No definition available.
Drug-induced interstitial lung disorders, unspecified
DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
60 |
4. Check minimum number of eventsNone |
60 |
5. Include endpointsNone |
60 |
6. Filter based on genotype QC (FinnGen only) |
60 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced interstitial lung disorders, unspecified
based on the number of shared cases.
Similar with more cases:
- Respiratory conditions due to other external agents
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 294 | 177 | 116 |
| Only index persons | 245 | 147 | 98 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.00 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 70.11 | 70.84 | 68.94 |
| Only index persons | 68.88 | 69.62 | 67.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 60 | 39 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 65.52 | 67.60 | 61.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 54
- Matched controls
- 539
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J70.4
ICD-10 Finland
Drug-induced interstitial lung disorders, unspecified
+∞
77.3
54
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
23.6
13.4
19
12
H02AB06
ATC
prednisolone; systemic
9.6
11.5
45
185
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.3
10.7
44
186
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
18.3
9.3
14
10
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
9.2
8.7
19
30
JN4AD
NOMESCO Finland
Body CT examination
10.7
8.7
17
22
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
40.0
8.4
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.8
8.4
30
95
B01AB10
ATC
tinzaparin; parenteral
9.8
7.9
16
22
A03FA01
ATC
metoclopramide; systemic, rectal
5.7
7.9
27
80
N02AA05
ATC
oxycodone; systemic
6.8
7.4
20
43
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.3
7.1
25
75
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.0
7.0
13
15
JN4BD
NOMESCO Finland
Extensive body CT
6.2
6.5
18
40
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.2
6.4
14
22
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
+∞
6.4
6
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.3
6.3
15
27
M04AA01
ATC
allopurinol; systemic
5.4
6.0
19
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
74
8.12
15.13
5.4
3.3
0.8
0.8
mmol/l
0.29
32
67
13
10
16.32
13.82
1.7
1.9
—
—
—
0
0
13
10
16.32
13.82
1.7
1.7
—
—
—
0
0
15
15
13.00
13.71
1.6
2.0
—
—
—
0
0
32
83
7.12
13.24
2.5
2.1
—
—
—
0
0
27
60
7.36
13.00
2.3
2.1
—
—
—
0
0
26
59
7.01
12.17
2.3
2.0
—
—
—
0
0
14
16
11.11
11.60
1.6
1.9
—
—
—
0
0
21
44
6.80
10.47
6.3
4.0
1.2
1.2
mmol/l
0.09
21
38
22
51
6.23
9.86
6.3
6.9
1.1
1.0
mmol/l
0.16
22
46
10
10
11.80
8.89
1.7
1.9
—
—
—
0
0
48
232
6.34
8.81
8.4
6.2
1.2
1.2
mmol/l
0.23
48
208
50
255
6.76
8.47
9.2
7.5
1.2
1.2
mmol/l
0.68
37
212
19
45
5.72
8.19
5.9
3.4
—
—
—
0
0
52
297
6.62
8.03
22.1
10.8
4.6
4.2
e9/l
0.57
47
257
11
6
21.97
7.94
1.8
2.2
—
—
—
0
0
12
18
8.08
7.93
4.0
12.9
24.0
26.1
mmol/l
0.72
12
18
10
13
9.03
7.35
1.7
1.9
—
—
—
0
0
36
155
4.31
7.21
4.1
3.1
0.4
0.3
e6/l
0.14
31
117
40
192
4.25
6.75
4.5
3.2
—
—
—
0
0
10
15
7.80
6.53
2.3
1.3
—
—
—
0
0
21
74
3.83
5.32
2.8
2.4
10.8
12.3
umol/l
0.45
21
64
5
0
+∞
5.27
1.6
0.0
—
—
—
0
0
8
6
15.09
5.24
1.8
1.8
—
—
—
0
0
9
10
10.33
4.98
1.8
1.7
—
—
—
0
0
9
10
10.33
4.98
1.8
1.9
—
—
—
0
0
10
20
5.80
4.97
3.4
3.0
—
—
—
0
0
54
388
4.91
4.65
19.8
7.8
73.9
78.4
u/l
0.59
54
357
12
32
4.44
4.33
5.5
11.4
93.7
94.0
%
0.05
12
32
12
34
4.16
4.00
5.5
10.8
0.6
0.8
%
0.99
12
34
12
34
4.16
4.00
5.5
10.8
1.6
1.5
%
0.10
12
34
14
47
3.58
3.70
4.5
4.2
5.9
5.9
kpa
0.02
14
47
6
6
10.91
3.58
2.5
1.0
—
—
—
0
0
35
205
2.70
3.45
6.3
3.7
18.8
40.7
ng/l
0.65
27
150
28
147
2.70
3.42
4.6
4.3
0.0
0.0
estimate
0.00
20
48
9
19
5.37
3.39
1.1
1.1
—
—
—
0
0
16
64
3.05
3.19
4.9
8.3
0.6
2.1
mmol/l
0.71
16
52
7
13
5.93
2.96
2.1
1.7
—
—
—
0
0
7
13
5.93
2.96
2.1
1.7
—
—
—
0
0
6
9
7.25
2.94
4.5
1.4
80.8
93.7
%
—
6
9
7
14
5.50
2.82
5.4
5.1
—
—
—
0
0
6
10
6.52
2.77
4.5
2.8
238.3
139.6
%
—
6
10
8
20
4.44
2.67
5.9
3.9
24.1
23.9
mmol/l
—
8
20
5
7
7.65
2.60
1.8
1.0
—
—
—
0
0
37
250
2.25
2.35
6.6
5.1
0.0
0.0
estimate
0.00
20
50
7
18
4.25
2.33
4.1
1.7
—
—
—
0
0
37
254
2.19
2.21
5.2
3.9
0.0
0.0
estimate
0.00
20
51
8
27
3.26
2.02
1.6
1.6
—
—
—
0
0
8
28
3.13
1.94
1.9
1.3
—
—
—
0
0
36
254
2.04
1.90
5.3
3.9
0.0
0.0
estimate
0.00
20
54
5
12
4.44
1.86
4.6
2.0
0.0
0.0
g/l
—
5
12
5
12
4.44
1.86
2.0
1.6
—
—
—
0
0
5
12
4.44
1.86
1.2
1.3
—
—
—
0
0
33
230
1.97
1.76
6.2
3.9
—
—
—
0
0
5
13
4.09
1.75
1.0
1.2
—
—
—
0
0
5
14
3.79
1.65
1.8
2.4
—
—
—
0
0
30
206
1.91
1.64
4.8
4.0
—
—
—
0
0
35
255
1.89
1.58
3.0
2.7
—
—
—
0
0
25
166
1.87
1.48
4.9
2.9
34.4
29.6
u/l
0.65
25
156
16
91
2.03
1.47
4.2
2.7
0.6
0.9
e6/l
0.35
11
55
14
80
1.98
1.26
4.6
2.9
0.7
2.8
e6/l
—
9
45
8
41
2.09
1.14
1.4
1.7
—
—
—
0
0
28
206
1.67
1.11
2.1
2.1
85.2
93.4
pmol/l
0.32
14
93
14
89
1.75
0.91
1.4
1.3
49.0
38.2
iu/ml
—
5
32
5
26
2.00
0.72
3.2
3.1
54.4
44.9
%
—
5
26
16
115
1.53
0.65
4.3
2.1
—
—
—
0
0
5
29
1.79
0.65
3.0
2.9
2.2
1.0
%
—
5
29
15
107
1.54
0.63
1.5
1.7
1702.7
1262.5
nmol/l
—
10
82
10
75
1.40
0.32
1.9
1.5
—
—
—
0
0
10
75
1.40
0.32
2.2
3.0
0.3
0.6
ug/l
—
5
52
6
81
0.71
0.26
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
36.2
—
0
11
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
78
0.74
0.16
8.2
8.2
—
—
—
0
0
47
469
1.01
0.00
4.9
5.0
6.1
5.9
mmol/l
0.36
41
424
47
474
0.96
0.00
4.6
4.7
5.0
4.6
mmol/l
1.10
42
427
0
5
0.00
0.00
0.0
1.2
—
1.6
—
0
5
0
6
0.00
0.00
0.0
1.3
—
1146.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
116.3
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
146.7
—
0
6
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
2.8
—
113.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE | 2.1 [1.45, 3.04] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.217 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 143 females with DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.214% | No data |
| 5 | 1.23% | No data |
| 10 | 3.312% | No data |
| 15 | 5.661% | No data |
| 20 | 9.969% | No data |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE – Drug-induced interstitial lung disorders, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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