ovarian disease: A disease involving the ovary.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
210 |
4. Check minimum number of eventsNone |
210 |
5. Include endpointsNone |
210 |
6. Filter based on genotype QC (FinnGen only) |
210 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Ovarian dysfunction, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Ovarian dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1225 | 1225 | - |
| Only index persons | 1157 | 1157 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | - |
| Only index persons | 0.04 | 0.04 | - |
| Median age at first event (years) | |||
| Whole population | - | 32.36 | - |
| Only index persons | - | 31.95 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 210 | 210 | - |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | - |
| Median age at first event (years) | 32.98 | 32.98 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.8
ICD-10 Finland
Other ovarian dysfunction
+∞
89.2
78
*
E28.9
ICD-10 Finland
Ovarian dysfunction, unspecified
+∞
52.7
48
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
85.7
46.0
50
8
E28.3
ICD-10 Finland
Primary ovarian failure
+∞
32.3
30
*
25691
ICD-8 Finland
NA
+∞
20.2
19
*
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
8.6
19.3
44
65
25699
ICD-8 Finland
Ovarian dysfunction, Other and unspecified
+∞
19.1
18
*
25698
ICD-8 Finland
Ovarian dysfunction, Alia definita
+∞
15.9
15
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
3.4
13.6
116
628
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.9
10.4
101
557
H02AB09
ATC
hydrocortisone; systemic
16.2
9.7
15
10
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
38.8
9.1
11
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
8.4
8.9
19
25
62800
ICD-8 Finland
Sterility, female, Sterilitas primaria
21.3
8.6
12
6
ZXE20
NOMESCO Finland
More than three and less than five hours
4.3
8.5
32
86
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.7
7.9
22
43
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
21.0
7.2
10
5
R4110
NOMESCO Finland
Physiotherapy
2.7
7.1
54
245
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.2
7.0
16
24
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
3.9
6.9
28
81
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
6.3
6
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
6.3
6
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.1
6.2
13
17
Mortality – FinRegistry
↥Association
Association between endpoint E4_OVARDYSNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_OVARDYSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_OVARDYSNAS – Ovarian dysfunction, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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