parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- L12_PAPULOSQUAMOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L41
- Name in latin
- Pityriasis lichenoides chronica
Similar endpoints
↥List of similar endpoints to
Pityriasis lichenoides chronica
based on the number of shared cases.
Similar with more cases:
- Parapsoriasis
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1094 | 573 | 516 |
| Only index persons | 1012 | 541 | 471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 47.37 | 51.09 | 43.22 |
| Only index persons | 46.68 | 50.15 | 42.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 69 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 55.49 | 52.79 | 58.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 126
- Matched controls
- 1260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L41.1
ICD-10 Finland
Pityriasis lichenoides chronica
+∞
170.9
122
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
20.7
38.8
62
56
E0000UV
ATC
NA
6.6
21.6
89
336
L30.9
ICD-10 Finland
Dermatitis, unspecified
7.5
20.5
57
125
D07AB02
ATC
hydrocortisone butyrate; topical
6.0
19.1
70
217
D07AC01
ATC
betamethasone; topical
5.5
17.9
75
266
D07AB08
ATC
desonide; topical
8.0
15.8
38
64
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
84.2
13.9
15
*
D07AC13
ATC
mometasone; topical
4.5
13.7
63
227
D07AD01
ATC
clobetasol; topical
6.1
13.7
41
92
E000001
ATC
NA
4.7
12.1
48
146
L41.4
ICD-10 Finland
Large plaque parapsoriasis
+∞
11.6
11
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
47.9
11.1
13
*
E000002
ATC
NA
5.6
10.2
31
69
D07BA04
ATC
hydrocortisone and antiseptics; topical
5.8
9.9
29
62
L41.0
ICD-10 Finland
Pityriasis lichenoides et varioliformis acuta
+∞
8.4
8
*
XQ848
NOMESCO Finland
Dermatological photography
15.9
8.4
13
9
D07AA02
ATC
hydrocortisone; topical
4.3
8.1
31
88
D02AE01
ATC
carbamide; topical
6.4
7.8
20
36
E000007
ATC
NA
7.8
7.3
16
23
D09AB01
ATC
zinc bandage without supplements; topical
17.9
6.9
10
6
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.7
6.6
29
93
L43.8
ICD-10 Finland
Other lichen planus
73.4
6.5
7
*
Mortality – FinRegistry
↥Association
Association between endpoint L12_PARAPSO_PITYLICHCHRON and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PARAPSO_PITYLICHCHRON | 1.103 [0.81, 1.5] | 0.535 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 434 males with L12_PARAPSO_PITYLICHCHRON died.
Mortality risk
Mortality risk for people of age
years, who have L12_PARAPSO_PITYLICHCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.262% |
| 5 | No data | 1.381% |
| 10 | No data | 3.296% |
| 15 | No data | 5.941% |
| 20 | No data | 10.029% |
Relationships between endpoints
↥Index endpoint: L12_PARAPSO_PITYLICHCHRON – Pityriasis lichenoides chronica
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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