Megavitamin-B6 syndrome

E4_MEGA_VIT_B6

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E67.2 Cause of death: ICD-10 — E67.2 2 out of 7 registries used, show all original rules.	9
4. Check minimum number of events None	9
5. Include endpoints None	9
6. Filter based on genotype QC (FinnGen only)	9

Control definitions (FinnGen only)

Control exclude: E4_OBESITY_HYPER

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E67
Name in latin: Hypervitaminosis B6 permagna

NAME	E4_MEGA_VIT_B6
CONTROL_EXCLUDE	E4_OBESITY_HYPER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E672
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E672
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Megavitamin-B6 syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	15	7	8
Only index persons	11	6	5
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	61.38	73.28
Only index persons	57.21	48.12	68.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	9	6	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	69.05	69.51	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(36304419) Bacteria [Presence] in Urine

0.00

0.45

0.0

2.6

—

(40761511) CBC panel - Blood by Automated count

+∞

0.45

16.8

16.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.23

0.0

2.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.23

0.0

1.8

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.23

0.0

2.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.23

0.0

4.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.0

2.6

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.0

5.6

—

3.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.0

9.4

—

25.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

7.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.00

0.0

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.00

0.0

3.9

—

(3026361) Erythrocytes [#/volume] in Blood

+∞

0.00

22.9

22.5

e12/l

4.6

4.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.00

0.0

7.8

—

102.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40761535) Cells panel - Urine sediment

0.00

0.0

3.3

—

(3010813) Leukocytes [#/volume] in Blood

+∞

0.00

23.2

22.5

e9/l

6.1

6.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

0.00

0.0

1.1

—

28.1

—

(3002256) Pathology report gross observation

0.00

0.0

1.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

8.8

—

1.7

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

35.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

8.8

—

0.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_MEGA_VIT_B6 and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_MEGA_VIT_B6.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: E4_MEGA_VIT_B6 – Megavitamin-B6 syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Megavitamin-B6 syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints