Risteys · J10_RESPCONDEXT

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J70 Hospital discharge: ICD-9 — 508 Cause of death: ICD-10 — J70 Cause of death: ICD-9 — 508 2 out of 7 registries used, show all original rules.	695
4. Check minimum number of events None	695
5. Include endpoints None	695
6. Filter based on genotype QC (FinnGen only)	695

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5135	2989	2077
Only index persons	3638	2249	1389
Unadjusted period prevalence (%)
Whole population	0.07	0.09	0.06
Only index persons	0.07	0.08	0.05
Median age at first event (years)
Whole population	69.92	70.17	69.46
Only index persons	67.98	67.98	67.97

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	695	402	293
Unadjusted period prevalence (%)	0.13	0.14	0.13
Median age at first event (years)	66.68	63.64	70.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
631: Matched controls
6308

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J70.2

ICD-10 Finland

Acute drug-induced interstitial lung disorders

+∞

262.3

233

J70.0

ICD-10 Finland

Acute pulmonary manifestations due to radiation

+∞

251.3

224

H02AB06

ATC

prednisolone; systemic

7.0

102.5

500

2217

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

17.5

97.4

160

120

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

6.9

71.3

203

404

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.6

70.3

432

2015

UGC12

NOMESCO Finland

Flexible bronchoscopy

7.8

67.1

171

287

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.6

64.7

306

1075

H02AB02

ATC

dexamethasone; systemic

6.3

61.9

188

398

A03FA01

ATC

metoclopramide; systemic, rectal

4.7

61.8

270

866

TGC00

NOMESCO Finland

Bronchial lavation

21.7

58.6

J70.4

ICD-10 Finland

Drug-induced interstitial lung disorders, unspecified

+∞

57.1

XX3DW

NOMESCO Finland

Time consuming IT work

6.4

57.0

169

343

A04AA02

ATC

granisetron; systemic, transdermal

7.8

52.4

130

203

J70.3

ICD-10 Finland

Chronic drug-induced interstitial lung disorders

+∞

51.8

YG1BD

NOMESCO Finland

Extensive CT examination of thorax for dose design of radiotherapy

10.6

49.4

100

110

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

6.6

48.1

135

250

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

13.3

46.8

115

Kela drug reimbursment

Breast cancer

5.8

45.7

143

303

J70.1

ICD-10 Finland

Chronic and other pulmonary manifestations due to radiation

+∞

40.0

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

6.8

39.1

105

180

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

3.1

37.6

288

1332

JN4BD

NOMESCO Finland

Extensive body CT

4.5

37.6

150

408

GD1AD

NOMESCO Finland

Thorax CT examination

8.6

37.3

110

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

5.3

34.2

114

254

WF049

NOMESCO Finland

Radiotherapy of metastasis

9.7

34.1

JN4AD

NOMESCO Finland

Body CT examination

5.3

34.0

113

251

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

11.9

33.8

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

7.7

33.6

118

L02BG04

ATC

letrozole; oral

5.8

33.3

101

201

130

Kela drug reimbursment

Malignant tumour

4.7

33.1

123

308

J01MA12

ATC

levofloxacin; systemic

3.3

32.2

200

779

ZX080

NOMESCO Finland

Image guided radiotherapy

12.7

32.0

N02AA05

ATC

oxycodone; systemic

3.5

31.8

173

607

A02BC02

ATC

pantoprazole; systemic

2.9

31.8

479

3266

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.7

30.3

307

1631

HA1AA

NOMESCO Finland

X-ray mammography

4.7

30.2

112

278

ZX070

NOMESCO Finland

Intensity modified radiotherapy

11.7

29.9

WD105

NOMESCO Finland

Cystostatic therapy of methastized malignancy

7.1

29.8

120

R50.9

ICD-10 Finland

Fever, unspecified

3.6

29.3

151

505

R06.0

ICD-10 Finland

Dyspnoea

2.8

28.8

237

1101

WZC30

NOMESCO Finland

Teaching

3.7

28.5

142

461

WB203

NOMESCO Finland

Simple adjuvant hormone therapy of malignancy

9.0

28.2

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

6.0

27.8

148

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

18.2

26.5

A49.9

ICD-10 Finland

Bacterial infection, unspecified

3.6

25.4

128

417

J70.9

ICD-10 Finland

Respiratory conditions due to unspecified external agent

+∞

25.2

D70.82

ICD-10 Finland

Drug-induced neutropenia

12.3

24.8

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.8

24.8

207

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

4.8

24.7

203

C03CA01

ATC

furosemide; systemic

2.4

23.6

280

1558

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

5.3

23.2

155

WF003

NOMESCO Finland

Adjuvant radiotherapy

6.6

23.0

101

L03AA14

ATC

lipegfilgrastim; parenteral

10.4

22.9

A04AA55

ATC

palonosetron, combinations; systemic

8.1

22.8

JN4JR

NOMESCO Finland

Whole body extensive metabolic PET with CT

24.0

22.8

L03AA13

ATC

pegfilgrastim; parenteral

6.1

22.4

113

B01AB10

ATC

tinzaparin; parenteral

4.4

22.0

212

ZXE00

NOMESCO Finland

One hour or less

2.3

21.7

300

1777

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

5.9

21.6

114

D38.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung

6.6

21.6

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

4.4

21.4

203

TPH04

NOMESCO Finland

Cathetrisation of vein

2.6

21.4

189

887

PJA12

NOMESCO Finland

Sentinel node biopsy

3.8

21.3

282

JN4CD

NOMESCO Finland

Very extensive body CT

5.8

20.4

110

XGX32

NOMESCO Finland

Bronchoscopic ultrasonography

19.6

20.1

Z51.5

ICD-10 Finland

Palliative care

4.1

19.9

217

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.1

19.8

123

461

WD405

NOMESCO Finland

Simple antiboidy therapy of methastized malignancy

8.2

19.6

C79.8

ICD-10 Finland

Secondary malignant neoplasm of other specified sites

6.1

19.5

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

4.5

19.1

170

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

5.0

19.1

137

A04AA01

ATC

ondansetron; systemic, rectal

4.3

18.3

177

HAB40

NOMESCO Finland

Wedge excision of mammary gland

4.3

18.0

175

WF004

NOMESCO Finland

Palliative radiotherapy

8.9

17.9

TGD00

NOMESCO Finland

Needle biopsy of lung

37.9

17.7

XW000

NOMESCO Finland

Bone marrow biopsy

5.1

17.6

117

WF002

NOMESCO Finland

Radical radiotherapy

4.5

17.2

148

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.6

17.1

140

619

J01MA14

ATC

moxifloxacin; systemic

3.4

16.9

284

HA1AT

NOMESCO Finland

Biopsy of mammary glands with ultrasound guidance

7.4

16.8

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

3.2

16.8

319

WD305

NOMESCO Finland

Simple therapy of methastized malignancy with biomodifiers

10.5

16.6

HA1DG

NOMESCO Finland

Very extensive MRI examination of mammary gland with high intensity magnet

23.8

16.5

NK6AN

NOMESCO Finland

Total body bone isotope imaging

6.1

16.2

I26.9

ICD-10 Finland

Pulmonary embolism without mention of acute cor pulmonale

4.0

16.0

179

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.9

15.9

105

405

C01BD01

ATC

amiodarone; systemic

5.6

15.4

ZXD05

NOMESCO Finland

Urgent procedure

2.1

15.3

220

1271

M05BX04

ATC

denosumab; parenteral

3.9

15.2

182

WW500

NOMESCO Finland

Blood transfusion

4.8

15.2

113

WD325

NOMESCO Finland

Demanding therapy of methastized malignancy with biomodifiers

20.7

15.2

ZXE10

NOMESCO Finland

More than one and less than three hours

2.0

15.0

267

1682

A02BC01

ATC

omeprazole; systemic

2.1

15.0

219

1273

HAC20

NOMESCO Finland

Total mastectomy

4.1

14.7

156

A04AD12

ATC

aprepitant; systemic

7.0

14.7

WB113

NOMESCO Finland

Multiple adjuvant cytostatic therapy

4.4

14.4

129

YG1AD

NOMESCO Finland

CT examination of thorax for dose design of radiotherapy

8.5

14.4

L03AA02

ATC

filgrastim; parenteral

6.5

14.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.9

14.3

309

2085

B01AB05

ATC

enoxaparin; parenteral

2.0

14.3

231

1393

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

4.8

13.9

105

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.2

13.9

169

903

HA003

NOMESCO Finland

Radiotherapy after partial ablation of mammary gland

4.5

13.7

116

J84.1

ICD-10 Finland

Other interstitial pulmonary diseases with fibrosis

6.8

13.7

N03AX16

ATC

pregabalin; oral

2.1

13.7

178

980

5088A

ICD-9 Finland

Respiratory conditions due to other and unspecified external agents, Respiratory conditions due to other specified external agents[MORBI ORGANORUM RESPIRATIONIS E PHARMACO]

+∞

13.6

TPH07

NOMESCO Finland

Cathetrisation of artery

2.7

13.5

394

C50.99

ICD-10 Finland

Breast, unspecified

5.3

13.4

WD415

NOMESCO Finland

Demanding antibody therapy of methastized malignancy

8.4

13.4

L02BA01

ATC

tamoxifen; oral

4.5

13.3

110

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.1

13.3

260

C07AB07

ATC

bisoprolol; oral

1.9

13.3

346

2473

L02BG06

ATC

exemestane; oral

8.2

13.2

C34.11

ICD-10 Finland

Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma

12.5

13.2

M04AA01

ATC

allopurinol; systemic

2.4

13.1

120

557

GD5AD

NOMESCO Finland

Thorax and upper abdomen combined CT examination of

11.9

12.9

WD135

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

12.6

12.7

XX1XN

NOMESCO Finland

Other isotope examination

11.3

12.6

YG1CD

NOMESCO Finland

Very extensive CT examination of thorax for dose design of radiotherapy

13.5

12.5

L01CA04

ATC

vinorelbine; systemic

13.5

12.5

L02BG03

ATC

anastrozole; oral

6.7

12.5

C79.5

ICD-10 Finland

Secondary malignant neoplasm of bone and bone marrow

7.4

12.4

I50.9

ICD-10 Finland

Heart failure, unspecified

2.3

12.4

127

621

C50.21

ICD-10 Finland

Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor

5.8

12.2

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

4.0

12.1

131

C34.1

ICD-10 Finland

Malignant neoplasm: Upper lobe, bronchus or lung

7.5

12.1

N05CF01

ATC

zopiclone; oral

1.9

12.0

242

1562

J70.8

ICD-10 Finland

Respiratory conditions due to other specified external agents

+∞

11.5

X76

ICPC

Malignant neoplasm breast female

6.2

11.5

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

7.2

11.4

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.7

11.3

328

ZX120

NOMESCO Finland

Intravenous

2.6

11.3

359

GD1CD

NOMESCO Finland

Thorax extensive CT-examination

9.9

11.3

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

4.2

11.3

109

WX402

NOMESCO Finland

General anaesthesia

2.3

11.3

118

581

NK6AQ

NOMESCO Finland

Whole body bone SPET with low dose CT

35.7

11.3

WB401

NOMESCO Finland

Simple antibody therapy of primary tumour

9.1

10.8

C34.12

ICD-10 Finland

Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma

9.1

10.8

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

10.8

182

1094

N02AX02

ATC

tramadol; systemic, rectal

1.8

10.8

292

2061

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.4

10.8

411

ED1AA

NOMESCO Finland

Mandipular X-ray examination

61.0

10.7

HA6AA

NOMESCO Finland

Extra corporeal mammography of operated mammary gland

4.4

10.6

R03AC02

ATC

salbutamol; inhalant

1.8

10.6

322

2348

N02AA01

ATC

morphine; systemic, rectal

8.7

10.6

C83.31

ICD-10 Finland

Diffuse lymphoma with large B cells

6.7

10.6

HA4AT

NOMESCO Finland

Labeling mammary gland pathology with ultrasound guidance

4.9

10.4

R05

ICD-10 Finland

Cough

2.1

10.3

137

749

UGC18

NOMESCO Finland

Flexible bronchoscopy with biopsy of lung

19.2

10.3

J01CA04

ATC

amoxicillin; systemic

1.9

10.3

484

4031

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

4.7

10.2

GD5BD

NOMESCO Finland

Thorax and upper abdomen combined extensive CT examination of

5.3

10.1

EE1AA

NOMESCO Finland

X-ray of upper jaw or palate

40.7

10.0

HAB50

NOMESCO Finland

Partial excision of mammary gland with reconstructive operation

6.1

9.9

JN4KR

NOMESCO Finland

Whole body very extensive metabolic PET with CT

12.4

9.9

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

3.0

9.8

196

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.0

9.8

144

819

XG410

NOMESCO Finland

Flow-volume spirometry

3.9

9.8

104

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

2.5

9.7

361

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

8.0

9.7

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.5

9.7

322

N02BE01

ATC

paracetamol; systemic, rectal

2.0

9.6

537

4678

A07EC01

ATC

sulfasalazine; oral, rectal

2.8

9.5

244

ZX095

NOMESCO Finland

Combined chemoradiotherapy

12.6

9.4

5088X

ICD-9 Finland

Respiratory conditions due to other and unspecified external agents, Respiratory conditions due to other specified external agents[MORBI ORGANORUM RESP CAUSA EXT ALIA DEFINITA]

+∞

9.4

L04AX01

ATC

azathioprine; systemic

3.9

9.4

103

M05BA04

ATC

alendronic acid; oral

2.4

9.4

344

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.1

9.1

117

628

C50.29

ICD-10 Finland

Malignant tumor of the upper inner quadrant of the mammary gland, other or undeterminated histology

15.9

9.1

XX9AQ

NOMESCO Finland

Supplementary SPECT-CT or additional scan

37.2

9.0

ZXE20

NOMESCO Finland

More than three and less than five hours

2.1

9.0

109

573

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.5

9.0

298

R03BB04

ATC

tiotropium bromide; inhalant

2.3

8.9

402

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.8

8.8

200

1312

8520/3-C50.9

ICD-O-3

Lobular carcinoma, NOS, of breast, NOS

6.5

8.8

WB121

NOMESCO Finland

Demanding neoadjuvant cytostatic therapy

9.7

8.8

A06AD11

ATC

lactulose; oral

2.0

8.8

117

637

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

3.8

8.7

100

C50.81

ICD-10 Finland

Overall malignant tumor of the mammary gland, ductal tumor

6.3

8.7

GD1CT

NOMESCO Finland

Biopsy of the lung with CT guidance

5.9

8.7

B99

ICD-10 Finland

Other and unspecified infectious diseases

5.9

8.7

N02AJ06

ATC

codeine and paracetamol; systemic

1.7

8.6

220

1496

HAB99

NOMESCO Finland

Other partial excision of mammary gland

4.9

8.6

JN6AD

NOMESCO Finland

CT of torso and neck

8.4

8.6

YX9AD

NOMESCO Finland

Other CT eamination for dose design of radiotherapy

4.7

8.6

D64.9

ICD-10 Finland

Anaemia, unspecified

2.3

8.5

401

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.3

8.4

367

C34.32

ICD-10 Finland

Malignant tumor of the lower lobe, bronchus or lung adenocarcinoma

8.0

8.4

XZZ00

NOMESCO Finland

Active surveillance of a diagnosed cancer

8.0

8.4

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

2.9

8.4

182

NK6BQ

NOMESCO Finland

Whole body extensive bone SPET with low dose CT

13.0

8.4

C34.31

ICD-10 Finland

Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma

10.9

8.3

J01DB01

ATC

cefalexin; oral

1.7

8.3

483

4116

R04.2

ICD-10 Finland

Haemoptysis

3.6

8.3

104

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.2

8.3

422

AA1BD

NOMESCO Finland

Extensive CT of head and brain

4.2

8.3

C50

ICD-10 Finland

Malignant neoplasm of breast

4.5

8.2

L04AA13

ATC

leflunomide; oral

4.5

8.2

PJ5AN

NOMESCO Finland

Localisation of sentinell lymphnode with isotope imaging

4.8

8.2

J01MA02

ATC

ciprofloxacin; systemic

1.7

8.1

252

1806

TGD04

NOMESCO Finland

Needle biopsy of the lungs in bronchoscopy

17.4

8.1

R84

ICPC

Malignant neoplasm bronchus/lung

17.4

8.1

J01FF01

ATC

clindamycin; systemic

1.8

8.1

168

1068

HA3AT

NOMESCO Finland

Pucture of mammary gland cyst with ultrasound examination

10.2

8.1

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.8

8.0

165

1047

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.8

7.9

195

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

2.7

7.9

196

8500/3-C50.4

ICD-O-3

Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast

4.4

7.8

WD115

NOMESCO Finland

Multiple cystostatic therapy of methastized malignancy

5.1

7.8

WX892

NOMESCO Finland

Monitored bed care

2.4

7.8

275

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.6

7.7

274

2026

GA4YT

NOMESCO Finland

Puncture of pleura with ultrasound guidance

3.8

7.7

C50.4

ICD-10 Finland

Malignant neoplasm: Upper-outer quadrant of breast

8.2

7.6

WD205

NOMESCO Finland

Therapy of methastized malignancy with hormones

8.2

7.6

WB133

NOMESCO Finland

Very demanding adjuvant cytostatic therapy

18.6

7.6

J17.3*B59

ICD-10 Finland

Pneumonia due to Pneumocystis carinii

18.6

7.6

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

5.3

7.6

XF600

NOMESCO Finland

Bloodpressure measurement

2.6

7.6

213

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.9

7.5

115

659

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.3

7.5

113

C34.10

ICD-10 Finland

Malignant tumor of the upper lobe, bronchus or lung without histology

6.6

7.5

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

5.4

7.4

T88.7

ICD-10 Finland

Unspecified adverse effect of drug or medicament

6.1

7.4

J01AA02

ATC

doxycycline; systemic

1.7

7.3

486

4197

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.7

7.3

160

1033

PD4CG

NOMESCO Finland

Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet

6.4

7.3

J96.1

ICD-10 Finland

Chronic respiratory failure

4.2

7.3

WD515

NOMESCO Finland

Demanding therapy of malignancy with enzyme inhibitors and similar treatments

15.9

7.2

C81.9

ICD-10 Finland

Hodgkin lymphoma, unspecified

30.4

7.2

OAB38

NOMESCO Finland

Psychosocial guidance and counselling

30.4

7.2

YN7BD

NOMESCO Finland

Extensive CT examination of spine for dose design of radiotherapy

20.3

7.1

I48

ICD-10 Finland

Atrial fibrillation and flutter

1.7

7.1

171

1129

J96.0

ICD-10 Finland

Acute respiratory failure

5.4

7.1

QDB99

NOMESCO Finland

Other procedure for wound of skin of lower limb

12.2

7.1

A02BC05

ATC

esomeprazole; systemic

1.6

7.1

254

1870

SPAT1263

SPAT

Sampling

1.6

7.1

261

1935

J01DA01

ATC

[U] cefalexin; systemic

1.6

7.1

373

3021

Z31.5

ICD-10 Finland

Genetic counselling

3.4

7.0

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.0

7.0

460

HAD30

NOMESCO Finland

Reduction mammoplasty with transposition of areola

3.6

7.0

L04AA06

ATC

mycophenolic acid; systemic

5.3

7.0

C50.11

ICD-10 Finland

Malignant tumor of the central part of the mammary gland,ductal tumor

5.3

7.0

B01AA03

ATC

warfarin; systemic

1.7

7.0

154

995

R03AL01

ATC

fenoterol and ipratropium bromide; inhalant

4.1

6.8

WF099

NOMESCO Finland

Other radiotherapy

9.4

6.8

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

40.5

6.8

8070/3-C34.1

ICD-O-3

Squamous cell carcinoma, NOS, of upper lobe, lung

16.9

6.8

C77.1

ICD-10 Finland

Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes

16.9

6.8

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.7

6.7

165

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

5.3

6.7

PJD42

NOMESCO Finland

Excision of axillary lymph nodes

6.0

6.6

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

2.5

6.6

203

C81.1

ICD-10 Finland

Nodular sclerosis classical Hodgkin lymphoma

70.5

6.4

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.9

6.4

515

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

6.6

6.4

I70.9

ICD-10 Finland

Generalized and unspecified atherosclerosis

4.3

6.4

C50.91

ICD-10 Finland

Malignant tumor in another specified localization in ductal mammary gland

5.3

6.4

WX722

NOMESCO Finland

PEEP

3.0

6.4

126

166

Kela drug reimbursment

Dalteparin and tinzaparin (treatment for more than 6 months)

8.3

6.4

8140/3-C34.3

ICD-O-3

Adenocarcinoma, NOS, of lower lobe, lung

18.2

6.3

J80

ICD-10 Finland

Adult respiratory distress syndrome

18.2

6.3

Z85.3

ICD-10 Finland

Personal history of malignant neoplasm of breast

7.1

6.2

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

1.9

6.2

535

WB123

NOMESCO Finland

Demanding adjuvant cytostatic therapy

6.4

6.2

Z3231

NOMESCO Finland

Registered nurse

1.6

6.2

172

1182

I50.0

ICD-10 Finland

Congestive heart failure

2.1

6.2

323

GCA98

NOMESCO Finland

Other bronchoscopic procedure on bronchus

7.8

6.1

XW1AT

NOMESCO Finland

Biopsy from other organ close to skin with ultrasound quidance

12.7

6.1

A41.9

ICD-10 Finland

Sepsis, unspecified

3.0

6.1

115

C50.22

ICD-10 Finland

Malignant tumor of the upper inner quadrant of the mammary gland,lobular tumor

10.1

6.0

8070/3-C34.9

ICD-O-3

Squamous cell carcinoma, NOS, of lung, NOS

6.1

6.0

JN1DG

NOMESCO Finland

Very extensive MRI examination of upper part of abdomen with high intensity magnet

6.1

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint J10_RESPCONDEXT and mortality.

Females

Parameter	HR [95% CI]	p-value
J10_RESPCONDEXT	2.553 [2.22, 2.94]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.283

During the follow-up period (1.1.1998 — 31.12.2019), 1081 out of 2197 females with J10_RESPCONDEXT died.

Males

Parameter	HR [95% CI]	p-value
J10_RESPCONDEXT	4.277 [3.44, 5.32]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.005

During the follow-up period (1.1.1998 — 31.12.2019), 953 out of 1460 males with J10_RESPCONDEXT died.

Mortality risk

Mortality risk for people of age

years, who have J10_RESPCONDEXT.

N-year risk	Females	Males
1	0.267%	0.724%
5	1.56%	4.682%
10	3.869%	11.389%
15	6.993%	21.879%
20	12.541%	33.517%

NAME	J10_RESPCONDEXT
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J70
HD_ICD_9	508
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J70
COD_ICD_9	508
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Respiratory conditions due to other external agents

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints