Diastasis of muscle

M13_DIASTASIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M62.0 Cause of death: ICD-10 — M62.0 2 out of 7 registries used, show all original rules.	278
4. Check minimum number of events None	278
5. Include endpoints None	278
6. Filter based on genotype QC (FinnGen only)	278

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M62
Name in latin: Diastasis musculi

NAME	M13_DIASTASIS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M620
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M620
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Diastasis of muscle based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1432	834	588
Only index persons	1376	813	563
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.03	0.03	0.02
Median age at first event (years)
Whole population	48.12	41.83	57.15
Only index persons	48.03	41.56	57.37

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	278	183	95
Unadjusted period prevalence (%)	0.06	0.06	0.04
Median age at first event (years)	49.47	43.45	61.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
237: Matched controls
2371

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M62.0

ICD-10 Finland

Diastasis of muscle

+∞

323.0

237

QBJ30

NOMESCO Finland

Correction of abdominal apron

674.1

56.0

K42.9

ICD-10 Finland

Umbilical hernia without obstruction or gangrene

21.6

38.8

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

17.0

28.6

JAG96

NOMESCO Finland

Other reconstruction of abdominal wall

253.5

23.0

N02AX02

ATC

tramadol; systemic, rectal

3.8

20.6

122

514

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.3

16.0

113

515

M79.6

ICD-10 Finland

Pain in limb

3.8

15.9

286

N02BE01

ATC

paracetamol; systemic, rectal

4.7

14.9

216

1622

N03AX12

ATC

gabapentin; oral

5.0

13.4

106

JN3AD

NOMESCO Finland

Abdominal CT examination

6.4

12.8

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.1

11.6

314

S18

ICPC

Laceration/cut

2.7

11.1

100

505

A02BC02

ATC

pantoprazole; systemic

2.6

10.8

154

995

M19.0

ICD-10 Finland

Primary arthrosis of other joints

6.5

10.5

M54.5

ICD-10 Finland

Low back pain

2.7

10.4

447

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

42.0

10.1

JAF10

NOMESCO Finland

Repair of umbilical hernia

11.4

10.0

ZXE10

NOMESCO Finland

More than one and less than three hours

2.6

9.9

498

JAG60

NOMESCO Finland

Reconstruction of abdominal wall using prosthetic material

104.0

9.5

O30.0

ICD-10 Finland

Twin pregnancy

10.2

9.4

JN3BD

NOMESCO Finland

Extensive abdominal CT

4.1

9.2

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.4

9.0

107

611

R51.80

ICD-10 Finland

Headache

3.3

8.7

165

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.3

8.5

110

645

K45.8

ICD-10 Finland

Other specified abdominal hernia without obstruction or gangrene

+∞

8.4

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

5.4

8.3

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.9

8.3

211

Z01.8

ICD-10 Finland

Other specified special examinations

2.8

8.1

247

SPAT1262

SPAT

Handing over of treatment supplies

3.1

8.0

171

G47.3

ICD-10 Finland

Sleep apnoea

2.7

8.0

262

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.6

8.0

328

J01DB01

ATC

cefalexin; oral

2.6

7.7

199

1588

R10.1

ICD-10 Finland

Pain localized to upper abdomen

3.1

7.7

163

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.1

7.7

164

N03AX16

ATC

pregabalin; oral

2.8

7.6

222

SPAT1249

SPAT

Treatment-related counselling outside office

2.2

7.6

106

637

L03

ICPC

Low back symptom/complaint

2.6

7.5

286

A02BC05

ATC

esomeprazole; systemic

2.3

7.4

528

J01AA02

ATC

doxycycline; systemic

2.3

7.4

183

1407

L57.4

ICD-10 Finland

Cutis laxa senilis

+∞

7.3

QBE20

NOMESCO Finland

Excision and repair of scar or web of skin of trunk

+∞

7.3

M79.1

ICD-10 Finland

Myalgia

3.6

7.3

103

M65.3

ICD-10 Finland

Trigger finger

16.4

7.3

QBB10

NOMESCO Finland

Major dressing of wound of skin of trunk

6.4

7.2

E66.8

ICD-10 Finland

Other obesity

4.6

7.2

G56.0

ICD-10 Finland

Carpal tunnel syndrome

3.6

7.2

R03AC02

ATC

salbutamol; inhalant

2.1

7.0

126

836

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

2.9

7.0

184

SPAT1263

SPAT

Sampling

2.1

6.9

109

684

J01FA10

ATC

azithromycin; systemic

2.1

6.9

140

973

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.2

6.8

121

M79.0

ICD-10 Finland

Rheumatism, unspecified

23.3

6.7

N02AJ06

ATC

codeine and paracetamol; systemic

2.2

6.7

502

SPAT1153

SPAT

Removal of sutures

2.3

6.7

382

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

6.6

513

T90

ICPC

Diabetes non-insulin dependent

2.5

6.5

243

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.1

6.5

129

UJF32

NOMESCO Finland

Coloscopy

2.4

6.5

286

SFA10

NOMESCO Finland

Fillning on one surface of tooth

2.0

6.5

132

909

M79.7

ICD-10 Finland

Fibromyalgia

14.8

6.5

H02AB06

ATC

prednisolone; systemic

2.1

6.4

103

644

A10BA02

ATC

metformin; oral

2.3

6.4

333

N06AX21

ATC

duloxetine; oral

3.6

6.3

K42

ICD-10 Finland

Umbilical hernia

18.6

6.3

SPAT1310

SPAT

Counselling related to known health issue

2.2

6.3

436

4211

FHL

Transeptal septal resection and reconstruction

27.5

6.3

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.7

6.2

180

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

2.0

6.2

123

832

WX408

NOMESCO Finland

General anesthesy, balanced

2.3

6.2

337

J01FF01

ATC

clindamycin; systemic

2.3

6.0

334

R01AD09

ATC

mometasone; nasal

2.0

6.0

112

740

Mortality – FinRegistry

↥

Association

Association between endpoint M13_DIASTASIS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
M13_DIASTASIS	0.982 [0.75, 1.28]	0.891
Birth year	0.99 [0.98, 1.0]	0.051

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 493 males with M13_DIASTASIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_DIASTASIS.

N-year risk	Females	Males
1	No data	0.197%
5	No data	1.252%
10	No data	3.111%
15	No data	5.867%
20	No data	10.226%

Relationships between endpoints

↥

Index endpoint: M13_DIASTASIS – Diastasis of muscle

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Diastasis of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints