hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.
Pre-eclampsia superimposed on chronic hypertension
DOID EFO Endpoint Browser PheWeb
O15_PREECLAMPS_CHRONIC_HYPERT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
194 |
4. Check minimum number of eventsNone |
194 |
5. Include endpointsNone |
194 |
6. Filter based on genotype QC (FinnGen only) |
189 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O10-O16
- Name in latin
- Hypertensio prae-existens cum proteinuria superposita
Similar endpoints
↥List of similar endpoints to
Pre-eclampsia superimposed on chronic hypertension
based on the number of shared cases.
Similar with more cases:
- Pre-eclampsia or eclampsia
- Pre-eclampsia or poor fetal growth
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1336 | 1336 | - |
| Only index persons | 1325 | 1325 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | - |
| Only index persons | 0.05 | 0.05 | - |
| Median age at first event (years) | |||
| Whole population | - | 32.55 | - |
| Only index persons | - | 32.55 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 189 | 189 | - |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | - |
| Median age at first event (years) | 33.04 | 33.04 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 194
- Matched controls
- 1940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O11
ICD-10 Finland
Pre-eclampsia superimposed on chronic hypertension
+∞
280.8
194
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
124.9
106
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1583.9
99.2
88
*
I10
ICD-10 Finland
Essential (primary) hypertension
14.2
60.1
136
274
C07AG01
ATC
labetalol; systemic
235.0
52.8
52
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
52.5
48
*
205
Kela drug reimbursment
Chronic hypertension
17.5
35.6
58
46
C09AA02
ATC
enalapril; systemic
12.8
31.4
59
64
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
6.4
29.5
100
277
C08CA01
ATC
amlodipine; oral
8.3
28.5
71
126
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
6.3
26.2
84
210
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
+∞
25.6
24
*
C08CA05
ATC
nifedipine; systemic
16.5
24.6
40
30
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
24.5
23
*
C07AB02
ATC
metoprolol; systemic
8.3
23.9
57
92
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
5.5
22.9
82
227
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
6.1
19.3
58
126
103
Kela drug reimbursment
Diabetes, insulin-treated
6.0
17.2
51
108
C07AB07
ATC
bisoprolol; oral
4.2
17.1
84
301
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.9
16.7
50
107
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
12.9
14.8
26
23
K85
ICPC
Elevated blood pressure
7.3
14.5
36
59
A10BA02
ATC
metformin; oral
4.8
14.2
52
138
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
3.9
13.5
65
223
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.3
13.4
94
432
C09CA01
ATC
losartan; oral
4.7
12.6
46
121
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
40.4
12.4
15
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
4.4
11.9
46
127
E66.01
ICD-10 Finland
Obesity due to excess calories
4.7
11.9
43
111
C09BA02
ATC
enalapril and diuretics; systemic
20.5
11.8
17
9
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
11.6
11
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
9.8
11.1
22
25
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.9
11.0
93
468
C09DA03
ATC
valsartan and diuretics; oral
23.1
10.9
15
7
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.0
10.8
20
20
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.6
10.5
19
18
O10.1
ICD-10 Finland
Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium
+∞
10.5
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.9
10.4
29
56
C09AA05
ATC
ramipril; oral
5.2
10.0
31
68
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.9
9.9
33
78
B01AB05
ATC
enoxaparin; parenteral
3.2
9.9
61
246
SPAT1262
SPAT
Handing over of treatment supplies
4.6
9.8
35
89
T90
ICPC
Diabetes non-insulin dependent
4.6
9.7
34
85
C03AA03
ATC
hydrochlorothiazide; oral
9.8
9.3
18
20
E66.8
ICD-10 Finland
Other obesity
4.9
8.9
29
67
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
7.6
8.8
20
29
A10AE04
ATC
insulin glargine; parenteral
6.2
8.8
23
41
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
6.2
8.8
23
41
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
8.0
8.7
19
26
C09CA03
ATC
valsartan; oral
7.3
8.6
20
30
C09CA06
ATC
candesartan; oral
3.2
8.5
50
192
O16
ICD-10 Finland
Unspecified maternal hypertension
+∞
8.4
8
*
A10BJ06
ATC
semaglutide; parenteral
11.5
7.9
14
13
O60
ICD-10 Finland
Preterm labour and delivery
5.1
7.8
24
52
ZXD05
NOMESCO Finland
Urgent procedure
2.4
7.8
86
478
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.7
7.7
17
24
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
5.2
7.6
23
49
XMA22
NOMESCO Finland
General examination of pregnant woman
3.1
7.5
43
163
C09DA01
ATC
losartan and diuretics; oral
6.3
7.4
19
33
E66.00
ICD-10 Finland
Metabolic syndrome
6.3
7.4
19
33
6420X
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
7.3
7
*
H3603, E103
ICD-10 Finland
NA
31.3
7.2
9
*
H04AA01
ATC
glucagon; nasal, parenteral
9.3
7.2
14
16
O82.0
ICD-10 Finland
Delivery by elective caesarean section
3.5
7.2
33
106
A10AE05
ATC
insulin detemir; parenteral
6.8
7.1
17
27
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.4
7.1
35
119
C09DA06
ATC
candesartan and diuretics; oral
8.0
7.0
15
20
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
6.1
7.0
18
32
W84
ICPC
Pregnancy high risk
4.0
6.9
27
75
J01DB01
ATC
cefalexin; oral
3.0
6.8
173
1417
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
12.9
6.7
11
9
T89
ICPC
Diabetes insulin dependent
5.9
6.5
17
31
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
11.6
6.4
11
10
WX320
NOMESCO Finland
Spinalanesthesy
2.6
6.4
51
236
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
27.7
6.3
8
*
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
5.3
6.2
18
37
A10BK03
ATC
empagliflozin; oral
6.4
6.1
15
25
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
3.1
6.1
34
125
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.5
6.0
53
257
Mortality – FinRegistry
↥Association
Association between endpoint O15_PREECLAMPS_CHRONIC_HYPERT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_PREECLAMPS_CHRONIC_HYPERT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_PREECLAMPS_CHRONIC_HYPERT – Pre-eclampsia superimposed on chronic hypertension
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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