Complications of anaesthesia during labour and delivery

O15_LABOUR_ANEST_COMPLIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O74
  • Hospital discharge: ICD-9 668
  • Hospital discharge: ICD-8 6629
  • Cause of death: ICD-10 O74
  • Cause of death: ICD-9 668
  • Cause of death: ICD-8 6629

2 out of 7 registries used, show all original rules.

141

4. Check minimum number of events

None

141

5. Include endpoints

None

141

6. Filter based on genotype QC (FinnGen only)

141

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O60-O75
Name in latin
Complicationes ex anaesthesia intra labores/partum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1122 1122 -
Only index persons 1109 1109 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.04 0.04 -
Median age at first event (years)
Whole population - 29.82 -
Only index persons - 29.87 -

-FinnGen-

Key figures

All Female Male
Number of individuals 141 141 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 30.09 30.09 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
127
Matched controls
1269
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O74.5
ICD-10 Finland
Spinal and epidural anaesthesia-induced headache during labour and delivery
+∞
93.7
78
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
159.6
68.8
68
9
O81.4
ICD-10 Finland
Vacuum extractor delivery
36.5
19.2
24
8
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
+∞
18.1
17
*
ZXD05
NOMESCO Finland
Urgent procedure
5.2
16.8
72
255
MAE00
NOMESCO Finland
Outlet vacuum delivery
39.1
16.3
20
6
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
4.6
13.8
60
205
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
4.4
13.0
62
226
O74.0
ICD-10 Finland
Aspiration pneumonitis due to anaesthesia during labour and delivery
+∞
12.7
12
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
4.5
12.7
55
184
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
3.6
10.8
77
380
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.6
10.3
59
244
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.4
9.6
30
69
W78
ICPC
Pregnancy
3.5
9.4
57
238
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
4.2
9.1
37
112
O99.80
ICD-10 Finland
The fear of childbirth
6.6
9.0
23
41
SPAT1379
SPAT
Health check-up of pregnant person
3.6
8.8
46
172
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
5.2
8.6
27
62
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
3.7
8.6
44
160
Z3232
NOMESCO Finland
Midwife
3.8
8.6
40
136
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
+∞
8.4
8
*
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
+∞
8.4
8
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
4.0
8.4
36
114
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.8
7.6
34
111
6688X
ICD-9 Finland
Complications of the administration of anaesthetic or other sedation in labour and delivery, Other complications of anaesthesia or other sedation in labour and delivery
+∞
7.4
7
*
O74.8
ICD-10 Finland
Other complications of anaesthesia during labour and delivery
+∞
7.4
7
*
O60
ICD-10 Finland
Preterm labour and delivery
+∞
7.4
7
*
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
32.0
7.2
9
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
8.3
7.1
15
20
SPAT1197
SPAT
Extensive health check-up of expecting family
3.0
6.8
45
194
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
+∞
6.3
6
*
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
+∞
6.3
6
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.6
6.3
78
482
WX306
NOMESCO Finland
Lumbar epidural anesthesy
4.1
6.0
23
65

Mortality – FinRegistry

Association

Association between endpoint O15_LABOUR_ANEST_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_ANEST_COMPLIC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_LABOUR_ANEST_COMPLIC – Complications of anaesthesia during labour and delivery

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data