No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
88 |
4. Check minimum number of eventsNone |
88 |
5. Include endpointsNone |
88 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Spondylopathia traumatica
Similar endpoints
↥List of similar endpoints to
Traumatic spondylopathy
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 861 | 449 | 403 |
| Only index persons | 672 | 376 | 296 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 59.90 | 63.11 | 56.48 |
| Only index persons | 59.56 | 62.52 | 55.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 53 | 35 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 55.91 | 57.95 | 52.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 81
- Matched controls
- 809
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.3
ICD-10 Finland
Traumatic spondylopathy
+∞
79.9
63
*
M48.0
ICD-10 Finland
Spinal stenosis
132.3
26.5
27
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
44.1
20.8
25
8
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
37.8
14.6
18
6
M54.5
ICD-10 Finland
Low back pain
6.9
13.0
38
91
71320
ICD-8 Finland
Osteo-arthritis and allied conditions, Traumatic spondylopathy
+∞
12.8
12
*
N03AX12
ATC
gabapentin; oral
11.2
11.5
22
26
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
69.4
10.9
12
*
N02AX02
ATC
tramadol; systemic, rectal
5.0
10.5
48
182
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
30.5
10.2
13
5
N03AX16
ATC
pregabalin; oral
6.0
9.6
29
69
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
9.6
9
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
56.2
8.9
10
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
23.1
8.8
12
6
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
99.9
8.6
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.0
8.3
24
53
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
28.1
7.8
10
*
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
87.7
7.5
8
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
7.4
7
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
+∞
7.4
7
*
N06AX21
ATC
duloxetine; oral
8.9
7.3
15
20
M03BX02
ATC
tizanidine; oral
3.6
7.0
52
271
M54.4
ICD-10 Finland
Lumbago with sciatica
9.4
6.6
13
16
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
29.2
6.4
8
*
N05CD07
ATC
temazepam; oral
4.6
6.1
22
61
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOTRAUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOTRAUM | 1.502 [1.12, 2.01] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.184 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 278 females with M13_SPONDYLOTRAUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOTRAUM | 1.588 [1.09, 2.31] | 0.015 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 217 males with M13_SPONDYLOTRAUM died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOTRAUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.098% | 0.327% |
| 5 | 0.726% | 2.047% |
| 10 | 2.085% | 4.789% |
| 15 | 4.192% | 8.912% |
| 20 | 7.266% | 14.514% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOTRAUM – Traumatic spondylopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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