Risteys · E4_HYPERALI

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E67.8 Hospital discharge: ICD-9 — 2788X Hospital discharge: ICD-8 — 2789 Cause of death: ICD-10 — E67.8 Cause of death: ICD-9 — 2788X Cause of death: ICD-8 — 2789 2 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	237	141	89
Only index persons	153	96	57
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	43.41	44.51	40.35
Only index persons	34.97	39.47	27.37

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	16	11
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	39.51	39.67	39.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

3.13

2.07

3.2

3.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.81

1.67

2.6

2.2

—

(4035726)

3.84

1.60

1.0

1.3

—

(3019225) pH of Specimen

3.58

1.51

7.2

4.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

107

2.59

1.49

7.8

6.6

mmol/l

1.2

1.13

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.54

1.48

2.9

2.0

pmol/l

124.1

89.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.51

1.45

5.6

3.2

—

(36304419) Bacteria [Presence] in Urine

2.31

1.15

7.6

2.9

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

2.23

1.14

7.9

6.5

mmol/l

1.2

0.88

(3024354) Oxygen [Partial pressure] in Venous blood

2.55

1.08

1.4

2.9

kpa

2.9

3.4

—

(3044640) Blood type and Crossmatch panel - Blood

2.16

1.04

3.0

2.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.16

0.97

1.8

2.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.37

0.96

6.2

4.1

umol/l

7.2

9.1

—

(42870588) Differential panel, method unspecified - Blood

2.08

0.95

6.7

5.7

—

(3023368) Bacteria identified in Blood by Culture

2.04

0.89

6.3

5.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.12

0.88

1.8

—

(3012544) pH of Venous blood

2.13

0.75

1.8

3.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.13

0.75

1.0

1.5

—

(3022145) Colonoscopy Study observation

2.13

0.75

1.2

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.04

0.72

1.8

3.9

kpa

5.5

6.0

—

(3003694) ABO and Rh group [Type] in Blood

1.82

0.65

1.4

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

145

1.72

0.64

7.0

4.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.98

0.64

9.2

8.5

mmol/l

105.2

103.9

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

123

1.74

0.61

6.1

5.8

mmol/l

6.8

0.03

109

(3003338) MCHC [Mass/volume]

180

0.63

0.46

40.5

22.0

g/l

330.3

331.5

0.15

180

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.69

0.45

2.0

—

(40768797) Stomach Pathology biopsy report

1.63

0.44

1.2

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.42

0.0

12.5

—

92.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.42

0.0

12.5

—

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.42

0.0

12.4

—

0.6

—

(3018418) pH of Serum or Plasma

1.32

0.30

4.4

4.2

—

7.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

191

1.45

0.29

30.3

17.1

39.5

40.0

0.15

137

(3015736) pH of Urine

1.42

0.28

3.7

4.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

169

1.42

0.27

13.8

8.3

u/l

78.3

79.8

0.09

157

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

221

0.78

0.22

17.1

11.4

u/l

35.4

24.9

0.90

215

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

2.0

—

0.0

—

(3020891) Body temperature

0.00

0.22

0.0

3.6

—

(40768443) Skin Pathology biopsy report

0.00

0.22

0.0

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.22

0.0

2.3

—

(3008898) HLA-B27 [Presence]

0.00

0.22

0.0

1.0

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.22

0.0

1.8

—

254.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

2.5

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

42.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.26

0.21

4.7

4.8

ug/l

4.9

2.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.3

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.3

—

3.7

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.3

—

7.6

—

(40768804) Tissue Pathology biopsy report

1.27

0.15

3.6

2.2

—

(3007461) Platelets [#/volume] in Blood

228

0.81

0.11

38.4

23.9

e9/l

253.5

244.4

0.30

222

(3044889) 12 lead EKG panel

143

0.82

0.11

4.8

4.0

—

(40761511) CBC panel - Blood by Automated count

216

0.88

0.10

24.4

13.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.12

0.09

5.3

3.4

ng/l

25.2

48.9

—

(1761868) Lipid panel - Serum or Plasma

0.80

0.09

4.2

2.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

211

1.23

0.09

31.1

19.4

mmol/l

138.8

139.7

0.91

205

(40758558) Short blood count panel - Blood

0.80

0.09

11.8

7.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.82

0.08

3.3

4.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

130

0.86

0.06

2.6

3.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

142

0.97

0.00

5.9

3.0

u/l

38.8

48.9

0.41

137

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

3.0

—

1.5

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.2

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

5.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

81.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.8

—

125.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

2.2

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

5.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

9.7

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

21.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.7

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.2

—

(4034850)

0.00

0.0

9.9

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

141.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

10.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.95

0.00

4.0

3.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

217

1.07

0.00

27.7

19.5

umol/l

76.0

77.7

0.15

217

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.0

—

4.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.3

—

16.8

—

(3013512) EKG study

0.87

0.00

7.2

3.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

204

1.13

0.00

27.4

17.4

mg/l

30.2

23.6

0.42

160

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.0

—

107.8

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.87

0.00

4.4

4.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.0

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.3

—

3.8

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

2.4

—

223.0

—

(3026008) Bacteria identified in Urine by Culture

1.05

-0.00

2.4

2.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPERALI_NAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERALI_NAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_HYPERALI_NAS – Hyperalimentation, other specified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	E4_HYPERALI_NAS
CONTROL_EXCLUDE	E4_OBESITY_HYPER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E678
HD_ICD_9	2788X
HD_ICD_8	2789
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E678
COD_ICD_9	2788X
COD_ICD_8	2789
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Hyperalimentation, other specified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints