Disorders of endocrine glands in diseases classified elsewhere

E4_ENDINOTH

endocrine system disease: A disease involving the endocrine system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E35 Cause of death: ICD-10 — E35 2 out of 7 registries used, show all original rules.	64
4. Check minimum number of events None	64
5. Include endpoints None	64
6. Filter based on genotype QC (FinnGen only)	64

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E20-E35
Name in latin: Morbositates glandularum endocrinarum in morbis alibi classificatis

NAME	E4_ENDINOTH
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E35
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E35
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorders of endocrine glands in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	359	201	156
Only index persons	303	172	131
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	48.72	48.00	49.57
Only index persons	47.76	46.75	49.08

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	64	35	29
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	48.06	51.56	43.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
57: Matched controls
571

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H01AC01

ATC

somatropin; parenteral

236.5

17.5

H02AB09

ATC

hydrocortisone; systemic

29.2

15.7

E35.8

ICD-10 Finland

Disorders of other endocrine glands in diseases classified elsewhere

+∞

11.9

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

18.1

11.7

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

36.2

11.4

ZX120

NOMESCO Finland

Intravenous

10.0

9.7

101

Kela drug reimbursment

Anterior pituitary hypofunction

+∞

8.5

Z94.0

ICD-10 Finland

Kidney transplant status

26.7

8.4

JN3DE

NOMESCO Finland

Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation

52.5

8.0

Z01.0

ICD-10 Finland

Examination of eyes and vision

6.8

7.8

301

Kela drug reimbursment

Growth hormone

91.5

7.6

L04AX01

ATC

azathioprine; systemic

11.2

7.6

KA1MN

NOMESCO Finland

Glomerular filtration rate (GFR) Isotope mesurement

19.0

7.6

A11CC03

ATC

alfacalcidol; systemic

19.0

7.6

127

Kela drug reimbursment

Transplant complication

14.8

7.5

E35.0

ICD-10 Finland

Disorders of thyroid gland in diseases classified elsewhere

+∞

7.4

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

9.3

7.3

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

16.6

7.2

RD210

NOMESCO Finland

19.8

7.0

A12AA04

ATC

calcium carbonate; oral

45.6

6.9

602

Kela drug reimbursment

Children's severe malnutrition

14.8

6.9

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

6.3

6.8

K00.40

ICD-10 Finland

Postnatal enamel hypoplasia

16.9

6.7

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

78.3

6.6

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

6.7

6.6

E35.1

ICD-10 Finland

Disorders of adrenal glands in diseases classified elsewhere

+∞

6.4

186

Kela drug reimbursment

Growth retardation associated with renal failure (growth hormone)

+∞

6.4

E34.39

ICD-10 Finland

Short stature, not elsewhere classified

+∞

6.4

E34.35

ICD-10 Finland

Abnormal growth retardation

+∞

6.4

D35.0

ICD-10 Finland

Benign neoplasm: Adrenal gland

+∞

6.4

D35.2

ICD-10 Finland

Benign neoplasm: Pituitary gland

+∞

6.4

7143C

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]

+∞

6.4

Z63.7

ICD-10 Finland

Other stressful life events affecting family and household

9.8

6.2

H02AB04

ATC

methylprednisolone; systemic

6.1

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.3

6.1

ZXE20

NOMESCO Finland

More than three and less than five hours

5.3

6.1

WX408

NOMESCO Finland

General anesthesy, balanced

4.3

6.1

105

I35.0

ICD-10 Finland

Aortic (valve) stenosis

13.1

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ENDINOTH and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
E4_ENDINOTH	2.635 [1.58, 4.39]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.016

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 142 males with E4_ENDINOTH died.

Mortality risk

Mortality risk for people of age

years, who have E4_ENDINOTH.

N-year risk	Females	Males
1	No data	0.513%
5	No data	3.446%
10	No data	8.439%
15	No data	15.679%
20	No data	25.275%

Relationships between endpoints

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Index endpoint: E4_ENDINOTH – Disorders of endocrine glands in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Disorders of endocrine glands in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints