No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M43
- Name in latin
- Alia fusio columnae vertebralis
Similar endpoints
↥List of similar endpoints to
Other fusion of spine
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 412 | 227 | 184 |
| Only index persons | 396 | 221 | 175 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 51.00 | 53.38 | 48.01 |
| Only index persons | 50.22 | 53.20 | 46.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 40 | 19 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 53.20 | 53.62 | 52.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 52
- Matched controls
- 519
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M43.2
ICD-10 Finland
Other fusion of spine
+∞
74.4
52
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
21.3
19
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
245.7
17.7
17
*
M43.1
ICD-10 Finland
Spondylolisthesis
+∞
15.3
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
49.0
14.6
17
5
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
186.8
14.2
14
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
93.4
13.3
14
*
N03AX12
ATC
gabapentin; oral
22.2
13.1
19
13
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
+∞
13.0
12
*
N03AX16
ATC
pregabalin; oral
11.3
12.1
25
39
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
152.4
12.0
12
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
11.9
11
*
N02AX02
ATC
tramadol; systemic, rectal
8.5
11.6
37
116
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
+∞
10.8
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
16.2
10.5
17
15
M54.5
ICD-10 Finland
Low back pain
8.0
10.3
28
66
M43.0
ICD-10 Finland
Spondylolysis
+∞
9.7
9
*
M54.4
ICD-10 Finland
Lumbago with sciatica
9.2
8.4
18
28
M53.1
ICD-10 Finland
Cervicobrachial syndrome
11.9
7.3
13
14
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
46.2
7.0
8
*
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
30.8
6.4
8
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
6.4
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.4
6
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.5
6.4
17
36
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPINEFUSION and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_SPINEFUSION.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_SPINEFUSION – Other fusion of spine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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