info icon

This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Vulva

CD2_BENIGN_VAGINA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D28.0&
  • Hospital discharge: ICD-8 2212
  • Cause of death: ICD-10 D28.0&
  • Cause of death: ICD-8 2212

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D28
Name in latin
Neoplasma benignum vulvae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 754 754 -
Unadjusted period prevalence (%) 0.26 0.26 -
Median age at first event (years) 41.68 41.68 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
678
Matched controls
6779
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
11666.0
323.0
457
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
91.6
162.5
177
26
22120
ICD-8 Finland
Benign neoplasm of other female genital organs, Vulva
+∞
131.7
122
*
PJA12
NOMESCO Finland
Sentinel node biopsy
679.0
63.9
62
*
115
Kela drug reimbursment
Breast cancer
+∞
59.2
56
*
22121
ICD-8 Finland
NA
+∞
51.7
49
*
22122
ICD-8 Finland
NA
+∞
50.7
48
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
46.4
44
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
50.8
36.1
43
9
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
33.6
32
*
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
37.2
33.2
42
12
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
8.4
30.8
70
92
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
30.4
29
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
27.3
26
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
54.0
26.4
31
6
H02AB02
ATC
dexamethasone; systemic
13.8
25.5
44
34
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
135.0
24.8
26
*
130
Kela drug reimbursment
Malignant tumour
+∞
24.1
23
*
L02BG04
ATC
letrozole; oral
12.7
24.1
43
36
A04AA02
ATC
granisetron; systemic, transdermal
237.7
22.8
23
*
HAC20
NOMESCO Finland
Total mastectomy
124.2
22.7
24
*
L02BA01
ATC
tamoxifen; oral
56.7
19.0
22
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
18.8
18
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
17.8
17
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
184.6
17.6
18
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
16.7
16
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
16.7
16
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
16.7
16
*
L02BG03
ATC
anastrozole; oral
+∞
15.7
15
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
15.7
15
*
C50
ICD-10 Finland
Malignant neoplasm of breast
87.1
15.6
17
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.9
13.8
45
97
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.6
13.2
101
425
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
12.5
12
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
12.5
12
*
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
66.1
11.6
13
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
11.5
11
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
11.5
11
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
11.5
11
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
11.5
11
*
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
+∞
11.5
11
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
10.4
10
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
10.4
10
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
10.4
10
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
10.4
10
*
HA1AA
NOMESCO Finland
X-ray mammography
3.6
10.2
45
131
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.3
10.1
102
492
HAB99
NOMESCO Finland
Other partial excision of mammary gland
9.7
9.8
19
20
J01DA01
ATC
[U] cefalexin; systemic
1.7
9.7
438
3519
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
9.7
114
590
L03AA13
ATC
pegfilgrastim; parenteral
101.4
9.4
10
*
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
9.4
9
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.4
9
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
9.4
187
1175
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
13.9
9.2
15
11
N75.0
ICD-10 Finland
Cyst of Bartholin gland
7.1
8.6
20
29
XX3DW
NOMESCO Finland
Time consuming IT work
3.3
8.5
42
134
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
91.2
8.4
9
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
8.3
8
*
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
+∞
8.3
8
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
8.3
8
*
A02BC02
ATC
pantoprazole; systemic
1.6
8.3
437
3578
JN4BD
NOMESCO Finland
Extensive body CT
3.3
8.1
39
122
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
10.2
8.1
15
15
LFC00
NOMESCO Finland
Partial excision of vulva
22.3
8.0
11
5
S18
ICPC
Laceration/cut
1.6
7.9
263
1904
8473
FHL
Guinea pig or gland excision
9.6
7.8
15
16
J01AA02
ATC
doxycycline; systemic
1.7
7.5
539
4718
ULA02
NOMESCO Finland
Kolposcopy
2.0
7.5
91
478
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
+∞
7.3
7
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
7.3
7
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
7.3
7
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
7.3
7
*
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
+∞
7.3
7
*
A79
ICPC
Malignancy NOS
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
7.3
7
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.0
250
1829
R01AD09
ATC
mometasone; nasal
1.5
7.0
325
2533
A02BC05
ATC
esomeprazole; systemic
1.6
7.0
289
2194
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.9
240
1743
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.9
125
756
R03AC02
ATC
salbutamol; inhalant
1.5
6.8
368
2964
LFW96
NOMESCO Finland
Other operation on vulva or perineum
40.5
6.8
8
*
X76
ICPC
Malignant neoplasm breast female
40.5
6.8
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.8
192
1324
J02AC01
ATC
fluconazole; systemic
1.5
6.6
336
2663
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
70.5
6.4
7
*
N90.7
ICD-10 Finland
Vulvar cyst
9.4
6.3
12
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
6.3
243
1802
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
+∞
6.3
6
*
HA1BG
NOMESCO Finland
MRI examination of mammary gland with high intensity magnet
+∞
6.3
6
*
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
Z51.5
ICD-10 Finland
Palliative care
5.8
6.2
16
28
62212
ICD-8 Finland
Infective diseases of uterus (except cervix), vagina and vulva, Bartholinitis acuta
10.1
6.0
11
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_VAGINA_EXALLC – Benign neoplasm: Vulva

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).