No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1495 |
4. Check minimum number of eventsNone |
1495 |
5. Include endpointsNone |
1495 |
6. Filter based on genotype QC (FinnGen only) |
1495 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- M46
- Name in latin
- Enthesopathia spinalis
Similar endpoints
↥List of similar endpoints to
Spinal enthesopathy
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33053 | 17098 | 15067 |
| Only index persons | 13197 | 8115 | 5082 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.49 | 0.42 |
| Only index persons | 0.26 | 0.30 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 55.76 | 56.06 | 55.36 |
| Only index persons | 50.71 | 51.48 | 49.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1495 | 596 | 899 |
| Unadjusted period prevalence (%) | 0.32 | 0.20 | 0.40 |
| Median age at first event (years) | 49.71 | 48.39 | 50.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1386
- Matched controls
- 13853
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
71312
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis lumbalis sive lumbosacralis
+∞
323.0
594
*
71310
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis cervicalis
+∞
323.0
602
*
M46.0
ICD-10 Finland
Spinal enthesopathy
+∞
208.6
195
*
M48.0
ICD-10 Finland
Spinal stenosis
53.8
176.6
211
46
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
132.4
125
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
121.6
115
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
105.5
100
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
35.3
96.9
126
39
71319
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis NUD
+∞
76.7
73
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
69.9
619
3031
M45
ICD-10 Finland
Ankylosing spondylitis
230.4
64.7
66
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
70.1
58.7
67
10
M54.5
ICD-10 Finland
Low back pain
3.6
58.2
300
980
N03AX16
ATC
pregabalin; oral
3.6
57.9
296
960
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
20.5
57.7
87
45
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
56.6
54
*
71311
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis thoracica
+∞
54.5
52
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
7.6
53.1
130
186
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
95.3
50.2
55
6
71798
ICD-8 Finland
Other nonarticular rheumatism, Other muscular rheumatism, fibrositis and myalgia
30.9
48.7
65
22
N03AX12
ATC
gabapentin; oral
4.5
48.5
188
470
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
29.0
47.3
64
23
72820
ICD-8 Finland
Vertebrogenic pain syndrome, Diffuse syndrome cerviocobrachial
+∞
46.1
44
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
216.0
41.1
42
*
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
408.2
40.3
40
*
35399
ICD-8 Finland
Sciatica
12.6
39.7
72
60
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.1
39.3
112
197
M47.9
ICD-10 Finland
Spondylosis, unspecified
26.9
37.8
52
20
7210A
ICD-9 Finland
Spondylosis and allied disorders, Cervical spondylosis without myelopathy
+∞
37.6
36
*
72898
ICD-8 Finland
Vertebrogenic pain syndrome, Alia definita
+∞
37.6
36
*
7231A
ICD-9 Finland
Other disorders of cervical region, Cervicalgia
+∞
36.6
35
*
7240B
ICD-9 Finland
Other and unspecified disorders of back, Spinal stenosis, other than cervical[STENOSIS CANALIS SPINALIS LUMBOSACRALIS]
+∞
35.5
34
*
7213A
ICD-9 Finland
Spondylosis and allied disorders, Lumbosacral spondylosis without myelopathy
+∞
35.5
34
*
A07EC01
ATC
sulfasalazine; oral, rectal
4.2
34.5
139
357
M54.4
ICD-10 Finland
Lumbago with sciatica
4.8
33.7
117
259
72800
ICD-8 Finland
Vertebrogenic pain syndrome, Cervicalgia
36.0
32.9
42
12
9212
FHL
Other posterior root decompression surgery (eg laminectomy, Gill)
323.6
32.0
32
*
72899
ICD-8 Finland
Vertebrogenic pain syndrome, Other and unspecified
+∞
31.3
30
*
78050
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Vertigo
7.1
29.9
75
111
72830
ICD-8 Finland
Vertebrogenic pain syndrome, Radicular syndrome of upper limbs
+∞
28.2
27
*
N06AA09
ATC
amitriptyline; systemic
3.3
28.1
152
498
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
27.7
244
1088
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
27.5
175
642
M03BX02
ATC
tizanidine; oral
2.0
27.4
486
2969
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
13.9
26.9
46
34
9211
FHL
Exploration or removal of diskusprolapse
+∞
26.1
25
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
25.5
392
2254
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
14.3
25.4
43
31
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
7.0
25.3
63
93
M47.82
ICD-10 Finland
Other spondylosis, cervical region
15.6
25.1
41
27
N05BA01
ATC
diazepam; systemic, rectal
2.5
24.4
216
959
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
24.1
417
2495
N02AC04
ATC
dextropropoxyphene; oral
3.3
24.1
128
413
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
16.9
24.1
38
23
71300
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) coxae
9.5
23.8
49
53
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.9
22.9
76
161
71710
ICD-8 Finland
Other nonarticular rheumatism, Scapulohumeral myofibrosis
11.7
22.3
41
36
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
14.6
22.2
37
26
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
22.2
211
973
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
10.5
22.1
43
42
40199
ICD-8 Finland
Essential benign hypertension
3.6
22.1
102
295
H02AB06
ATC
prednisolone; systemic
1.8
22.1
585
4032
71700
ICD-8 Finland
NA
+∞
21.9
21
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
63.5
21.9
25
*
M25.5
ICD-10 Finland
Pain in joint
2.3
21.6
221
1053
M54.3
ICD-10 Finland
Sciatica
6.8
21.6
55
84
M54.2
ICD-10 Finland
Cervicalgia
5.7
21.6
63
115
N06AX21
ATC
duloxetine; oral
3.9
20.9
88
235
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
+∞
20.9
20
*
A02BA02
ATC
ranitidine; systemic
2.0
20.8
341
1983
79199
ICD-8 Finland
Headache
8.4
20.5
45
55
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
21.1
20.0
29
14
M54.6
ICD-10 Finland
Pain in thoracic spine
6.1
19.8
54
91
M01AH02
ATC
rofecoxib; oral
2.4
19.7
188
865
L86
ICPC
Back syndrome with radiating pain
6.4
19.4
51
82
M43.1
ICD-10 Finland
Spondylolisthesis
18.5
19.1
29
16
A02BC05
ATC
esomeprazole; systemic
1.8
19.0
417
2668
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
19.0
467
3098
M03BC01
ATC
orphenadrine (citrate); systemic
2.6
18.8
152
637
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
192.2
18.6
19
*
M01AC06
ATC
meloxicam; systemic, rectal
1.8
18.1
364
2258
J01DA01
ATC
[U] cefalexin; systemic
1.6
18.0
787
6133
R07.3
ICD-10 Finland
Other chest pain
2.8
17.9
121
460
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
67.4
17.7
20
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
17.7
17
*
R03AC02
ATC
salbutamol; inhalant
1.7
17.3
523
3669
L03
ICPC
Low back symptom/complaint
2.3
17.2
176
834
30041
ICD-8 Finland
Neuroses, Depressiva
6.2
17.2
46
76
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.8
17.2
74
203
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
16.9
551
3940
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
9.6
16.9
34
36
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.1
16.9
97
332
M79.6
ICD-10 Finland
Pain in limb
1.9
16.8
310
1860
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
16.7
16
*
71308
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) alia (spinali excepta)
18.1
16.5
25
14
A02BC03
ATC
lansoprazole; oral
1.8
16.4
367
2347
R06.0
ICD-10 Finland
Dyspnoea
1.8
16.3
322
1977
M01AX17
ATC
nimesulide; oral
1.9
16.3
298
1780
40299
ICD-8 Finland
Hypertensive heart disease
4.9
16.3
53
111
M01AH01
ATC
celecoxib; oral (coxibs)
2.1
16.2
204
1060
R51.80
ICD-10 Finland
Headache
2.6
16.1
121
488
A02BC01
ATC
omeprazole; systemic
1.7
16.0
391
2566
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
15.9
462
3183
M46.4
ICD-10 Finland
Discitis, unspecified
+∞
15.6
15
*
71240
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Spondylitis ankylopoietica
+∞
15.6
15
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.0
15.5
234
1303
M01AH05
ATC
etoricoxib; oral
1.7
15.3
427
2906
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
15.2
300
1839
75618
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Maleformationes columnae vertebralis aliae
20.3
15.1
22
11
M54.1
ICD-10 Finland
Radiculopathy
9.0
15.0
31
35
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.7
14.7
64
178
M47.8
ICD-10 Finland
Other spondylosis
+∞
14.6
14
*
73599
ICD-8 Finland
Other and unspecified curvature of spine
+∞
14.6
14
*
7200A
ICD-9 Finland
Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis
+∞
14.6
14
*
E9999
ICD-8 Finland
Late effect of injury due to war operations
11.0
14.5
27
25
G44.2
ICD-10 Finland
Tension-type headache
2.6
14.4
104
411
N05CF01
ATC
zopiclone; oral
1.6
13.9
483
3468
L04AB01
ATC
etanercept; parenteral
13.7
13.7
23
17
72850
ICD-8 Finland
Vertebrogenic pain syndrome, Pain in thoracic spine
+∞
13.6
13
*
C01DA14
ATC
isosorbide mononitrate; oral
1.6
13.5
408
2819
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
13.3
847
6991
Y0599
ICD-8 Finland
Investigation of digestive system
4.0
13.3
52
132
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
7.3
13.3
31
43
M13.9
ICD-10 Finland
Arthritis, unspecified
3.0
13.1
77
268
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
13.1
250
1508
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
12.8
463
3339
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.9
12.8
78
277
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.3
12.7
115
514
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.1
12.7
49
123
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.9
12.7
31
46
M01AB05
ATC
diclofenac; systemic, rectal
1.5
12.7
610
4704
J01AA02
ATC
doxycycline; systemic
1.5
12.6
891
7482
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
70.4
12.6
14
*
XA402
NOMESCO Finland
ENMG
8.3
12.5
27
33
M48.9
ICD-10 Finland
Spondylopathy, unspecified
+∞
12.5
12
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
12.5
12
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
12.5
12
*
M46.3
ICD-10 Finland
Infection of intervertebral disc (pyogenic)
+∞
12.5
12
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.8
12.5
82
307
M01AB55
ATC
diclofenac, combinations; oral
2.4
12.5
110
483
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
12.3
195
1100
71303
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) multiplex
11.8
11.8
21
18
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.5
11.8
91
373
78739
ICD-8 Finland
Symptoms referable to limbs and joints, Arthralgia alia sive NUD
14.8
11.8
19
13
UJF32
NOMESCO Finland
Coloscopy
1.7
11.7
280
1804
41299
ICD-8 Finland
Chronic ischaemic heart disease, Without mention of hypertensive disease
5.1
11.7
36
72
A06AD11
ATC
lactulose; oral
1.6
11.6
311
2066
N06AB04
ATC
citalopram; systemic
1.7
11.6
262
1659
J01FA06
ATC
roxithromycin; oral
1.5
11.6
455
3329
72519
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis et lumbosacralis NUD
+∞
11.5
11
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
11.5
11
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
11.2
285
1866
I20.09
ICD-10 Finland
Unstable angina
2.2
11.0
120
583
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
10.7
62
215
M70.6
ICD-10 Finland
Trochanteric bursitis
2.3
10.6
101
462
R06AE07
ATC
cetirizine; oral
1.6
10.6
366
2588
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
2.3
10.6
101
464
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
10.6
172
978
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
10.6
105
489
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
10.5
315
2152
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
+∞
10.4
10
*
72500
ICD-8 Finland
Displacement of intervertebral disk, Cervicalis cum prolapsu disci
+∞
10.4
10
*
7228C
ICD-9 Finland
Intervertebral disk disorders, Postlaminectomy syndrome[SYNDROMA LUMBOSACRALE POSTLAMINECTOMIAM]
+∞
10.4
10
*
72810
ICD-8 Finland
Vertebrogenic pain syndrome, Cervicocranial syndrome
+∞
10.4
10
*
7225A
ICD-9 Finland
Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGENERATIO DISCI INTERVERTEBRALIS THORAC SEU LUMB]
+∞
10.4
10
*
7214A
ICD-9 Finland
Spondylosis and allied disorders, Thoracic or lumbar spondylosis with myelopathy
+∞
10.4
10
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
10.3
205
1246
J46
ICD-10 Finland
Status asthmaticus
4.0
10.2
40
103
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
2.7
10.2
68
258
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.5
10.1
29
54
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
10.1
423
3121
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
3.0
10.0
58
201
45599
ICD-8 Finland
Haemorrhoids
2.6
10.0
72
286
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.9
9.9
156
878
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
2.8
9.8
61
220
M54.8
ICD-10 Finland
Other dorsalgia
4.8
9.8
31
65
A03CA02
ATC
clidinium and psycholeptics; oral
2.2
9.7
98
463
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
3.9
9.7
39
103
30040
ICD-8 Finland
Neuroses, Neurotico-depressiva
7.4
9.7
22
30
M19.9
ICD-10 Finland
Arthrosis, unspecified
3.3
9.7
47
145
N02AA05
ATC
oxycodone; systemic
1.7
9.7
203
1255
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
55.3
9.6
11
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
55.3
9.6
11
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.6
191
1157
A02BC02
ATC
pantoprazole; systemic
1.4
9.6
667
5434
M02AA10
ATC
ketoprofen; topical
1.8
9.5
177
1050
H02AB04
ATC
methylprednisolone; systemic
1.8
9.4
171
1012
72509
ICD-8 Finland
Displacement of intervertebral disk, Cervicalis NUD
+∞
9.4
9
*
7233A
ICD-9 Finland
Other disorders of cervical region, Cervicobrachial syndrome (diffuse)
+∞
9.4
9
*
7244A
ICD-9 Finland
Other and unspecified disorders of back, Thoracic or lumbosacral neuritis or radiculitis, unspecified
+∞
9.4
9
*
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
+∞
9.4
9
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.1
9.4
104
511
A02BA04
ATC
nizatidine; systemic
1.9
9.3
144
805
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.9
9.3
142
792
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.4
9.2
78
336
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
9.2
87
399
A02BX02
ATC
sucralfate; oral
2.3
9.2
84
380
N05BA04
ATC
oxazepam; oral
1.5
9.0
300
2094
M50.3
ICD-10 Finland
Other cervical disc degeneration
18.7
8.9
13
7
41397
ICD-8 Finland
Angina pectoris, Suspecta, hypertonia non indicata
4.1
8.9
33
82
53503
ICD-8 Finland
Gastritis and duodenitis, Gastritis chronica NUD
8.7
8.8
18
21
78719
ICD-8 Finland
Symptoms referable to limbs and joints, Dolor extremitatis aliud sive NUD
9.5
8.8
17
18
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
8.7
130
718
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
8.7
259
1758
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
50.2
8.7
10
*
C03CA01
ATC
furosemide; systemic
1.4
8.7
617
5020
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
8.6
182
1125
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
8.6
456
3507
M01AE02
ATC
naproxen; oral, rectal
1.4
8.6
484
3768
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
8.5
195
1233
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
8.5
269
1849
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
27.6
8.5
11
*
B01AC07
ATC
dipyridamole; systemic
1.8
8.5
161
965
B01AB05
ATC
enoxaparin; parenteral
1.5
8.4
290
2037
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.4
328
2370
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
8.4
136
773
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
8.4
123
674
R05FB02
ATC
cough suppressants and expectorants
1.4
8.4
478
3726
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.7
8.3
163
982
7249X
ICD-9 Finland
Other and unspecified disorders of back, Other unspecified back disorders
+∞
8.3
8
*
7225B
ICD-9 Finland
Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGEN DISCI INTERVERT THORAC SEU LUMBOSACR CUM INST]
+∞
8.3
8
*
C07AA05
ATC
propranolol; systemic
1.8
8.3
158
946
M02AA07
ATC
piroxicam; topical
1.4
8.3
437
3350
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
2.2
8.2
83
394
R52.2
ICD-10 Finland
Other chronic pain
4.3
8.2
29
69
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
8.2
77
353
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
8.1
66
282
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
8.1
501
3960
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.4
8.1
404
3068
X58
ICD-10 Finland
Exposure to other specified factors
2.0
8.0
101
525
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
3.2
8.0
40
128
M79.1
ICD-10 Finland
Myalgia
2.1
8.0
90
448
R03DC03
ATC
montelukast; oral
1.9
7.9
112
605
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.8
7.9
134
771
J02AC01
ATC
fluconazole; systemic
1.5
7.9
287
2033
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
7.9
58
234
N06AX16
ATC
venlafaxine; oral
2.2
7.9
75
346
L04AB04
ATC
adalimumab; parenteral
7.8
7.9
17
22
M01AX01
ATC
nabumetone; oral
2.7
7.8
51
193
N06AX03
ATC
mianserin; oral
2.5
7.8
58
236
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
8.5
7.8
16
19
41300
ICD-8 Finland
Angina pectoris, Cum hypertonia
4.0
7.8
29
73
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.9
7.8
24
50
N05CD07
ATC
temazepam; oral
1.5
7.7
254
1762
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
45.2
7.7
9
*
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
11.9
7.6
13
11
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
7.6
195
1274
N06AB03
ATC
fluoxetine; oral
1.9
7.5
103
551
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
7.5
285
2037
R03AC03
ATC
terbutaline; inhalant
1.8
7.5
136
804
K59.0
ICD-10 Finland
Constipation
2.0
7.5
91
467
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.8
7.5
46
169
M01AC01
ATC
piroxicam; systemic, rectal
1.7
7.5
149
905
M01AE51
ATC
ibuprofen, combinations; systemic
4.1
7.5
27
66
A03FA02
ATC
cisapride; oral, rectal
1.8
7.5
125
718
A03DA02
ATC
pitofenone and analgesics; systemic
2.9
7.5
44
157
L88
ICPC
Rheumatoid/seropositive arthritis
3.1
7.4
38
124
WX308
NOMESCO Finland
Sacral anesthesy
80.4
7.4
8
*
L04AB06
ATC
golimumab; parenteral
13.4
7.4
12
9
R53
ICD-10 Finland
Malaise and fatigue
1.5
7.3
264
1869
7242A
ICD-9 Finland
Other and unspecified disorders of back, Lumbago
+∞
7.3
7
*
79019
ICD-8 Finland
Nervousness and debility, Debilitas et fatigatio abnormis alia sive NUD
+∞
7.3
7
*
72599
ICD-8 Finland
Displacement of intervertebral disk, Unspecified site
+∞
7.3
7
*
72840
ICD-8 Finland
Vertebrogenic pain syndrome, Cervial myelopathy
+∞
7.3
7
*
7221A
ICD-9 Finland
Intervertebral disk disorders, Displacement of thoracic or lumbar intervertebral disk without myelopathy
+∞
7.3
7
*
M54
ICD-10 Finland
Dorsalgia
2.2
7.3
71
332
P01BA02
ATC
hydroxychloroquine; oral
2.2
7.3
73
344
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.0
7.3
27
68
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
5.5
7.2
20
37
M01AG02
ATC
tolfenamic acid; oral, rectal
1.9
7.2
102
555
72398
ICD-8 Finland
Other diseases of bone, Alii definiti
20.1
7.1
10
5
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.3
7.1
62
275
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.0
7.1
39
134
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.6
7.1
169
1082
N02BE01
ATC
paracetamol; systemic, rectal
1.4
7.1
886
7817
78551
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Symptomata abdominalis acuta NUD
3.2
7.1
35
112
G04CA02
ATC
tamsulosin; oral
1.4
7.1
358
2712
35708
ICD-8 Finland
Other diseases of peripheral nerves except autonomic, Alterius nervi
8.8
7.0
14
16
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.4
7.0
418
3262
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
10.1
7.0
13
13
49099
ICD-8 Finland
Bronchitis, unspecified
4.3
7.0
24
56
J01DB01
ATC
cefalexin; oral
1.4
6.9
774
6688
M04AA01
ATC
allopurinol; systemic
1.5
6.9
217
1483
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.7
6.9
44
163
J01DA08
ATC
[U] cefaclor; oral
2.1
6.9
77
381
S22.3
ICD-10 Finland
Fracture of rib
2.1
6.7
74
365
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.1
6.7
76
379
R52.9
ICD-10 Finland
Pain, unspecified
2.2
6.7
64
295
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
6.7
33
106
SPAT1229
SPAT
Assessment of need for aid
1.8
6.7
102
571
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
2.8
6.6
39
140
L17
ICPC
Foot/toe symptom/complaint
1.6
6.6
192
1289
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
4.6
6.6
21
46
N05CD05
ATC
triazolam; oral, sublingual
2.8
6.6
39
141
A02BA03
ATC
famotidine; systemic
2.0
6.5
77
390
C07AB02
ATC
metoprolol; systemic
1.4
6.5
373
2885
A07EC02
ATC
mesalazine; oral, rectal
2.3
6.5
55
241
C02DE04
ATC
NA
1.9
6.5
89
480
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
6.5
212
1467
34609
ICD-8 Finland
Migraine, Unspecified
6.2
6.5
16
26
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.4
264
1915
L85
ICPC
Acquired deformity of spine
70.0
6.4
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.4
177
1177
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.0
6.4
82
430
62699
ICD-8 Finland
Disorders of menstruation, Other
2.7
6.3
41
155
ZXA05
NOMESCO Finland
Left side
1.4
6.3
296
2203
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.8
6.3
110
644
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
2.9
6.3
36
125
E990A
ICD-9 Finland
Injury due to war operations by fires and conflagrations
5.5
6.3
17
31
AA1AD
NOMESCO Finland
CT of head and brain
1.5
6.3
274
2009
71599
ICD-8 Finland
Arthritis, unspecified
11.1
6.3
11
10
M79.9
ICD-10 Finland
Soft tissue disorder, unspecified
9.3
6.3
12
13
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
6.2
6
*
M48.1
ICD-10 Finland
Ankylosing hyperostosis [Forestier]
+∞
6.2
6
*
7227A
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[KAULANIKAMAN VÄLILEVYTYRÄ JUURIOIREINEEN]
+∞
6.2
6
*
7232A
ICD-9 Finland
Other disorders of cervical region, Cervicocranial syndrome
+∞
6.2
6
*
7373A
ICD-9 Finland
Curvature of spine, Kyphoscoliosis and scoliosis
+∞
6.2
6
*
ABC99
NOMESCO Finland
Other decompressive operation on spinal cord or nerve root
+∞
6.2
6
*
55130
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Diaphragmatic
4.8
6.2
19
40
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
2.3
6.2
56
253
WZA90
NOMESCO Finland
Other doctors statement
1.6
6.2
142
899
C01CA24
ATC
epinephrine; parenteral
3.0
6.2
33
112
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.0
6.2
33
112
H02.3
ICD-10 Finland
Blepharochalasis
2.2
6.1
56
256
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.1
367
2859
73398
ICD-8 Finland
Other diseases of muscle, tendon and fascia, Alii definiti
4.7
6.1
19
41
M01AB51
ATC
indometacin, combinations; oral, rectal
3.0
6.1
32
108
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
3.6
6.1
25
70
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
2.4
6.1
47
198
M53.3
ICD-10 Finland
Sacrococcygeal disorders, not elsewhere classified
12.6
6.1
10
8
SPAT1301
SPAT
No procedures
1.4
6.0
309
2338
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.0
247
1790
N02BA71
ATC
acetylsalicylic acid, combinations with psycholeptics; systemic
2.8
6.0
35
125
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPINENTHES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINENTHES | 1.453 [1.13, 1.87] | 0.004 |
| Birth year | 0.996 [0.99, 1.01] | 0.406 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 699 females with M13_SPINENTHES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPINENTHES | 1.31 [1.04, 1.65] | 0.022 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 629 males with M13_SPINENTHES died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPINENTHES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.208% |
| 5 | 0.821% | 1.478% |
| 10 | 2.233% | 3.758% |
| 15 | 4.166% | 7.268% |
| 20 | 7.308% | 12.053% |
Relationships between endpoints
↥Index endpoint: M13_SPINENTHES – Spinal enthesopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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