No definition available.
Atypical virus infections of central nervous system
AB1_ATYPICAL_CNS_VIRUS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
344 |
4. Check minimum number of eventsNone |
344 |
5. Include endpointsNone |
344 |
6. Filter based on genotype QC (FinnGen only) |
344 |
Control definitions (FinnGen only)
- Control exclude
- AB1_VIRAL_CNS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Atypical virus infections of central nervous system
based on the number of shared cases.
Similar with more cases:
- Viral infections of the central nervous system
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2894 | 1340 | 1530 |
| Only index persons | 2514 | 1171 | 1343 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 23.36 | 28.47 | 18.42 |
| Only index persons | 20.77 | 26.75 | 15.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 344 | 203 | 141 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | 26.33 | 26.53 | 26.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 319
- Matched controls
- 3188
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
+∞
238.6
198
*
04597
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Suspecta
+∞
49.3
46
*
A81.0
ICD-10 Finland
Creutzfeldt-Jakob disease
+∞
25.3
24
*
A81.2
ICD-10 Finland
Progressive multifocal leukoencephalopathy
+∞
21.1
20
*
04500
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Coxsackie virus
+∞
13.6
13
*
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
62.1
10.7
12
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
7.3
52
215
A81.8
ICD-10 Finland
Other atypical virus infections of central nervous system
+∞
6.3
6
*
A81.9
ICD-10 Finland
Atypical virus infection of central nervous system, unspecified
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint AB1_ATYPICAL_CNS_VIRUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ATYPICAL_CNS_VIRUS | 4.8 [2.84, 8.11] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 229 females with AB1_ATYPICAL_CNS_VIRUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ATYPICAL_CNS_VIRUS | 8.359 [4.15, 16.85] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 186 males with AB1_ATYPICAL_CNS_VIRUS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_ATYPICAL_CNS_VIRUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.359% | 1.382% |
| 5 | 2.327% | 8.753% |
| 10 | 5.99% | 22.142% |
| 15 | 11.43% | 38.663% |
| 20 | 19.64% | 57.268% |
Relationships between endpoints
↥Index endpoint: AB1_ATYPICAL_CNS_VIRUS – Atypical virus infections of central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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