No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleonly females |
293145 |
2. Check conditionsNone |
293145 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
97 |
4. Check minimum number of eventsNone |
97 |
5. Include endpointsNone |
97 |
6. Filter based on genotype QC (FinnGen only) |
92 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF10
- Parent code in ICD-10
- O10-O16
- Name in latin
- Eclampsia
Similar endpoints
↥List of similar endpoints to
Eclampsia
based on the number of shared cases.
Similar with more cases:
- Pre-eclampsia or eclampsia
- Pre-eclampsia or poor fetal growth
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 602 | 602 | - |
| Only index persons | 597 | 597 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | - |
| Only index persons | 0.02 | 0.02 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.59 | - |
| Only index persons | - | 28.56 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 92 | 92 | - |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | - |
| Median age at first event (years) | 28.27 | 28.27 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 97
- Matched controls
- 970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O15.0
ICD-10 Finland
Eclampsia in pregnancy
+∞
40.5
36
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
+∞
32.1
29
*
6426A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , ENNEN SYNNYTYSTÄ]
+∞
19.4
18
*
O15.1
ICD-10 Finland
Eclampsia in labour
+∞
17.2
16
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
15.0
14
*
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
13.9
13
*
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
148.4
12.8
13
*
6426B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , SYNNYTYKSEN AIKANA]
+∞
11.7
11
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
4.5
11.5
42
142
O15.2
ICD-10 Finland
Eclampsia in the puerperium
+∞
10.6
10
*
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
14.5
9.8
16
13
C07AG01
ATC
labetalol; systemic
98.2
8.6
9
*
8811
FHL
Cesarean section
7.9
8.1
18
27
6462A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension
+∞
7.4
7
*
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
8.2
7.0
15
21
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
3.5
6.9
30
110
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.7
6.1
22
71
TimeCodeWAS
↥TimeCodeWAS is a tool for exploring time-dependent associations between an endpoint and health codes (diagnoses, lab tests, procedures, etc.).
The TimeCodeWAS analysis is done in three steps:
- Build a matched case-control set for this endpoint. Each case is matched to 5–10 controls on sex and year of birth, and controls must be at risk at the same age as the case's age of onset. TimeCodeWAS allows for controls to be reused.
- Count cases and controls. For each health code, and for each time window: tally the counts into a 2×2 table. To be eligible in a time window, a case or control must have data coverage for at least 50% of that time window.
- Perform association tests. If all cells of the 2×2 table have N≥10, then a χ² test is performed, otherwise a Fisher's exact test is done. The corresponding p-value and confidence interval are reported below, along with the standard odds ratio when a χ² test is done, or Fisher's MLE odds ratio otherwise.
TimeCodeWAS currently uses the same default set of time windows for all the endpoints. Please reach out to us if you have suggestions for better time windows for some endpoints.
The default time windows are:
LabWAS
↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
186
3.36
7.73
2.3
1.8
1.99
1.03
mg/l
1.08
37
150
60
342
2.98
6.34
9.8
5.4
1.20
1.21
mmol/l
0.89
52
306
38
177
2.89
5.73
7.1
3.6
43.24
3.58
mg/mmol
1.10
29
101
63
405
2.58
4.73
3.0
2.6
—
—
estimate
—
0
0
20
71
3.29
4.73
10.1
4.8
1.08
1.06
mmol/l
0.18
20
58
16
51
3.56
4.44
10.4
7.3
0.46
1.47
mmol/l
0.64
16
43
40
225
2.32
3.84
2.0
2.7
8.13
15.83
ng/l
3.92
19
97
25
119
2.48
3.42
2.3
3.3
38.85
36.40
ng/l
0.03
13
55
21
92
2.64
3.40
1.3
1.9
—
—
—
0
0
17
69
2.77
3.17
6.5
5.3
102.88
105.46
mmol/l
1.63
17
69
23
111
2.41
3.04
4.3
2.1
2.51
2.44
g/l
0.20
23
103
11
32
3.74
3.01
3.1
1.8
84.45
105.06
%
1.63
11
32
36
211
2.12
3.00
1.6
1.3
1.60
9.40
u/ml
1.85
23
93
21
98
2.46
2.98
4.8
2.1
23.14
24.58
%
0.21
21
92
38
229
2.08
2.94
1.4
1.4
17.49
27.38
iu/ml
—
8
80
5
6
8.69
2.78
1.0
1.7
11.38
11.67
umol/l
—
5
6
15
61
2.73
2.78
1.3
1.8
—
—
—
0
0
8
19
4.49
2.74
1.6
1.2
—
—
—
0
0
10
30
3.59
2.69
3.3
2.2
187.90
147.80
%
—
10
30
32
189
2.03
2.57
2.6
1.9
—
—
—
0
0
58
421
1.94
2.55
5.8
5.5
7.82
9.39
umol/l
1.86
53
402
15
68
2.43
2.24
1.3
1.8
—
—
—
0
0
8
24
3.54
2.23
1.3
1.2
—
—
—
0
0
40
270
1.82
2.10
1.5
1.3
1.20
1.43
u/ml
0.12
14
70
37
246
1.81
2.03
5.4
2.8
—
—
—
0
0
10
39
2.74
2.01
1.5
1.3
—
—
—
0
0
9
33
2.90
1.99
12.3
5.1
23.52
25.40
mmol/l
—
9
33
8
27
3.13
1.98
9.9
8.9
0.93
0.74
%
—
8
27
8
27
3.13
1.98
9.9
9.0
1.34
1.23
%
—
8
27
8
27
3.13
1.98
1.3
1.4
—
—
—
0
0
7
23
3.20
1.83
1.3
1.2
—
—
—
0
0
6
18
3.48
1.77
1.3
1.3
—
—
—
0
0
8
32
2.63
1.64
5.1
1.8
24.14
24.89
mmol/l
—
8
32
5
14
3.70
1.63
3.4
3.6
25.52
24.09
mmol/l
—
5
14
11
51
2.30
1.57
6.0
1.9
1.11
1.91
mmol/l
0.33
11
42
33
227
1.69
1.55
4.1
3.0
0.00
0.00
estimate
-0.00
12
88
31
210
1.70
1.54
2.1
1.9
93.84
106.73
u/l
0.24
31
203
11
52
2.26
1.51
1.8
2.4
0.22
0.23
g/l
0.16
11
52
9
39
2.44
1.47
2.6
1.4
—
—
—
0
0
46
349
1.60
1.46
5.0
2.9
0.00
0.01
estimate
—
10
79
5
16
3.23
1.45
1.2
1.3
—
—
—
0
0
56
449
1.58
1.39
5.6
3.4
0.00
0.00
estimate
-0.00
12
90
14
76
1.98
1.38
1.6
1.3
925.48
102.42
u/ml
0.60
14
68
8
35
2.40
1.30
1.4
2.5
—
—
—
0
0
29
204
1.60
1.23
5.9
3.1
1.02
1.02
kg/l
1.02
21
138
8
38
2.20
1.21
1.5
1.5
56.76
54.96
ug/l
—
8
38
8
39
2.14
1.18
1.3
1.3
—
14.00
—
0
7
55
450
1.51
1.17
5.7
3.4
0.00
0.00
estimate
—
10
90
54
444
1.49
1.10
5.7
3.3
0.00
0.00
estimate
-0.00
12
90
5
21
2.45
1.10
1.0
1.0
—
—
—
0
0
9
46
2.05
1.07
2.3
1.7
—
—
—
0
0
9
47
2.01
1.05
1.4
1.8
—
—
—
0
0
5
22
2.34
1.04
1.2
1.3
—
—
—
0
0
7
35
2.08
1.02
1.3
1.1
—
5.61
—
0
8
37
286
1.47
1.01
1.5
1.5
—
—
—
0
0
88
818
1.82
0.99
14.9
9.4
90.36
91.94
ml/min/173m2
0.28
81
744
35
271
1.46
0.94
3.4
2.7
0.00
0.01
estimate
—
9
74
6
28
2.22
0.93
1.2
1.6
—
—
—
0
0
6
29
2.14
0.91
2.8
1.8
1.40
1.27
%
—
6
29
6
31
2.00
0.86
1.8
1.5
—
—
—
0
0
8
46
1.80
0.85
1.0
1.0
0.93
0.83
g/l
—
8
46
8
46
1.80
0.85
1.0
1.0
1.69
1.67
g/l
—
8
46
40
323
1.41
0.84
1.9
2.0
111.12
98.35
pmol/l
0.72
18
178
17
118
1.53
0.76
6.4
2.6
8.14
3.84
e6/l
0.35
11
54
9
56
1.67
0.75
1.2
1.8
—
—
—
0
0
13
85
1.61
0.73
2.8
1.8
388.03
2121.30
u/l
—
6
25
5
26
1.97
0.71
1.2
1.1
1.00
36.33
e6/l
—
5
15
5
26
1.97
0.71
1.2
1.1
127.00
123.19
e6/l
—
5
16
26
200
1.41
0.71
6.2
2.6
0.10
0.26
e6/l
0.74
21
136
18
130
1.47
0.67
6.7
2.5
0.73
0.78
e6/l
0.05
12
64
5
29
1.76
0.64
1.4
1.8
—
—
—
0
0
5
30
1.70
0.62
1.4
1.8
—
—
—
0
0
6
35
1.76
0.59
1.0
1.7
0.25
0.23
g/l
—
6
35
6
37
1.66
0.56
1.0
1.7
1.28
1.16
g/l
—
6
37
9
61
1.52
0.56
1.3
1.5
—
—
—
0
0
88
843
1.47
0.47
19.2
10.1
3.90
3.87
mmol/l
0.43
88
822
88
843
1.47
0.47
18.9
10.1
139.16
139.83
mmol/l
2.18
88
826
88
842
1.49
0.47
7.4
5.7
1.71
1.68
mu/l
0.07
88
809
13
95
1.43
0.46
1.3
1.3
252.46
143.67
u/ml
—
7
43
16
122
1.37
0.46
1.6
1.7
1109.55
948.55
mu/l
0.27
11
105
89
857
1.47
0.40
16.6
11.2
18.79
17.98
mg/l
0.10
77
657
9
66
1.40
0.40
7.0
4.4
—
—
—
0
0
9
68
1.36
0.39
1.0
1.1
—
—
—
0
0
11
81
1.40
0.38
4.1
3.5
4.45
4.65
pmol/l
0.35
11
73
88
846
1.43
0.38
5.3
4.2
4.78
4.86
mmol/l
0.38
88
821
32
280
1.21
0.33
1.8
1.8
—
—
—
0
0
11
84
1.35
0.31
1.9
1.6
1120.05
1062.07
nmol/l
0.11
11
66
77
735
1.23
0.30
3.9
4.0
—
—
—
0
0
8
66
1.23
0.27
1.0
1.3
—
—
—
0
0
24
210
1.19
0.25
1.7
2.0
—
—
—
0
0
5
39
1.30
0.23
1.4
1.6
0.45
0.35
nmol/l
—
5
31
5
40
1.26
0.23
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
5.0
—
1.29
—
0
6
81
789
1.16
0.16
4.4
3.5
1.42
1.16
mmol/l
1.86
81
754
8
96
0.82
0.14
1.8
1.9
368.88
386.98
nmol/l
—
8
91
7
67
1.05
0.08
1.9
1.4
—
—
—
0
0
12
123
0.97
0.00
1.6
1.9
—
—
—
0
0
24
235
1.03
0.00
2.0
2.1
—
—
—
0
0
15
149
1.01
0.00
1.5
2.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
2.8
—
142.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
371.40
—
0
5
7
71
0.98
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1.07
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
6.78
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1933.57
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint O15_ECLAMPSIA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_ECLAMPSIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_ECLAMPSIA – Eclampsia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data