Atopic dermatitis, strict definition

ATOPIC_STRICT

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 L20.0
Hospital discharge: ICD-9 6918B
Hospital discharge: ICD-8 69100
Cause of death: ICD-10 L20.0
Cause of death: ICD-9 6918B
Cause of death: ICD-8 69100

8144

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8144

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Check minimum number of events None

8144

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Include endpoints None

8144

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ATOPIC_STRICT

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 L20
Name in latin Eczema atopicum

Summary Statistics

Key figures

All Female Male
Number of individuals 7895 5515 2380
Unadjusted prevalence (%) 2.56 3.18 1.76
Mean age at first event (years) 26.40 26.72 25.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.93 [1.37, 2.72] 1.6e-4 164
15 years 0.01 1.30 [0.91, 1.87] 1.5e-1 75
5 years 0.00 2.36 [1.52, 3.65] 1.3e-4 36
1 year 0.00 4.20 [2.23, 7.92] 9.3e-6 12

Correlations

Index endpoint: ATOPIC_STRICT – Atopic dermatitis, strict definition
GWS hits: 25

Survival analyses between endpoints

Plot

before Atopic dermatitis, strict definition
after Atopic dermatitis, strict definition

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Drugs most likely to be purchased after Atopic dermatitis, strict definition