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Other specified disorders of muscle

DOID EFO Endpoint Browser PheWeb

M13_MUSCLEDISNAS

myopathy: a disease of the muscle in which the muscle fibers do not function properly. This results in muscular weakness.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M62.8, M62.9
  • Hospital discharge: ICD-9 — 728[8-9]
  • Hospital discharge: ICD-8 — 733
  • Hospital discharge: excluded ICD-8 — 733|777[0-1]|73390
  • Cause of death: ICD-10 — M62.8, M62.9
  • Cause of death: ICD-9 — 728[8-9]
  • Cause of death: ICD-8 — 733
  • Cause of death: excluded ICD-8 — 733|777[0-1]|73390

2 out of 7 registries used, show all original rules.

1124

4. Check minimum number of events

None

1124

5. Include endpoints

None

1124

6. Filter based on genotype QC (FinnGen only)

1124

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9189 3986 5122
Only index persons 7812 3527 4285
Unadjusted period prevalence (%)
Whole population 0.13 0.11 0.14
Only index persons 0.15 0.13 0.16
Median age at first event (years)
Whole population 42.20 47.51 37.87
Only index persons 38.80 45.33 33.43

-FinnGen-

Key figures

All Female Male
Number of individuals 1124 581 543
Unadjusted period prevalence (%) 0.22 0.20 0.24
Median age at first event (years) 41.67 43.47 39.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1034
Matched controls
10338
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
9476
FHL
Splitting of fascia or aponeurosis
474.8
323.0
325
10
7288A
ICD-9 Finland
Disorders of muscle, ligament and fascia, Other disorders of muscle, ligament and fascia[SYNDR TIBIALE, PENIKKATAUTI]
+∞
323.0
325
*
M62.9
ICD-10 Finland
Disorder of muscle, unspecified
3430.0
295.3
271
*
M62.8
ICD-10 Finland
Other specified disorders of muscle
1608.6
264.4
246
*
7288X
ICD-9 Finland
Disorders of muscle, ligament and fascia, Other disorders of muscle, ligament and fascia[MORBI MUSCULI, LIGAMENTI ET FASCIAE ALIA DEFINITA]
+∞
176.2
164
*
M79.6
ICD-10 Finland
Pain in limb
3.5
61.2
369
1423
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
22.4
51.3
75
36
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.9
49.1
232
716
7289X
ICD-9 Finland
Disorders of muscle, ligament and fascia, Unspecified disorder of muscle, ligament and fascia
+∞
48.3
46
*
N03AX12
ATC
gabapentin; oral
4.1
45.6
196
552
N02AX02
ATC
tramadol; systemic, rectal
2.6
43.0
468
2515
N03AX16
ATC
pregabalin; oral
3.1
40.6
269
1057
G72.8
ICD-10 Finland
Other specified myopathies
13.9
33.5
58
44
G72.9
ICD-10 Finland
Myopathy, unspecified
25.3
32.9
46
19
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
9.2
32.8
70
81
N06AA09
ATC
amitriptyline; systemic
4.1
32.5
136
368
M25.5
ICD-10 Finland
Pain in joint
2.5
31.2
298
1432
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.6
28.6
142
443
M54.5
ICD-10 Finland
Low back pain
2.3
27.3
336
1813
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
27.1
469
2940
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
26.6
26.3
36
14
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
26.3
117
333
M01AX17
ATC
nimesulide; oral
2.4
25.9
259
1258
M19.0
ICD-10 Finland
Primary arthrosis of other joints
4.3
25.8
100
251
M03BX02
ATC
tizanidine; oral
2.0
25.3
635
4570
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
25.3
372
2160
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.8
25.2
73
133
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
24.9
107
295
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
24.8
401
2420
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.9
24.1
162
625
N02BE01
ATC
paracetamol; systemic, rectal
2.3
23.8
855
7026
M79.0
ICD-10 Finland
Rheumatism, unspecified
18.6
23.6
36
20
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
66.5
22.9
26
*
N06AX21
ATC
duloxetine; oral
3.3
22.7
123
408
M01AH05
ATC
etoricoxib; oral
1.9
22.7
580
4126
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.1
22.6
92
241
A02BC05
ATC
esomeprazole; systemic
2.0
22.5
405
2526
AA1AD
NOMESCO Finland
CT of head and brain
2.3
22.2
246
1245
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
63.9
21.9
25
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
21.8
114
368
M01AB05
ATC
diclofenac; systemic, rectal
1.9
21.7
672
5084
M01AE02
ATC
naproxen; oral, rectal
1.9
21.3
547
3860
M79.1
ICD-10 Finland
Myalgia
3.2
20.9
117
397
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
20.8
194
898
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
20.6
226
1133
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
20.5
267
1444
M54.4
ICD-10 Finland
Lumbago with sciatica
2.6
20.4
161
680
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
20.0
267
1460
A02BC02
ATC
pantoprazole; systemic
1.8
19.8
620
4636
9481
FHL
Detachment or severance of a muscle or tendon
203.7
19.6
20
*
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
19.1
248
1337
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
18.5
329
2007
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.8
18.3
81
229
M48.0
ICD-10 Finland
Spinal stenosis
2.9
18.2
121
459
N05AH04
ATC
quetiapine; oral
2.3
18.1
182
870
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
6.3
18.0
48
79
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
18.0
78
217
H02AB06
ATC
prednisolone; systemic
1.8
17.8
442
3017
J01DB01
ATC
cefalexin; oral
1.9
17.5
812
6779
J01FA06
ATC
roxithromycin; oral
1.8
17.3
397
2632
M70.6
ICD-10 Finland
Trochanteric bursitis
3.0
17.3
105
377
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
9.5
17.2
35
38
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
5.3
17.2
53
105
M02AA07
ATC
piroxicam; topical
1.9
17.0
343
2174
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.2
17.0
66
166
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.6
16.9
128
526
L28
ICPC
Limited function/disability (L)
2.5
16.9
140
606
G44.2
ICD-10 Finland
Tension-type headache
2.6
16.8
130
541
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
5.8
16.6
47
84
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
16.6
278
1648
R53
ICD-10 Finland
Malaise and fatigue
2.1
16.6
214
1142
A02BC03
ATC
lansoprazole; oral
1.9
16.5
285
1707
1220
FHL
Arthroscopy
4.3
16.5
61
147
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
4.3
16.4
62
152
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
16.2
160
753
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
16.2
399
2693
J01DA01
ATC
[U] cefalexin; systemic
1.7
16.0
608
4677
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.9
16.0
67
181
M01AC06
ATC
meloxicam; systemic, rectal
1.8
16.0
333
2126
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.2
15.9
185
943
M01AH01
ATC
celecoxib; oral (coxibs)
2.3
15.9
165
798
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
15.9
96
343
L17
ICPC
Foot/toe symptom/complaint
2.1
15.8
218
1191
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
15.7
157
746
M01AC01
ATC
piroxicam; systemic, rectal
2.4
15.4
144
662
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
15.2
165
812
S18
ICPC
Laceration/cut
1.8
15.2
377
2539
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.8
14.9
50
109
N05CF01
ATC
zopiclone; oral
1.8
14.8
315
2016
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.7
226
1286
M01AH02
ATC
rofecoxib; oral
2.5
14.7
123
533
73398
ICD-8 Finland
Other diseases of muscle, tendon and fascia, Alii definiti
+∞
14.6
14
*
M79.7
ICD-10 Finland
Fibromyalgia
7.7
14.5
33
44
J01MA02
ATC
ciprofloxacin; systemic
1.7
14.5
367
2478
ZXA00
NOMESCO Finland
Right side
1.9
14.4
239
1399
R51.80
ICD-10 Finland
Headache
2.4
14.4
135
620
N05BA01
ATC
diazepam; systemic, rectal
2.3
14.4
139
648
M65.3
ICD-10 Finland
Trigger finger
7.3
14.4
34
48
N02AA05
ATC
oxycodone; systemic
2.3
14.3
136
629
L01
ICPC
Neck symptom/complaint
2.4
14.3
123
541
M77.1
ICD-10 Finland
Lateral epicondylitis
3.4
13.9
69
215
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.6
13.7
108
451
M54.2
ICD-10 Finland
Cervicalgia
3.1
13.5
77
264
X58
ICD-10 Finland
Exposure to other specified factors
2.2
13.5
141
683
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.6
13.5
105
438
NBG10
NOMESCO Finland
Acromioplastia
18.5
13.4
20
11
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
13.3
258
1592
M54.1
ICD-10 Finland
Radiculopathy
4.4
13.2
47
110
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
6.4
13.1
34
55
N06AX11
ATC
mirtazapine; oral
1.8
13.0
297
1926
G54.0
ICD-10 Finland
Brachial plexus disorders
6.5
13.0
33
52
NXL00
NOMESCO Finland
Biopsy of muscle
28.8
13.0
17
6
M02AA10
ATC
ketoprofen; topical
2.1
12.9
149
753
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
12.9
259
1613
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
11.7
12.8
23
20
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
12.8
355
2440
N06AX16
ATC
venlafaxine; oral
2.2
12.6
137
674
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
12.6
107
466
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
32.4
12.6
16
5
7261X
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]
+∞
12.5
12
*
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
10.2
12.5
24
24
T79.6
ICD-10 Finland
Traumatic ischaemia of muscle
24.6
12.5
17
7
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
4.6
12.3
42
94
L08
ICPC
Shoulder symptom/complaint
2.1
12.3
155
814
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
38.0
12.2
15
*
N03AE01
ATC
clonazepam; systemic
3.2
12.1
65
215
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
12.1
176
976
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
12.1
129
631
N06AB04
ATC
citalopram; systemic
1.9
12.0
203
1191
N99
ICPC
Neurological disease other
10.7
11.8
22
21
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
9.1
11.8
24
27
L14
ICPC
Leg/thigh symptom/complaint
2.8
11.6
73
269
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.3
11.6
116
548
ZXA05
NOMESCO Finland
Left side
1.8
11.6
219
1331
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
13.8
11.5
19
14
M60.8
ICD-10 Finland
Other myositis
+∞
11.5
11
*
M54.3
ICD-10 Finland
Sciatica
3.2
11.5
59
190
N05CD07
ATC
temazepam; oral
2.2
11.5
124
607
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
121.3
11.4
12
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.7
11.4
49
137
R60.0
ICD-10 Finland
Localized oedema
2.4
11.3
99
439
M60.9
ICD-10 Finland
Myositis, unspecified
35.4
11.3
14
*
SPAT1153
SPAT
Removal of sutures
1.7
11.2
282
1871
A02BA02
ATC
ranitidine; systemic
1.9
11.2
178
1019
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
20.3
11.1
16
8
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
5.3
11.1
33
64
R52.9
ICD-10 Finland
Pain, unspecified
2.7
11.1
77
302
Z50.1
ICD-10 Finland
Other physical therapy
3.2
11.0
56
179
H02AB04
ATC
methylprednisolone; systemic
2.1
11.0
134
692
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
11.0
185
1079
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
7.5
11.0
25
34
B01AB05
ATC
enoxaparin; parenteral
1.7
10.9
261
1704
L12
ICPC
Hand/finger symptom/complaint
2.2
10.9
118
579
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
10.9
139
732
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
10.7
10.8
20
19
C07AB07
ATC
bisoprolol; oral
1.6
10.8
409
3023
L03
ICPC
Low back symptom/complaint
1.8
10.8
203
1229
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
4.9
10.7
34
71
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.3
10.7
106
499
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
18.0
10.7
16
9
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.3
10.7
39
94
G47.3
ICD-10 Finland
Sleep apnoea
1.8
10.7
201
1216
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
21.7
10.7
15
7
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.8
10.6
34
72
R03AC02
ATC
salbutamol; inhalant
1.6
10.6
464
3547
M67.4
ICD-10 Finland
Ganglion
4.3
10.5
38
91
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
9.3
10.5
21
23
M76.6
ICD-10 Finland
Achilles tendinitis
4.1
10.5
40
101
M77.4
ICD-10 Finland
Metatarsalgia
3.9
10.4
41
107
R42
ICD-10 Finland
Dizziness and giddiness
1.8
10.4
185
1099
R13
ICD-10 Finland
Dysphagia
2.8
10.4
66
246
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
8.9
10.3
21
24
R07.3
ICD-10 Finland
Other chest pain
2.4
10.3
88
387
UJF32
NOMESCO Finland
Coloscopy
1.7
10.3
222
1405
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
10.2
52
167
C03CA01
ATC
furosemide; systemic
1.7
10.2
236
1520
A02BC01
ATC
omeprazole; systemic
1.7
10.2
242
1574
R52.2
ICD-10 Finland
Other chronic pain
4.9
10.1
32
67
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
10.0
206
1281
G71.9
ICD-10 Finland
Primary disorder of muscle, unspecified
40.5
10.0
12
*
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
40.5
10.0
12
*
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
5.0
10.0
31
64
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
9.9
83
361
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.1
9.9
111
553
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.3
9.9
93
429
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
8.2
9.9
21
26
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
6.6
9.8
24
37
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.1
9.7
52
173
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
9.7
97
460
R03DC03
ATC
montelukast; oral
1.9
9.7
142
788
N05BA04
ATC
oxazepam; oral
1.7
9.7
227
1465
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
9.6
871
7831
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
9.6
182
1103
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
9.6
157
906
A28
ICPC
Limited function/disability NOS
2.0
9.5
121
633
J02AC01
ATC
fluconazole; systemic
1.6
9.5
336
2420
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.7
9.5
63
239
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.1
9.5
50
165
J01FF01
ATC
clindamycin; systemic
1.7
9.5
244
1621
M33.2
ICD-10 Finland
Polymyositis
100.9
9.4
10
*
7263A
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of elbow region[EPICONDYLITIS LATERALIS HUMERI]
+∞
9.4
9
*
SPAT1263
SPAT
Sampling
1.5
9.4
375
2783
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
9.3
251
1684
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
9.3
69
279
D07AC01
ATC
betamethasone; topical
1.6
9.3
307
2175
N06AA12
ATC
doxepin; systemic
2.8
9.2
58
214
SPAT1254
SPAT
Administration of medicine
2.0
9.2
125
675
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
3.8
9.2
37
99
R03BA01
ATC
beclometasone; inhalant
2.0
9.1
126
681
R06AE07
ATC
cetirizine; oral
1.5
9.1
379
2832
9242
FHL
Other reconstruction or plastic surgery of shoulder joint (including ac joint)
11.6
9.1
16
14
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.6
9.1
64
252
M89.0
ICD-10 Finland
Algoneurodystrophy
15.7
9.0
14
9
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
37.0
9.0
11
*
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.4
8.9
73
312
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.1
8.9
96
473
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.9
235
1568
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
8.8
75
326
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
8.8
243
1641
J01AA02
ATC
doxycycline; systemic
1.5
8.8
731
6334
M01AH03
ATC
valdecoxib; oral
2.6
8.8
63
252
R01AD09
ATC
mometasone; nasal
1.5
8.8
392
2973
M54.6
ICD-10 Finland
Pain in thoracic spine
2.7
8.7
59
228
M01AX05
ATC
glucosamine; oral
1.8
8.7
158
942
R20.2
ICD-10 Finland
Paraesthesia of skin
2.6
8.7
63
254
N06AB03
ATC
fluoxetine; oral
2.0
8.7
119
644
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
8.7
164
989
-1
NOMESCO Finland
NA
1.6
8.7
295
2097
A46
ICD-10 Finland
Erysipelas
1.9
8.7
124
679
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
8.6
47
160
9694A
ICD-9 Finland
Poisoning by psychotropic agents, Benzodiazepine-based tranquillisers
11.7
8.6
15
13
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
8.5
116
625
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.7
8.5
56
214
R4120
NOMESCO Finland
Occupational therapy
2.7
8.5
55
208
WX725
NOMESCO Finland
Noninvasive ventilation
2.9
8.5
50
178
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
5.7
8.5
23
41
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.3
8.4
41
129
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
8.3
78
360
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.8
8.3
26
55
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
3.2
8.3
42
136
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
7.1
8.3
19
27
M01AG02
ATC
tolfenamic acid; oral, rectal
1.8
8.3
141
825
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
4.1
8.2
30
74
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
8.2
59
236
SPAT1301
SPAT
No procedures
1.6
8.2
273
1927
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
8.1
262
1833
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
8.1
74
337
SPAT1229
SPAT
Assessment of need for aid
2.4
8.1
65
276
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.1
343
2558
J01CA04
ATC
amoxicillin; systemic
1.5
8.1
751
6586
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
8.1
469
3738
M75.2
ICD-10 Finland
Bicipital tendinitis
5.9
8.0
21
36
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.0
576
4788
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.8
8.0
32
86
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
7.3
8.0
18
25
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.9
105
562
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.9
162
1005
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
7.8
132
766
SPAT1260
SPAT
Consultation of another employee
1.8
7.8
149
902
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
7.8
74
342
QBJ30
NOMESCO Finland
Correction of abdominal apron
10.9
7.8
14
13
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
7.8
77
365
H02AB07
ATC
prednisone; oral
1.8
7.8
125
717
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.8
250
1745
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
7.7
425
3338
G71.08
ICD-10 Finland
Other muscular dystrophy
45.3
7.7
9
*
A06AD11
ATC
lactulose; oral
1.9
7.7
119
673
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.0
7.7
44
153
KMAK
NOMESCO Finland
NA
1.5
7.7
469
3761
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
6.0
7.7
20
34
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.2
7.7
39
127
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
8.1
7.6
16
20
P76
ICPC
Depressive disorder
2.6
7.6
53
211
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.6
140
840
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.0
7.5
41
140
L15
ICPC
Knee symptom/complaint
1.7
7.5
159
991
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
7.5
82
405
R04.2
ICD-10 Finland
Haemoptysis
3.3
7.5
36
112
M76.9
ICD-10 Finland
Enthesopathy of lower limb, unspecified
10.1
7.5
14
14
S83.2
ICD-10 Finland
Tear of meniscus, current
2.4
7.5
64
281
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.7
7.5
171
1092
SPAT1216
SPAT
Assessment of functional ability
1.8
7.5
124
717
M13.9
ICD-10 Finland
Arthritis, unspecified
2.3
7.5
64
283
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
80.6
7.4
8
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.6
7.4
20
36
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
7.4
67
306
M01AX01
ATC
nabumetone; oral
3.0
7.4
42
146
XA402
NOMESCO Finland
ENMG
4.4
7.4
25
58
M09AX01
ATC
hyaluronic acid; parenteral
2.9
7.3
43
154
Z3226
NOMESCO Finland
Physiotherapist
1.7
7.3
149
919
ACC51
NOMESCO Finland
Release of median nerve
2.4
7.3
60
260
Z00.0
ICD-10 Finland
General medical examination
1.7
7.3
152
946
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.3
150
928
N06AX03
ATC
mianserin; oral
2.7
7.3
47
179
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.8
7.2
115
657
S80.0
ICD-10 Finland
Contusion of knee
2.5
7.2
54
223
G04BD09
ATC
trospium; oral
3.6
7.2
30
84
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.2
135
812
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
7.2
331
2501
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.2
636
5451
L16
ICPC
Ankle symptom/complaint
2.1
7.2
75
365
M01AB08
ATC
etodolac; oral
2.3
7.1
60
264
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
4.1
7.1
26
65
M03BX01
ATC
baclofen; systemic
5.3
7.1
20
38
M02AA15
ATC
diclofenac; topical (antiinflammatory prep., non-steroids for topical use)
2.3
7.1
64
290
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
7.1
69
324
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.3
7.1
62
279
I20.09
ICD-10 Finland
Unstable angina
2.6
7.0
47
183
A04
ICPC
Weakness/tiredness general
1.9
7.0
104
578
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
7.0
140
859
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
7.0
175
1146
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
7.0
68
318
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.0
179
1177
C07AA05
ATC
propranolol; systemic
1.7
6.9
164
1059
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.7
6.9
28
77
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
6.9
68
322
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.0
6.9
90
480
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.0
6.9
83
426
TAB00
NOMESCO Finland
Lumbar puncture
2.6
6.9
46
180
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
6.8
91
486
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
11.0
6.8
12
11
N04BC05
ATC
pramipexole; oral
2.3
6.8
62
283
A02BC04
ATC
rabeprazole; oral
2.1
6.8
74
367
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.3
6.7
23
54
WX204
NOMESCO Finland
Axillary plexus blockaced
3.2
6.7
33
106
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
6.7
44
170
A01
ICPC
Pain general/multiple sites
2.3
6.6
58
259
M23.8
ICD-10 Finland
Other internal derangements of knee
3.1
6.6
34
113
SPAT1240
SPAT
Therapeutic discussion
2.0
6.6
85
448
S01
ICPC
Pain/tenderness of skin
2.9
6.6
38
135
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.1
6.6
71
352
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
6.6
55
240
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
3.2
6.5
32
103
J01FA01
ATC
erythromycin; systemic
1.8
6.5
117
696
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.5
6.4
49
205
9502
FHL
Tendon splitting (De Quervain, click finger)
70.2
6.4
7
*
M77.0
ICD-10 Finland
Medial epicondylitis
4.7
6.4
20
43
ZA1.0
ICD-10 Finland
Shoulder region
4.4
6.4
21
48
A03FA02
ATC
cisapride; oral, rectal
2.1
6.4
67
328
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
6.4
304
2305
J01FA10
ATC
azithromycin; systemic
1.4
6.3
502
4171
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
3.3
6.3
30
94
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
11.1
6.3
11
10
NBL22
NOMESCO Finland
Myotomy, tenotomy or excision of tendon of upper arm
11.1
6.3
11
10
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.1
6.3
69
344
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.3
321
2465
L02
ICPC
Back symptom/complaint
2.1
6.3
68
335
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
18.1
6.3
9
5
9491
FHL
Local soft tissue exploration, drainage, or removal
18.1
6.3
9
5
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.2
6.3
30
95
7290A
ICD-9 Finland
Other disorders of soft tissues, Rheumatism, unspecified and fibrositis
+∞
6.3
6
*
XF402
NOMESCO Finland
ECG with work load test
1.9
6.2
92
511
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
7.1
6.2
14
20
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.2
105
613
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
3.6
6.2
26
74
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
6.2
74
381
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.2
437
3556
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.9
6.1
35
122
NBE45
NOMESCO Finland
Plastic repair of ligament of shoulder not using prosthetic material, arthroscopic
7.7
6.1
13
17
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.1
279
2092
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.7
6.1
19
41
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
12.6
6.1
10
8
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.1
100
578
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.4
6.1
49
210
M76.0
ICD-10 Finland
Gluteal tendinitis
6.7
6.0
14
21
M70.8
ICD-10 Finland
Other soft tissue disorders related to use, overuse and pressure
10.1
6.0
11
11
E0000UV
ATC
NA
1.4
6.0
332
2583
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
5.6
6.0
16
29
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
5.6
6.0
16
29

Mortality – FinRegistry

↥

Association

Association between endpoint M13_MUSCLEDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_MUSCLEDISNAS 1.523 [1.23, 1.88] < 0.001
Birth year 0.996 [0.99, 1.0] 0.35

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 1423 females with M13_MUSCLEDISNAS died.

Males

Parameter HR [95% CI] p-value
M13_MUSCLEDISNAS 1.778 [1.42, 2.23] < 0.001
Birth year 0.986 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 1426 males with M13_MUSCLEDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_MUSCLEDISNAS.

N-year risk Females Males
1 0.127% 0.334%
5 0.75% 2.097%
10 2.016% 5.547%
15 4.304% 10.075%
20 7.466% 15.835%

Relationships between endpoints

↥

Index endpoint: M13_MUSCLEDISNAS – Other specified disorders of muscle

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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