info icon

Acute lymphocytic leukaemia, helper endpoint

HLP_C3_ALL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 981[1-8]|9835
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

247

4. Check minimum number of events

None

247

5. Include endpoints

None

247

6. Filter based on genotype QC (FinnGen only)

222

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 222 127 95
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 8.84 6.80 11.56

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
247
Matched controls
2467
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11349.3
307.7
239
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
290.3
218
*
H02AB02
ATC
dexamethasone; systemic
217.4
286.4
141
15
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
+∞
245.7
193
*
TAB00
NOMESCO Finland
Lumbar puncture
65.7
233.4
147
54
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
137.8
220.5
113
15
XW000
NOMESCO Finland
Bone marrow biopsy
115.7
209.6
110
17
H02AB09
ATC
hydrocortisone; systemic
53.7
192.2
122
44
L01BB02
ATC
mercaptopurine; oral
534.2
185.8
164
9
L04AX03
ATC
methotrexate; systemic
25.9
139.4
118
84
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
67.3
127.5
72
15
TPX10
NOMESCO Finland
Implantation of vascular injection port
57.5
105.1
61
14
A04AA01
ATC
ondansetron; systemic, rectal
32.3
103.7
72
31
Z85.6
ICD-10 Finland
Personal history of leukaemia
+∞
95.0
85
*
A41.9
ICD-10 Finland
Sepsis, unspecified
29.5
83.5
59
26
L01BA01
ATC
methotrexate; systemic
27.8
74.0
53
24
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
20.1
70.6
59
38
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.9
69.9
75
75
WW500
NOMESCO Finland
Blood transfusion
25.8
68.0
50
24
L03AA02
ATC
filgrastim; parenteral
376.6
60.1
58
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
10.6
55.8
72
92
2040A
ICD-9 Finland
Lymphoid leukaemia, Acute
+∞
55.3
51
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
228.7
54.3
54
*
9811/3-C42.1
ICD-O-3
B lymphoblastic leukemia/lymphoma, NOS, of bone marrow
+∞
53.0
49
*
127
Kela drug reimbursment
Transplant complication
22.1
52.8
41
22
ZX131
NOMESCO Finland
Intrathecal
+∞
45.2
42
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
44.1
41
*
R50.9
ICD-10 Finland
Fever, unspecified
6.1
42.9
111
292
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.7
37.5
99
261
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.7
37.5
74
149
K03.66
ICD-10 Finland
Tooth plaque
6.2
36.7
80
177
H02AB06
ATC
prednisolone; systemic
5.2
36.5
150
567
ZXD00
NOMESCO Finland
Emergency procedure
15.7
36.3
33
24
A05AA02
ATC
ursodeoxycholic acid; oral
15.8
35.4
32
23
J02AC01
ATC
fluconazole; systemic
4.9
34.3
127
438
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
+∞
34.1
32
*
J05AB11
ATC
valaciclovir; oral
5.9
32.9
73
163
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
368.8
32.7
32
*
ZX120
NOMESCO Finland
Intravenous
7.4
29.5
48
78
ZX114
NOMESCO Finland
Intramuscular
44.9
28.9
35
9
M04AA01
ATC
allopurinol; systemic
8.9
28.9
39
51
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
+∞
28.7
27
*
1XX02, ,
NOMESCO Finland
+∞
28.7
27
*
20400
ICD-8 Finland
Lymphatic leukaemia, Acute
+∞
28.7
27
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
28.7
27
*
9101
FHL
Bone biopsy
+∞
28.7
27
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
28.7
27
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
28.7
27
*
A01AB09
ATC
miconazole; local oral
7.0
28.1
48
82
ZXE00
NOMESCO Finland
One hour or less
4.2
27.1
146
637
A06AD11
ATC
lactulose; oral
6.0
27.0
55
112
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.2
25.2
93
308
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.9
24.6
51
105
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
+∞
24.4
23
*
A04AA02
ATC
granisetron; systemic, transdermal
264.3
24.1
24
*
ZXD05
NOMESCO Finland
Urgent procedure
3.9
24.0
111
429
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
23.3
22
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
22.7
75
227
ZXE10
NOMESCO Finland
More than one and less than three hours
3.7
22.6
112
450
ZX121
NOMESCO Finland
Central venous catheter
69.1
22.3
25
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
22.2
21
*
Z92.6
ICD-10 Finland
Personal history of chemotherapy for neoplastic disease
+∞
21.1
20
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
21.0
75
239
J05AB01
ATC
aciclovir; systemic
4.0
20.9
77
251
Z3229
NOMESCO Finland
Other healthcare associate professional
5.1
20.3
49
115
D64.9
ICD-10 Finland
Anaemia, unspecified
6.3
20.3
37
67
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
20.1
19
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.4
19.7
131
620
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
28.8
19.6
26
10
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.4
19.0
26
34
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
19.0
18
*
2301
FHL
Lumbar puncture in anesthesia or operating room
+∞
19.0
18
*
L03AA10
ATC
lenograstim; parenteral
+∞
19.0
18
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
24.0
18.6
26
12
602
Kela drug reimbursment
Children's severe malnutrition
8.2
18.6
26
35
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
18.5
110
483
L01BB03
ATC
tioguanine; oral
+∞
17.9
17
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
+∞
17.9
17
*
FM2CE, ,
NOMESCO Finland
6.8
17.6
29
47
XF400
NOMESCO Finland
ECG with 12 standard connections
3.8
17.6
67
221
N02AA05
ATC
oxycodone; systemic
6.0
17.3
33
62
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.5
16.4
34
69
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
170.1
15.7
16
*
Z2446
NOMESCO Finland
Social worker
3.9
15.5
53
161
L04AA01
ATC
[U] ciclosporin
30.9
15.4
20
7
G62.0
ICD-10 Finland
Drug-induced polyneuropathy
85.2
14.7
16
*
WW409
NOMESCO Finland
Other aferesis
+∞
14.7
14
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
38.6
14.6
18
5
9109
FHL
Other measure in this category
158.8
14.6
15
*
J01MA12
ATC
levofloxacin; systemic
4.0
14.4
46
133
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.7
14.0
23
37
R4110
NOMESCO Finland
Physiotherapy
3.0
13.9
86
376
C95.9
ICD-10 Finland
Leukaemia, unspecified
+∞
13.7
13
*
2AX04, ,
NOMESCO Finland
+∞
13.7
13
*
B02.9
ICD-10 Finland
Zoster without complication
6.6
13.6
23
38
A02BC01
ATC
omeprazole; systemic
3.1
13.5
75
308
ZXA00
NOMESCO Finland
Right side
3.2
12.9
62
234
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
5.7
12.8
25
48
C90.0
ICD-10 Finland
Multiple myeloma
136.5
12.5
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
12.4
83
376
Z3226
NOMESCO Finland
Physiotherapist
2.9
12.3
71
297
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
11.5
11
*
B73
ICPC
Leukaemia
+∞
11.5
11
*
J02AC04
ATC
posaconazole; systemic
+∞
11.5
11
*
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
+∞
11.5
11
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.5
11.5
23
45
Z2221
NOMESCO Finland
Medical doctor
2.6
10.7
86
422
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
10.7
111
614
J02AC03
ATC
voriconazole; systemic
62.7
10.7
12
*
JN4BD
NOMESCO Finland
Extensive body CT
9.4
10.5
21
24
L03AA13
ATC
pegfilgrastim; parenteral
114.5
10.5
11
*
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
+∞
10.5
10
*
WW304
NOMESCO Finland
Transfer of stem cells from registered domestic donator
+∞
10.5
10
*
Z08.2
ICD-10 Finland
Follow-up examination after chemotherapy for malignant neoplasm
+∞
10.5
10
*
2AA01, ,
NOMESCO Finland
+∞
10.5
10
*
A01AB04
ATC
amphotericin B; local oral
10.2
10.5
20
21
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
4.1
10.4
30
80
L04AD01
ATC
ciclosporin; systemic
9.8
10.2
20
22
0388X
ICD-9 Finland
Septicaemia, Other specified septicaemias
41.8
10.0
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.5
10.0
20
39
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
21.1
9.9
14
7
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
31.3
9.5
12
*
5639
FHL
Other measure in this category
+∞
9.4
9
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
9.4
9
*
WB133
NOMESCO Finland
Very demanding adjuvant cytostatic therapy
+∞
9.4
9
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
9.4
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
9.3
65
296
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
19.5
9.0
13
7
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
25.1
9.0
12
5
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
25.1
9.0
12
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.2
9.0
19
39
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.5
8.8
32
100
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
8.8
40
144
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
12.2
8.7
15
13
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
8.6
95
530
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
28.6
8.5
11
*
5604
FHL
Vascular preparation or cannulation in the operating room
93.0
8.5
9
*
189
Kela drug reimbursment
Imatinib
+∞
8.4
8
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
4.8
8.3
19
42
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.4
8.2
16
18
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
8.0
59
274
A03FA01
ATC
metoclopramide; systemic, rectal
3.1
8.0
36
129
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
13.6
8.0
13
10
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.8
7.9
25
71
L04AA06
ATC
mycophenolic acid; systemic
8.5
7.7
16
20
K02.0
ICD-10 Finland
Caries limited to enamel
2.2
7.7
94
542
WF002
NOMESCO Finland
Radical radiotherapy
82.4
7.5
8
*
IEP02
NOMESCO Finland
Child-centred family therapy
6.1
7.4
19
33
L01XE06
ATC
[U] dasatinib
+∞
7.3
7
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
7.3
7
*
150
Kela drug reimbursment
Dasatinib
+∞
7.3
7
*
M87.3
ICD-10 Finland
Other secondary osteonecrosis
+∞
7.3
7
*
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
+∞
7.3
7
*
WA010
NOMESCO Finland
Adjuvant whole body radiotherapy
+∞
7.3
7
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
6.9
7.2
17
26
Z3231
NOMESCO Finland
Registered nurse
2.2
7.2
86
489
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.3
7.2
19
47
QXB05
NOMESCO Finland
Skin wound assessment, unspecified location
31.0
7.2
9
*
ZX108
NOMESCO Finland
Inhalation
20.7
7.2
10
5
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.3
7.1
16
23
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.5
7.0
25
77
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
14.3
7.0
11
8
Z31.6
ICD-10 Finland
General counselling and advice on procreation
8.6
6.9
14
17
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.7
6.9
13
14
J01MA14
ATC
moxifloxacin; systemic
3.8
6.7
21
59
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
6.7
123
815
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
8.2
6.7
14
18
ZXA05
NOMESCO Finland
Left side
2.5
6.7
49
226
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.3
6.7
26
85
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
9.1
6.6
13
15
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
6.6
53
255
WW200
NOMESCO Finland
Immunization
6.9
6.4
15
23
SAA03
NOMESCO Finland
Extended examination of mouth
2.0
6.4
137
953
Z01.9
ICD-10 Finland
Special examination, unspecified
4.0
6.4
18
47
I50.1
ICD-10 Finland
Left ventricular failure
9.6
6.4
12
13
R4190
NOMESCO Finland
Nutritional therapy
2.8
6.3
33
128
K12.18
ICD-10 Finland
Other forms of stomatitis
18.6
6.3
9
5
C90.1
ICD-10 Finland
Plasma cell leukaemia
+∞
6.3
6
*
RK224, ,
NOMESCO Finland
+∞
6.3
6
*
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
+∞
6.3
6
*
0539X
ICD-9 Finland
Herpes zoster without mention of complication
+∞
6.3
6
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
+∞
6.3
6
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
+∞
6.3
6
*
1CX01, ,
NOMESCO Finland
+∞
6.3
6
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
27.4
6.3
8
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
6.3
31
117
A98
ICPC
Health maint/preventive medicine
0.4
6.2
213
2331
B34.9
ICD-10 Finland
Viral infection, unspecified
3.4
6.2
22
68
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.1
6.1
17
44
A07AA02
ATC
nystatin; oral
4.1
6.1
17
44

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
62
47
17.26
68.09
12.7
1.3
—
—
—
0
0
49
23
26.30
67.24
5.8
2.7
37.39
35.95
%
0.14
49
23
42
13
38.67
66.21
1.7
1.8
—
—
—
0
0
43
18
28.68
61.42
11.2
2.8
—
—
—
0
0
59
59
12.81
54.34
13.2
1.3
27.89
370.00
e6/l
0.63
47
53
59
59
12.81
54.34
13.2
1.2
9.62
6.80
e6/l
0.13
47
51
47
34
16.82
52.43
15.1
1.2
—
—
—
0
0
40
21
22.51
52.02
10.3
1.2
—
—
—
0
0
48
0
+∞
51.91
23.2
0.0
0.49
—
umol/l
—
48
0
40
28
16.83
45.19
7.4
2.4
1.28
1.51
e9/l
0.40
33
23
83
162
7.20
43.93
6.8
2.3
7.56
9.97
g/l
6.67
83
155
38
28
15.84
41.66
6.2
2.4
7.21
10.29
%
0.97
38
28
38
28
15.84
41.66
6.2
2.4
76.82
61.75
%
2.23
38
28
45
45
11.99
41.00
3.2
2.9
12.96
34.09
mu/l
0.59
45
40
36
26
16.02
39.85
7.9
2.0
0.13
0.23
e9/l
1.15
28
21
67
115
7.61
39.77
2.9
1.8
8.35
13.53
iu/l
1.19
51
96
66
116
7.39
38.24
3.0
1.9
6.72
8.00
u/l
0.36
47
96
35
27
14.92
37.29
8.1
1.9
667.00
515.81
e6/l
0.57
27
21
75
154
6.55
37.26
10.6
3.4
55.84
64.29
e9/l
1.14
51
115
34
32
12.15
31.99
3.9
3.8
51.47
53.78
%
0.37
34
32
34
32
12.15
31.99
2.9
3.7
3.19
3.80
e9/l
0.68
34
32
40
14
33.73
30.93
1.3
1.4
—
—
—
0
0
37
11
39.20
29.67
8.2
1.5
—
—
—
0
0
48
88
6.52
26.20
1.5
1.8
—
—
—
0
0
28
28
11.14
25.15
7.4
2.9
6.32
18.00
%
2.23
28
28
33
13
29.03
24.69
1.2
1.2
—
—
—
0
0
33
13
29.03
24.69
1.0
1.0
—
—
—
0
0
73
205
4.63
24.55
13.4
4.3
5.39
6.83
umol/l
0.38
64
168
45
86
6.17
23.45
1.9
1.8
97.38
100.20
u/ml
—
8
10
80
253
4.19
22.85
18.6
4.6
31.25
30.31
s
0.55
80
248
51
114
5.37
22.42
11.7
5.0
0.65
0.51
%
0.34
26
42
47
101
5.51
21.56
1.4
2.0
104.64
171.63
u/ml
1.92
33
49
46
102
5.31
20.32
12.3
5.4
0.18
0.03
%
0.70
22
29
45
98
5.39
20.29
12.0
5.6
0.14
0.00
%
1.08
21
25
175
979
3.69
20.18
39.0
6.7
—
—
—
0
0
31
47
7.39
20.05
1.7
1.5
0.25
0.43
nmol/l
0.81
24
40
44
100
5.13
18.84
11.1
4.8
0.75
0.24
%
1.25
20
34
180
1053
3.61
18.72
37.9
6.3
0.03
0.04
e9/l
5.08
167
899
180
1053
3.61
18.72
37.9
6.3
0.50
0.57
e9/l
3.35
167
899
182
1078
3.61
18.42
43.4
6.8
0.15
0.20
e9/l
6.23
171
935
25
34
8.06
17.69
1.3
1.3
—
—
—
0
0
182
1093
3.52
17.69
38.2
6.3
2.25
2.19
e9/l
0.10
173
959
59
180
3.99
17.30
1.5
1.7
—
—
—
0
0
26
38
7.52
17.30
2.6
2.6
—
—
—
0
0
119
577
3.05
16.46
17.3
7.0
35.01
37.02
g/l
2.97
113
548
28
23
13.56
16.30
7.4
2.4
183.50
452.50
e6/l
1.32
20
16
90
376
3.19
16.10
13.4
2.5
1.71
0.92
mg/l
1.31
75
274
28
25
12.46
15.71
7.4
2.0
34.25
21.28
%
3.35
28
25
86
359
3.14
15.30
15.4
3.4
—
—
—
0
0
178
1149
2.96
13.44
60.2
7.5
2.85
3.91
e9/l
12.52
165
981
58
212
3.26
12.68
2.1
1.8
—
—
—
0
0
139
810
2.63
12.53
30.9
10.2
1.22
1.22
mmol/l
0.19
121
741
21
35
6.46
12.32
1.3
1.1
—
—
—
0
0
130
742
2.58
12.11
30.6
11.0
1.23
1.23
mmol/l
0.03
125
698
61
237
3.09
11.98
3.3
2.5
341.03
364.51
nmol/l
0.44
61
227
89
427
2.69
11.79
32.8
5.4
89.73
90.53
%
0.13
89
420
15
5
31.73
11.78
2.9
1.0
—
—
—
0
0
28
65
4.72
11.54
1.4
1.6
—
—
—
0
0
154
968
2.56
11.48
22.0
6.4
6.06
6.48
mmol/l
1.82
147
882
52
189
3.21
11.40
1.7
3.5
26.27
22.86
%
0.71
47
179
75
336
2.77
11.30
1.7
1.5
—
—
—
0
0
20
36
5.95
10.87
1.3
1.1
—
—
—
0
0
105
569
2.47
10.58
13.5
3.1
32.06
32.31
u/l
0.04
105
549
152
977
2.44
10.39
50.5
7.7
0.00
0.00
e9/l
0.78
133
759
13
5
27.26
9.91
6.8
3.4
0.26
0.27
e9/l
—
13
5
93
494
2.41
9.62
14.0
2.4
—
—
—
0
0
97
541
2.30
8.84
6.8
10.4
1.02
1.27
inr
6.40
27
161
20
45
4.74
8.52
14.3
3.0
—
—
—
0
0
11
5
22.89
8.08
2.6
3.4
—
—
—
0
0
11
5
22.89
8.08
2.7
3.4
17.36
13.40
%
—
11
5
77
402
2.33
8.08
11.5
3.2
7.40
7.40
ph
0.19
17
53
97
558
2.21
8.06
4.6
3.9
39.70
55.00
e6/l
0.25
79
429
93
529
2.21
7.92
59.4
6.3
—
—
—
0
0
14
13
11.32
7.89
6.6
2.0
34.21
33.54
pg
0.18
14
13
90
508
2.21
7.79
4.7
3.9
0.17
0.26
e6/l
0.52
71
385
15
18
8.78
7.43
59.6
5.1
10.23
12.62
%
2.66
15
18
90
522
2.14
7.17
1.8
1.7
—
—
—
0
0
47
209
2.54
6.93
2.7
2.1
—
—
—
0
0
87
505
2.11
6.87
4.9
3.8
—
—
—
0
0
17
32
5.62
6.27
53.8
4.6
—
—
—
0
0
16
28
6.03
6.25
56.3
4.4
68.31
71.59
%
0.38
16
28
15
26
6.06
5.93
2.7
2.3
—
—
—
0
0
51
253
2.28
5.87
30.1
10.8
—
—
—
0
0
103
666
1.93
5.83
5.8
4.7
56.08
84.91
e6/l
0.33
83
452
12
16
7.81
5.70
19.3
2.1
—
—
—
0
0
39
177
2.43
5.47
35.9
6.8
105.49
104.66
mmol/l
0.47
39
177
12
18
6.94
5.31
19.3
2.2
—
—
—
0
0
20
64
3.31
5.31
45.3
5.4
0.45
0.66
%
1.86
20
64
5
0
+∞
5.22
1.4
0.0
—
—
—
0
0
5
0
+∞
5.22
1.2
0.0
—
—
—
0
0
40
188
2.34
5.19
1.6
1.5
—
—
—
0
0
96
627
1.87
5.13
2.7
1.5
1.56
1.95
g/l
1.34
79
339
112
770
1.83
5.07
10.5
2.7
—
—
—
0
0
19
61
3.29
5.02
1.4
1.9
—
—
—
0
0
13
24
5.65
4.98
1.8
1.1
—
—
—
0
0
12
20
6.24
4.97
1.1
1.1
—
—
—
0
0
10
13
7.95
4.89
6.8
1.9
—
—
—
0
0
37
178
2.27
4.54
3.6
1.7
—
—
—
0
0
16
49
3.42
4.54
1.3
1.2
—
—
—
0
0
29
126
2.47
4.46
11.7
15.2
0.73
0.57
mmol/l
0.07
20
100
52
289
2.01
4.42
44.8
6.6
1.83
1.43
mmol/l
0.67
46
224
22
85
2.74
4.26
2.3
1.1
—
—
—
0
0
8
10
8.21
4.09
1.4
1.1
—
—
—
0
0
28
132
2.26
3.61
1.9
1.6
353.86
316.60
mu/l
0.23
28
126
188
1587
1.77
3.57
3.9
3.5
2.73
2.76
mmol/l
0.17
183
1491
146
1161
1.63
3.41
5.3
4.1
83.71
296.00
e6/l
—
7
13
69
461
1.69
3.19
2.1
3.3
2.53
2.70
mg/l
0.28
61
402
39
220
1.92
3.16
6.4
12.8
—
—
—
0
0
31
164
2.02
3.01
1.7
1.4
137.80
307.98
u/ml
0.56
26
155
51
318
1.76
3.01
4.6
3.8
2.64
2.99
e6/l
0.12
27
186
13
47
2.86
2.85
1.3
1.2
—
—
—
0
0
74
524
1.59
2.67
2.5
1.6
—
—
—
0
0
18
80
2.35
2.67
6.3
3.0
1.24
1.23
mmol/l
0.27
18
68
6
11
5.55
2.55
1.2
1.0
—
—
—
0
0
22
110
2.10
2.49
14.6
16.8
97.13
95.37
%
0.90
22
105
6
12
5.09
2.41
2.0
1.4
—
—
—
0
0
13
53
2.53
2.31
1.1
1.6
—
54.00
—
0
5
8
23
3.55
2.28
1.1
1.3
—
—
—
0
0
85
640
1.50
2.28
2.4
1.7
—
—
—
0
0
6
13
4.69
2.28
2.0
3.8
73.82
145.48
ug/l
—
6
13
62
441
1.54
2.16
2.5
2.9
18.61
31.31
ng/l
1.00
40
230
13
55
2.44
2.15
5.9
11.9
—
—
—
0
0
5
10
5.07
2.08
1.2
1.0
—
—
—
0
0
7
20
3.57
2.07
2.4
3.9
24.43
29.20
mmol/l
—
7
20
14
64
2.26
1.98
19.8
25.8
—
—
—
0
0
214
1972
1.63
1.85
37.3
7.4
36.44
26.18
u/l
6.02
214
1907
5
137
0.35
1.81
1.2
1.4
—
—
—
0
0
15
75
2.06
1.73
18.4
16.7
0.79
0.69
%
0.58
15
75
174
1906
0.70
1.71
72.9
13.4
337.07
334.61
g/l
3.16
174
1891
35
230
1.61
1.71
7.9
12.3
25.02
24.13
mmol/l
1.90
35
225
15
76
2.03
1.67
18.4
16.6
1.49
1.51
%
0.03
15
76
15
76
2.03
1.67
18.4
16.6
94.34
94.19
%
0.04
15
76
18
98
1.90
1.66
5.1
2.9
—
—
—
0
0
106
884
1.35
1.48
4.0
3.5
0.00
0.00
estimate
-0.00
19
166
107
895
1.34
1.47
4.0
3.5
0.00
0.00
estimate
-0.00
19
155
7
28
2.54
1.46
5.6
3.1
3.57
3.80
mmol/l
—
7
28
106
886
1.34
1.46
5.9
5.1
0.00
0.00
estimate
-0.00
19
163
43
308
1.48
1.45
3.1
3.2
—
—
—
0
0
64
495
1.39
1.43
2.9
2.7
—
—
—
0
0
199
1835
1.43
1.41
66.5
13.2
13.92
13.75
%
0.43
199
1807
12
60
2.05
1.40
1.0
1.5
—
—
—
0
0
6
23
2.64
1.37
1.0
1.0
166.50
187.61
mg/l
—
6
23
6
23
2.64
1.37
1.0
1.1
—
—
—
0
0
217
2266
0.64
1.37
75.7
15.3
37.77
42.40
%
1.54
210
2161
57
440
1.38
1.29
4.0
3.5
—
—
—
0
0
218
2271
0.65
1.28
71.2
15.2
127.84
135.85
g/l
8.18
218
2239
15
250
0.57
1.28
1.2
1.3
—
—
—
0
0
218
2268
0.66
1.21
70.7
14.9
30.00
29.61
pg
2.60
218
2238
38
277
1.44
1.18
3.3
3.6
130.96
727.54
ng/l
0.83
26
173
218
2267
0.66
1.18
70.7
14.9
89.22
88.30
fl
1.92
218
2238
57
449
1.35
1.13
3.4
3.6
0.00
0.01
estimate
0.50
18
159
5
21
2.41
1.09
3.6
2.6
10.46
12.99
umol/l
—
5
21
5
21
2.41
1.09
1.4
2.1
3.22
5.37
mmol/24h
—
5
21
5
22
2.30
1.03
1.8
1.6
—
—
—
0
0
21
139
1.56
1.03
1.6
1.1
—
—
—
0
0
5
108
0.45
1.03
1.4
1.2
0.23
1.81
u/ml
—
5
70
139
1249
1.26
0.98
5.6
4.3
—
—
—
0
0
79
674
1.25
0.86
1.9
2.1
—
—
—
0
0
8
46
1.76
0.83
5.5
5.5
—
—
—
0
0
111
988
1.22
0.81
3.6
2.8
—
—
—
0
0
0
25
0.00
0.79
0.0
19.3
—
1171.44
—
0
25
0
27
0.00
0.78
0.0
1.5
—
22043.70
—
0
20
0
27
0.00
0.78
0.0
2.1
—
4.17
—
0
27
32
246
1.34
0.76
1.5
1.6
388.65
442.07
pmol/l
0.39
26
221
7
38
1.86
0.74
2.6
3.7
—
—
—
0
0
15
216
0.67
0.73
1.3
1.9
—
—
—
0
0
5
25
2.02
0.73
1.0
1.0
—
—
—
0
0
7
40
1.77
0.72
5.6
3.7
1.09
1.30
mmol/l
—
7
40
21
278
0.73
0.65
1.1
1.3
1.15
8.23
u/ml
—
8
105
15
104
1.47
0.64
1.1
1.4
—
—
—
0
0
61
524
1.22
0.62
2.0
1.8
103.99
96.16
pmol/l
0.46
34
270
51
430
1.23
0.62
3.2
3.1
1.02
1.02
kg/l
—
7
64
5
30
1.68
0.61
1.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
2.3
—
—
—
0
0
8
52
1.55
0.60
1.1
1.2
—
—
—
0
0
56
480
1.21
0.58
2.1
1.7
—
—
—
0
0
17
124
1.40
0.57
1.1
1.4
361.62
278.55
miu/ml
—
5
67
6
36
1.68
0.57
7.7
17.3
1.52
1.23
mmol/l
—
6
29
9
59
1.54
0.55
1.2
1.8
—
—
—
0
0
163
1537
1.17
0.55
4.6
3.1
5.61
5.66
mmol/l
0.20
158
1408
84
752
1.18
0.55
3.8
3.2
6.42
5.86
ph
—
6
67
15
202
0.72
0.53
1.5
2.0
—
—
—
0
0
14
100
1.42
0.53
17.9
4.1
—
—
—
0
0
11
156
0.69
0.52
1.7
2.5
—
—
—
0
0
22
173
1.30
0.48
1.1
1.2
—
16.20
—
0
5
10
69
1.47
0.44
2.1
3.3
—
—
—
0
0
204
1972
1.19
0.44
47.2
10.5
18.21
21.39
mg/l
1.00
179
1423
8
56
1.44
0.43
1.1
1.1
—
—
—
0
0
5
33
1.52
0.41
1.2
4.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
19
230
0.81
0.33
1.4
1.9
—
—
—
0
0
14
110
1.29
0.32
1.6
1.1
—
—
—
0
0
7
99
0.70
0.31
1.1
1.6
—
—
—
0
0
19
228
0.82
0.31
1.4
1.9
—
—
—
0
0
52
572
0.88
0.30
3.0
2.2
—
—
—
0
0
19
227
0.82
0.30
1.4
1.9
—
—
—
0
0
19
227
0.82
0.30
1.4
1.9
—
—
—
0
0
14
173
0.80
0.30
1.4
2.1
—
—
—
0
0
15
183
0.81
0.29
1.5
1.4
—
—
—
0
0
54
492
1.12
0.28
3.4
3.0
—
—
—
0
0
20
168
1.21
0.28
2.2
2.4
24779.83
4662.35
u/l
—
6
67
8
66
1.22
0.27
1.3
1.1
—
—
—
0
0
8
66
1.22
0.27
1.3
1.1
—
—
—
0
0
5
75
0.66
0.26
2.4
1.1
—
—
—
0
0
18
151
1.21
0.25
3.0
3.3
—
—
—
0
0
5
37
1.36
0.23
2.2
3.4
—
—
—
0
0
5
37
1.36
0.23
1.4
2.2
—
—
—
0
0
17
144
1.19
0.22
1.1
1.4
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
6.3
—
1.20
—
0
12
9
113
0.79
0.20
1.2
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
46035.71
—
0
14
6
50
1.20
0.20
1.5
1.8
1.51
0.54
nmol/l
—
6
43
12
99
1.22
0.20
4.3
2.1
—
—
—
0
0
202
2051
0.91
0.19
23.3
9.2
—
—
—
0
0
30
327
0.90
0.16
3.5
4.1
6.31
63.46
mg/mmol
0.60
24
223
8
96
0.83
0.14
1.5
1.5
—
—
—
0
0
8
96
0.83
0.14
1.5
1.5
—
—
—
0
0
8
99
0.80
0.14
1.6
1.6
—
—
—
0
0
26
280
0.92
0.11
1.2
1.2
—
—
—
0
0
10
115
0.86
0.11
1.2
1.2
—
—
—
0
0
36
379
0.94
0.09
1.9
3.2
83.31
83.28
ug/g
0.00
28
300
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
6
58
1.03
0.08
1.0
1.4
—
—
—
0
0
30
317
0.94
0.08
2.9
3.5
1696.78
94.26
mg/l
0.46
25
223
5
62
0.80
0.08
9.2
7.2
—
—
—
0
0
5
63
0.79
0.08
1.0
1.0
5.55
7.75
mu/l
—
5
63
7
80
0.87
0.07
1.0
1.1
—
—
—
0
0
7
82
0.85
0.07
1.9
2.4
—
—
—
0
0
67
688
0.96
0.07
1.4
1.6
0.69
2.38
u/ml
2.04
19
144
30
285
1.06
0.06
1.1
1.3
10.03
31.46
iu/ml
—
6
84
20
190
1.06
0.03
1.2
1.2
182.81
142.64
iu/ml
0.24
12
73
10
108
0.92
0.03
1.5
2.3
—
—
—
0
0
20
192
1.04
0.02
1.2
1.3
—
—
—
0
0
46
454
1.01
0.00
1.6
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
4.52
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
2187.50
—
0
8
0
8
0.00
0.00
0.0
1.0
—
160.25
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
11.25
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
66.78
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
57.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
226.11
—
0
6
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: HLP_C3_ALL – Acute lymphocytic leukaemia, helper endpoint

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).