Tibial collateral bursitis [Pellegrini-Stieda]

M13_TIBIALCOLLATERAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M76.4
  • Hospital discharge: ICD-9 7266B|7266C
  • Cause of death: ICD-10 M76.4
  • Cause of death: ICD-9 7266B|7266C

2 out of 7 registries used, show all original rules.

406

4. Check minimum number of events

None

406

5. Include endpoints

None

406

6. Filter based on genotype QC (FinnGen only)

406

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M76
Name in latin
Bursitis anserina

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2376 1534 838
Only index persons 2289 1496 793
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.02
Only index persons 0.05 0.05 0.03
Median age at first event (years)
Whole population 51.13 54.01 45.92
Only index persons 50.96 53.82 45.56

-FinnGen-

Key figures

All Female Male
Number of individuals 406 284 122
Unadjusted period prevalence (%) 0.08 0.10 0.05
Median age at first event (years) 53.92 55.12 51.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
358
Matched controls
3578
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M76.4
ICD-10 Finland
Tibial collateral bursitis [Pellegrini-Stieda]
15441.0
323.0
326
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
24.5
40.8
58
28
M48.0
ICD-10 Finland
Spinal stenosis
33.1
37.6
49
17
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
6.8
34.4
96
184
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.8
33.8
136
402
M54.4
ICD-10 Finland
Lumbago with sciatica
7.6
30.0
75
121
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.5
27.5
208
1022
M79.6
ICD-10 Finland
Pain in limb
3.5
26.1
170
735
M25.5
ICD-10 Finland
Pain in joint
3.6
25.3
151
606
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
75.6
25.2
28
*
M01AH05
ATC
etoricoxib; oral
3.2
24.0
244
1426
M54.5
ICD-10 Finland
Low back pain
3.7
23.3
124
445
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
15.9
22.2
36
25
Z3226
NOMESCO Finland
Physiotherapist
3.7
19.2
97
329
M03BC01
ATC
orphenadrine (citrate); systemic
3.5
19.0
103
369
N03AX16
ATC
pregabalin; oral
3.6
18.4
94
321
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
9.1
18.0
38
46
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
14.9
17.6
29
21
M01AB05
ATC
diclofenac; systemic, rectal
2.8
17.5
256
1706
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.3
17.4
103
391
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
52.7
17.2
20
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.7
16.9
50
99
7266C
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of knee[TENDINITIS SEU BURSITIS REGIONIS LIG GENUS COLL LAT]
+∞
16.8
16
*
7266B
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of knee[TENDINITIS SEU BURSITIS REGIONIS LIG GENUS COLL MED]
+∞
16.8
16
*
M54.1
ICD-10 Finland
Radiculopathy
31.7
16.3
21
7
ZXA05
NOMESCO Finland
Left side
2.9
16.0
118
517
N02AX02
ATC
tramadol; systemic, rectal
2.6
15.4
152
788
N03AX12
ATC
gabapentin; oral
4.2
15.3
61
166
Z3231
NOMESCO Finland
Registered nurse
2.8
15.1
119
542
M19.0
ICD-10 Finland
Primary arthrosis of other joints
4.6
14.9
54
134
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
14.8
147
760
M03BX02
ATC
tizanidine; oral
2.5
14.8
231
1521
N02BE01
ATC
paracetamol; systemic, rectal
3.4
14.6
320
2550
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
16.3
14.6
23
15
L15
ICPC
Knee symptom/complaint
2.9
14.4
100
417
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.9
14.4
48
109
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
55.6
13.9
16
*
ZB0.1
ICD-10 Finland
Right side
145.3
13.5
14
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
3.5
13.5
68
226
M02AA07
ATC
piroxicam; topical
2.4
13.4
153
844
M76.6
ICD-10 Finland
Achilles tendinitis
7.2
13.3
32
48
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.8
13.0
57
168
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
5.8
13.0
37
70
R51.80
ICD-10 Finland
Headache
3.5
12.7
62
200
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.3
12.7
48
124
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
12.6
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
12.5
148
824
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
15.0
12.4
20
14
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.0
12.3
30
46
M01AE02
ATC
naproxen; oral, rectal
2.2
12.3
213
1416
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.7
11.9
95
426
M01AX05
ATC
glucosamine; oral
2.8
11.9
89
384
R07.4
ICD-10 Finland
Chest pain, unspecified
2.6
11.8
103
487
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
36.3
11.3
14
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
36.3
11.3
14
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
11.2
130
709
M54.2
ICD-10 Finland
Cervicalgia
6.9
11.0
27
42
R4110
NOMESCO Finland
Physiotherapy
2.4
10.5
108
550
ZXA00
NOMESCO Finland
Right side
2.4
10.5
110
568
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
10.5
10
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
10.5
10
*
P01AB01
ATC
metronidazole; oral, rectal
2.1
10.4
159
973
M70.6
ICD-10 Finland
Trochanteric bursitis
3.3
10.3
54
184
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.3
10.2
38
97
R03AC02
ATC
salbutamol; inhalant
2.1
10.2
192
1280
H02AB06
ATC
prednisolone; systemic
2.1
10.1
170
1079
R42
ICD-10 Finland
Dizziness and giddiness
