Atrial fibrillation and flutter

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I48
Hospital discharge: ICD-9 4273
Hospital discharge: ICD-8 42792
Cause of death: ICD-10 I48
Cause of death: ICD-9 4273
Cause of death: ICD-8 42792
KELA reimbursements: KELA codes 207|351
KELA reimbursements: ICD-10 I48

3 out of 7 registries used, show all original rules.

50713

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Check minimum number of events None

50713

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Include endpoints

50713

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Remove individuals based on genotype QC

45766

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I9_AF

Control definitions

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Summary Statistics

Key figures

All Female Male
Number of individuals 45766 17109 28657
Unadjusted prevalence (%) 12.14 8.12 17.23
Mean age at first event (years) 67.88 69.75 66.76

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.98 [2.71, 3.29] <1e-100 11278
15 years 0.01 1.60 [1.46, 1.74] 8.4e-26 4162
5 years 0.00 3.46 [3.22, 3.72] <1e-100 3828
1 year 0.00 9.71 [8.84, 10.68] <1e-100 2412

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 102

Survival analyses between endpoints

Plot

before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atrial fibrillation and flutter