No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
85 |
4. Check minimum number of eventsNone |
85 |
5. Include endpointsNone |
85 |
6. Filter based on genotype QC (FinnGen only) |
80 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF10
- Parent code in ICD-10
- O10-O16
- Name in latin
- Eclampsia
Similar endpoints
↥List of similar endpoints to
Eclampsia
based on the number of shared cases.
Similar with more cases:
- Pre-eclampsia or eclampsia
- Pre-eclampsia or poor fetal growth
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 602 | 602 | - |
| Only index persons | 597 | 597 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | - |
| Only index persons | 0.02 | 0.02 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.59 | - |
| Only index persons | - | 28.56 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 80 | 80 | - |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | - |
| Median age at first event (years) | 27.57 | 27.57 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 85
- Matched controls
- 848
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O15.0
ICD-10 Finland
Eclampsia in pregnancy
+∞
31.2
28
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
+∞
28.8
26
*
6426A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , ENNEN SYNNYTYSTÄ]
+∞
17.3
16
*
O15.1
ICD-10 Finland
Eclampsia in labour
+∞
16.1
15
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
13.9
13
*
6426B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , SYNNYTYKSEN AIKANA]
+∞
11.7
11
*
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
+∞
11.7
11
*
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
10.6
10
*
O15.2
ICD-10 Finland
Eclampsia in the puerperium
+∞
10.6
10
*
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
45.9
10.3
12
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
4.7
8.6
34
106
C07AG01
ATC
labetalol; systemic
+∞
8.5
8
*
8811
FHL
Cesarean section
7.6
7.4
17
27
6462A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension
+∞
7.4
7
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
4.7
6.9
24
65
Mortality – FinRegistry
↥Association
Association between endpoint O15_ECLAMPSIA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_ECLAMPSIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_ECLAMPSIA – Eclampsia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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