2.5
10.0
87
406
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
9.6
151
926
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
9.5
57
210
NGM20
NOMESCO Finland
Excision of synovial ganglion of knee or lower leg
102.6
9.5
10
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
4.2
9.5
35
89
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
9.4
9
*
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
9.1
9.4
19
22
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
8.7
9.2
19
23
M54.3
ICD-10 Finland
Sciatica
8.7
9.2
19
23
R06AE07
ATC
cetirizine; oral
2.0
9.1
161
1032
M01AX17
ATC
nimesulide; oral
2.3
9.0
93
472
R05
ICD-10 Finland
Cough
2.5
8.9
78
363
M67.4
ICD-10 Finland
Ganglion
4.1
8.8
34
90
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.9
8.8
28
61
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
8.8
74
335
A02BC02
ATC
pantoprazole; systemic
2.0
8.8
228
1684
M01AH02
ATC
rofecoxib; oral
2.9
8.7
56
217
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
12.0
8.6
15
13
Z50.1
ICD-10 Finland
Other physical therapy
4.2
8.4
31
79
M01AE03
ATC
ketoprofen; systemic, rectal
2.0
8.4
140
870
M01AH01
ATC
celecoxib; oral (coxibs)
2.5
8.3
69
311
1220
FHL
Arthroscopy
5.1
8.2
25
52
ZXD20
NOMESCO Finland
Day surgery
2.6
8.2
61
259
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
7.9
67
307
N05CF01
ATC
zopiclone; oral
2.0
7.8
115
673
J01AA02
ATC
doxycycline; systemic
2.0
7.7
279
2270
N06AX21
ATC
duloxetine; oral
3.2
7.6
40
137
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.6
102
573
G44.2
ICD-10 Finland
Tension-type headache
2.7
7.6
51
204
Z2221
NOMESCO Finland
Medical doctor
2.0
7.6
107
617
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.2
7.5
19
32
M01AE01
ATC
ibuprofen; systemic, rectal
2.4
7.5
318
2750
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
81.7
7.4
8
*
M01AC06
ATC
meloxicam; systemic, rectal
1.9
7.4
131
823
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
7.3
7
*
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
7.3
193
1394
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
5.0
7.3
22
46
N06AA09
ATC
amitriptyline; systemic
3.2
7.2
37
125
M79.7
ICD-10 Finland
Fibromyalgia
6.8
7.2
17
26
M23.8
ICD-10 Finland
Other internal derangements of knee
5.5
7.2
20
38
L86
ICPC
Back syndrome with radiating pain
5.5
7.2
20
38
L17
ICPC
Foot/toe symptom/complaint
2.1
7.2
89
486
R06.0
ICD-10 Finland
Dyspnoea
2.2
7.2
83
437
L02
ICPC
Back symptom/complaint
3.2
7.1
36
120
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
7.0
90
498
L14
ICPC
Leg/thigh symptom/complaint
3.7
7.0
29
83
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
14.1
6.9
11
8
A02BC03
ATC
lansoprazole; oral
2.0
6.9
99
570
XA402
NOMESCO Finland
ENMG
6.9
6.9
16
24
WX110
NOMESCO Finland
Local anesthesy
1.8
6.8
243
1912
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.0
6.8
103
605
J01DB01
ATC
cefalexin; oral
2.0
6.7
287
2401
M54.6
ICD-10 Finland
Pain in thoracic spine
4.8
6.7
21
46
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.6
6.7
50
214
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
6.7
137
898
M02AA10
ATC
ketoprofen; topical
2.3
6.7
62
296
M77.1
ICD-10 Finland
Lateral epicondylitis
3.2
6.7
33
109
J01EA01
ATC
trimethoprim; systemic
2.0
6.6
95
547
L01
ICPC
Neck symptom/complaint
2.6
6.6
48
201
ZXE00
NOMESCO Finland
One hour or less
1.8
6.6
149
1008
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
4.1
6.5
24
62
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.9
6.5
104
625
B01AB05
ATC
enoxaparin; parenteral
1.9
6.4
108
658
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.4
6.4
53
239
H60.9
ICD-10 Finland
Otitis externa, unspecified
3.6
6.4
27
79
L29
ICPC
Musculoskeletal sympt/complt other
3.3
6.3
30
96
L03
ICPC
Low back symptom/complaint
2.2
6.3
68
347
A02BC05
ATC
esomeprazole; systemic
1.8
6.3
138
922
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
6.3
102
613
M22.4
ICD-10 Finland
Chondromalacia patellae
5.5
6.2
17
32
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
6.2
166
1181
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.2
97
575
WX320
NOMESCO Finland
Spinalanesthesy
2.0
6.2
87
495
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.7
6.1
40
159
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
6.0
68
354
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.9
6.0
23
62

Mortality – FinRegistry

Association

Association between endpoint M13_TIBIALCOLLATERAL and mortality.

Females

Parameter HR [95% CI] p-value
M13_TIBIALCOLLATERAL 0.731 [0.58, 0.92] 0.008
Birth year 0.995 [0.99, 1.0] 0.297

During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 1195 females with M13_TIBIALCOLLATERAL died.

Males

Parameter HR [95% CI] p-value
M13_TIBIALCOLLATERAL 1.153 [0.89, 1.5] 0.286
Birth year 0.989 [0.98, 1.0] 0.031

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 529 males with M13_TIBIALCOLLATERAL died.

Mortality risk

Mortality risk for people of age

years, who have M13_TIBIALCOLLATERAL.

N-year risk Females Males
1 0.061% 0.217%
5 0.427% 1.509%
10 1.123% 3.654%
15 2.112% 6.848%
20 3.733% 12.032%

Relationships between endpoints

Index endpoint: M13_TIBIALCOLLATERAL – Tibial collateral bursitis [Pellegrini-Stieda]

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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