Pre-eclampsia superimposed on chronic hypertension

O15_PREECLAMPS_CHRONIC_HYPERT

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O11
  • Cause of death: ICD-10 O11

2 out of 7 registries used, show all original rules.

214

4. Check minimum number of events

None

214

5. Include endpoints

None

214

6. Filter based on genotype QC (FinnGen only)

208

Control definitions (FinnGen only)

Control exclude
O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O10-O16
Name in latin
Hypertensio prae-existens cum proteinuria superposita

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1336 1336 -
Only index persons 1325 1325 -
Unadjusted period prevalence (%)
Whole population 0.04 0.04 -
Only index persons 0.05 0.05 -
Median age at first event (years)
Whole population - 32.55 -
Only index persons - 32.55 -

-FinnGen-

Key figures

All Female Male
Number of individuals 208 208 -
Unadjusted period prevalence (%) 0.07 0.07 -
Median age at first event (years) 33.15 33.15 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
214
Matched controls
2140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O11
ICD-10 Finland
Pre-eclampsia superimposed on chronic hypertension
+∞
309.9
214
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
137.9
117
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1884.1
114.6
101
*
C09AA02
ATC
enalapril; systemic
17.4
73.1
69
57
205
Kela drug reimbursment
Chronic hypertension
19.4
71.2
62
44
I10
ICD-10 Finland
Essential (primary) hypertension
11.4
68.9
154
392
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
55.7
51
*
C07AG01
ATC
labetalol; systemic
183.8
54.8
55
*
C08CA05
ATC
nifedipine; systemic
20.0
50.0
41
25
C08CA01
ATC
amlodipine; oral
7.1
42.5
88
191
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.8
36.6
111
336
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
392.0
33.9
33
*
C07AB02
ATC
metoprolol; systemic
6.4
29.2
59
121
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
28.8
27
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
5.0
28.6
90
272
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
4.8
27.3
88
270
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
5.3
26.2
67
169
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
10.2
23.5
28
31
K85
ICPC
Elevated blood pressure
6.5
23.0
42
77
103
Kela drug reimbursment
Diabetes, insulin-treated
4.6
20.8
61
170
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.5
19.9
60
170
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.4
19.6
27
36
C07AB07
ATC
bisoprolol; oral
3.6
18.5
95
389
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.4
17.5
27
41
C09CA03
ATC
valsartan; oral
8.3
17.3
24
32
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.7
16.5
28
47
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
3.6
16.3
71
258
A10BJ06
ATC
semaglutide; parenteral
7.1
15.7
25
39
C09CA01
ATC
losartan; oral
4.0
15.3
51
154
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.1
14.9
110
545
O60
ICD-10 Finland
Preterm labour and delivery
6.0
14.4
27
50
A10AC01
ATC
insulin (human); parenteral
4.6
14.0
37
93
A10BA02
ATC
metformin; oral
3.4
13.4
60
219
C09AA05
ATC
ramipril; oral
4.6
13.4
35
87
W84
ICPC
Pregnancy high risk
4.8
13.2
32
75
E66.8
ICD-10 Finland
Other obesity
4.3
13.1
38
103
A10AB05
ATC
insulin aspart; parenteral
5.7
13.1
26
51
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.6
13.0
50
165
E66.01
ICD-10 Finland
Obesity due to excess calories
3.6
13.0
51
171
A10AB04
ATC
insulin lispro; parenteral
6.5
12.9
22
37
A10AE04
ATC
insulin glargine; parenteral
5.1
12.8
29
64
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
12.6
12
*
C09BA02
ATC
enalapril and diuretics; systemic
15.9
12.0
19
13
E66.00
ICD-10 Finland
Metabolic syndrome
5.9
11.6
22
41
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
4.7
11.2
28
67
B01AB05
ATC
enoxaparin; parenteral
2.8
10.8
73
334
O82.0
ICD-10 Finland
Delivery by elective caesarean section
3.7
10.7
37
113
T90
ICPC
Diabetes non-insulin dependent
3.6
10.7
40
129
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
15.3
10.7
17
12
C09DA01
ATC
losartan and diuretics; oral
5.1
10.5
23
49
O10.1
ICD-10 Finland
Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium
+∞
10.5
10
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.6
10.4
102
560
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.4
9.9
41
141
C08CA13
ATC
lercanidipine; oral
4.7
9.9
24
56
T89
ICPC
Diabetes insulin dependent
5.5
9.6
19
37
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
3.3
9.3
39
135
C10AA05
ATC
atorvastatin; oral
3.0
9.3
47
182
A10BH01
ATC
sitagliptin; oral
5.1
9.3
20
42
C09CA06
ATC
candesartan; oral
2.7
9.1
60
268
C03AA03
ATC
hydrochlorothiazide; oral
8.6
9.1
19
24
SPAT1262
SPAT
Handing over of treatment supplies
3.3
8.9
36
122
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
4.9
8.8
20
44
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.2
8.8
38
134
C09DA03
ATC
valsartan and diuretics; oral
12.3
8.7
15
13
A10AE05
ATC
insulin detemir; parenteral
5.2
8.5
18
37
O16
ICD-10 Finland
Unspecified maternal hypertension
+∞
8.4
8
*
6420X
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
8.4
8
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.9
8.3
19
42
A10AB01
ATC
insulin (human); parenteral
6.6
8.1
20
33
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.5
8.0
18
26
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
15.8
7.8
12
8
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.5
7.8
60
287
MAA00
NOMESCO Finland
Amniocentesis
4.4
7.7
20
49
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
4.0
7.7
23
63
K86
ICPC
Hypertension uncomplicated
6.4
7.6
19
32
H04AA01
ATC
glucagon; nasal, parenteral
7.8
7.3
16
22
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
31.2
7.2
9
*
ZXD05
NOMESCO Finland
Urgent procedure
2.2
7.0
93
560
WX320
NOMESCO Finland
Spinalanesthesy
2.4
6.8
59
296
C09DA06
ATC
candesartan and diuretics; oral
5.9
6.8
18
33
E66
ICD-10 Finland
Obesity
3.3
6.8
27
90
H3603, E103,
ICD-10 Finland
23.4
6.7
9
*
XMA22
NOMESCO Finland
General examination of pregnant woman
2.6
6.7
45
201
C07AB08
ATC
celiprolol; oral
71.9
6.5
7
*
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
3.4
6.4
24
77
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.7
6.4
12
13
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
3.9
6.4
19
52
6424A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]
+∞
6.3
6
*
C02EA02, ,
ATC
+∞
6.3
6
*
SPAT1263
SPAT
Sampling
2.1
6.3
96
603
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.1
6.2
125
866
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.1
6.2
27
95
MAC96
NOMESCO Finland
Other induction or advancement of labour
3.4
6.1
22
69
E66.9
ICD-10 Finland
Obesity, unspecified
3.8
6.0
19
54

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
250
6.76
42.63
5.9
2.7
178.13
334.01
mg/l
0.21
83
154
102
263
6.50
41.00
6.9
3.2
39.90
4.48
mg/mmol
2.42
84
157
108
329
5.61
35.11
5.6
2.4
7.46
7.93
mmol/l
0.56
99
294
85
455
2.44
8.81
8.2
5.5
1.01
1.02
inr
0.07
22
155
184
1463
2.84
6.89
7.1
3.7
42.06
36.93
mmol/mol
6.75
178
1411
72
402
2.19
6.42
2.2
1.7
1.12
0.57
mg/l
1.21
52
292
100
637
2.07
6.30
8.0
4.8
1.21
1.22
mmol/l
0.58
87
551
118
803
2.05
6.16
5.7
3.5
7.25
6.09
mmol/l
3.63
107
720
40
187
2.40
5.34
3.4
2.0
2.47
2.50
g/l
0.10
35
176
139
1041
1.96
5.12
2.9
2.6
—
—
—
0
0
35
160
2.42
4.89
2.9
1.8
28.80
29.63
s
0.49
35
155
43
220
2.19
4.63
1.2
1.3
104.84
165.50
iu/ml
0.81
19
100
39
194
2.24
4.49
3.7
2.8
0.90
0.83
mmol/l
0.46
39
186
82
539
1.85
4.34
1.9
1.8
100.56
98.21
pmol/l
0.19
51
313
16
51
3.31
4.30
17.3
5.3
—
—
—
0
0
151
1205
1.86
4.11
5.1
3.4
—
—
—
0
0
81
542
1.80
3.98
3.2
1.8
—
—
—
0
0
67
426
1.83
3.88
2.4
2.4
13.46
18.89
ng/l
0.27
32
134
27
123
2.37
3.80
4.0
3.8
—
—
—
0
0
12
31
4.04
3.55
10.8
1.7
22.91
23.53
mmol/l
0.33
12
31
52
314
1.87
3.51
3.8
2.4
—
—
—
0
0
12
33
3.79
3.35
2.7
2.7
1.13
0.23
g/l
—
5
11
152
1251
1.74
3.33
8.0
6.3
74.86
71.33
u/l
0.71
144
1180
73
497
1.71
3.27
1.8
1.6
—
—
—
0
0
189
1668
2.14
3.26
4.1
2.9
1.43
1.17
mmol/l
5.61
180
1598
196
1756
2.38
3.23
5.2
3.3
2.94
2.94
mmol/l
0.03
186
1698
194
1734
2.27
3.16
4.7
3.2
1.34
1.56
mmol/l
13.89
185
1678
9
20
4.65
3.15
1.0
1.2
—
—
—
0
0
194
1741
2.22
3.01
4.7
3.2
4.71
4.87
mmol/l
1.74
186
1688
62
412
1.71
3.00
2.6
1.9
—
—
—
0
0
54
350
1.73
2.85
3.8
2.2
0.56
0.23
e6/l
0.32
35
257
12
39
3.20
2.82
3.1
3.2
—
—
—
0
0
5
6
8.49
2.76
1.0
1.0
179.20
162.94
mmol/24h
—
5
6
9
24
3.87
2.70
1.1
1.1
—
—
nmol/l
—
0
0
9
24
3.87
2.70
1.1
1.1
—
—
—
0
0
6
11
5.58
2.56
3.3
1.9
—
—
—
0
0
92
699
1.55
2.53
2.9
2.5
5.68
5.84
ph
0.28
11
79
14
57
2.56
2.50
7.9
2.0
5.05
4.92
kpa
0.06
14
57
108
856
1.53
2.42
3.7
2.7
0.00
0.00
estimate
-0.00
27
172
204
1898
2.60
2.40
16.6
9.0
68.52
65.00
umol/l
0.73
204
1898
109
867
1.52
2.40
3.7
2.7
0.00
0.00
estimate
-0.00
27
161
43
276
1.70
2.33
1.9
2.1
—
—
—
0
0
107
855
1.50
2.26
5.1
3.9
0.00
0.01
estimate
0.50
26
165
10
35
2.95
2.24
1.6
1.5
—
—
—
0
0
5
9
5.66
2.22
6.6
1.6
61.60
68.67
%
—
5
9
5
9
5.66
2.22
1.4
1.6
55.00
76.44
nmol/24h
—
5
9
21
109
2.03
2.19
2.4
4.4
0.00
0.26
%
0.59
12
27
55
382
1.59
2.19
6.5
2.9
7.40
7.40
ph
0.24
12
64
71
524
1.53
2.17
3.0
2.2
—
—
—
0
0
53
368
1.59
2.11
3.8
2.2
—
—
—
0
0
56
394
1.57
2.11
2.1
2.0
3.09
2.60
mg/l
0.88
49
339
57
404
1.56
2.08
2.1
1.5
1.40
1.39
mmol/l
0.04
48
375
41
269
1.65
2.05
1.3
1.4
426.40
427.06
pmol/l
0.01
35
249
174
1558
1.62
2.04
5.4
4.4
14.25
14.13
pmol/l
0.31
167
1494
22
120
1.93
2.01
2.9
4.2
1.54
1.04
%
0.25
13
37
21
113
1.95
2.00
2.8
4.0
0.46
1.14
%
0.81
13
32
29
175
1.76
1.95
2.4
1.4
—
—
—
0
0
30
183
1.74
1.95
1.5
1.7
1071.59
1142.44
nmol/l
0.17
22
147
21
116
1.90
1.86
1.5
1.4
—
—
—
0
0
24
139
1.82
1.85
4.8
2.7
—
—
—
0
0
29
178
1.73
1.85
1.7
2.6
3.47
4.89
umol/l
2.36
19
155
21
117
1.88
1.82
1.5
1.4
—
—
—
0
0
7
23
3.11
1.81
1.1
1.1
—
—
—
0
0
21
118
1.86
1.78
1.5
1.4
—
—
—
0
0
20
111
1.88
1.75
1.5
1.4
—
—
—
0
0
5
13
3.91
1.72
4.0
3.0
39.44
14.24
mu/l
—
5
13
43
299
1.55
1.69
1.7
1.4
17.26
21.69
nmol/l
1.27
38
274
30
191
1.66
1.68
2.7
1.9
—
—
—
0
0
41
286
1.54
1.59
1.7
1.4
—
—
—
0
0
6
20
3.06
1.59
1.3
1.2
—
—
—
0
0
20
115
1.82
1.59
1.5
1.4
—
—
—
0
0
195
1830
1.74
1.50
14.4
9.2
16.11
15.98
mg/l
0.02
168
1352
52
390
1.44
1.42
3.9
2.3
24.69
83.18
e6/l
0.81
34
292
7
29
2.46
1.40
1.7
1.3
0.53
1.66
ug/l
—
7
24
9
41
2.25
1.39
2.0
5.0
—
—
—
0
0
179
1656
1.49
1.36
4.6
3.2
6.00
5.51
mmol/l
4.28
165
1585
38
270
1.50
1.36
3.4
2.1
10.73
10.81
e6/l
0.01
31
240
66
521
1.39
1.35
4.7
2.7
23.39
29.99
e6/l
0.20
40
322
19
114
1.73
1.33
3.1
4.3
0.00
0.16
%
—
10
31
37
264
1.49
1.30
4.5
3.0
—
—
—
0
0
23
149
1.61
1.23
3.9
2.3
33.28
34.07
u/l
0.04
18
126
31
216
1.51
1.22
4.2
2.6
4554.31
255.31
ng/l
0.44
13
93
55
431
1.37
1.17
4.4
2.8
0.00
0.01
estimate
0.80
26
166
5
20
2.53
1.15
2.2
4.2
3.76
3.63
mmol/l
—
5
20
5
20
2.53
1.15
1.2
1.3
—
—
—
0
0
8
40
2.04
1.13
2.1
4.1
23.45
24.63
mmol/l
—
8
40
27
186
1.52
1.13
1.7
1.2
—
—
—
0
0
52
407
1.37
1.11
1.3
1.3
13.96
21.35
iu/ml
0.87
22
139
64
520
1.33
1.08
1.6
1.2
0.57
2.18
u/ml
1.13
17
137
7
35
2.03
1.01
1.0
1.3
—
—
—
0
0
46
359
1.36
1.00
3.1
2.7
1.02
1.02
kg/l
—
9
41
55
442
1.33
0.99
1.6
1.3
2.51
2.05
g/l
1.16
35
275
177
1661
1.38
0.99
16.9
11.4
14.66
14.01
%
0.83
177
1646
7
36
1.98
0.98
11.1
1.9
0.56
0.70
%
—
7
36
7
37
1.92
0.95
15.0
7.5
1.41
1.34
%
—
7
37
7
37
1.92
0.95
17.0
7.5
95.50
94.86
%
—
7
37
7
37
1.92
0.95
17.0
7.5
0.69
0.72
%
—
7
37
10
55
1.86
0.93
1.6
1.2
—
—
—
0
0
203
1959
1.71
0.93
15.8
8.5
—
—
—
0
0
26
186
1.45
0.92
3.0
1.9
4.20
4.63
e6/l
—
10
90
41
320
1.35
0.90
1.5
1.4
1360.00
491.27
titre
—
9
71
73
620
1.27
0.87
1.9
1.8
—
—
—
0
0
15
97
1.59
0.84
1.1
1.1
—
—
—
0
0
51
417
1.29
0.82
1.5
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
20.3
—
1848.71
—
0
24
5
24
2.11
0.75
2.2
4.5
1.42
1.35
mmol/l
—
5
24
5
24
2.11
0.75
2.0
2.9
—
—
—
0
0
7
39
1.82
0.73
11.1
1.9
1.30
1.39
%
—
7
39
7
41
1.73
0.70
1.1
1.1
—
—
—
0
0
15
102
1.51
0.69
17.5
5.2
104.00
104.79
mmol/l
0.19
15
102
18
246
0.71
0.67
1.8
1.8
—
—
—
0
0
5
28
1.80
0.66
11.0
3.9
—
—
—
0
0
85
759
1.20
0.61
2.4
2.1
—
—
—
0
0
8
51
1.59
0.61
7.1
6.8
—
—
—
0
0
10
64
1.59
0.59
1.8
1.2
2.10
1.86
u/ml
—
5
5
0
23
0.00
0.58
0.0
16.5
—
999.70
—
0
23
43
360
1.24
0.58
4.0
2.9
—
—
—
0
0
12
82
1.49
0.55
1.5
1.2
—
—
—
0
0
6
38
1.60
0.55
16.8
7.6
—
—
—
0
0
14
100
1.43
0.53
1.0
1.4
—
—
—
0
0
69
612
1.19
0.53
2.0
1.6
—
—
—
0
0
38
318
1.24
0.52
1.3
1.3
—
—
—
0
0
7
47
1.51
0.48
1.1
2.2
—
—
—
0
0
10
141
0.69
0.46
1.1
1.2
—
—
—
0
0
8
57
1.42
0.42
1.1
1.5
—
—
—
0
0
22
177
1.27
0.42
1.5
1.4
—
—
—
0
0
97
899
1.14
0.41
5.8
5.6
0.04
0.04
e9/l
0.77
82
793
0
18
0.00
0.40
0.0
2.3
—
1.12
—
0
18
0
18
0.00
0.40
0.0
2.3
—
6.49
—
0
18
14
180
0.76
0.38
1.3
1.4
—
—
—
0
0
5
37
1.36
0.37
1.4
1.1
—
—
—
0
0
28
237
1.21
0.36
1.3
1.2
—
—
—
0
0
6
43
1.41
0.35
3.3
2.0
13.67
13.24
%
—
6
43
96
898
1.13
0.34
5.8
5.6
0.57
0.50
e9/l
1.92
82
795
24
201
1.22
0.34
1.3
1.2
—
—
—
0
0
10
74
1.37
0.33
2.3
2.1
2.18
5.40
iu/l
—
5
30
20
165
1.23
0.32
1.8
2.0
25.57
38.33
u/ml
0.33
20
158
13
101
1.31
0.32
1.6
1.4
—
—
—
0
0
40
356
1.15
0.30
1.4
1.4
—
—
—
0
0
30
261
1.17
0.29
4.1
2.2
540.33
545.83
mosm/kgh2o
0.05
24
230
7
56
1.26
0.29
2.1
2.6
54.14
78.28
ng/l
—
7
50
108
1025
1.11
0.29
7.9
8.8
4.42
3.89
e9/l
1.53
94
900
12
95
1.28
0.27
3.5
3.0
—
—
—
0
0
98
930
1.10
0.25
5.8
5.6
2.05
2.00
e9/l
0.20
86
840
16
133
1.22
0.25
1.7
1.3
—
—
—
0
0
16
134
1.21
0.23
1.7
1.3
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
89
845
1.09
0.22
6.4
5.5
7.47
7.77
%
0.41
83
791
92
875
1.09
0.22
6.1
5.3
28.30
29.80
%
0.84
84
823
0
11
0.00
0.21
0.0
1.2
—
109.67
—
0
11
0
11
0.00
0.21
0.0
12.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
30.00
—
0
10
0
10
0.00
0.21
0.0
2.1
—
1.04
—
0
10
0
10
0.00
0.21
0.0
1.8
—
173.50
—
0
10
0
10
0.00
0.21
0.0
2.5
—
1.20
—
0
10
86
817
1.09
0.21
6.2
5.3
0.66
0.71
%
0.38
79
754
0
12
0.00
0.21
0.0
2.2
—
105.33
—
0
12
0
12
0.00
0.21
0.0
2.2
—
3.91
—
0
12
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
10
80
1.26
0.21
2.1
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
87
830
1.08
0.19
2.1
1.8
—
—
—
0
0
90
860
1.08
0.19
6.5
5.6
—
—
—
0
0
10
81
1.25
0.19
1.9
1.7
—
—
—
0
0
44
407
1.10
0.19
1.3
1.3
8.29
9.62
u/ml
0.08
19
170
98
940
1.08
0.19
5.9
6.0
0.22
0.17
e9/l
1.82
87
844
91
871
1.08
0.18
5.8
5.1
57.28
56.75
%
0.17
83
817
16
138
1.17
0.18
1.7
1.4
—
—
—
0
0
8
72
1.12
0.16
1.5
1.3
—
—
—
0
0
88
845
1.07
0.16
6.2
5.3
2.86
2.72
%
0.27
81
791
6
77
0.77
0.16
2.0
1.3
0.54
0.37
nmol/l
—
6
61
80
766
1.07
0.16
10.7
7.1
0.00
0.00
e9/l
0.72
62
623
14
122
1.16
0.14
1.0
1.1
—
—
—
0
0
14
123
1.15
0.13
1.7
1.3
—
—
—
0
0
19
172
1.11
0.12
1.3
1.3
—
—
—
0
0
14
156
0.89
0.10
1.1
1.1
—
—
—
0
0
22
203
1.09
0.10
2.7
2.1
1011.52
2286.99
u/l
—
8
82
5
44
1.14
0.10
1.0
1.8
—
—
—
0
0
6
55
1.09
0.09
1.7
2.1
—
—
—
0
0
5
65
0.76
0.08
1.2
1.6
—
—
—
0
0
13
118
1.11
0.07
1.4
1.1
—
106.00
—
0
5
11
122
0.90
0.07
1.3
1.3
—
—
—
0
0
8
94
0.85
0.07
1.4
3.7
2.42
9.28
ug/l
—
8
69
10
110
0.90
0.05
1.4
1.2
278.80
258.06
miu/ml
—
5
59
48
469
1.03
0.03
5.4
6.4
—
—
—
0
0
18
189
0.95
0.03
1.2
1.3
—
—
—
0
0
10
94
1.07
0.01
2.5
2.2
—
—
—
0
0
22
225
0.98
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
8.40
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
—
10.91
—
0
7
0
9
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.02
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
1.58
—
0
8
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
6.81
—
0
6

Mortality – FinRegistry

Association

Association between endpoint O15_PREECLAMPS_CHRONIC_HYPERT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREECLAMPS_CHRONIC_HYPERT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_PREECLAMPS_CHRONIC_HYPERT – Pre-eclampsia superimposed on chronic hypertension

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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