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Lordosis

DOID Endpoint Browser PheWeb

M13_LORDOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M40.4, M40.5
  • Hospital discharge: ICD-9 — 7372
  • Cause of death: ICD-10 — M40.4, M40.5
  • Cause of death: ICD-9 — 7372

2 out of 7 registries used, show all original rules.

99

4. Check minimum number of events

None

99

5. Include endpoints

None

99

6. Filter based on genotype QC (FinnGen only)

99

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 734 405 324
Only index persons 657 367 290
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.32 51.11 46.88
Only index persons 48.27 50.05 46.00

-FinnGen-

Key figures

All Female Male
Number of individuals 99 53 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.78 47.41 48.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
90
Matched controls
900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M40.5
ICD-10 Finland
Lordosis, unspecified
+∞
64.5
54
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
321.9
40.4
38
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
38.3
34
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
20.8
28.3
45
41
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
20.6
19
*
D05AX02
ATC
calcipotriol; topical
27.4
19.1
26
13
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
28.1
18.6
25
12
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
13.9
17.9
32
34
A07EC01
ATC
sulfasalazine; oral, rectal
13.7
17.2
31
33
D05AX52
ATC
calcipotriol, combinations; topical
18.7
16.8
26
19
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
39.4
15.5
19
6
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
177.3
14.9
15
*
D07XC01
ATC
betamethasone, combinations; topical
9.9
14.5
31
45
L40.0
ICD-10 Finland
Psoriasis vulgaris
20.6
14.3
21
13
7372A
ICD-9 Finland
Curvature of spine, Lordosis (acquired)
+∞
13.9
13
*
M40.4
ICD-10 Finland
Other lordosis
+∞
13.9
13
*
M48.0
ICD-10 Finland
Spinal stenosis
163.3
13.8
14
*
L04AA13
ATC
leflunomide; oral
47.8
13.7
16
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
34.3
13.5
17
6
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
14.8
12.6
21
18
H02AB06
ATC
prednisolone; systemic
5.1
12.1
61
262
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
13.1
11.5
20
19
D07AC01
ATC
betamethasone; topical
4.8
10.9
49
180
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
10.6
10
*
L04AA01
ATC
[U] ciclosporin; systemic
+∞
10.6
10
*
D05AX03
ATC
calcitriol; topical
45.4
10.2
12
*
D07AD01
ATC
clobetasol; topical
5.9
9.9
30
70
E0000UV
ATC
NA
4.2
9.7
53
227
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
21.3
9.2
13
7
E000001
ATC
NA
4.7
9.0
35
107
N03AX16
ATC
pregabalin; oral
5.5
8.9
28
68
N02AX02
ATC
tramadol; systemic, rectal
4.0
8.6
46
187
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
98.7
8.6
9
*
M073, M405
ICD-10 Finland
NA
+∞
8.5
8
*
M43.1
ICD-10 Finland
Spondylolisthesis
+∞
8.5
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
14.9
8.2
13
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
10.3
7.9
15
17
L04AB01
ATC
etanercept; parenteral
49.3
7.9
9
*
N02AA05
ATC
oxycodone; systemic
6.6
7.8
20
37
D05AA
ATC
Tars
86.8
7.5
8
*
S91
ICPC
Psoriasis
+∞
7.4
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
7.3
22
50
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.1
6.5
14
20
M54.5
ICD-10 Finland
Low back pain
3.9
6.5
29
98
E000002
ATC
NA
4.9
6.5
21
52
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
19.7
6.4
9
5
M07.0
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
6.3
6
*
M43.0
ICD-10 Finland
Spondylolysis
+∞
6.3
6
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
+∞
6.3
6
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.6
6.2
32
119

Mortality – FinRegistry

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Association

Association between endpoint M13_LORDOSIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
M13_LORDOSIS 1.788 [1.23, 2.6] 0.002
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 251 males with M13_LORDOSIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_LORDOSIS.

N-year risk Females Males
1 No data 0.306%
5 No data 1.995%
10 No data 5.138%
15 No data 9.005%
20 No data 15.167%

Relationships between endpoints

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Index endpoint: M13_LORDOSIS – Lordosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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