No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
452 |
4. Check minimum number of eventsNone |
452 |
5. Include endpointsNone |
452 |
6. Filter based on genotype QC (FinnGen only) |
452 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M77
- Name in latin
- Calcar calcanei
Similar endpoints
↥List of similar endpoints to
Calcaneal spur
based on the number of shared cases.
Similar with more cases:
- Other enthesopathies
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2720 | 1874 | 838 |
| Only index persons | 2587 | 1803 | 784 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.76 | 50.96 | 50.30 |
| Only index persons | 50.62 | 50.84 | 50.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 452 | 328 | 124 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.05 |
| Median age at first event (years) | 50.97 | 50.97 | 50.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 404
- Matched controls
- 4038
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M77.3
ICD-10 Finland
Calcaneal spur
1907.4
323.0
322
8
7267C
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of ankle and tarsus[CALCANEODYNIA]
+∞
88.9
82
*
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
12.1
53.3
103
111
M75.1
ICD-10 Finland
Rotator cuff syndrome
5.9
39.6
127
291
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
366.3
34.5
34
*
M79.6
ICD-10 Finland
Pain in limb
4.1
34.3
170
602
M01AH05
ATC
etoricoxib; oral
3.4
29.4
286
1668
9476
FHL
Splitting of fascia or aponeurosis
111.6
29.1
31
*
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
38.1
27.9
35
10
M25.5
ICD-10 Finland
Pain in joint
3.6
27.5
158
610
M76.6
ICD-10 Finland
Achilles tendinitis
11.5
26.4
50
49
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
21.7
23.4
34
17
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
23.3
220
1172
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.0
22.8
66
127
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
37.4
22.3
28
8
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.4
21.8
124
460
N03AX12
ATC
gabapentin; oral
4.1
19.1
81
233
N02AX02
ATC
tramadol; systemic, rectal
2.7
18.9
192
1024
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
10.3
18.8
37
39
L17
ICPC
Foot/toe symptom/complaint
3.0
18.4
133
574
M02AA07
ATC
piroxicam; topical
2.7
18.3
179
930
N02BE01
ATC
paracetamol; systemic, rectal
3.8
18.3
366
2897
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
17.5
170
875
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
33.1
17.2
22
7
NHL16
NOMESCO Finland
Tenolysis or tenosynovectomy of achilles tendon
176.9
16.6
17
*
M70.6
ICD-10 Finland
Trochanteric bursitis
4.1
16.6
69
194
M01AX17
ATC
nimesulide; oral
2.8
16.4
129
578
M01AC06
ATC
meloxicam; systemic, rectal
2.5
16.1
179
980
M79.0
ICD-10 Finland
Rheumatism, unspecified
24.5
15.3
21
9
M01AE02
ATC
naproxen; oral, rectal
2.4
15.3
251
1658
9102
FHL
Trepanation or removal of the local bone process
58.9
14.9
17
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.5
14.7
75
249
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.0
14.5
48
107
N03AX16
ATC
pregabalin; oral
2.8
14.5
110
480
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
14.4
59
163
M01AX05
ATC
glucosamine; oral
2.8
14.4
107
461
M77.4
ICD-10 Finland
Metatarsalgia
6.0
14.3
40
73
M01AH01
ATC
celecoxib; oral (coxibs)
2.9
14.0
96
391
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
10.6
13.7
26
26
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
77.8
13.7
15
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
3.5
13.3
65
208
L15
ICPC
Knee symptom/complaint
2.7
13.3
103
452
R51.80
ICD-10 Finland
Headache
3.3
13.2
72
249
M79.1
ICD-10 Finland
Myalgia
3.8
13.0
58
172
M54.5
ICD-10 Finland
Low back pain
2.4
12.9
139
728
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.8
12.8
57
169
M01AB05
ATC
diclofenac; systemic, rectal
2.2
12.8
285
2083
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
6.6
12.2
31
50
E66.01
ICD-10 Finland
Obesity due to excess calories
4.3
12.1
46
118
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.2
12.1
177
1063
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.8
12.1
86
356
M77.1
ICD-10 Finland
Lateral epicondylitis
5.3
12.1
37
76
L08
ICPC
Shoulder symptom/complaint
2.8
12.0
85
351
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.2
11.9
65
225
WX320
NOMESCO Finland
Spinalanesthesy
2.5
11.8
107
510
A02BC05
ATC
esomeprazole; systemic
2.1
11.7
177
1078
NBG10
NOMESCO Finland
Acromioplastia
23.7
11.7
16
7
M54.4
ICD-10 Finland
Lumbago with sciatica
2.9
11.6
76
296
L16
ICPC
Ankle symptom/complaint
3.6
11.6
54
166
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
+∞
11.5
11
*
M48.0
ICD-10 Finland
Spinal stenosis
3.3
11.2
58
194
M03BX02
ATC
tizanidine; oral
2.1
10.9
263
1918
A02BC02
ATC
pantoprazole; systemic
2.1
10.9
269
1980
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.5
10.9
95
442
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.2
10.8
58
199
M03BC01
ATC
orphenadrine (citrate); systemic
2.4
10.5
105
523
M79.7
ICD-10 Finland
Fibromyalgia
12.5
10.4
18
15
NH2AA
NOMESCO Finland
Heel X-ray examination
24.1
10.3
14
6
J01AA02
ATC
doxycycline; systemic
2.3
10.2
331
2690
XA402
NOMESCO Finland
ENMG
8.0
10.0
22
29
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
6.6
10.0
25
40
R03AC02
ATC
salbutamol; inhalant
2.0
9.9
214
1469
M01AC01
ATC
piroxicam; systemic, rectal
2.7
9.9
71
294
A02BC03
ATC
lansoprazole; oral
2.2
9.9
122
669
H02AB06
ATC
prednisolone; systemic
2.0
9.6
191
1268
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
9.5
55
199
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
3.0
9.5
57
209
A02BC01
ATC
omeprazole; systemic
2.2
9.2
111
598
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
9.1
91
450
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
9.1
115
634
L12
ICPC
Hand/finger symptom/complaint
2.7
9.0
62
250
J01FA10
ATC
azithromycin; systemic
1.9
9.0
245
1807
NHM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of ankle or foot
24.6
9.0
12
5
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
14.4
8.7
14
10
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
8.6
163
1046
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
5.9
8.6
23
41
L13
ICPC
Hip symptom/complaint
2.5
8.5
73
332
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.6
8.4
62
259
M02AA10
ATC
ketoprofen; topical
2.4
8.3
77
365
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
8.2
155
991
N06AX21
ATC
duloxetine; oral
3.1
8.1
45
156
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
8.0
71
330
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
8.0
282
2227
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
7.9
197
1379
G47.3
ICD-10 Finland
Sleep apnoea
2.2
7.9
85
431
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.8
7.9
32
89
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.8
7.8
49
187
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.7
7.8
33
95
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.9
7.7
48
181
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
45.9
7.7
9
*
M54.2
ICD-10 Finland
Cervicalgia
3.6
7.7
34
101
M77.9
ICD-10 Finland
Enthesopathy, unspecified
6.9
7.7
18
27
S18
ICPC
Laceration/cut
1.9
7.6
161
1062
H02BX01
ATC
methylprednisolone, combinations; systemic
4.1
7.5
28
72
M67.4
ICD-10 Finland
Ganglion
5.2
7.5
22
44
ZXA05
NOMESCO Finland
Left side
2.0
7.5
106
604
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.9
7.4
23
49
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
13.7
7.4
12
9
ZXA00
NOMESCO Finland
Right side
2.0
7.4
113
665
M19.9
ICD-10 Finland
Arthrosis, unspecified
5.3
7.3
21
41
A99
ICPC
Disease/condition unspecnature/site
3.3
7.3
36
117
7287A
ICD-9 Finland
Disorders of muscle, ligament and fascia, Other fibromatoses[CONTRACTURA FASCIAE PLANTARIS]
+∞
7.3
7
*
L03
ICPC
Low back symptom/complaint
2.0
7.3
96
534
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
7.2
221
1639
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
7.2
68
327
M65.3
ICD-10 Finland
Trigger finger
6.2
7.2
18
30
R29
ICPC
Respiratory symptom/complaint other
3.5
7.1
32
98
J01DA01
ATC
[U] cefalexin; systemic
1.8
7.1
248
1914
L28
ICPC
Limited function/disability (L)
2.4
7.0
62
286
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
7.0
68
328
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.9
113
677
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
6.9
151
1002
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.7
6.8
28
79
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
9.5
6.8
13
14
B01AB05
ATC
enoxaparin; parenteral
1.9
6.8
123
767
R52.9
ICD-10 Finland
Pain, unspecified
3.0
6.8
38
133
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.8
137
886
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
6.8
38
134
Z50.1
ICD-10 Finland
Other physical therapy
3.5
6.7
30
91
M01AB55
ATC
diclofenac, combinations; oral
3.5
6.7
30
91
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.9
6.7
26
70
NBL22
NOMESCO Finland
Myotomy, tenotomy or excision of tendon of upper arm
22.9
6.7
9
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
8.0
6.7
14
18
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
12.5
6.6
11
9
R03BA05
ATC
fluticasone; inhalant
2.1
6.6
73
376
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.8
6.6
42
162
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
6.5
91
515
L60.0
ICD-10 Finland
Ingrowing nail
4.8
6.5
20
43
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
4.6
6.4
21
48
L29
ICPC
Musculoskeletal sympt/complt other
3.0
6.4
36
127
J01FA06
ATC
roxithromycin; oral
1.7
6.4
163
1131
WZA90
NOMESCO Finland
Other doctors statement
2.0
6.4
93
535
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
11.3
6.3
11
10
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.3
102
611
L11
ICPC
Wrist symptom/complaint
3.0
6.2
35
123
Z01.2
ICD-10 Finland
Dental examination
1.7
6.2
165
1152
KMAK
NOMESCO Finland
NA
1.7
6.2
207
1546
M09AX01
ATC
hyaluronic acid; parenteral
3.7
6.2
25
70
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.9
6.2
16
28
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
6.2
221
1686
XA420
NOMESCO Finland
Extensive sleep examination
12.8
6.1
10
8
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
6.1
46
197
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
6.0
53
243
Mortality – FinRegistry
↥Association
Association between endpoint M13_CALCANSPUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CALCANSPUR | 0.732 [0.58, 0.92] | 0.007 |
| Birth year | 1.001 [0.99, 1.01] | 0.826 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1118 females with M13_CALCANSPUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CALCANSPUR | 0.878 [0.67, 1.14] | 0.333 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 505 males with M13_CALCANSPUR died.
Mortality risk
Mortality risk for people of age
years, who have M13_CALCANSPUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | 0.161% |
| 5 | 0.563% | 0.926% |
| 10 | 1.335% | 2.199% |
| 15 | 2.585% | 4.304% |
| 20 | 4.505% | 7.431% |
Relationships between endpoints
↥Index endpoint: M13_CALCANSPUR – Calcaneal spur
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data