Eclampsia

O15_ECLAMPSIA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O15 Hospital discharge: ICD-9 — 6426 Cause of death: ICD-10 — O15 Cause of death: ICD-9 — 6426 2 out of 7 registries used, show all original rules.	93
4. Check minimum number of events None	93
5. Include endpoints None	93
6. Filter based on genotype QC (FinnGen only)	93

Control definitions (FinnGen only)

Control exclude: O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF10
Parent code in ICD-10: O10-O16
Name in latin: Eclampsia

NAME	O15_ECLAMPSIA
CONTROL_EXCLUDE	O15_OEDEM_PROTUR_HYPERT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O15
HD_ICD_9	6426
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O15
COD_ICD_9	6426
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Eclampsia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	602	602	-
Only index persons	597	597	-
Unadjusted period prevalence (%)
Whole population	0.02	0.02	-
Only index persons	0.02	0.02	-
Median age at first event (years)
Whole population	-	28.59	-
Only index persons	-	28.56	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	93	93	-
Unadjusted period prevalence (%)	0.03	0.03	-
Median age at first event (years)	29.23	29.23	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
85: Matched controls
848

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O15.0

ICD-10 Finland

Eclampsia in pregnancy

+∞

31.2

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

+∞

28.8

6426A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , ENNEN SYNNYTYSTÄ]

+∞

17.3

O15.1

ICD-10 Finland

Eclampsia in labour

+∞

16.1

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

+∞

13.9

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

+∞

11.7

6426B

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , SYNNYTYKSEN AIKANA]

+∞

11.7

O14.1

ICD-10 Finland

Severe pre-eclampsia

+∞

10.6

O15.2

ICD-10 Finland

Eclampsia in the puerperium

+∞

10.6

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

45.9

10.3

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

4.7

8.6

106

C07AG01

ATC

labetalol; systemic

+∞

8.5

8811

FHL

Cesarean section

7.6

7.4

6462A

ICD-9 Finland

Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension

+∞

7.4

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

4.7

6.9

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

131

3.35

6.73

1.4

1.5

222.9

629.1

titre

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

283

2.90

5.97

8.4

5.2

1.2

mmol/l

0.74

252

(3020682) Albumin/Creatinine [Ratio] in Urine

141

3.08

5.86

5.8

3.5

22.2

5.4

mg/mmol

0.51

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.82

5.35

9.7

4.3

1.0

mmol/l

0.07

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

162

2.86

5.32

2.2

1.8

1.7

0.7

mg/l

1.76

128

(3023368) Bacteria identified in Blood by Culture

128

2.84

4.75

3.0

3.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

177

2.57

4.36

1.4

1.3

12.1

27.0

iu/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

362

2.48

4.33

4.5

3.8

—

(3018418) pH of Serum or Plasma

170

2.58

4.33

4.9

3.0

7.4

—

(3012516) Albumin [Mass/volume] in Urine

136

2.65

4.18

5.1

2.9

1791.9

641.4

mg/l

0.28

(3022948) Iron [Moles/volume] in Serum or Plasma

2.86

4.01

3.8

2.0

13.8

15.1

umol/l

0.34

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.86

3.89

3.7

1.8

2.5

g/l

0.09

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

196

2.37

3.74

1.9

2.5

7.8

16.7

ng/l

4.17

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

103

2.64

3.59

2.0

3.3

10.7

39.7

ng/l

1.10

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

178

2.32

3.46

1.5

1.2

1.7

9.1

u/ml

1.48

(3026008) Bacteria identified in Urine by Culture

198

2.23

3.26

2.9

2.2

—

(3001604) Monocytes [#/volume] in Blood

376

2.13

3.13

5.6

6.0

0.5

e9/l

0.44

338

(3032080) INR in Blood by Coagulation assay

185

2.21

3.12

2.5

3.9

1.0

inr

0.52

(3006315) Basophils [#/volume] in Blood

377

2.12

3.10

5.6

6.0

0.0

e9/l

0.33

337

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.21

3.08

1.6

1.3

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

10.46

3.01

1.0

1.8

11.4

10.4

umol/l

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

5.04

2.99

1.6

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.59

2.90

1.3

1.7

—

(3003396) Base excess in Arterial blood by calculation

2.85

2.47

7.6

6.5

1.1

1.7

mmol/l

0.24

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

160

2.07

2.46

2.4

1.7

—

(3044889) 12 lead EKG panel

468

1.97

2.43

3.2

2.6

—

(3000991) Gas panel - Venous blood

3.45

2.38

8.9

5.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

214

1.93

2.26

1.3

1.2

0.6

1.6

u/ml

1.03

(3007853) Bacteria identified in Skin by Aerobe culture

2.37

2.24

1.9

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.50

2.19

2.0

1.4

—

(3019060) Gas panel - Arterial blood

3.40

2.15

8.4

5.3

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.83

2.08

1.7

2.3

0.2

g/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.55

2.05

1.3

1.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.52

2.01

4.9

8.3

0.9

0.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.52

2.01

4.9

8.3

94.7

94.9

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.52

2.01

4.9

8.3

1.4

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

4.73

1.96

1.2

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.45

1.90

1.2

1.7

—

(40761535) Cells panel - Urine sediment

2.74

1.86

6.8

3.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

501

1.80

1.85

5.8

4.0

—

39.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.92

1.84

1.6

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.20

1.84

1.1

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.20

1.84

2.3

2.0

81.7

106.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.49

1.77

1.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.82

1.77

5.4

1.8

5.2

5.6

kpa

—

(3029937) Albumin [Presence] in Urine by Test strip

187

1.80

1.74

4.2

2.8

0.0

estimate

—

(3020891) Body temperature

4.00

1.74

4.2

4.9

—

(3018405) Lactate [Moles/volume] in Arterial blood

4.00

1.74

3.8

4.7

1.7

1.0

mmol/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

154

1.85

1.73

5.8

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

539

1.77

1.70

5.7

3.9

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.30

1.69

6.0

1.4

24.3

24.8

mmol/l

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.64

1.64

1.1

1.2

—

15.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.64

1.64

1.4

2.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.27

1.63

1.5

1.3

1078.9

101.7

u/ml

0.61

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.13

1.61

10.7

8.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.55

1.58

2.1

1.3

—

(3025941) Bacteria identified in Stool by Culture

2.31

1.57

1.4

1.1

—

(42870588) Differential panel, method unspecified - Blood

245

1.69

1.56

5.3

5.7

—

(3044640) Blood type and Crossmatch panel - Blood

228

1.69

1.54

2.9

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.46

1.54

1.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

220

1.69

1.52

5.1

2.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.84

1.46

1.3

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.84

1.46

1.3

1.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.84

1.46

2.3

2.5

155.7

141.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.72

1.39

6.0

4.0

24.0

25.0

mmol/l

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.72

1.39

1.3

1.2

—

(3003694) ABO and Rh group [Type] in Blood

252

1.62

1.38

1.9

1.7

—

(40768793) Breast Pathology biopsy report

0.00

1.38

0.0

1.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

182

1.68

1.37

2.0

1.8

92.0

109.8

u/l

0.32

176

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.87

1.30

1.0

1.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.27

1.25

7.5

1.8

6.0

5.6

kpa

—

(3002032) Base excess in Venous blood by calculation

2.27

1.25

7.5

1.8

1.3

2.1

mmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

206

1.59

1.19

1.8

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

180

1.62

1.18

5.3

4.5

—

(3042936) Bacteria identified in Isolate by Culture

1.86

1.17

1.5

2.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.58

1.16

3.2

1.5

0.9

0.7

—

(3012544) pH of Venous blood

2.09

1.15

7.5

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.44

1.15

1.7

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.36

1.13

1.9

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.04

1.12

2.5

1.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

774

1.88

1.11

15.6

8.5

139.4

139.8

mmol/l

1.23

755

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

236

1.54

1.11

2.0

1.9

111.4

100.4

pmol/l

0.46

125

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.28

1.11

1.4

1.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.46

1.10

3.2

1.6

1.3

0.9

—

(3007164) IgA [Mass/volume] in Serum or Plasma

201

1.56

1.09

1.3

1.8

2.1

g/l

0.76

126

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

2.11

1.08

1.4

1.6

—

(3045414) Leukocytes [Presence] in Urine

2.14

1.05

3.1

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.14

1.05

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

372

1.47

1.01

5.4

3.0

0.0

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

296

1.48

1.01

4.9

2.8

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

778

1.82

1.00

15.8

8.5

3.9

mmol/l

0.11

756

(3023511) Choriogonadotropin [Units/volume] in Urine

1.92

0.96

1.3

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

262

1.47

0.94

1.5

1.4

—

(3019150) Specific gravity of Urine by Refractometry

164

1.53

0.91

6.0

2.9

1.0

kg/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.14

0.91

1.0

1.7

0.2

g/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

113

0.50

0.90

1.3

1.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

733

1.65

0.88

12.5

7.9

90.3

92.2

ml/min/173m2

0.29

588

(3030467) Casts [#/volume] in Urine by Automated count

175

1.50

0.86

5.6

2.4

0.1

0.2

e6/l

0.36

122

(36304419) Bacteria [Presence] in Urine

184

1.49

0.86

4.0

2.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.00

0.86

1.2

2.9

—

(3000330) Specific gravity of Urine by Test strip

2.00

0.86

7.5

2.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

106

1.62

0.86

5.8

2.2

0.4

0.9

e6/l

—

(3009261) Glucose [Presence] in Urine by Test strip

372

1.41

0.84

5.5

3.0

0.0

estimate

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.93

0.83

1.0

1.6

1.3

1.2

g/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

101

1.58

0.76

5.9

2.3

3.1

4.0

e6/l

—

(3034770) Mitochondria Ab [Titer] in Serum

2.14

0.76

1.0

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.14

0.76

1.2

1.5

—

(40758558) Short blood count panel - Blood

207

1.43

0.75

7.2

7.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

162

1.47

0.75

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

368

1.37

0.74

7.9

4.5

0.0

estimate

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.05

0.74

4.4

1.8

115.8

139.4

g/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.90

0.69

1.4

1.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.90

0.69

1.4

1.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.65

0.69

1.6

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.69

0.68

1.3

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.83

0.67

1.4

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.76

0.65

2.0

1.5

—

(40768443) Skin Pathology biopsy report

1.76

0.65

1.0

1.1

—

(3015736) pH of Urine

298

1.34

0.63

5.8

2.7

—

(4010399)

1.66

0.63

1.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.62

0.62

1.3

1.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.60

0.62

3.6

3.3

4.5

4.7

pmol/l

0.42

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.70

0.62

1.4

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

197

1.37

0.59

5.4

2.4

13.7

58.7

e6/l

0.79

144

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.54

0.59

2.2

1.8

329.2

388.3

nmol/l

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.59

0.0

1.2

—

380.9

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.62

0.55

1.2

1.5

57.8

46.1

pmol/l

—

(3008898) HLA-B27 [Presence]

1.45

0.53

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

143

0.66

0.53

1.2

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.43

0.52

7.0

4.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

249

1.30

0.51

1.9

2.0

—

(3022621) pH of Urine by Test strip

1.49

0.48

3.4

2.2

—

(3022145) Colonoscopy Study observation

1.47

0.45

1.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

244

1.27

0.44

6.1

3.1

4.8

43.4

e6/l

0.97

152

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

244

1.27

0.44

1.7

—

(3000492) Spirometry study

1.48

0.44

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.65

0.44

1.0

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.44

0.43

1.4

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.41

0.43

1.0

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

1.54

0.42

1.4

1.6

0.4

nmol/l

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.41

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

108

1.35

0.38

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.49

0.37

1.2

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

797

1.39

0.36

14.6

9.6

17.5

18.4

mg/l

0.11

588

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.39

0.36

1.4

1.3

294.2

150.8

iu/ml

—

(3009542) Hematocrit [Volume Fraction] of Blood

766

1.32

0.34

19.0

11.4

38.7

40.0

1.02

646

(3041096) Erythrocytes [Presence] in Urine by Automated

232

1.23

0.34

3.5

2.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.37

0.34

1.9

1.6

1120.1

1069.1

nmol/l

0.09

(3017143) Hepatitis C virus Ab [Presence] in Serum

120

1.30

0.32

1.9

1.5

—

(3019225) pH of Specimen

1.29

0.31

4.0

4.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

695

1.23

0.30

3.8

4.0

—

(21494755) Public health laboratory ask at order entry panel

122

1.27

0.29

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.22

0.26

1.4

1.3

—

(3002256) Pathology report gross observation

106

1.26

0.25

1.5

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.75

0.24

3.1

1.7

—

(36660697) Celiac disease serology panel - Serum

0.73

0.23

1.4

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.2

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.21

0.0

4.9

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.7

—

19.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

185

1.17

0.20

1.8

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.14

0.18

1.9

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.74

0.17

2.2

2.0

—

(3000494) Fungus identified in Specimen by Culture

0.78

0.15

1.3

—

(40768804) Tissue Pathology biopsy report

360

1.09

0.11

2.2

1.8

—

(1761868) Lipid panel - Serum or Plasma

329

0.91

0.11

3.0

2.3

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.12

0.10

9.6

3.7

—

0.0

—

(3025159) Blasts/100 leukocytes in Blood

1.07

0.09

9.6

3.5

—

0.0

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.04

0.09

9.6

3.4

—

0.6

—

(4035726)

1.14

0.09

1.7

1.2

—

(40768797) Stomach Pathology biopsy report

107

1.14

0.09

1.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.08

0.09

1.7

1.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.09

0.07

2.4

2.2

—

23.3

—

(3013512) EKG study

159

1.08

0.05

2.8

2.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

124

1.06

0.01

1.3

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

1.3

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

113

0.97

0.00

1.7

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

207

1.02

0.00

2.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.0

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.4

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

27.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.93

0.00

1.7

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

371.6

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.93

0.00

1.7

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.0

—

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.3

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

2.8

—

142.7

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

2.7

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.3

—

3.9

—

(3017181) Myelocytes/100 leukocytes in Blood

1.02

0.00

9.6

3.5

—

0.7

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.89

0.00

1.8

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.92

0.00

1.7

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

2.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

10.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

155.7

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

1855.9

—

(3005033) Fetal Nuchal fold Thickness US

0.90

0.00

1.8

1.4

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

3.7

—

(40761536) Microorganisms panel - Urine sediment

1.00

0.00

2.2

2.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.92

0.00

1.7

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.3

—

106.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

5.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.00

0.00

1.7

1.6

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_ECLAMPSIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ECLAMPSIA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_ECLAMPSIA – Eclampsia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Eclampsia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints