Risteys · O15_COMPLIC_LAB

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O60-O75 Cause of death: ICD-10 — O60-O75 2 out of 7 registries used, show all original rules.	42467
4. Check minimum number of events None	42467
5. Include endpoints O15_PRETERM O15_FAILED_INDUCT O15_LABOUR_ABNORM_FORCES O15_LABOUR_LONG O15_LABOUR_MALPOS O15_LABOUR_PELVIC_ABNORM O15_LABOUR_OBSTR_OTHER O15_LABOUR_INTRAPART_HAEMORRH O15_LABOUR_FETAL_STRESS O15_LABOUR_UMBILICAL O15_DELIV_PERIN_LACER O15_OBSTET_TRAUMA_OTHER O15_POSTPART_HEAMORRH O15_RETAINED_PLAC_MEMB_NO_HEAMORRH O15_LABOUR_ANEST_COMPLIC O15_LABOUR_OTHER	69785
6. Filter based on genotype QC (FinnGen only)	69785

	All	Female	Male
Number of individuals
Whole population	500391	500391	-
Only index persons	491434	491434	-
Unadjusted period prevalence (%)
Whole population	14.33	14.33	-
Only index persons	18.07	18.07	-
Median age at first event (years)
Whole population	-	29.01	-
Only index persons	-	29.00	-

	All	Female	Male
Number of individuals	69785	69785	-
Unadjusted period prevalence (%)	23.79	23.79	-
Median age at first event (years)	29.27	29.27	-

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
5384: Matched controls
44383

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z39.2

ICD-10 Finland

Routine postpartum follow-up

11.8

323.0

865

710

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

9.9

323.0

771

740

W78

ICPC

Pregnancy

8.4

323.0

1112

1337

SPAT1379

SPAT

Health check-up of pregnant person

9.3

323.0

1029

1104

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

10.1

323.0

1014

995

63497

ICD-8 Finland

Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis

+∞

323.0

1288

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

10.9

323.0

801

698

65400

ICD-8 Finland

Occipital presentation

+∞

323.0

775

SPAT1197

SPAT

Extensive health check-up of expecting family

10.0

323.0

938

918

SPAT1380

SPAT

Postpartum check-up

10.2

323.0

801

745

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

10.8

291.5

615

525

O81.4

ICD-10 Finland

Vacuum extractor delivery

274.0

285.9

311

65300

ICD-8 Finland

Occipital presentation

+∞

273.3

280

65200

ICD-8 Finland

Occipital presentation

+∞

269.3

276

MAE00

NOMESCO Finland

Outlet vacuum delivery

289.4

247.9

269

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

10.2

247.2

535

475

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

2066.9

239.4

248

65210

ICD-8 Finland

Occipital presentation

+∞

238.8

245

SPAT1399

SPAT

Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.

10.7

226.3

476

398

65310

ICD-8 Finland

Occipital presentation

+∞

212.3

218

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

24.3

208.4

317

114

WX307

NOMESCO Finland

Obstetric epidural analgesia

9.1

205.5

474

468

65696

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Complete or incomplete breech presentation

+∞

200.5

206

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

895.2

199.2

209

Z32.1

ICD-10 Finland

Pregnancy confirmed

6.8

199.1

555

737

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

65.6

196.5

243

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

8.9

196.3

456

455

MA3AE

NOMESCO Finland

Combined first trimester screening

9.0

193.9

447

440

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

10.2

187.2

402

347

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

8.3

186.8

454

488

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

9.2

182.2

415

399

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

9.9

173.7

380

339

O72.1

ICD-10 Finland

Other immediate postpartum haemorrhage

+∞

166.2

171

O80.0

ICD-10 Finland

Spontaneous vertex delivery

5.8

161.5

507

781

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

6.4

159.8

461

636

MAX99

NOMESCO Finland

Assistance to normal delivery

8.9

151.6

351

345

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

12.5

151.0

293

204

O75.6

ICD-10 Finland

Delayed delivery after spontaneous or unspecified rupture of membranes

+∞

141.8

146

O80.8

ICD-10 Finland

Other single spontaneous delivery

10.8

139.0

288

230

Z37.0

ICD-10 Finland

Single live birth

9.8

129.9

284

251

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

9.6

126.2

278

249

65580

ICD-8 Finland

Occipital presentation

+∞

122.3

126

O72.0

ICD-10 Finland

Third-stage haemorrhage

+∞

122.3

126

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

+∞

112.5

116

W90

ICPC

Uncompl labour/delivery livebirth

7.4

111.7

289

338

W85

ICPC

Gestational diabetes

11.8

109.2

216

156

O60

ICD-10 Finland

Preterm labour and delivery

+∞

108.6

112

8811

FHL

Cesarean section

10.7

107.6

224

180

W92

ICPC

Compl labour/ delivery livebirth

22.7

105.6

163

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

7.1

102.9

272

328

O99.80

ICD-10 Finland

The fear of childbirth

10.3

102.2

217

181

65220

ICD-8 Finland

Occipital presentation

+∞

99.9

103

Y6099

ICD-8 Finland

Prenatal care and observation

3.2

97.1

578

1605

OAA11

SPAT

7.0

96.1

258

318

O64.0

ICD-10 Finland

Obstructed labour due to incomplete rotation of fetal head

+∞

95.0

66030

ICD-8 Finland

Occipital presentation

+∞

93.0

SPAT1200

SPAT

Guidance for breast-feeding and breast care

11.2

89.5

181

137

W84

ICPC

Pregnancy high risk

8.9

89.3

205

197

SPAT1373

SPAT

Combined screening in early pregnancy

15.4

87.0

153

66130

ICD-8 Finland

Occipital presentation

+∞

86.2

SPAT1189

SPAT

Other ultrasound examination during pregnancy

8.3

85.6

204

209

Z34

ICD-10 Finland

Supervision of normal pregnancy

9.8

84.6

183

158

O63.0

ICD-10 Finland

Prolonged first stage (of labour)

+∞

82.3

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

8.4

81.9

194

197

MAC10

NOMESCO Finland

Antepartum dilatation of cervical canal

11.4

81.8

164

122

SPAT1195

SPAT

Antenatal classes

12.1

77.4

151

106

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

173.7

74.3

63230

ICD-8 Finland

Haemorrhage of pregnancy, Threatened abortion

3.6

73.2

364

875

MAC40

NOMESCO Finland

Pharmacological induction or advancement of labor

15.4

73.0

128

O42.9

ICD-10 Finland

Premature rupture of membranes, unspecified

14.5

72.9

131

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

31.4

71.6

101

MBC30

NOMESCO Finland

Repair of partial rupture of perineum

26.2

69.8

103

O48

ICD-10 Finland

Prolonged pregnancy

11.2

68.9

139

105

O36.6

ICD-10 Finland

Maternal care for excessive fetal growth

15.4

67.9

119

Z3232

NOMESCO Finland

Midwife

4.3

67.2

271

540

65590

ICD-8 Finland

Occipital presentation

+∞

65.8

Z39.1

ICD-10 Finland

Care and examination of lactating mother

16.5

62.1

106

OAA12

SPAT

9.3

61.8

137

124

W29

ICPC

Pregnancy symptom/complaint other

8.0

58.4

141

148

O21.9

ICD-10 Finland

Vomiting of pregnancy, unspecified

9.2

58.3

130

119

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

11.1

57.9

117

65690

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Occipital presentation

+∞

57.1

WYA40

NOMESCO Finland

Assessment of oral health and treatment needs for family expecting first child

11.3

55.0

110

O36.8

ICD-10 Finland

Maternal care for other specified fetal problems

20.2

54.8

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

2.2

54.7

650

2633

65406

ICD-8 Finland

Complete or incomplete breech presentation

+∞

54.2

O47.9

ICD-10 Finland

False labour, unspecified

12.8

49.0

TMA00

NOMESCO Finland

Episiotomy

14.2

47.3

SPAT1375

SPAT

Structural ultrasound screening, weeks 18+0-21+6

22.3

46.9

64399

ICD-8 Finland

Spontaneous abortion, Without mention of sepsis or toxaemia

2.4

46.3

421

1494

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

11.2

45.9

O70.0

ICD-10 Finland

First degree perineal laceration during delivery

+∞

45.5

63499

ICD-8 Finland

Other complications of pregnancy, Other

3.7

45.5

213

486

O41.1

ICD-10 Finland

Infection of amniotic sac and membranes

208.1

45.4

O75.0

ICD-10 Finland

Maternal distress during labour and delivery

+∞

44.5

OAA10

SPAT

6.1

44.2

128

176

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

9.2

43.9

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

6.3

43.9

124

165

O26.82

ICD-10 Finland

Exhaustion and fatigue pregnancy-related

7.6

43.1

107

118

O99.3

ICD-10 Finland

Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium

9.6

42.6

MBC10

NOMESCO Finland

Repair of obstetric laceration of vagina

12.0

42.5

WX322

NOMESCO Finland

Combined spinal-epidural analgesia in obstetrics

13.8

41.9

6440B

ICD-9 Finland

Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]

+∞

41.6

WX230

NOMESCO Finland

Plexus blockade of nervus pudendus

11.2

41.2

O61.0

ICD-10 Finland

Failed medical induction of labour

+∞

40.6

65480

ICD-8 Finland

Occipital presentation

+∞

40.6

63494

ICD-8 Finland

Other complications of pregnancy, Insufficientia cervicis

5.6

39.2

121

181

W05

ICPC

Pregnancy vomiting/nausea

9.2

39.0

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

7.4

38.5

110

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

12.5

38.1

O61.8

ICD-10 Finland

Other failed induction of labour

+∞

37.7

O32.1

ICD-10 Finland

Maternal care for breech presentation

11.1

36.5

6441A

ICD-9 Finland

Early or threatened labour, Other threatened labour

+∞

35.8

O42.0

ICD-10 Finland

Premature rupture of membranes, onset of labour within 24 hours

23.2

35.1

OAA70

SPAT

8.8

35.0

O47.1

ICD-10 Finland

False labour at or after 37 completed weeks of gestation

7.8

33.8

WZB00

SPAT

0.4

33.7

156

3037

MAC96

NOMESCO Finland

Other induction or advancement of labour

16.6

33.4

O35.8

ICD-10 Finland

Maternal care for other (suspected) fetal abnormality and damage

10.3

32.5

6522B

ICD-9 Finland

Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,SYNNYTYKSEN AIKANA]

+∞

31.9

Z36.8

ICD-10 Finland

Other antenatal screening

8.7

31.4

O71.4

ICD-10 Finland

Obstetric high vaginal laceration

+∞

30.0

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

13.6

29.8

O23.5

ICD-10 Finland

Infections of the genital tract in pregnancy

12.7

29.5

MBA04

NOMESCO Finland

Curettage of uterus after delivery

51.1

29.3

SPAT1196

SPAT

Monitoring of normal pregnancy

6.3

29.3

109

MAC01

NOMESCO Finland

Rupture of aminiotic membrane for induction of labor

8.1

28.9

O36.5

ICD-10 Finland

Maternal care for poor fetal growth

7.4

28.5

WX234

NOMESCO Finland

Paracervical blockade

4.6

28.2

102

184

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

9.6

27.7

8221

FHL

Sterilization of the laparotomy pathway

2.7

27.3

196

609

O26.88

ICD-10 Finland

Other specified pregnancy-related conditions

9.1

26.5

ZYC02

SPAT

0.2

26.2

1077

65694

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Occipital presentation, posterior position

+∞

26.1

63496

ICD-8 Finland

Other complications of pregnancy, Labores inhibiti

3.4

25.8

130

317

XMA22

NOMESCO Finland

General examination of pregnant woman

7.1

25.5

65698

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Other or imprecisely defined presentation

+∞

25.1

65490

ICD-8 Finland

Occipital presentation

+∞

24.2

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.7

24.2

586

3018

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

19.2

23.4

O64.1

ICD-10 Finland

Obstructed labour due to breech presentation

+∞

23.2

65586

ICD-8 Finland

Complete or incomplete breech presentation

+∞

23.2

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

+∞

23.2

O03.9

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, without complication

4.6

23.0

154

O21

ICD-10 Finland

Excessive vomiting in pregnancy

6.7

22.8

MBA30

NOMESCO Finland

Manual removal of placenta from delivered uterus

58.1

22.7

O02.1

ICD-10 Finland

Missed abortion

5.7

22.6

100

O26.7

ICD-10 Finland

Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium

9.5

22.5

SPAT1246

SPAT

Screening of depression or other psychiatric problem

2.1

22.4

270

1091

O68.1

ICD-10 Finland

Labour and delivery complicated by meconium in amniotic fluid

+∞

22.2

O47

ICD-10 Finland

False labour

9.6

21.7

Z39.0

ICD-10 Finland

Care and examination immediately after delivery

8.0

21.3

O41.8

ICD-10 Finland

Other specified disorders of amniotic fluid and membranes

38.6

21.2

O41.0

ICD-10 Finland

Oligohydramnios

11.9

21.0

O20.0

ICD-10 Finland

Threatened abortion

12.4

21.0

O86.0

ICD-10 Finland

Infection of obstetric surgical wound

17.6

21.0

SPAT1249

SPAT

Treatment-related counselling outside office

1.3

20.9

2315

16101

O73.1

ICD-10 Finland

Retained portions of placenta and membranes, without haemorrhage

+∞

20.3

6531B

ICD-9 Finland

Disproportion, Generally contracted pelvis[PELVIS ANGUSTA,SYNNYTYKSEN AIKANA]

