vulvar carcinoma: A carcinoma that arises from epithelial cells of the mammalian vulva
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
754 |
4. Check minimum number of eventsNone |
754 |
5. Include endpointsNone |
754 |
6. Filter based on genotype QC (FinnGen only) |
754 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D28
- Name in latin
- Neoplasma benignum vulvae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Vulva
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Vulva
- Benign neoplasm of other and unspecified female genital organs
- Benign neoplasm of other and unspecified female genital organs
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5127 | 5127 | - |
| Only index persons | 4729 | 4729 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.15 | - |
| Only index persons | 0.17 | 0.17 | - |
| Median age at first event (years) | |||
| Whole population | - | 42.27 | - |
| Only index persons | - | 41.49 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 754 | 754 | - |
| Unadjusted period prevalence (%) | 0.26 | 0.26 | - |
| Median age at first event (years) | 41.68 | 41.68 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 678
- Matched controls
- 6780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
+∞
323.0
457
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
82.1
160.0
177
29
22120
ICD-8 Finland
Benign neoplasm of other female genital organs, Vulva
+∞
131.6
122
*
22121
ICD-8 Finland
NA
+∞
51.7
49
*
22122
ICD-8 Finland
NA
+∞
50.7
48
*
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
27.9
31.0
42
16
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
6.2
25.2
70
123
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.6
12.7
101
434
8473
FHL
Guinea pig or gland excision
25.5
11.2
15
6
N75.0
ICD-10 Finland
Cyst of Bartholin gland
8.5
9.6
20
24
J01DA01
ATC
[U] cefalexin; systemic
1.7
9.1
438
3546
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.1
8.5
102
533
R01AD09
ATC
mometasone; nasal
1.6
8.0
325
2483
N90.7
ICD-10 Finland
Vulvar cyst
15.2
7.7
12
8
LFW96
NOMESCO Finland
Other operation on vulva or perineum
80.9
7.4
8
*
A02BC05
ATC
esomeprazole; systemic
1.6
7.1
289
2188
ULA02
NOMESCO Finland
Kolposcopy
2.0
7.0
91
489
62212
ICD-8 Finland
Infective diseases of uterus (except cervix), vagina and vulva, Bartholinitis acuta
13.9
6.9
11
8
LFC00
NOMESCO Finland
Partial excision of vulva
13.9
6.9
11
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.9
250
1835
X01
ICPC
Genital pain female
6.9
6.5
15
22
R03AC02
ATC
salbutamol; inhalant
1.5
6.4
368
2988
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_VAGINA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_VAGINA | 0.981 [0.85, 1.14] | 0.799 |
| Birth year | 0.997 [0.99, 1.01] | 0.46 |
During the follow-up period (1.1.1998 — 31.12.2019), 326 out of 2726 females with CD2_BENIGN_VAGINA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_VAGINA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.496% | No data |
| 10 | 1.422% | No data |
| 15 | 2.908% | No data |
| 20 | 5.287% | No data |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_VAGINA – Benign neoplasm: Vulva
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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