Pre-eclampsia or eclampsia

O15_PRE_OR_ECLAMPSIA

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule

Sex only females

230709

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Check conditions None

230709

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O11, O14, O15
Hospital discharge: ICD-9 642[4-7]
Hospital discharge: ICD-8 6370[349]|63710|63799|66120
Cause of death: ICD-10 O11, O14, O15
Cause of death: ICD-9 642[4-7]
Cause of death: ICD-8 6370[349]|63710|63799|66120

2 out of 7 registries used, show all original rules.

7779

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Check minimum number of events None

7779

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Include endpoints None

7779

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Remove individuals based on genotype QC

7212

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O15_PRE_OR_ECLAMPSIA

Control definitions

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

Key figures

All Female Male
Number of individuals 7212 7212 -
Unadjusted prevalence (%) 1.91 3.42 -
Mean age at first event (years) 29.03 29.03 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.63 [0.44, 0.89] 8.4e-3 130
15 years 0.00 0.36 [0.23, 0.57] 9.0e-6 33
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 3

Survival analyses between endpoints

Plot

before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

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Drugs most likely to be purchased after Pre-eclampsia or eclampsia