No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
88 |
4. Check minimum number of eventsNone |
88 |
5. Include endpointsNone |
88 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M60-M63
- Name in latin
- Calcificatio et ossificatio musculi
Similar endpoints
↥List of similar endpoints to
Calcification and ossification of muscle
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 594 | 264 | 323 |
| Only index persons | 508 | 233 | 275 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 53.41 | 53.62 | 53.09 |
| Only index persons | 52.03 | 52.67 | 51.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 42 | 46 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 52.01 | 46.69 | 56.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 82
- Matched controls
- 819
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M61.9
ICD-10 Finland
Calcification and ossification of muscle, unspecified
+∞
36.1
32
*
M61.4
ICD-10 Finland
Other calcification of muscle
+∞
17.3
16
*
M61.3
ICD-10 Finland
Calcification and ossification of muscles associated with burns
+∞
10.6
10
*
M61.2
ICD-10 Finland
Paralytic calcification and ossification of muscle
+∞
9.6
9
*
M61.5
ICD-10 Finland
Other ossification of muscle
+∞
9.6
9
*
N03AX16
ATC
pregabalin; oral
4.6
8.0
31
95
N03AX12
ATC
gabapentin; oral
6.3
7.4
20
40
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.0
7.2
20
42
N02AX02
ATC
tramadol; systemic, rectal
3.6
7.1
42
184
ZXA00
NOMESCO Finland
Right side
3.7
6.3
32
120
7281X
ICD-9 Finland
Disorders of muscle, ligament and fascia, Muscular calcification and ossification[CALCIFICATIO ET OSSIFICATIO MUSCULI ALIA]
+∞
6.3
6
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
6.0
6.3
17
34
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
16.6
6.1
9
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_CALCIOSSIMUSCLE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CALCIOSSIMUSCLE | 1.461 [1.02, 2.09] | 0.037 |
| Birth year | 0.993 [0.98, 1.0] | 0.108 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 217 males with M13_CALCIOSSIMUSCLE died.
Mortality risk
Mortality risk for people of age
years, who have M13_CALCIOSSIMUSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.288% |
| 5 | No data | 2.012% |
| 10 | No data | 5.072% |
| 15 | No data | 9.751% |
| 20 | No data | 16.361% |
Relationships between endpoints
↥Index endpoint: M13_CALCIOSSIMUSCLE – Calcification and ossification of muscle
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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