+∞

20.3

O42.1

ICD-10 Finland

Premature rupture of membranes, onset of labour after 24 hours

26.7

20.3

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

18.9

20.2

Y1901

ICD-8 Finland

Other studies, Pregnancy study

3.3

20.1

104

261

OAB30

SPAT

8.9

20.0

O26.6

ICD-10 Finland

Liver disorders in pregnancy, childbirth and the puerperium

11.2

20.0

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

182.0

19.9

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

11.7

19.9

63299

ICD-8 Finland

Haemorrhage of pregnancy, Other and unspecified

4.6

19.9

128

O28.8

ICD-10 Finland

Other abnormal findings on antenatal screening of mother

8.1

19.9

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

9.4

19.7

O46.9

ICD-10 Finland

Antepartum haemorrhage, unspecified

16.1

19.7

WX306

NOMESCO Finland

Lumbar epidural anesthesy

2.1

19.7

221

867

O36.9

ICD-10 Finland

Maternal care for fetal problem, unspecified

10.8

19.7

WYA50

NOMESCO Finland

Student oral health check consistent with decree to assess need for oral health guidance and services

0.4

19.4

1815

O70.21

ICD-10 Finland

III degree perineal tear involving less than one half of external anal sphincter thickness torn during childbirth

+∞

19.3

6610B

ICD-9 Finland

Abnormality of forces of labour, Primary uterine inertia

+∞

19.3

O80.9

ICD-10 Finland

Single spontaneous delivery, unspecified

23.2

18.9

Z35.7

ICD-10 Finland

Supervision of high-risk pregnancy due to social problems

10.2

18.6

SPAT1391

SPAT

Counselling and guidance related to family situation

4.5

18.5

123

MA3AE

SPAT

8.3

18.4

MBC33

NOMESCO Finland

Repair of complete rupture of perineum

+∞

18.4

O82.0

ICD-10 Finland

Delivery by elective caesarean section

5.7

18.2

SPAT1393

SPAT

Guidance to support interaction between parent and child

11.2

18.0

O04.9

ICD-10 Finland

Medical abortion, complete or unspecified, without complication

2.3

17.7

173

637

Z35.6

ICD-10 Finland

Supervision of very young primigravida

10.7

17.7

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.4

17.7

1108

7003

W27

ICPC

Fear of complications of pregnancy

10.0

17.5

63701

ICD-8 Finland

Pre-eclampsia, eclampsia and toxaemia, unspecified, Hypertonia

2.2

17.5

177

664

6660A

ICD-9 Finland

Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM STADII III]

+∞

17.4

O99.0

ICD-10 Finland

Anaemia complicating pregnancy, childbirth and the puerperium

6.8

17.4

66180

ICD-8 Finland

Occipital presentation

2.2

17.4

185

708

SPAT1381

SPAT

Extensive health check-up at 4 months of age

11.4

17.2

MAA00

NOMESCO Finland

Amniocentesis

11.5

16.8

WZA10

SPAT

0.1

16.6

449

O91.2

ICD-10 Finland

Nonpurulent mastitis associated with childbirth

7.0

16.6

66136

ICD-8 Finland

Complete or incomplete breech presentation

+∞

16.4

6534B

ICD-9 Finland

Disproportion, Foetopelvic disproportion[DISPROPORTIO FOETOPELVICA,SYNNYTYKSEN AIKANA]

+∞

16.4

Z35

ICD-10 Finland

Supervision of high-risk pregnancy

9.7

16.4

O40

ICD-10 Finland

Polyhydramnios

16.0

16.2

SPAT1283

SPAT

Restricted health certificate

1.4

16.0

719

4265

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

1.7

16.0

330

1618

OAA41

SPAT

4.0

16.0

138

O86.1

ICD-10 Finland

Other infection of genital tract following delivery

11.8

15.9

MBA05

NOMESCO Finland

Curettage of uterus after abortion

14.9

15.8

N61

ICD-10 Finland

Inflammatory disorders of breast

2.7

15.7

113

355

N97.0

ICD-10 Finland

Female infertility associated with anovulation

4.7

15.6

FM1QE

NOMESCO Finland

Extensive ultrasound of fetal heart

6.5

15.5

O66.0

ICD-10 Finland

Obstructed labour due to shoulder dystocia

+∞

15.5

O69.1

ICD-10 Finland

Labour and delivery complicated by cord around neck, with compression

+∞

15.5

Y4300

ICD-8 Finland

Preventive sterilization, Legal sterilization, medical reasons (illness or physical injury)

1.8

15.3

256

1174

O03.4

ICD-10 Finland

Spontaneous abortion, Incomplete, without complication

6.8

14.9

LCH11

NOMESCO Finland

Pharmacologic abortion

2.3

14.8

140

508

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

9.2

14.6

O75.2

ICD-10 Finland

Pyrexia during labour, not elsewhere classified

+∞

14.5

65401

ICD-8 Finland

Face and brow presentation

+∞

14.5

O73.0

ICD-10 Finland

Retained placenta without haemorrhage

+∞

14.5

ZXD05

NOMESCO Finland

Urgent procedure

1.3

14.1

1164

7648

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.3

14.0

2479

17980

Z32

ICD-10 Finland

Pregnancy examination and test

7.6

13.9

SPAT1187

SPAT

General ultrasound examination in early pregnancy

8.0

13.5

6522A

ICD-9 Finland

Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,RASKAUDEN AIKANA]

+∞

13.5

6611B

ICD-9 Finland

Abnormality of forces of labour, Secondary uterine inertia

+∞

13.5

65697

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Multiple pregnancy, all presentations

+∞

13.5

IHZ05

SPAT

0.4

13.5

946

TMW99

NOMESCO Finland

Other minor surgical procedure in obstetrics

10.2

13.5

OAB39

SPAT

0.4

13.3

1275

Z86.4

ICD-10 Finland

Personal history of psychoactive substance abuse

9.3

13.3

63310

ICD-8 Finland

Iron deficiency anaemia of pregnancy

4.9

13.2

IHZ02

SPAT

0.2

13.1

516

SPAT1357

SPAT

Monitoring of problem during pregnancy

7.6

13.1

SAA01

NOMESCO Finland

Simple examination of mouth

1.2

13.1

3402

25699

Z39

ICD-10 Finland

Postpartum care and examination

8.9

13.0

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.2

13.0

2484

18119

LA2AE

NOMESCO Finland

Ultrasound examination of ovarian cyst

7.0

12.8

OAB42

SPAT

0.6

12.8

153

2203

OAB36

SPAT

0.2

12.6

504

O68.3

ICD-10 Finland

Labour and delivery complicated by biochemical evidence of fetal stress

+∞

12.6

63495

ICD-8 Finland

Other complications of pregnancy, Effluxus liquoris amnii praetemporarius

3.9

12.5

111

W03

ICPC

Antepartum bleeding

7.1

12.2

W94

ICPC

Puerperal mastitis

7.7

12.0

O21.0

ICD-10 Finland

Mild hyperemesis gravidarum

8.6

11.9

O70.22

ICD-10 Finland

III degree perineal tear involving one half or more of external anal sphincter thickness torn during childbirth

+∞

11.6

65510

ICD-8 Finland

Occipital presentation

+∞

11.6

O61.1

ICD-10 Finland

Failed instrumental induction of labour

+∞

11.6

O68.2

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly with meconium in amniotic fluid

+∞

11.6

O64.8

ICD-10 Finland

Obstructed labour due to other malposition and malpresentation

+∞

11.6

6531A

ICD-9 Finland

Disproportion, Generally contracted pelvis[PELVIS ANGUSTA,RASKAUDEN AIKANA]

+∞

11.6

O30.00

ICD-10 Finland

Twin pregnancy with separate amniotic and chorionic sacs

12.4

11.6

SGA01

NOMESCO Finland

Tooth opening as first aid

1.5

11.6

470

2728

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

13.8

11.5

6500B

ICD-9 Finland

Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]

2.0

11.5

151

635

MBA40

NOMESCO Finland

Pharmacological evacuation of uterus after abortion

4.6

11.3

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.3

11.2

1314

9011

MAC02

NOMESCO Finland

Rupture of aminiotic membrane for advancement of labor

7.0

10.9

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

6.6

10.9

N71.0

ICD-10 Finland

Acute inflammatory disease of uterus

2.6

10.9

263

MA5AE

SPAT

5.5

10.9

W18

ICPC

Post-partum symptom/complaint other

11.8

10.8

N02BE01

ATC

paracetamol; systemic, rectal

1.3

10.7

4432

34803

SPAT1312

SPAT

General health counselling

1.2

10.7

1998

14431

G03GA01

ATC

chorionic gonadotrophin; parenteral

4.6

10.7

28000

ICD-8 Finland

Iron deficiency anaemias, Posthaemorrhagica

3.5

10.7

115

O28.3

ICD-10 Finland

Abnormal ultrasonic finding on antenatal screening of mother

10.2

10.6

O66.5

ICD-10 Finland

Failed application of vacuum extractor and forceps, unspecified

+∞

10.6

65201

ICD-8 Finland

Face and brow presentation

+∞

10.6

65581

ICD-8 Finland

Face and brow presentation

+∞

10.6

65695

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Cephalic presentation, transverse position

+∞

10.6

67000

ICD-8 Finland

Sepsis of childbirth and the puerperium, Endometritis

2.3

10.6

346

O70.9

ICD-10 Finland

Perineal laceration during delivery, unspecified

99.1

10.5

KAY20

NOMESCO Finland

0.4

10.5

837

63702

ICD-8 Finland

Pre-eclampsia, eclampsia and toxaemia, unspecified, Oedema

2.5

10.5

262

R3110

NOMESCO Finland

Psychosocial training

5.2

10.4

N97.9

ICD-10 Finland

Female infertility, unspecified

3.3

10.4

131

O20.8

ICD-10 Finland

Other haemorrhage in early pregnancy

9.7

10.3

WX600

NOMESCO Finland

Single shot through catheter

3.4

10.3

123

O41.9

ICD-10 Finland

Disorder of amniotic fluid and membranes, unspecified

28.9

10.2

63400

ICD-8 Finland

Other complications of pregnancy, Hydatidiform mole

5.9

10.2

64594

ICD-8 Finland

Other abortion, Retentio ovi (partialis)

2.1

10.1

117

469

KAY40

NOMESCO Finland

0.4

10.1

985

SPAT1128

SPAT

Instruction of pelvic floor / sphincter exercises

3.9

10.0

W99

ICPC

Disorder of pregn/delivery other

16.5

10.0

8502

FHL

Evacuation and abrasion

2.1

9.9

106

412

V252A

ICD-9 Finland

Contraceptive management, Sterilisation

1.4

9.9

514

3126

O99.4

ICD-10 Finland

Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium

10.5

9.8

64598

ICD-8 Finland

Other abortion

2.4

9.8

284

Z64.0

ICD-10 Finland

Problems related to unwanted pregnancy

3.1

9.7

143

MAE20

NOMESCO Finland

Failed vacuum delivery

+∞

9.7

65693

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Brow presentation, posterior position

+∞

9.7

65290

ICD-8 Finland

Occipital presentation

+∞

9.7

65404

ICD-8 Finland

Occipital presentation, posterior position

+∞

9.7

OAB38

SPAT

0.3

9.6

628

63500

ICD-8 Finland

Urinary infections arising during pregnancy and the puerperium, Pyelonephritis

3.0

9.6

152

O34.3

ICD-10 Finland

Maternal care for cervical incompetence

12.8

9.6

NE1AG

NOMESCO Finland

MRI pelvimetry with high intensity magnet

12.8

9.6

M54.5

ICD-10 Finland

Low back pain

1.2

9.5

1480

10452

E66.01

ICD-10 Finland

Obesity due to excess calories

1.6

9.3

263

1409

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.2

9.3

1726

12408

63700

ICD-8 Finland

Pre-eclampsia, eclampsia and toxaemia, unspecified, Albuminuria (proteinuria)

2.7

9.3

200

Z30.1

ICD-10 Finland

Insertion of (intrauterine) contraceptive device

1.5

9.3

356

2041

N71.9

ICD-10 Finland

Inflammatory disease of uterus, unspecified

5.1

9.1

IGY99

SPAT

0.2

9.0

348

Z36.4

ICD-10 Finland

Antenatal screening for fetal growth retardation using ultrasound and other physical methods

12.0

8.9

63703

ICD-8 Finland

Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia levis

1.9

8.8

124

539

O35.9

ICD-10 Finland

Maternal care for (suspected) fetal abnormality and damage, unspecified

9.3

8.8

MBC20

NOMESCO Finland

Repair of obstetric laceration of vulva

13.8

8.8

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

8.3

8.7

O75.7

ICD-10 Finland

Vaginal delivery following previous caesarean section

+∞

8.7

6622B

ICD-9 Finland

Long labour, Prolonged second stage

+∞

8.7

6671A

ICD-9 Finland

Retained placenta or membranes, without haemorrhage, Retained portions of placenta or membranes, without haemorrhage

+∞

8.7

65691

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Face and brow presentation

+∞

8.7

O67.9

ICD-10 Finland

Intrapartum haemorrhage, unspecified

+∞

8.7

65206

ICD-8 Finland

Complete or incomplete breech presentation

+∞

8.7

MAB20

NOMESCO Finland

Failed external version

7.5

8.7

O00.9

ICD-10 Finland

Ectopic pregnancy, unspecified

6.9

8.6

SPAT1190

SPAT

Insertion or removal of intrauterine contraceptive device

1.7

8.6

192

969

-2

ICD-10 Finland

0.5

8.6

961

O12.0

ICD-10 Finland

Gestational oedema

24.8

8.5

WX110

NOMESCO Finland

Local anesthesy

1.2

8.5

3323

25524

TLW00

NOMESCO Finland

Insemination

4.9

8.4

J01CA08

ATC

pivmecillinam; oral

1.2

8.4

2635

19838

G03GA05

ATC

follitropin alfa; parenteral

4.0

8.3

63298

ICD-8 Finland

Haemorrhage of pregnancy, Alia definita

4.7

8.1

6440A

ICD-9 Finland

Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]

5.0

8.1

W01

ICPC

Question of pregnancy

2.5

8.0

198

O35.1

ICD-10 Finland

Maternal care for (suspected) chromosomal abnormality in fetus

7.1

8.0

SPAT1193

SPAT

Pap smear

1.4

8.0

335

1961

R51.80

ICD-10 Finland

Headache

1.3

7.9

691

4546

W79

ICPC

Unwanted pregnancy

2.2

7.8

308

SPAT1382

SPAT

Extensive health check-up at 18 months of age

7.4

7.8

65500

ICD-8 Finland

Occipital presentation

+∞

7.7

O75.3

ICD-10 Finland

Other infection during labour

+∞

7.7

65584

ICD-8 Finland

Occipital presentation, posterior position

+∞

7.7

SPAT1192

SPAT

Gynaecological examination

1.3

7.7

479

3000

MAW96

NOMESCO Finland

Other operation in pregnancy or at delivery

22.7

7.7

O14.1

ICD-10 Finland

Severe pre-eclampsia

13.4

7.6

FM1NE

NOMESCO Finland

Ultrasound examination of fetal heart

7.8

7.6

6423A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]

5.6

7.5

SPAT1310

SPAT

Counselling related to known health issue

1.2

7.4

1891

13931

QXA70

SPAT

0.3

7.4

385

6582B

ICD-9 Finland

Other problems associated with amniotic cavity and membranes, Delayed delivery after spontaneous or unspecified rupture of membranes

27.5

7.3

6488A

ICD-9 Finland

Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance

3.8

7.3

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.2

7.3

980

6789

66100

ICD-8 Finland

Occipital presentation

2.2

7.3

285

67008

ICD-8 Finland

Sepsis of childbirth and the puerperium, Alia definita

2.5

7.3

178

8831

FHL

Uterine exploration and / or scraping or suction emptying (ad 24 hours)

18.2

7.2

D10

ICPC

Vomiting

1.5

7.2

253

1430

64593

ICD-8 Finland

Other abortion, Abortus inhibitus, cum abortu

3.1

7.2

MAC99

NOMESCO Finland

Other augmentation of labor

37.1

7.0

8832

FHL

Manual placenta removal and associated scraping

37.1

7.0

W78

ICD-10 Finland

Inhalation of gastric contents

10.7

7.0

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

1.3

6.9

463

2939

Z76.0

ICD-10 Finland

Issue of repeat prescription

0.8

6.9

433

4559

N76.0

ICD-10 Finland

Acute vaginitis

1.5

6.8

264

1521

O03.6

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage

8.9

6.8

A02BC01

ATC

omeprazole; systemic

1.2

6.8

1246

8898

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.2

6.8

1522

11067

MAB10

NOMESCO Finland

External version

15.1

6.8

SPAT1263

SPAT

Sampling

1.2

6.8

2295

17274

6535B

ICD-9 Finland

Disproportion, Unusually large foetus causing disproportion[EPÄTAVALLISEN ISO SIKIÖ (YLI 4500 G), SYNN AIKANA]

+∞

6.8

6533A

ICD-9 Finland

Disproportion, Outlet contraction of pelvis[PELVIS ANGUSTA, ANOM APERT INFER,RASKAUDEN AIKANA]

+∞

6.8

6660C

ICD-9 Finland

Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC PARTIALI]

+∞

6.8

65596

ICD-8 Finland

Complete or incomplete breech presentation

+∞

6.8

65486

ICD-8 Finland

Complete or incomplete breech presentation

+∞

6.8

6533B

ICD-9 Finland

Disproportion, Outlet contraction of pelvis[PELVIS ANGUSTA, ANOM APERT INFER,SYNNYTYKSEN AIKANA]

+∞

6.8

O62.3

ICD-10 Finland

Precipitate labour

+∞

6.8

65207

ICD-8 Finland

Multiple pregnancy, all presentations

+∞

6.8

O62.1

ICD-10 Finland

Secondary uterine inertia

+∞

6.8

66137

ICD-8 Finland

Multiple pregnancy, all presentations

+∞

6.8

65692

ICD-8 Finland

Delivery complicated by malpresentation of foetus, Face presentation, posterior position

+∞

6.8

SAD01

NOMESCO Finland

Assessment of need for oral health care, standard

1.3

6.7

515

3329

8801

FHL

Suction cup delivery

9.8

6.7

P01AB01

ATC

metronidazole; oral, rectal

1.2

6.7

1782

13153

K02.1

ICD-10 Finland

Caries of dentine

1.2

6.6

2494

18912

Z12

ICPC

Relationship problem with partner

2.5

6.6

153

O03.1

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage

5.0

6.6

O80.1

ICD-10 Finland

Spontaneous breech delivery

11.0

6.5

25009

ICD-8 Finland

Diabetes mellitus, Unspecified

2.9

6.5

109

K04.0

ICD-10 Finland

Pulpitis

1.5

6.5

237

1350

MBW96

NOMESCO Finland

Other operation after delivery or abortion

24.8

6.5

O30.0

ICD-10 Finland

Twin pregnancy

24.8

6.5

K04.00

ICD-10 Finland

Hyperemia of pulp

1.8

6.5

112

527

SPAT1308

SPAT

Sexual health counselling

1.2

6.4

770

5259

MBA96

NOMESCO Finland

Other removal of retained products of conception after delivery or abortion

5.5

6.4

O16

ICD-10 Finland

Unspecified maternal hypertension

16.5

6.4

O44.0

ICD-10 Finland

Placenta praevia specified as without haemorrhage

16.5

6.4

Z35.1

ICD-10 Finland

Supervision of pregnancy with history of abortive outcome

8.9

6.4

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.2

6.4

1828

13557

D09

ICPC

Nausea

1.4

6.4

286

1699

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

7.7

6.3

6563B

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, SYNNYTYKSEN AIKANA]

4.7

6.3

O23.1

ICD-10 Finland

Infections of bladder in pregnancy

9.9

6.2

67791

ICD-8 Finland

Other and unspecified complications of the puerperium, Haemorrhagia tarde (alia)

4.5

6.2

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.2

6.2

2081

15612

J01EA01

ATC

trimethoprim; systemic

1.2

6.2

1414

10291

SPAT1301

SPAT

No procedures

1.2

6.1

1745

12924

IDY99

SPAT

0.1

6.1

153

SPAT1364

SPAT

Health check-up performed during second study year in students of upper secondary schools, vocational schools etc.

0.7

6.1

232

2628

J01DB01

ATC

cefalexin; oral

1.2

6.1

3929

30946

65710

ICD-8 Finland

Occipital presentation

1.9

6.0

369

63498

ICD-8 Finland

Other complications of pregnancy, Graviditas prolongata

2.8

6.0

106

NAME	O15_COMPLIC_LAB_DELIV
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE	O15_PRETERM\|O15_FAILED_INDUCT\|O15_LABOUR_ABNORM_FORCES\|O15_LABOUR_LONG\|O15_LABOUR_MALPOS\|O15_LABOUR_PELVIC_ABNORM\|O15_LABOUR_OBSTR_OTHER\|O15_LABOUR_INTRAPART_HAEMORRH\|O15_LABOUR_FETAL_STRESS\|O15_LABOUR_UMBILICAL\|O15_DELIV_PERIN_LACER\|O15_OBSTET_TRAUMA_OTHER\|O15_POSTPART_HEAMORRH\|O15_RETAINED_PLAC_MEMB_NO_HEAMORRH\|O15_LABOUR_ANEST_COMPLIC\|O15_LABOUR_OTHER
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O[6-7]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O[6-7]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
O15_COMPLIC_LAB_DELIV	0.617 [0.54, 0.7]	< 0.001
Birth year	0.994 [0.98, 1.0]	0.144

N-year risk	Females	Males
1	0.039%	No data
5	0.357%	No data
10	0.88%	No data
15	1.746%	No data
20	3.042%	No data

Complications of labour and delivery

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints