Chronic drug-induced interstitial lung disorders

CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J70.3# 1 out of 7 registries used, show all original rules.	52
4. Check minimum number of events None	52
5. Include endpoints None	52
6. Filter based on genotype QC (FinnGen only)	52

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J703
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic drug-induced interstitial lung disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	444	290	152
Only index persons	328	215	113
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	73.02	75.38	68.75
Only index persons	71.67	74.75	65.82

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	52	29	23
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	64.70	63.82	65.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

10.08

7.85

2.0

1.0

—

(42870588) Differential panel, method unspecified - Blood

151

4.62

6.67

14.3

5.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

7.50

6.20

2.6

2.2

—

(3006315) Basophils [#/volume] in Blood

217

5.20

6.20

13.0

6.7

0.0

e9/l

0.41

196

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.59

6.02

2.6

2.0

—

(40758558) Short blood count panel - Blood

122

4.11

5.96

11.9

9.5

—

(3013115) Eosinophils [#/volume] in Blood

223

4.96

5.83

14.4

6.8

0.2

e9/l

0.20

204

(3001604) Monocytes [#/volume] in Blood

218

4.62

5.56

13.3

6.6

0.7

0.6

e9/l

0.75

194

(3019198) Lymphocytes [#/volume] in Blood

223

4.44

5.27

13.4

6.5

2.1

1.7

e9/l

0.89

203

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.22

5.25

2.6

1.9

—

(3019060) Gas panel - Arterial blood

4.92

5.06

3.6

4.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

4.67

5.04

2.4

2.1

267.4

122.6

ng/l

0.52

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.43

4.20

10.8

7.3

24.6

24.9

mmol/l

0.12

(3000492) Spirometry study

4.43

4.20

2.0

1.7

—

(3018418) pH of Serum or Plasma

157

3.15

3.97

6.1

4.8

7.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.29

3.90

2.6

2.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.89

3.80

2.4

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

4.03

3.74

16.5

10.9

0.7

0.6

0.36

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

8.76

3.68

1.4

1.8

—

(3000991) Gas panel - Venous blood

3.70

3.54

14.3

10.7

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

7.88

3.48

2.1

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

7.88

3.48

1.6

1.7

—

(36304419) Bacteria [Presence] in Urine

145

2.79

3.24

4.0

3.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.95

3.19

2.9

2.8

0.6

3.8

e6/l

1.21

(3009445) Proteinase 3 Ab [Units/volume] in Serum

4.95

3.16

1.3

1.0

—

(3023368) Bacteria identified in Blood by Culture

148

2.71

3.08

7.4

4.8

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

10.86

3.04

3.0

1.4

4.1

5.8

e9/l

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.61

3.01

17.7

10.2

1.4

1.2

0.36

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.18

3.00

2.5

4.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.75

2.83

2.6

2.7

1.0

0.8

e6/l

0.16

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.59

2.83

2.7

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

189

2.59

2.77

4.5

3.3

—

(4010399)

4.13

2.72

1.7

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.21

2.70

2.7

1.7

—

(3023419) Bacteria identified in Sputum by Culture

6.00

2.62

3.5

2.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

6.00

2.62

1.3

1.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

7.74

2.60

3.0

2.0

57.0

52.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

294

2.87

2.52

10.1

5.1

—

97.9

—

(3020891) Body temperature

4.10

2.48

5.5

4.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

307

2.91

2.45

9.4

4.8

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

2.43

0.0

4.3

—

30.8

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.06

2.34

1.5

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

6.00

2.26

2.4

1.1

0.2

g/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.71

2.19

39.3

19.2

—

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

102

2.36

2.12

6.3

3.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.18

2.12

2.3

2.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

5.40

2.12

1.6

1.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

5.40

2.12

2.4

1.1

g/l

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

5.40

2.12

1.2

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

5.40

2.12

3.2

1.2

—

(3000494) Fungus identified in Specimen by Culture

2.60

2.04

1.9

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

2.86

1.97

2.1

5.0

66.5

74.9

e9/l

—

(3026008) Bacteria identified in Urine by Culture

156

2.16

1.93

6.6

3.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

250

2.22

1.90

15.4

7.4

1.2

mmol/l

0.04

208

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.48

1.87

3.2

1.6

—

(3052851) Hemolysis interference index of Serum or Plasma

3.62

1.80

1.5

4.0

—

(3013512) EKG study

164

0.40

1.78

4.3

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.33

1.74

3.2

2.3

2.4

2.3

g/l

0.23

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

188

2.06

1.74

2.0

2.1

81.4

99.0

pmol/l

1.00

(40760892) CBC W Ordered Manual Differential panel - Blood

2.12

1.59

7.4

6.4

—

(3012544) pH of Venous blood

2.36

1.51

1.3

3.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

224

1.95

1.49

8.8

6.3

0.0

estimate

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.81

1.41

2.2

3.3

0.5

0.8

—

(3009261) Glucose [Presence] in Urine by Test strip

227

1.91

1.40

6.5

4.5

0.0

estimate

—

(3021589) Normoblasts [#/volume] in Blood

210

1.86

1.34

22.1

13.0

0.0

e9/l

0.61

177

(3006184) Hemoglobin [Mass/volume] in Capillary blood

2.96

1.31

1.2

2.4

—

120.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.58

1.28

2.2

3.2

1.3

1.5

—

(3015736) pH of Urine

176

1.81

1.24

5.9

4.2

—

(3044889) 12 lead EKG panel

338

2.01

1.20

6.9

4.3

—

(3042936) Bacteria identified in Isolate by Culture

1.98

1.16

2.7

1.9

—

(3025941) Bacteria identified in Stool by Culture

2.45

1.15

1.6

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.45

1.15

6.9

4.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.45

1.15

2.1

3.2

132.3

128.7

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.45

1.15

1.3

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.14

1.15

1.3

1.5

—

(40761536) Microorganisms panel - Urine sediment

2.15

1.11

7.7

3.8

—

(3049717) Cytology report of Urine Cyto stain

2.40

1.06

1.6

3.2

—

(3035350) Ketones [Presence] in Urine by Test strip

221

1.71

1.04

7.4

4.5

0.0

estimate

—

(4035726)

1.92

1.01

1.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.05

0.87

21.8

10.1

—

(3017732) Neutrophils [#/volume] in Blood

0.00

0.80

0.0

3.0

—

3.5

—

(40761511) CBC panel - Blood by Automated count

460

0.55

0.79

27.8

16.1

—

(3010813) Leukocytes [#/volume] in Blood

479

0.55

0.73

52.9

25.6

7.8

6.6

e9/l

1.57

463

(3000963) Hemoglobin [Mass/volume] in Blood

479

0.55

0.73

53.3

25.6

130.1

133.6

g/l

0.76

470

(3026361) Erythrocytes [#/volume] in Blood

479

0.55

0.73

52.9

25.5

4.3

4.4

e12/l

0.53

463

(3024731) MCV [Entitic volume]

479

0.55

0.73

52.8

25.4

92.4

91.9

0.25

469

(3035941) MCH [Entitic mass]

479

0.55

0.73

52.8

25.3

30.5

0.01

469

(3013707) Erythrocyte sedimentation rate by Westergren method

337

1.63

0.73

9.6

4.6

16.5

12.6

mm/h

0.97

303

(3007461) Platelets [#/volume] in Blood

478

0.57

0.72

53.0

25.5

251.5

244.4

e9/l

0.22

463

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.87

0.68

2.8

3.4

44.1

39.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.80

0.65

2.4

3.2

24.9

25.1

mmol/l

—

(36660697) Celiac disease serology panel - Serum

1.80

0.65

1.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.59

0.65

4.4

2.3

—

(3002385) Erythrocyte distribution width [Ratio]

375

1.62

0.62

46.5

21.7

14.8

14.0

1.56

368

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.62

0.0

1.0

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.62

0.0

4.5

—

0.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.61

0.0

5.4

—

(40768804) Tissue Pathology biopsy report

184

1.45

0.58

2.0

1.9

—

(1761868) Lipid panel - Serum or Plasma

153

0.64

0.56

2.5

3.6

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.56

0.53

1.2

2.0

1.9

1.5

—

(3032080) INR in Blood by Coagulation assay

216

1.41

0.52

18.0

11.0

1.2

1.3

inr

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

471

0.67

0.48

28.2

12.1

24.0

24.6

u/l

0.13

454

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.45

0.44

1.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

47.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.41

0.0

1.9

—

(4034850)

0.00

0.41

0.0

7.4

—

(3022313) Gas panel - Capillary blood

0.00

0.40

0.0

1.8

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.40

0.0

1.3

—

(40761535) Cells panel - Urine sediment

1.47

0.40

9.2

3.9

—

(3022145) Colonoscopy Study observation

1.34

0.32

1.3

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

221

1.25

0.28

2.6

2.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

384

1.32

0.27

50.3

18.6

38.9

39.2

0.12

253

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.5

—

4.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.5

—

107.8

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.20

0.0

4.2

—

26.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.20

0.20

1.3

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

207

1.20

0.20

5.6

4.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

461

0.82

0.19

42.4

20.8

83.9

81.5

umol/l

0.28

461

(3044640) Blood type and Crossmatch panel - Blood

140

1.21

0.18

5.3

2.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

328

0.86

0.14

4.6

4.3

15.3

15.0

pmol/l

0.21

287

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

173

1.15

0.13

8.6

4.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

144

1.16

0.12

2.9

4.2

1.2

8.0

mg/mmol

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.15

0.10

1.0

1.3

—

(3012516) Albumin [Mass/volume] in Urine

136

1.14

0.10

2.9

3.3

6.0

60.8

mg/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.10

0.10

2.4

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.07

0.10

1.4

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

130

1.11

0.05

5.6

4.6

—

(3003694) ABO and Rh group [Type] in Blood

118

0.91

0.03

1.5

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

123

1.08

0.02

12.2

4.7

0.0

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

125

0.95

0.00

2.8

5.0

18.6

21.4

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

0.5

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.0

—

418.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

14.5

—

(4146454)

0.00

0.0

2.7

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.1

—

85.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

3.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD and mortality.

Females

Parameter	HR [95% CI]	p-value
CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD	2.051 [1.56, 2.7]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.297

During the follow-up period (1.1.1998 — 31.12.2019), 160 out of 262 females with CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD.

N-year risk	Females	Males
1	0.17%	No data
5	1.353%	No data
10	3.344%	No data
15	6.493%	No data
20	11.182%	No data

Relationships between endpoints

↥

Index endpoint: CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD – Chronic drug-induced interstitial lung disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic drug-induced interstitial lung disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints