
ciprofloxacin; systemic
1.9
17.8
382
2486
K50.8
ICD-10 Finland
Other Crohn disease
7.7
17.8
41
55
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
17.2
115
439
132
Kela drug reimbursment
Sarcoidosis
14.4
16.9
28
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
16.3
356
2313
A02BC02
ATC
pantoprazole; systemic
1.7
15.8
647
5093
UJF32
NOMESCO Finland
Coloscopy
1.9
15.7
263
1551
J01FF01
ATC
clindamycin; systemic
1.9
15.3
291
1796
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
10.6
14.8
28
27
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
14.6
191
1022
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
14.6
291
1821
J01DB01
ATC
cefalexin; oral
1.9
14.6
824
7071
K50.9
ICD-10 Finland
Crohn disease, unspecified
7.6
14.0
32
43
K51.5
ICD-10 Finland
Left sided colitis
4.6
14.0
48
108
1350A
ICD-9 Finland
Sarcoidosis[SARCOIDOSIS]
26.1
13.4
18
7
ZX120
NOMESCO Finland
Intravenous
2.5
13.3
111
479
TGC00
NOMESCO Finland
Bronchial lavation
4.7
12.9
43
94
R60.0
ICD-10 Finland
Localized oedema
2.3
12.8
122
567
K50.1
ICD-10 Finland
Crohn disease of large intestine
8.4
12.6
27
33
K50.0
ICD-10 Finland
Crohn disease of small intestine
7.1
12.2
29
42
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
11.8
111
511
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
12.7
11.7
20
16
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
11.6
140
719
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
4.0
11.6
45
115
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
11.6
195
1142
M13.9
ICD-10 Finland
Arthritis, unspecified
2.5
11.5
89
370
M14.8*D86.8
ICD-10 Finland
Arthropathy in sarcoidosis
121.3
11.4
12
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
11.3
117
563
J01DA01
ATC
[U] cefalexin; systemic
1.6
11.2
625
5105
E0000UV
ATC
NA
1.6
11.1
397
2897
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.5
11.1
50
146
D07AC01
ATC
betamethasone; topical
1.6
11.1
329
2289
M14.8
ICD-10 Finland
Arthropathies in other specified diseases classified elsewhere
43.8
10.9
13
*
A07EA06
ATC
budesonide; oral, local oral
3.5
10.7
49
145
M04AA01
ATC
allopurinol; systemic
2.2
10.2
103
490
H02AB04
ATC
methylprednisolone; systemic
2.0
10.2
147
809
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
3.2
10.0
52
170
SPAT1255
SPAT
Intravenous administration of medicine
2.6
9.8
72
289
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
9.8
59
213
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
9.8
191
1168
K50
ICD-10 Finland
Crohn disease [regional enteritis]
55.5
9.7
11
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.5
9.6
77
326
L50.9
ICD-10 Finland
Urticaria, unspecified
5.8
9.5
26
46
13599
ICD-8 Finland
Sarcoidosis, Unspecified
15.2
9.5
15
10
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
6.7
9.5
23
35
C03CA01
ATC
furosemide; systemic
1.7
9.3
238
1578
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.4
9.3
32
74
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
9.2
169
1012
J01MA12
ATC
levofloxacin; systemic
1.8
9.1
163
970
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.9
169
1023
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.1
8.8
46
151
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.5
8.8
67
278
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
8.7
85
399
TQW80
NOMESCO Finland
Local dermatologic skincare
3.9
8.7
34
89
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
10.1
8.5
16
16
D07AC13
ATC
mometasone; topical
1.6
8.5
267
1863
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.0
8.5
103
530
R03AC02
ATC
salbutamol; inhalant
1.5
8.3
505
4072
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.3
224
1498
D86.3
ICD-10 Finland
Sarcoidosis of skin
14.6
8.2
13
9
SPAT1263
SPAT
Sampling
1.5
8.2
415
3220
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
8.1
105
555
K51.8
ICD-10 Finland
Other ulcerative colitis
4.9
8.1
25
52
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.9
354
2675
H02AB09
ATC
hydrocortisone; systemic
4.1
7.8
29
73
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
7.8
76
355
S18
ICPC
Laceration/cut
1.5
7.7
371
2838
A07EA02
ATC
hydrocortisone; rectal
3.7
7.6
31
85
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
7.6
52
204
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.4
7.4
61
264
L04AA06
ATC
mycophenolic acid; systemic
4.3
7.2
25
59
C03DA01
ATC
spironolactone; oral
2.0
7.2
94
499
J01AA02
ATC
doxycycline; systemic
1.5
7.2
736
6504
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.2
411
3247
SPAT1262
SPAT
Handing over of treatment supplies
1.7
7.2
154
967
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
20.2
7.1
10
5
M30.0
ICD-10 Finland
Polyarteritis nodosa
20.2
7.1
10
5
L95.8
ICD-10 Finland
Other vasculitis limited to skin
12.1
7.1
12
10
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
7.1
258
1852
J01FA06
ATC
roxithromycin; oral
1.4
7.0
377
2939
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
7.0
231
1621
S97
ICPC
Chronic ulcer skin
2.5
6.9
53
223
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.9
386
3029
L04AA01
ATC
[U] ciclosporin; systemic
4.7
6.7
21
45
D07AB08
ATC
desonide; topical
1.9
6.7
92
499
XG410
NOMESCO Finland
Flow-volume spirometry
2.7
6.6
43
164
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
6.6
54
235
E000001
ATC
NA
1.6
6.6
190
1289
ZX108
NOMESCO Finland
Inhalation
8.8
6.6
13
15
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
4.2
6.5
23
56
XW000
NOMESCO Finland
Bone marrow biopsy
2.8
6.5
40
149
104
Kela drug reimbursment
Thyroid insufficiency
2.1
6.5
72
359
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
6.5
33
109
J01CA04
ATC
amoxicillin; systemic
1.5
6.5
788
7113
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
6.4
122
739
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
6.4
123
745
L50.3
ICD-10 Finland
Dermatographic urticaria
14.4
6.4
10
7
L50.8
ICD-10 Finland
Other urticaria
14.4
6.4
10
7
D07AD01
ATC
clobetasol; topical
1.7
6.3
140
885
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.5
6.3
46
189
M79.6
ICD-10 Finland
Pain in limb
1.4
6.3
333
2574
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.7
6.3
25
68
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
9.3
6.3
12
13
L04AB04
ATC
adalimumab; parenteral
3.6
6.2
26
74
K51
ICD-10 Finland
Ulcerative colitis
6.3
6.2
15
24
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
5.8
6.2
16
28
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
6.1
84
456
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.1
212
1498
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
12.6
6.1
10
8
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.1
115
693
N03AX16
ATC
pregabalin; oral
1.5
6.1
206
1451
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.0
146
946
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMANODOSUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.225 [1.06, 1.41] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 3301 females with L12_ERYTHEMANODOSUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.581 [1.26, 1.98] | < 0.001 |
| Birth year | 0.984 [0.97, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 1122 males with L12_ERYTHEMANODOSUM died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMANODOSUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.252% |
| 5 | 0.531% | 1.652% |
| 10 | 1.452% | 4.087% |
| 15 | 2.738% | 7.634% |
| 20 | 5.092% | 12.892% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMANODOSUM – Erythema nodosum
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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