Eclampsia

O15_ECLAMPSIA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule only females	293218
2. Check conditions None	293218
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O15 Hospital discharge: ICD-9 — 6426 Cause of death: ICD-10 — O15 Cause of death: ICD-9 — 6426 2 out of 7 registries used, show all original rules.	95
4. Check minimum number of events None	95
5. Include endpoints None	95
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF10
Parent code in ICD-10: O10-O16
Name in latin: Eclampsia

NAME	O15_ECLAMPSIA
CONTROL_EXCLUDE	O15_OEDEM_PROTUR_HYPERT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O15
HD_ICD_9	6426
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O15
COD_ICD_9	6426
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Eclampsia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	602	602	-
Only index persons	597	597	-
Unadjusted period prevalence (%)
Whole population	0.02	0.02	-
Only index persons	0.02	0.02	-
Median age at first event (years)
Whole population	-	28.59	-
Only index persons	-	28.56	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	91	-
Unadjusted period prevalence (%)	0.03	0.03	-
Median age at first event (years)	28.63	28.63	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O15.0

ICD-10 Finland

Eclampsia in pregnancy

+∞

38.1

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

+∞

32.1

6426A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , ENNEN SYNNYTYSTÄ]

+∞

19.4

O15.1

ICD-10 Finland

Eclampsia in labour

+∞

17.2

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

+∞

13.9

O14.1

ICD-10 Finland

Severe pre-eclampsia

+∞

12.8

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

148.8

12.8

6426B

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Eclampsia[ECLAMPSIA , SYNNYTYKSEN AIKANA]

+∞

11.7

O15.2

ICD-10 Finland

Eclampsia in the puerperium

+∞

10.6

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

4.2

10.5

139

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

13.4

8.9

C07AG01

ATC

labetalol; systemic

98.4

8.6

8811

FHL

Cesarean section

8.0

8.1

6462A

ICD-9 Finland

Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension

+∞

7.4

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

8.7

7.2

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

3.5

6.7

106

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

3.9

6.5

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020682) Albumin/Creatinine [Ratio] in Urine

139

3.40

7.17

6.1

3.3

23.93

4.01

mg/mmol

0.70

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

284

3.09

6.79

9.5

5.2

1.20

1.22

mmol/l

0.93

254

(3037522) Nuclear Ab [Titer] in Serum

133

3.27

6.53

1.4

1.5

222.86

629.09

titre

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

161

3.13

6.42

2.4

1.8

1.99

0.69

mg/l

1.92

127

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.99

5.95

9.4

4.3

1.03

1.05

mmol/l

0.10

(3012516) Albumin [Mass/volume] in Urine

134

2.95

5.32

5.7

2.9

1680.57

641.05

mg/l

0.27

(3023368) Bacteria identified in Blood by Culture

128

2.96

5.26

2.9

3.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

368

2.59

4.78

2.8

2.3

—

(3018418) pH of Serum or Plasma

171

2.66

4.70

5.0

3.0

7.39

7.40

—

(3022217) INR in Platelet poor plasma by Coagulation assay

215

2.49

4.36

2.8

5.6

0.99

1.03

inr

0.69

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

178

2.53

4.28

1.4

1.3

17.49

29.43

iu/ml

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.95

4.26

3.6

1.8

2.54

2.50

g/l

0.11

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

102

2.81

4.16

2.0

3.3

39.31

39.69

ng/l

0.00

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

198

2.42

4.02

1.9

2.5

7.81

16.72

ng/l

4.17

(3003396) Base excess in Arterial blood by calculation

3.48

3.83

11.0

6.6

0.59

1.72

mmol/l

0.61

(3000991) Gas panel - Venous blood

4.64

3.64

13.4

5.4

—

(3026008) Bacteria identified in Urine by Culture

206

2.30

3.62

2.8

2.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

178

2.31

3.45

1.5

1.2

1.66

9.11

u/ml

1.48

(3006315) Basophils [#/volume] in Blood

385

2.20

3.42

5.5

6.0

0.04

e9/l

0.51

346

(3001604) Monocytes [#/volume] in Blood

385

2.20

3.42

5.5

6.0

0.51

0.52

e9/l

0.10

347

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.18

3.36

7.2

5.3

102.71

105.45

mmol/l

1.39

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.20

3.08

1.6

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

163

2.23

3.04

2.4

1.7

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

10.45

3.01

1.0

1.8

11.38

10.40

umol/l

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

5.03

2.99

1.6

1.2

—

(3044889) 12 lead EKG panel

471

2.10

2.86

3.1

2.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

4.21

2.85

2.9

2.0

78.67

105.83

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.54

2.82

1.3

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

365

1.94

2.55

6.3

6.2

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

4.06

2.52

9.9

8.5

0.93

0.82

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

4.06

2.52

9.9

8.5

1.34

—

(3014007) Fractional oxyhemoglobin in Arterial blood

4.06

2.52

9.9

8.4

94.63

95.05

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.87

2.42

3.0

2.5

178.13

141.18

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.87

2.42

12.8

4.0

23.46

25.10

mmol/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

222

1.91

2.27

1.4

1.2

1.33

1.61

u/ml

0.12

(3024354) Oxygen [Partial pressure] in Venous blood

3.20

2.21

5.1

1.8

5.14

5.44

kpa

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.89

2.19

5.7

1.4

24.29

24.80

mmol/l

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.50

2.18

2.0

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.33

2.17

1.9

1.4

—

(3019060) Gas panel - Arterial blood

3.40

2.15

8.4

5.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

152

1.98

2.12

5.8

3.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.69

2.10

10.9

8.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.82

2.07

1.7

2.3

0.23

0.24

g/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.55

2.04

1.2

1.7

—

(3025941) Bacteria identified in Stool by Culture

2.55

2.04

1.3

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

221

1.84

2.01

5.3

2.6

—

(3044640) Blood type and Crossmatch panel - Blood

232

1.81

1.93

2.9

1.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

548

1.85

1.92

5.7

3.9

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.35

1.92

1.3

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.35

1.92

1.3

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.45

1.89

1.2

1.7

—

(40761535) Cells panel - Urine sediment

2.73

1.85

6.8

3.1

—

(3043409) Potassium [Moles/volume] in Arterial blood

4.33

1.84

3.8

5.3

3.82

3.71

mmol/l

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.20

1.84

1.3

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.20

1.84

1.1

1.3

—

(3031040) Bacteria [#/volume] in Urine by Automated count

512

1.77

1.80

5.7

3.9

—

39.56

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.48

1.77

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

4.00

1.73

1.2

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

4.00

1.73

3.8

4.9

1.66

0.98

mmol/l

—

(3020891) Body temperature

4.00

1.73

4.2

5.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.72

1.70

1.6

1.7

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.63

1.64

1.4

2.0

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.63

1.64

1.1

1.2

—

15.45

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.63

1.64

1.8

1.3

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.71

1.63

3.4

3.6

25.52

24.09

mmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

191

1.75

1.60

4.2

2.8

0.00

estimate

—

(3045414) Leukocytes [Presence] in Urine

2.55

1.58

3.3

1.6

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.22

1.57

1.5

1.3

1078.89

100.08

u/ml

0.61

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.46

1.54

1.0

1.3

—

(3002032) Base excess in Venous blood by calculation

2.58

1.52

7.1

1.8

1.36

1.96

mmol/l

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.58

1.52

7.1

1.8

6.06

5.61

kpa

—

(3003694) ABO and Rh group [Type] in Blood

256

1.65

1.50

1.9

1.7

—

(3012544) pH of Venous blood

2.38

1.44

7.1

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

107

1.84

1.38

5.7

2.2

0.66

0.89

e6/l

0.24

(40768793) Breast Pathology biopsy report

0.00

1.38

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

208

1.65

1.36

1.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.13

1.33

1.3

1.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

183

1.66

1.33

2.0

1.8

92.04

109.42

u/l

0.31

177

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.47

1.33

2.1

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

236

1.61

1.32

1.9

111.43

100.45

pmol/l

0.46

125

(3030467) Casts [#/volume] in Urine by Automated count

175

1.67

1.31

5.7

2.4

0.11

0.22

e6/l

0.44

121

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

2.15

1.31

1.4

1.7

—

(36304419) Bacteria [Presence] in Urine

184

1.65

1.30

4.3

2.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.87

1.30

1.0

1.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

102

1.81

1.27

5.8

2.3

8.37

4.04

e6/l

0.35

(3035350) Ketones [Presence] in Urine by Test strip

379

1.54

1.24

5.4

3.0

0.00

estimate

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

787

1.98

1.23

16.3

8.4

139.24

139.80

mmol/l

1.58

767

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.72

1.23

3.2

1.5

0.92

0.69

—

(3000492) Spirometry study

1.90

1.18

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.58

1.16

3.2

1.7

1.32

0.93

—

(3007164) IgA [Mass/volume] in Serum or Plasma

208

1.57

1.13

1.3

1.77

2.06

g/l

0.75

130

(3000330) Specific gravity of Urine by Test strip

2.36

1.13

7.0

2.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.36

1.13

1.7

1.3

—

(3042936) Bacteria identified in Isolate by Culture

1.83

1.12

1.5

2.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

752

1.82

1.11

12.8

7.8

90.31

92.38

ml/min/173m2

0.34

604

(3023103) Potassium [Moles/volume] in Serum or Plasma

791

1.92

1.11

16.5

8.4

3.89

3.88

mmol/l

0.24

768

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.28

1.10

1.4

1.8

—

(40758558) Short blood count panel - Blood

210

1.55

1.08

6.9

7.3

—

(3009261) Glucose [Presence] in Urine by Test strip

378

1.48

1.07

5.5

3.0

0.00

estimate

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.08

1.02

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

373

1.45

0.98

7.8

4.5

0.00

estimate

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.82

0.98

1.6

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

198

1.51

0.94

5.6

2.4

13.10

58.65

e6/l

0.81

144

(3019832) Treponema pallidum Ab [Presence] in Serum

164

1.53

0.91

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.99

0.91

2.5

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

112

0.50

0.90

1.3

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

264

1.45

0.90

1.5

1.4

—

(3019150) Specific gravity of Urine by Refractometry

165

1.52

0.89

6.0

2.9

1.02

1.01

kg/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

302

1.43

0.89

4.9

2.8

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.07

0.88

1.0

1.6

0.25

0.24

g/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.00

0.86

1.2

2.9

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.87

0.80

1.0

1.6

1.28

1.16

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.14

0.75

1.2

1.5

—

(3034770) Mitochondria Ab [Titer] in Serum

2.14

0.75

1.0

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.05

0.74

4.4

1.8

115.80

140.72

g/l

—

(3018095) Leukocytes [#/volume] in Urine

246

1.39

0.71

6.4

3.1

5.95

43.00

e6/l

0.92

153

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.90

0.69

1.4

1.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.69

0.68

1.3

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.83

0.67

1.4

1.9

—

(40768443) Skin Pathology biopsy report

1.76

0.64

1.0

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.76

0.64

2.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.76

0.64

1.4

1.1

—

(3022621) pH of Urine by Test strip

1.69

0.64

3.5

2.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.65

0.63

1.3

1.6

—

(4200892) Spirometry reversibility

1.65

0.63

1.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

251

1.35

0.62

1.8

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.70

0.62

1.4

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.1

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.59

0.0

1.2

—

380.88

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

146

0.65

0.57

1.2

1.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

108

1.46

0.57

1.5

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.58

0.57

1.3

1.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.55

0.56

3.6

3.3

4.46

4.71

pmol/l

0.43

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

247

1.31

0.53

1.7

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.53

0.52

1.2

1.5

57.83

46.12

pmol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.42

0.52

7.0

4.5

—

(3008898) HLA-B27 [Presence]

1.42

0.52

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

811

1.46

0.46

14.6

9.4

17.42

18.21

mg/l

0.10

598

(3022145) Colonoscopy Study observation

1.46

0.45

1.0

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.65

0.44

1.0

1.1

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

1.54

0.42

1.4

1.6

0.45

0.35

nmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.36

0.41

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

191

1.27

0.38

1.7

1.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.46

0.36

1.2

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.66

0.35

2.0

1.8

318.67

388.29

nmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

712

1.25

0.34

3.8

4.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.37

0.34

1.9

1.6

1120.05

1069.13

nmol/l

0.09

(3017143) Hepatitis C virus Ab [Presence] in Serum

120

1.30

0.32

1.9

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.35

0.31

1.4

1.3

294.20

151.08

iu/ml

—

(3019225) pH of Specimen

1.29

0.31

4.0

4.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.29

0.31

1.6

1.5

—

(21494755) Public health laboratory ask at order entry panel

122

1.27

0.29

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.22

0.26

1.4

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

239

1.18

0.25

3.5

2.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.75

0.23

3.1

1.7

—

(36660697) Celiac disease serology panel - Serum

0.73

0.23

1.4

1.1

—

(40768797) Stomach Pathology biopsy report

107

1.25

0.23

1.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

454.80

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.3

—

(3002256) Pathology report gross observation

108

1.24

0.21

1.5

1.2

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.21

0.0

4.9

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

3.5

—

19.34

—

(40768804) Tissue Pathology biopsy report

362

1.13

0.19

2.2

1.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.72

0.17

2.2

1.9

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.16

0.17

1.6

1.5

—

(3000494) Fungus identified in Specimen by Culture

0.77

0.15

1.3

—

(3013512) EKG study

161

1.15

0.14

2.7

2.5

—

(1761868) Lipid panel - Serum or Plasma

329

0.91

0.11

3.0

2.3

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.09

0.10

9.6

3.7

—

0.00

—

(3025159) Blasts/100 leukocytes in Blood

1.04

0.09

9.6

3.6

—

0.07

—

(3005033) Fetal Nuchal fold Thickness US

1.12

0.09

1.7

1.4

—

(4035726) Immunohistochemistry procedure

1.12

0.09

1.7

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.10

0.09

1.7

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

215

1.09

0.08

2.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.12

0.08

1.9

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.10

0.08

1.6

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.10

0.08

1.6

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.08

0.08

1.6

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.08

0.08

1.6

1.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.09

0.07

2.4

2.2

—

22.10

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

113

1.07

0.02

1.7

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

1.3

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

125

1.05

0.00

1.3

1.7

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

149.20

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.0

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(36304052) Adalimumab Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

5.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.3

—

106.13

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

3.7

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

371.60

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

0.0

1.6

—

55.40

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.40

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.0

—

1.28

—

(44786774) Adalimumab [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

11.51

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

68.00

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

4.0

—

10.84

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

27.50

—

(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

6.78

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.3

—

3.92

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

2.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

1950.50

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

142.67

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

155.67

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40761536) Microorganisms panel - Urine sediment

0.93

-0.00

2.2

2.4

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

1.0

—

44.17

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.02

-0.00

9.6

3.4

—

0.88

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3017181) Myelocytes/100 leukocytes in Blood

1.00

-0.00

9.6

3.6

—

0.67

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_ECLAMPSIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ECLAMPSIA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_ECLAMPSIA – Eclampsia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Eclampsia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints