No definition available.
Acute lymphocytic leukaemia, excluding all cancers (controls excluding all cancers)
C3_ALL_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
237 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
237 |
4. Check minimum number of eventsNone |
237 |
5. Include endpoints |
237 |
6. Filter based on genotype QC (FinnGen only) |
237 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
- Control conditions
- not HLP_C3_ALL
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Acute lymphocytic leukaemia, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Acute lymphocytic leukaemia, helper endpoint
- Acute lymphocytic leukaemia
- Any event in cancer register
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 237 | 132 | 105 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 9.22 | 6.99 | 12.02 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 237
- Matched controls
- 2368
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
15564.5
316.5
229
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
268.8
204
*
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
+∞
237.2
186
*
L01BB02
ATC
mercaptopurine; oral
573.2
168.4
149
7
H02AB02
ATC
dexamethasone; systemic
546.7
142.2
128
5
TAB00
NOMESCO Finland
Lumbar puncture
84.5
126.9
139
39
XW000
NOMESCO Finland
Bone marrow biopsy
169.5
105.7
105
11
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
161.1
102.0
102
11
H02AB09
ATC
hydrocortisone; systemic
52.4
92.7
111
39
Z85.6
ICD-10 Finland
Personal history of leukaemia
1042.7
79.1
73
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
125.6
68.4
71
8
L03AA02
ATC
filgrastim; parenteral
+∞
68.1
62
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
21.1
66.5
105
86
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
347.6
55.7
54
*
2040A
ICD-9 Finland
Lymphoid leukaemia, Acute
+∞
53.2
49
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
80.8
50.9
56
9
9811/3-C42.1
ICD-O-3
B lymphoblastic leukemia/lymphoma, NOS, of bone marrow
+∞
50.9
47
*
A04AA01
ATC
ondansetron; systemic, rectal
35.3
48.7
63
24
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
28.1
45.8
63
30
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
45.3
42
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
19.4
44.6
70
50
ZX131
NOMESCO Finland
Intrathecal
+∞
41.9
39
*
WW500
NOMESCO Finland
Blood transfusion
34.8
38.8
50
18
R50.9
ICD-10 Finland
Fever, unspecified
7.4
36.3
103
223
J05AB11
ATC
valaciclovir; oral
10.2
34.9
75
103
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
34.2
32
*
A41.9
ICD-10 Finland
Sepsis, unspecified
22.3
34.1
50
28
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
+∞
33.1
31
*
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
+∞
33.1
31
*
H02AB06
ATC
prednisolone; systemic
5.4
32.9
148
554
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
22.0
32.6
48
27
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
10.7
32.2
66
82
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
32.0
30
*
127
Kela drug reimbursment
Transplant complication
32.7
31.5
41
15
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
29.8
28
*
K03.66
ICD-10 Finland
Tooth plaque
8.2
29.0
71
118
20400
ICD-8 Finland
Lymphatic leukaemia, Acute
+∞
28.7
27
*
ZX114
NOMESCO Finland
Intramuscular
37.0
27.8
35
11
J02AC01
ATC
fluconazole; systemic
4.8
27.3
128
469
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
26.6
25
*
1XX02
NOMESCO Finland
NA
+∞
26.6
25
*
A05AA02
ATC
ursodeoxycholic acid; oral
24.1
26.2
37
18
A04AA02
ATC
granisetron; systemic, transdermal
+∞
25.5
24
*
9101
FHL
Bone biopsy
145.3
25.1
26
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
24.4
23
*
ZXE00
NOMESCO Finland
One hour or less
4.1
23.4
145
655
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.4
23.3
68
141
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
+∞
23.3
22
*
ZX121
NOMESCO Finland
Central venous catheter
132.9
23.0
24
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.8
22.9
91
270
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.4
22.4
77
194
ZXD05
NOMESCO Finland
Urgent procedure
4.0
21.0
114
446
M04AA01
ATC
allopurinol; systemic
9.6
20.0
42
52
ZXD00
NOMESCO Finland
Emergency procedure
15.1
19.9
33
25
121
Kela drug reimbursment
Severe hypofunction of sexual glands
29.0
19.6
26
10
A06AD11
ATC
lactulose; oral
6.8
19.5
52
94
J05AB01
ATC
aciclovir; systemic
4.7
19.1
75
214
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
19.0
18
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
+∞
19.0
18
*
ZX120
NOMESCO Finland
Intravenous
7.0
18.2
47
81
2301
FHL
Lumbar puncture in anesthesia or operating room
+∞
17.9
17
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
17.9
17
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
17.8
74
222
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
16.9
16
*
L03AA10
ATC
lenograstim; parenteral
+∞
16.9
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.5
16.8
106
449
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
16.2
69
209
A01AB09
ATC
miconazole; local oral
6.7
15.9
42
74
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
24.1
15.9
22
10
XF400
NOMESCO Finland
ECG with 12 standard connections
4.2
15.4
66
200
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
+∞
14.7
14
*
L01BB03
ATC
tioguanine; oral
+∞
14.7
14
*
L04AA01
ATC
[U] ciclosporin; systemic
38.7
14.7
18
5
JN4BD
NOMESCO Finland
Extensive body CT
13.2
14.5
25
21
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
14.1
105
485
J01MA12
ATC
levofloxacin; systemic
4.8
14.1
50
125
L04AA06
ATC
mycophenolic acid; systemic
21.7
14.0
20
10
D70.89
ICD-10 Finland
Neutropenic splenomegaly
25.7
14.0
19
8
N02AA05
ATC
oxycodone; systemic
7.9
13.9
32
46
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.0
13.8
115
572
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
79.9
13.7
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.0
13.7
34
55
2AX04
NOMESCO Finland
NA
+∞
13.7
13
*
G62.0
ICD-10 Finland
Drug-induced polyneuropathy
+∞
13.7
13
*
9109
FHL
Other measure in this category
148.1
13.6
14
*
R4110
NOMESCO Finland
Physiotherapy
3.3
13.4
81
321
602
Kela drug reimbursment
Children's severe malnutrition
12.6
13.1
23
20
ZXA00
NOMESCO Finland
Right side
3.5
13.0
69
247
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.3
12.9
22
18
C90.0
ICD-10 Finland
Multiple myeloma
+∞
12.6
12
*
J02AC03
ATC
voriconazole; systemic
+∞
12.6
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.9
12.6
43
103
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
12.5
45
114
D64.9
ICD-10 Finland
Anaemia, unspecified
6.7
12.5
32
54
A02BC01
ATC
omeprazole; systemic
3.2
12.3
74
291
ZX108
NOMESCO Finland
Inhalation
28.4
12.2
16
6
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
11.5
11
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
11.5
11
*
WW409
NOMESCO Finland
Other aferesis
+∞
11.5
11
*
L01XE06
ATC
[U] dasatinib; systemic
+∞
11.5
11
*
Z92.6
ICD-10 Finland
Personal history of chemotherapy for neoplastic disease
+∞
11.5
11
*
C95.9
ICD-10 Finland
Leukaemia, unspecified
+∞
11.5
11
*
0388X
ICD-9 Finland
Septicaemia, Other specified septicaemias
125.9
11.5
12
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
26.5
11.3
15
6
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
62.9
10.7
12
*
FM2CE
NOMESCO Finland
NA
6.2
10.5
28
50
1CX01
NOMESCO Finland
NA
+∞
10.5
10
*
150
Kela drug reimbursment
Dasatinib
+∞
10.5
10
*
B73
ICPC
Leukaemia
+∞
10.5
10
*
WW304
NOMESCO Finland
Transfer of stem cells from registered domestic donator
+∞
10.5
10
*
J02AC04
ATC
posaconazole; systemic
+∞
10.5
10
*
Z2446
NOMESCO Finland
Social worker
3.6
10.5
51
169
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.5
10.1
102
542
A01AB04
ATC
amphotericin B; local oral
10.2
10.0
19
20
Z3226
NOMESCO Finland
Physiotherapist
2.9
9.9
68
287
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.1
9.7
26
47
2AA01
NOMESCO Finland
NA
+∞
9.4
9
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
9.4
9
*
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
+∞
9.4
9
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
9.4
9
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
9.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
9.0
81
398
SAA03
NOMESCO Finland
Extended examination of mouth
2.3
8.9
131
826
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
7.1
8.9
21
32
Z2221
NOMESCO Finland
Medical doctor
2.5
8.8
86
440
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
28.7
8.6
11
*
A07AA02
ATC
nystatin; oral
6.7
8.5
21
34
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.3
8.5
22
38
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.4
8.5
25
51
5604
FHL
Vascular preparation or cannulation in the operating room
93.2
8.5
9
*
WB133
NOMESCO Finland
Very demanding adjuvant cytostatic therapy
+∞
8.4
8
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
8.4
8
*
Z08.2
ICD-10 Finland
Follow-up examination after chemotherapy for malignant neoplasm
+∞
8.4
8
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
8.4
8
*
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
34.6
8.1
10
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.4
8.1
29
73
L04AD01
ATC
ciclosporin; systemic
7.0
8.1
19
29
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
7.8
117
730
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.1
7.8
18
27
B02.9
ICD-10 Finland
Zoster without complication
6.6
7.7
19
31
K02.0
ICD-10 Finland
Caries limited to enamel
2.4
7.7
74
372
ZXA05
NOMESCO Finland
Left side
2.9
7.6
50
203
J01MA14
ATC
moxifloxacin; systemic
5.7
7.6
21
40
5639
FHL
Other measure in this category
82.6
7.5
8
*
Y84.8
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
82.6
7.5
8
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.8
7.4
15
18
EBA15
NOMESCO Finland
Extraction of large number of teeth
6.6
7.4
18
29
189
Kela drug reimbursment
Imatinib
+∞
7.3
7
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
5.6
7.3
20
38
QXB05
NOMESCO Finland
Skin wound assessment, unspecified location
31.0
7.2
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.8
7.1
19
35
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
7.1
55
245
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
14.3
7.0
11
8
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
9.7
6.9
13
14
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
17.3
6.8
10
6
IEP04
NOMESCO Finland
Focused parenting intervention
23.3
6.7
9
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.4
6.7
32
105
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
6.7
19
38
TGC00
NOMESCO Finland
Bronchial lavation
12.7
6.6
11
9
IEP02
NOMESCO Finland
Child-centred family therapy
10.5
6.6
12
12
WW200
NOMESCO Finland
Immunization
6.5
6.6
16
26
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
6.6
91
538
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
6.6
36
128
A03FA01
ATC
metoclopramide; systemic, rectal
3.1
6.5
36
130
5BA08
NOMESCO Finland
NA
71.7
6.5
7
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
8.5
6.4
13
16
Z31.6
ICD-10 Finland
General counselling and advice on procreation
9.7
6.4
12
13
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
11.5
6.4
11
10
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.3
6.3
18
36
GD1LA
NOMESCO Finland
GD
18.6
6.3
9
5
4CJ01
NOMESCO Finland
NA
+∞
6.3
6
*
C90.1
ICD-10 Finland
Plasma cell leukaemia
+∞
6.3
6
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
115
Kela drug reimbursment
Breast cancer
+∞
6.3
6
*
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
+∞
6.3
6
*
324
Kela drug reimbursment
Dasatinib
+∞
6.3
6
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
6.6
6.3
15
24
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.6
6.3
15
24
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
27.5
6.3
8
*
ZXA10
NOMESCO Finland
Bilateral
2.5
6.2
50
225
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
13.0
6.1
10
8
JN4AD
NOMESCO Finland
Body CT examination
10.4
6.1
11
11
A98
ICPC
Health maint/preventive medicine
0.4
6.0
199
2220
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_ALL_EXALLC – Acute lymphocytic leukaemia, excluding all cancers (controls excluding all cancers)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).