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Other specified/unspecified deforming dorsopathies

EFO MESH Endpoint Browser PheWeb

M13_DEFORMDORSONAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M43.8, M43.9
  • Hospital discharge: ICD-9 — 732[8-9]|737[8-9]
  • Hospital discharge: ICD-8 — 735
  • Cause of death: ICD-10 — M43.8, M43.9
  • Cause of death: ICD-9 — 732[8-9]|737[8-9]
  • Cause of death: ICD-8 — 735

2 out of 7 registries used, show all original rules.

728

4. Check minimum number of events

None

728

5. Include endpoints

None

728

6. Filter based on genotype QC (FinnGen only)

728

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6805 4430 2315
Only index persons 5608 3751 1857
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.06
Only index persons 0.12 0.14 0.07
Median age at first event (years)
Whole population 27.44 27.05 27.44
Only index persons 20.06 19.14 21.92

-FinnGen-

Key figures

All Female Male
Number of individuals 728 526 202
Unadjusted period prevalence (%) 0.15 0.18 0.09
Median age at first event (years) 21.31 17.19 32.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
658
Matched controls
6580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
73599
ICD-8 Finland
Other and unspecified curvature of spine
+∞
323.0
303
*
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
90.8
85
*
7328A
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[JALKATERÄN YLIMÄÄRÄISTEN LUIDEN AIHEUTTAMAT OIREET]
+∞
77.7
73
*
7328B
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[MUIDEN YLIMÄÄRÄISTEN LUIDEN AIHEUTTAMAT OIREET]
+∞
76.6
72
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
28.4
66.4
91
37
9102
FHL
Trepanation or removal of the local bone process
61.2
65.5
76
14
M48.0
ICD-10 Finland
Spinal stenosis
35.4
54.2
70
22
M41.9
ICD-10 Finland
Scoliosis, unspecified
191.8
51.7
53
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
21.7
48.7
72
37
M43.1
ICD-10 Finland
Spondylolisthesis
57.5
45.3
53
10
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
52.8
41.3
49
10
9103
FHL
Partial or complete bone removal
422.2
40.6
40
*
N03AX12
ATC
gabapentin; oral
6.0
40.4
120
235
7373A
ICD-9 Finland
Curvature of spine, Kyphoscoliosis and scoliosis
+∞
40.0
38
*
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
+∞
37.9
36
*
M41.2
ICD-10 Finland
Other idiopathic scoliosis
+∞
34.7
33
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
19.4
34.2
52
29
M43.0
ICD-10 Finland
Spondylolysis
+∞
32.6
31
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
32.5
274
1308
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
+∞
31.5
30
*
N03AX16
ATC
pregabalin; oral
3.7
31.4
158
519
7378X
ICD-9 Finland
Curvature of spine, Other curvatures of spine
+∞
30.4
29
*
M54.5
ICD-10 Finland
Low back pain
3.1
30.0
203
830
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
47.4
29.9
36
8
M43.8
ICD-10 Finland
Other specified deforming dorsopathies
+∞
29.4
28
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.5
27.3
85
173
M47.9
ICD-10 Finland
Spondylosis, unspecified
64.9
27.2
31
5
N06AX21
ATC
duloxetine; oral
4.8
26.6
94
220
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
26.2
25
*
M54.4
ICD-10 Finland
Lumbago with sciatica
4.5
25.0
95
239
7328X
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[OSTEOCHONDROPATHIAE ALIA DEFINITA]
+∞
24.1
23
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
20.4
22.3
33
17
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.2
21.9
70
146
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.9
20.8
53
83
L03
ICPC
Low back symptom/complaint
2.7
18.4
141
599
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
45.4
18.3
22
5
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
11.1
18.1
34
32
7231A
ICD-9 Finland
Other disorders of cervical region, Cervicalgia
+∞
16.7
16
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
16.7
16
*
71798
ICD-8 Finland
Other nonarticular rheumatism, Other muscular rheumatism, fibrositis and myalgia
48.8
16.1
19
*
7329X
ICD-9 Finland
Osteochondropathies, Unspecified osteochondropathy
+∞
15.7
15
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
87.2
15.6
17
*
M47.82
ICD-10 Finland
Other spondylosis, cervical region
14.2
15.6
26
19
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
14.4
15.1
25
18
M03BX02
ATC
tizanidine; oral
1.9
14.7
392
2853
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
14.7
229
1358
72898
ICD-8 Finland
Vertebrogenic pain syndrome, Alia definita
+∞
14.6
14
*
M41.8
ICD-10 Finland
Other forms of scoliosis
+∞
14.6
14
*
N02AC04
ATC
dextropropoxyphene; oral
7.8
14.6
33
44
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.0
14.4
35
52
N02AA05
ATC
oxycodone; systemic
3.0
14.3
86
313
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
76.8
13.6
15
*
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
13.6
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
13.5
163
865
N06AA09
ATC
amitriptyline; systemic
3.4
12.9
63
197
M54.6
ICD-10 Finland
Pain in thoracic spine
4.9
12.6
41
88
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
12.5
12
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
12.5
12
*
73500
ICD-8 Finland
NA
+∞
12.5
12
*
N05BA04
ATC
oxazepam; oral
2.1
12.2
163
898
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.2
236
1500
SPAT1229
SPAT
Assessment of need for aid
3.6
12.1
55
163
M01AB55
ATC
diclofenac, combinations; oral
3.8
12.0
51
143
M41
ICD-10 Finland
Scoliosis
47.6
11.9
14
*
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
15.0
11.8
19
13
M54.3
ICD-10 Finland
Sciatica
6.7
11.7
29
45
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
11.6
100
448
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.2
11.5
61
203
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
+∞
11.5
11
*
N05CF01
ATC
zopiclone; oral
1.9
11.5
203
1243
H02AB06
ATC
prednisolone; systemic
1.8
11.4
283
1943
M54.1
ICD-10 Finland
Radiculopathy
10.8
11.3
21
20
L86
ICPC
Back syndrome with radiating pain
5.0
11.3
36
76
M50.3
ICD-10 Finland
Other cervical disc degeneration
17.4
11.2
17
10
N06AX11
ATC
mirtazapine; oral
1.9
10.9
199
1228
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
10.8
48
140
R52.2
ICD-10 Finland
Other chronic pain
6.5
10.7
27
43
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
21.9
10.7
15
7
R06.0
ICD-10 Finland
Dyspnoea
2.1
10.7
136
728
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.7
10.6
22
26
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.0
10.6
62
222
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
10.4
10
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
10.4
10
*
N06AX16
ATC
venlafaxine; oral
2.4
10.4
95
439
M01AH02
ATC
rofecoxib; oral
2.7
10.4
73
293
M79.6
ICD-10 Finland
Pain in limb
1.8
10.4
205
1298
L02
ICPC
Back symptom/complaint
3.0
10.3
59
207
A02BA02
ATC
ranitidine; systemic
2.2
10.2
115
583
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
8.1
10.2
22
28
M01AH05
ATC
etoricoxib; oral
1.7
10.2
358
2706
L29
ICPC
Musculoskeletal sympt/complt other
3.2
10.1
52
170
R03AC02
ATC
salbutamol; inhalant
1.7
10.0
326
2403
72800
ICD-8 Finland
Vertebrogenic pain syndrome, Cervicalgia
40.7
10.0
12
*
L17
ICPC
Foot/toe symptom/complaint
2.0
9.9
138
767
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
12.4
9.9
17
14
M01AE51
ATC
ibuprofen, combinations; systemic
12.4
9.9
17
14
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
12.4
9.9
17
14
A02BC05
ATC
esomeprazole; systemic
1.8
9.9
242
1635
L28
ICPC
Limited function/disability (L)
2.4
9.8
86
390
9359
FHL
Other measure in this category
55.8
9.7
11
*
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
101.4
9.4
10
*
M41.3
ICD-10 Finland
Thoracogenic scoliosis
101.4
9.4
10
*
M41.5
ICD-10 Finland
Other secondary scoliosis
+∞
9.4
9
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
9.4
9
*
71310
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis cervicalis
+∞
9.4
9
*
71312
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis lumbalis sive lumbosacralis
+∞
9.4
9
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
9.3
139
790
R07.3
ICD-10 Finland
Other chest pain
2.8
9.3
59
222
R51.80
ICD-10 Finland
Headache
2.3
9.0
88
419
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.0
8.8
125
697
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.5
8.8
25
47
SPAT1240
SPAT
Therapeutic discussion
2.5
8.8
69
295
AA1AD
NOMESCO Finland
CT of head and brain
2.0
8.7
124
692
A02BC03
ATC
lansoprazole; oral
1.8
8.6
167
1038
A02BC01
ATC
omeprazole; systemic
1.8
8.6
161
990
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
8.6
170
1064
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
8.6
260
1850
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
8.3
8
*
72850
ICD-8 Finland
Vertebrogenic pain syndrome, Pain in thoracic spine
+∞
8.3
8
*
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
8.3
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
8.2
201
1340
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
8.2
62
259
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
8.1
216
1476
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.9
7.8
24
50
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.8
85
426
P03
ICPC
Feeling depressed
2.5
7.7
59
247
71300
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) coxae
45.5
7.7
9
*
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
45.5
7.7
9
*
J01DA01
ATC
[U] cefalexin; systemic
1.6
7.7
395
3192
SPAT1260
SPAT
Consultation of another employee
2.0
7.7
98
522
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.6
7.6
53
212
R52.1
ICD-10 Finland
Chronic intractable pain
25.3
7.6
10
*
A02BC02
ATC
pantoprazole; systemic
1.6
7.5
377
3022
M79.7
ICD-10 Finland
Fibromyalgia
4.9
7.5
23
48
M03BX01
ATC
baclofen; systemic
7.2
7.5
17
24
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
81.0
7.4
8
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
9193
FHL
Spondylodesis (also includes correction)
+∞
7.3
7
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
7.3
7
*
M01AX17
ATC
nimesulide; oral
1.8
7.3
133
809
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.2
214
1501
A02BA04
ATC
nizatidine; systemic
2.6
7.1
49
196
N03AE01
ATC
clonazepam; systemic
3.3
7.0
34
108
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.0
104
586
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.0
7.0
21
43
SPAT1301
SPAT
No procedures
1.7
7.0
162
1055
M01AB05
ATC
diclofenac; systemic, rectal
1.6
7.0
396
3240
M01AH01
ATC
celecoxib; oral (coxibs)
2.0
6.9
96
528
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
6.2
6.8
17
28
1220
FHL
Arthroscopy
3.2
6.7
33
107
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.7
98
554
SPAT1263
SPAT
Sampling
1.6
6.6
235
1715
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
6.6
70
345
N06AB04
ATC
citalopram; systemic
1.7
6.6
133
834
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.9
6.5
25
66
N06AX03
ATC
mianserin; oral
3.3
6.5
30
93
9211
FHL
Exploration or removal of diskusprolapse
70.5
6.4
7
*
J01EA01
ATC
trimethoprim; systemic
1.7
6.4
158
1048
M25.5
ICD-10 Finland
Pain in joint
1.7
6.4
159
1059
M70.6
ICD-10 Finland
Trochanteric bursitis
2.2
6.3
63
301
M01AC06
ATC
meloxicam; systemic, rectal
1.6
6.3
195
1370
N05BA01
ATC
diazepam; systemic, rectal
2.0
6.3
76
398
7233A
ICD-9 Finland
Other disorders of cervical region, Cervicobrachial syndrome (diffuse)
+∞
6.3
6
*
9183
FHL
Posterolateral spondylodesis
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
2309
FHL
Other measure in this category
+∞
6.3
6
*
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
6.3
6
*
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.2
519
4589
N05AH04
ATC
quetiapine; oral
1.9
6.2
96
553
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
7.8
6.1
13
17
A06AD11
ATC
lactulose; oral
2.1
6.1
71
366
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.1
72
372
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
6.0
41
164
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
6.0
137
886

Mortality – FinRegistry

↥

Association

Association between endpoint M13_DEFORMDORSONAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_DEFORMDORSONAS 1.568 [1.23, 2.0] < 0.001
Birth year 0.997 [0.99, 1.01] 0.519

During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 546 females with M13_DEFORMDORSONAS died.

Males

Parameter HR [95% CI] p-value
M13_DEFORMDORSONAS 1.136 [0.78, 1.64] 0.5
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 373 males with M13_DEFORMDORSONAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_DEFORMDORSONAS.

N-year risk Females Males
1 0.184% 0.208%
5 1.08% 1.234%
10 2.375% 3.06%
15 4.839% 5.699%
20 8.709% 9.628%

Relationships between endpoints

↥

Index endpoint: M13_DEFORMDORSONAS – Other specified/unspecified deforming dorsopathies

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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