≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Other hyperalimentation

DOID Endpoint Browser PheWeb

E4_HYPERALI

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E67, E68
  • Cause of death: ICD-10 — E67, E68

2 out of 7 registries used, show all original rules.

94

4. Check minimum number of events

None

94

5. Include endpoints

113

6. Filter based on genotype QC (FinnGen only)

113

Control definitions (FinnGen only)

Control exclude
E4_OBESITY_HYPER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 767 460 298
Only index persons 615 384 231
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.68 48.81 50.63
Only index persons 48.07 47.96 48.24

-FinnGen-

Key figures

All Female Male
Number of individuals 113 74 39
Unadjusted period prevalence (%) 0.02 0.03 0.02
Median age at first event (years) 50.61 47.99 55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1071
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E68
ICD-10 Finland
Sequelae of hyperalimentation
+∞
68.2
58
*
E66.8
ICD-10 Finland
Other obesity
225.2
32.7
32
*
E66.01
ICD-10 Finland
Obesity due to excess calories
46.8
27.6
33
10
E66.00
ICD-10 Finland
Metabolic syndrome
91.2
20.6
22
*
E66.9
ICD-10 Finland
Obesity, unspecified
71.3
16.3
18
*
QBJ30
NOMESCO Finland
Correction of abdominal apron
+∞
16.0
15
*
E67.3
ICD-10 Finland
Hypervitaminosis D
+∞
11.7
11
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
10.6
10
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
24.4
9.6
13
6
T82
ICPC
Obesity
15.6
9.5
15
11
E67.8
ICD-10 Finland
Other specified hyperalimentation
+∞
9.5
9
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
9.5
9
*
103
Kela drug reimbursment
Diabetes, insulin-treated
4.1
9.2
43
152
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
+∞
8.4
8
*
E67.2
ICD-10 Finland
Megavitamin-B6syndrome
+∞
8.4
8
*
27899
ICD-8 Finland
Other hyperalimentation, Other and unspecified
+∞
8.4
8
*
G47.3
ICD-10 Finland
Sleep apnoea
4.4
8.0
31
91
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.8
7.7
37
131
A10BA02
ATC
metformin; oral
3.6
7.6
42
164
SPAT1262
SPAT
Handing over of treatment supplies
4.0
7.1
30
95
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.5
6.9
36
135
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
5.0
6.8
22
53
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
16.2
6.0
9
6

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
370
3.61
9.97
5.1
4.3
35.5
35.8
g/l
0.15
65
351
68
341
3.50
9.71
2.7
1.8
112.5
95.6
pmol/l
1.44
42
164
49
202
3.52
9.56
2.6
1.8
3.0
3.1
mg/l
0.11
41
178
41
171
3.19
7.59
2.1
1.7
1124.3
1304.2
nmol/l
0.50
32
128
12
21
6.27
6.74
1.7
1.0
—
—
—
0
0
49
242
2.81
6.55
4.0
2.7
7.5
7.3
mmol/l
0.04
37
205
48
237
2.78
6.39
4.9
3.5
6.7
6.2
mg/mmol
0.05
28
148
21
70
3.46
5.44
7.5
5.4
—
—
—
0
0
42
212
2.56
5.18
1.9
1.5
21.3
21.9
nmol/l
0.08
35
178
38
184
2.60
5.09
2.0
1.7
517.8
477.0
pmol/l
0.19
31
155
43
222
2.51
5.04
4.1
2.9
63.4
332.7
mg/l
0.43
24
137
50
282
2.39
4.78
2.9
2.4
—
—
—
0
0
18
61
3.32
4.52
1.1
2.1
—
—
—
0
0
36
180
2.47
4.44
2.4
2.6
534.8
545.1
mosm/kgh2o
0.07
29
153
51
303
2.25
4.21
2.5
3.4
2.3
2.4
mmol/l
1.57
44
270
19
71
3.01
4.07
2.8
2.5
4.1
3.6
e9/l
0.53
12
53
39
213
2.27
3.89
1.6
1.7
0.9
1.1
mg/l
0.29
29
168
56
359
2.11
3.70
4.7
7.2
1.1
1.2
inr
0.22
15
117
18
69
2.91
3.68
2.9
4.1
—
—
—
0
0
12
36
3.61
3.59
7.5
4.0
—
—
—
0
0
45
270
2.11
3.49
4.0
3.0
45.0
268.1
e6/l
0.47
35
213
27
132
2.37
3.43
1.1
1.3
—
—
—
0
0
22
99
2.52
3.32
4.4
1.6
—
—
—
0
0
57
379
2.02
3.31
4.1
2.7
103.8
102.1
ug/l
0.03
50
344
13
45
3.13
3.14
1.5
1.1
—
—
—
0
0
12
40
3.24
3.07
3.2
2.3
—
—
—
0
0
41
252
1.98
2.90
4.3
2.8
0.1
0.5
e6/l
1.86
31
195
70
517
1.93
2.85
5.5
4.7
6.8
6.6
mmol/l
0.37
70
473
80
619
2.00
2.82
5.3
4.2
—
—
—
0
0
62
442
1.89
2.79
7.0
6.1
27.0
27.7
%
0.22
57
410
26
138
2.15
2.70
2.2
1.8
29.4
29.6
s
0.05
26
132
86
688
2.05
2.69
5.1
4.0
14.7
14.8
pmol/l
0.14
74
625
39
242
1.93
2.65
5.4
4.5
—
—
—
0
0
33
197
1.95
2.49
1.7
1.4
2.3
2.6
g/l
0.39
23
118
40
257
1.86
2.42
5.4
3.8
—
—
—
0
0
22
115
2.13
2.36
1.6
1.3
128.0
391.5
titre
—
5
33
20
101
2.19
2.33
1.2
1.3
—
—
—
0
0
6
13
4.81
2.30
3.2
2.8
—
—
—
0
0
15
67
2.43
2.29
3.9
3.7
65.6
78.9
ng/l
—
10
59
47
322
1.79
2.29
4.7
3.4
45.8
63.5
e6/l
0.28
35
229
97
829
2.20
2.28
8.4
5.2
41.9
39.5
mmol/mol
1.34
88
781
35
221
1.85
2.21
1.3
1.2
0.5
0.8
u/ml
—
9
55
23
126
2.04
2.19
2.7
1.8
—
—
—
0
0
14
62
2.44
2.18
1.9
1.3
1.3
1.2
g/l
0.08
14
53
11
43
2.73
2.17
1.0
1.1
—
—
—
0
0
36
231
1.82
2.16
2.8
3.1
347.5
4627.0
umol/l
1.06
27
198
9
31
3.06
2.12
1.1
1.5
—
—
—
0
0
14
63
2.40
2.11
1.6
1.3
—
—
—
0
0
43
298
1.72
1.96
6.4
5.4
—
—
—
0
0
12
52
2.46
1.95
8.9
10.5
—
—
—
0
0
61
465
1.68
1.95
6.2
5.7
0.0
0.0
e9/l
0.70
52
406
38
255
1.74
1.94
4.5
2.7
—
—
—
0
0
6
17
3.66
1.86
1.2
1.0
—
—
—
0
0
60
462
1.64
1.79
6.3
5.7
0.6
0.6
e9/l
0.30
52
400
9
36
2.63
1.78
1.7
1.2
—
—
—
0
0
7
24
3.04
1.75
5.9
3.1
—
—
—
0
0
61
476
1.61
1.70
6.4
5.8
0.2
0.2
e9/l
0.46
53
421
11
49
2.38
1.69
1.5
1.3
—
—
—
0
0
14
70
2.14
1.67
2.3
3.0
75.0
67.8
e9/l
—
9
54
6
20
3.11
1.60
2.3
2.3
6.1
7.3
mmol/l
—
6
20
60
475
1.56
1.52
6.3
5.7
1.9
1.8
e9/l
0.39
52
422
46
344
1.57
1.49
3.5
3.8
—
—
—
0
0
47
354
1.56
1.47
5.1
4.1
63.9
30.8
ng/l
0.48
35
240
6
22
2.82
1.45
4.5
4.0
—
—
—
0
0
9
41
2.30
1.40
4.1
3.2
—
—
—
0
0
6
23
2.70
1.38
2.8
2.3
135.0
126.7
g/l
—
6
15
5
17
3.03
1.37
1.2
1.0
—
—
—
0
0
5
18
2.86
1.30
6.2
1.8
—
—
—
0
0
5
18
2.86
1.30
3.4
2.7
—
—
—
0
0
37
271
1.54
1.28
2.4
2.8
—
—
—
0
0
8
36
2.31
1.27
9.4
10.5
24.6
24.6
mmol/l
—
8
31
6
25
2.48
1.26
1.2
1.2
—
—
—
0
0
14
79
1.88
1.23
1.1
1.2
—
—
—
0
0
15
87
1.83
1.22
1.5
1.7
—
—
—
0
0
5
20
2.57
1.16
1.4
1.0
—
—
—
0
0
7
32
2.26
1.10
2.9
2.3
—
—
—
0
0
9
46
2.04
1.06
2.1
2.8
124.0
132.1
g/l
—
9
46
14
84
1.76
1.03
1.2
1.4
—
—
—
0
0
7
37
1.95
0.96
10.9
6.2
—
—
—
0
0
36
279
1.43
0.92
8.5
4.0
7.4
7.4
ph
—
9
60
32
244
1.43
0.89
1.5
1.4
—
—
—
0
0
53
442
1.37
0.88
5.6
5.2
0.0
0.0
estimate
0.00
11
102
63
541
1.37
0.87
8.3
10.2
4.7
4.0
e9/l
1.49
57
474
91
832
1.48
0.86
6.6
4.6
1.9
1.9
mu/l
0.01
83
753
93
854
1.50
0.86
5.1
3.8
1.5
1.2
mmol/l
1.06
82
786
12
73
1.72
0.85
2.4
2.3
—
16.8
—
0
6
53
445
1.36
0.84
3.6
4.0
0.0
0.0
estimate
0.00
12
100
5
98
0.49
0.82
1.2
1.3
—
—
—
0
0
91
835
1.46
0.82
24.0
13.7
38.8
40.1
%
0.65
62
625
6
33
1.86
0.80
2.3
1.3
—
—
—
0
0
101
948
1.62
0.79
23.9
12.6
—
—
—
0
0
53
449
1.34
0.78
3.8
3.9
0.0
0.0
estimate
0.00
13
96
5
23
2.23
0.77
3.8
1.6
—
—
—
0
0
5
23
2.23
0.77
1.2
1.3
—
—
—
0
0
95
883
1.48
0.75
5.8
4.2
1.4
1.5
mmol/l
1.19
86
817
50
422
1.33
0.74
11.7
9.9
0.0
0.0
e9/l
0.41
44
343
7
42
1.71
0.70
3.4
2.9
26.7
24.9
mmol/l
—
7
42
98
922
1.47
0.66
24.1
14.1
28.5
21.5
mg/l
1.30
92
709
22
166
1.40
0.65
1.6
1.7
—
—
—
0
0
95
890
1.42
0.64
5.6
4.2
4.5
4.7
mmol/l
0.97
86
828
10
63
1.64
0.64
1.2
1.2
—
41.6
—
0
6
8
50
1.64
0.63
10.1
8.8
0.5
0.8
%
—
8
50
12
81
1.54
0.60
1.3
1.1
—
—
—
0
0
6
35
1.75
0.59
2.3
1.3
—
—
—
0
0
6
35
1.75
0.59
2.3
1.3
—
—
—
0
0
6
35
1.75
0.59
2.3
1.2
—
—
—
0
0
6
36
1.70
0.57
2.3
1.3
—
—
—
0
0
32
262
1.31
0.57
3.6
3.4
—
—
—
0
0
77
706
1.28
0.56
5.6
4.0
17.9
10.6
mm/h
2.64
71
645
93
876
1.35
0.53
5.8
4.3
6.4
5.9
mmol/l
2.02
82
802
21
165
1.33
0.49
1.6
1.2
19.7
28.4
iu/ml
—
6
58
7
46
1.56
0.49
6.7
5.5
24.2
25.5
mmol/l
—
7
46
7
50
1.43
0.46
9.7
8.9
0.9
1.5
%
—
7
50
11
78
1.45
0.45
13.9
4.0
1.2
1.2
mmol/l
0.87
11
66
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
5
34
1.49
0.41
3.0
1.6
—
—
—
0
0
6
45
1.35
0.34
1.2
1.2
—
—
—
0
0
28
241
1.22
0.33
2.0
1.5
1.9
1.3
mmol/l
1.16
22
206
15
121
1.28
0.30
1.2
1.3
—
—
—
0
0
17
140
1.25
0.29
1.4
1.6
—
—
—
0
0
22
254
0.83
0.27
3.5
4.4
0.0
0.0
estimate
0.00
12
99
42
382
1.16
0.27
2.7
2.0
—
—
—
0
0
94
908
1.21
0.26
6.2
4.6
2.5
2.7
mmol/l
1.95
84
835
19
161
1.22
0.26
1.4
1.2
1.3
10.3
u/ml
—
5
63
31
346
0.86
0.26
4.1
2.7
—
—
—
0
0
5
41
1.23
0.22
4.4
3.3
9.8
230.4
u/ml
—
5
35
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
649.8
—
0
6
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
75
781
0.88
0.21
26.5
16.5
14.0
13.7
%
1.12
75
767
0
13
0.00
0.21
0.0
1.1
—
3.5
—
0
5
0
14
0.00
0.20
0.0
4.5
—
—
—
0
0
21
187
1.15
0.17
3.7
4.7
1.0
1.0
kg/l
—
6
22
11
92
1.22
0.16
3.7
3.6
—
—
—
0
0
20
222
0.88
0.15
5.6
5.5
—
—
—
0
0
12
104
1.17
0.13
1.2
1.6
—
—
—
0
0
7
65
1.08
0.08
7.0
3.2
—
—
—
0
0
7
65
1.08
0.08
1.6
1.4
—
—
—
0
0
7
66
1.06
0.08
1.1
1.6
—
—
—
0
0
7
80
0.87
0.07
3.3
4.1
—
—
—
0
0
102
1009
1.11
0.06
35.1
20.8
129.9
135.0
g/l
2.63
102
993
12
110
1.10
0.05
1.4
1.4
—
—
—
0
0
25
259
0.96
0.03
7.5
7.0
—
—
—
0
0
61
618
0.97
0.02
4.0
3.8
—
—
—
0
0
14
142
0.98
0.00
3.0
2.9
0.7
0.7
ug/l
—
9
91
20
203
0.98
0.00
3.4
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
5
50
1.00
0.00
2.8
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
33.1
—
0
9
0
7
0.00
0.00
0.0
12.4
—
0.7
—
0
7
8
89
0.89
0.00
2.8
1.5
—
—
—
0
0
5
55
0.90
0.00
5.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
6.8
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
6.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPERALI and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPERALI 2.001 [1.3, 3.08] 0.002
Birth year 0.997 [0.99, 1.01] 0.458

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 272 females with E4_HYPERALI died.

Males

Parameter HR [95% CI] p-value
E4_HYPERALI 3.536 [2.12, 5.89] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 172 males with E4_HYPERALI died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERALI.

N-year risk Females Males
1 0.189% 0.859%
5 1.144% 4.315%
10 3.079% 10.302%
15 5.724% 18.891%
20 9.954% 29.966%

Relationships between endpoints

↥

Index endpoint: E4_HYPERALI – Other hyperalimentation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data