hyperprolactinemia: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1385 |
4. Check minimum number of eventsNone |
1385 |
5. Include endpointsNone |
1385 |
6. Filter based on genotype QC (FinnGen only) |
1385 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E22
- Name in latin
- Hyperprolactinaemia
Similar endpoints
↥List of similar endpoints to
Hyperprolactinaemia
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7858 | 6346 | 1386 |
| Only index persons | 7530 | 6218 | 1312 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.04 |
| Only index persons | 0.20 | 0.23 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 35.99 | 33.41 | 47.97 |
| Only index persons | 35.83 | 33.35 | 47.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1385 | 1145 | 240 |
| Unadjusted period prevalence (%) | 0.34 | 0.39 | 0.11 |
| Median age at first event (years) | 36.66 | 33.92 | 49.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1263
- Matched controls
- 12629
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02CB01
ATC
bromocriptine; systemic
53.3
323.0
451
130
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
774.0
323.0
382
7
E22.1
ICD-10 Finland
Hyperprolactinaemia
4503599627370496.0
323.0
1235
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
583.0
323.0
404
10
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
308.9
292.4
287
12
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
164.3
176.7
183
13
N91.1
ICD-10 Finland
Secondary amenorrhoea
12.7
76.9
142
125
G02CB04
ATC
quinagolide; oral
+∞
66.2
63
*
N05AX08
ATC
risperidone; systemic
6.2
65.9
192
357
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.2
64.0
216
478
H02AB09
ATC
hydrocortisone; systemic
16.1
63.0
104
70
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
59.9
57
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
154.6
56.4
59
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
50.3
48
*
G03DB01
ATC
dydrogesterone; oral
2.9
46.4
330
1352
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
46.1
44
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
46.1
44
*
N05AH03
ATC
olanzapine; systemic
4.6
43.6
163
395
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.0
43.6
126
228
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
431.5
42.4
42
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
144.7
40.0
42
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.3
39.0
83
95
N05AX12
ATC
aripiprazole; systemic
5.1
38.3
127
270
N05AH04
ATC
quetiapine; oral
2.6
36.3
312
1405
N05AB03
ATC
perphenazine; systemic, rectal
5.7
31.8
95
178
N05AH02
ATC
clozapine; systemic
7.7
31.3
74
101
H03AA01
ATC
levothyroxine sodium; systemic
2.3
31.2
359
1862
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
19.3
28.4
43
23
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.0
28.4
530
3358
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
28.2
27
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
27.2
26
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
143.1
26.7
28
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
26.1
25
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
74.3
25.9
29
*
E23.05
ICD-10 Finland
Lack of TSH
+∞
25.1
24
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
25.1
89
203
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
24.0
23
*
N04BC01
ATC
bromocriptine; oral
244.4
23.7
24
*
N05AA02
ATC
levomepromazine; systemic
4.7
23.7
83
187
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
6.2
22.8
62
104
N05BA06
ATC
lorazepam; systemic, sublingual
4.4
22.5
85
206
N06AB04
ATC
citalopram; systemic
2.1
22.2
306
1681
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
7.4
21.4
51
71
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.6
21.3
99
290
XLA10
NOMESCO Finland
NA
3.3
21.0
113
370
P72
ICPC
Schizophrenia
6.5
21.0
55
88
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
20.4
178
785
N03AG01
ATC
valproic acid; systemic, rectal
3.2
20.4
111
367
N97.0
ICD-10 Finland
Female infertility associated with anovulation
5.0
19.7
64
133
N97.9
ICD-10 Finland
Female infertility, unspecified
2.7
19.7
144
574
N06AX16
ATC
venlafaxine; oral
2.2
19.7
235
1209
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.2
19.1
223
1134
F20.9
ICD-10 Finland
Schizophrenia, unspecified
5.6
19.1
56
104
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
11.6
19.0
35
31
N04AA02
ATC
biperiden; systemic
5.9
18.9
53
93
N05AN01
ATC
lithium; oral
5.1
18.6
59
120
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
8.0
18.1
41
53
N03AX09
ATC
lamotrigine; oral
3.1
18.0
103
352
XCK00
NOMESCO Finland
Perimetry
3.3
17.9
93
297
C07AA05
ATC
propranolol; systemic
1.9
17.0
285
1668
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
16.7
16
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
16.0
271
1589
N05AF03
ATC
chlorprothixene; systemic
4.5
16.0
57
132
N05BA04
ATC
oxazepam; oral
1.8
15.9
316
1960
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
8.5
15.8
34
41
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.5
15.7
76
230
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.5
15.7
56
130
102
Kela drug reimbursment
Diabetes insipidus
+∞
15.7
15
*
2542
FHL
Transasal hypophysectomy
+∞
15.7
15
*
N06AB03
ATC
fluoxetine; oral
2.1
15.2
179
907
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
14.6
14
*
D352, E221
ICD-10 Finland
NA
+∞
14.6
14
*
N05CD07
ATC
temazepam; oral
2.5
14.3
117
498
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
14.1
201
1102
E21.0
ICD-10 Finland
Primary hyperparathyroidism
40.5
13.2
16
*
N06AX11
ATC
mirtazapine; oral
1.6
13.1
382
2630
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.7
13.0
56
155
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
9.5
13.0
26
28
N05AE03
ATC
sertindole; oral
15.6
12.6
20
13
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.3
12.6
46
110
188
Kela drug reimbursment
Psychosis requiring demanding treatment
6.0
12.3
33
56
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
12.2
113
510
R51.80
ICD-10 Finland
Headache
1.8
12.1
215
1272
N05AF05
ATC
zuclopenthixol; systemic
7.6
11.9
27
36
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.9
11.9
48
126
P29
ICPC
Psychological sympt/compl other
2.4
11.9
106
470
N05AA01
ATC
chlorpromazine; systemic, rectal
5.6
11.7
33
60
F23.8
ICD-10 Finland
Other acute and transient psychotic disorders
19.1
11.6
17
9
N05CF01
ATC
zopiclone; oral
1.6
11.5
323
2185
ZYC01
NOMESCO Finland
Remote contact by phone
2.8
11.4
72
265
AA1AD
NOMESCO Finland
CT of head and brain
1.8
11.4
202
1191
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
7.0
11.4
27
39
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
7.0
11.4
27
39
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
8.3
10.8
23
28
L17
ICPC
Foot/toe symptom/complaint
1.7
10.8
267
1744
X05
ICPC
Menstruation absent/scanty
5.3
10.8
32
62
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
10.8
392
2829
N05AE04
ATC
ziprasidone; systemic
6.8
10.7
26
39
R53
ICD-10 Finland
Malaise and fatigue
1.7
10.7
242
1539
N05AD01
ATC
haloperidol; systemic
4.1
10.5
40
101
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
10.4
10
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.3
10.3
50
154
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
10.2
287
1937
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.7
10.0
33
72
N03AE01
ATC
clonazepam; systemic
2.6
10.0
74
299
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
7.3
10.0
23
32
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
9.2
9.5
19
21
N05AC02
ATC
thioridazine; oral
3.8
9.5
38
101
H01CB02
ATC
octreotide; parenteral
30.3
9.4
12
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
4.2
9.4
34
82
E23.03
ICD-10 Finland
Lack of ACTH
+∞
9.4
9
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
9.4
9
*
UJF32
NOMESCO Finland
Coloscopy
1.7
9.4
231
1499
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.7
9.3
39
108
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
5.8
9.2
25
44
N06AX21
ATC
duloxetine; oral
1.9
9.2
141
790
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.2
204
1288
N05AF01
ATC
flupentixol; systemic
4.8
9.2
29
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.1
366
2682
N05BA01
ATC
diazepam; systemic, rectal
1.9
9.1
140
786
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
7.1
9.0
21
30
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
10.1
9.0
17
17
ZY010
NOMESCO Finland
Hospital outpatient
2.3
9.0
80
359
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
3.0
8.9
51
177
N06AB05
ATC
paroxetine; oral
2.2
8.9
86
398
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.8
8.9
36
97
N05AX13
ATC
paliperidone; systemic
8.0
8.9
19
24
C03CA01
ATC
furosemide; systemic
1.8
8.7
164
982
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
50.3
8.7
10
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
6.2
8.6
22
36
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
8.6
101
511
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
8.6
172
1052
AA400
NOMESCO Finland
Electroconvulsive therapy
5.8
8.6
23
40
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.0
8.6
113
597
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
4.8
8.6
27
57
N06AB06
ATC
sertraline; oral
1.8
8.5
153
905
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.4
8.5
40
122
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.5
8.5
64
261
K59.0
ICD-10 Finland
Constipation
2.7
8.5
57
218
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
8.4
481
3775
E23.2
ICD-10 Finland
Diabetes insipidus
90.6
8.4
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
8.4
267
1849
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
4.3
8.3
29
68
F28
ICD-10 Finland
Other nonorganic psychotic disorders
10.8
8.3
15
14
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
8.3
142
827
X21
ICPC
Breast sympt/compl female other
3.2
8.2
41
131
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.8
8.2
52
193
R11
ICD-10 Finland
Nausea and vomiting
2.1
8.2
94
473
N06AG02
ATC
moclobemide; oral
2.6
8.2
56
218
F22.0
ICD-10 Finland
Delusional disorder
4.7
8.1
26
56
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
8.1
106
561
N05AL01
ATC
sulpiride; systemic
5.1
8.0
24
48
F61.0
ICD-10 Finland
Mixed personality disorders
3.5
7.9
35
102
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.3
7.9
73
334
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
4.1
7.9
29
72
Z2446
NOMESCO Finland
Social worker
2.1
7.8
82
399
P28
ICPC
Limited function/disability (P)
6.4
7.7
19
30
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
6.4
7.7
19
30
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
7.5
7.7
17
23
ZY000
NOMESCO Finland
Hospital inpatient
4.2
7.6
27
65
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
6.7
7.6
18
27
A02BC02
ATC
pantoprazole; systemic
1.4
7.6
688
5839
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
7.6
95
493
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
10.1
7.5
14
14
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
3.3
7.5
36
112
S18
ICPC
Laceration/cut
1.4
7.5
379
2891
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.2
7.5
37
118
N03AX16
ATC
pregabalin; oral
1.6
7.5
232
1593
Z3231
NOMESCO Finland
Registered nurse
1.5
7.4
271
1932
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.4
230
1579
ZXY49
NOMESCO Finland
Other health care provider
6.5
7.4
18
28
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.8
7.4
134
793
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
7.4
266
1890
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.3
229
1576
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
7.3
7
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
7.3
7
*
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
7.3
7
*
X78
ICD-10 Finland
Intentional self-harm by sharp object
5.8
7.2
19
33
G03GA01
ATC
chorionic gonadotrophin; parenteral
2.1
7.2
77
374
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
3.4
7.1
32
95
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
20.1
7.1
10
5
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
7.1
115
658
Z2445
NOMESCO Finland
Psychologist
2.4
7.1
59
256
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.1
221
1518
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.1
436
3446
IEY19
NOMESCO Finland
Psychiatric health counselling and guidance
12.1
7.1
12
10
F21
ICD-10 Finland
Schizotypal disorder
6.1
7.1
18
30
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.3
7.0
62
278
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
10.1
7.0
13
13
F25.11
ICD-10 Finland
Schizoaffective syndrome, depressive type with prolonged schizophrenic than bipolar symptoms
10.1
7.0
13
13
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
7.0
45
169
X07
ICPC
Menstruation irregular/frequent
3.4
6.9
31
92
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.9
130
779
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.0
6.9
37
126
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.9
138
845
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
40.3
6.8
8
*
XF404
NOMESCO Finland
Ambulatory ECG
2.1
6.7
76
378
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.2
6.7
67
318
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
6.7
143
891
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.9
6.7
39
139
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
3.8
6.7
26
69
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.7
182
1211
N06AX18
ATC
reboxetine; oral
5.2
6.6
19
37
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
7.9
6.6
14
18
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
5.5
6.6
18
33
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
5.9
6.6
17
29
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
6.6
127
767
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
10.1
6.5
12
12
F23.3
ICD-10 Finland
Other acute predominantly delusional psychotic disorders
6.9
6.5
15
22
R07.3
ICD-10 Finland
Other chest pain
1.9
6.5
87
465
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
5.1
6.5
19
38
P01
ICPC
Feeling anxious/nervous/tense
1.6
6.5
173
1144
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
6.4
184
1235
E66.8
ICD-10 Finland
Other obesity
2.0
6.4
76
387
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.1
6.3
71
353
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.3
186
1259
N05BE01
ATC
buspirone; oral
2.8
6.3
37
133
O92.6
ICD-10 Finland
Galactorrhoea
11.1
6.3
11
10
E29.1
ICD-10 Finland
Testicular hypofunction
9.3
6.3
12
13
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
6.3
6
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
6.3
6
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
7.1
6.2
14
20
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
7.1
6.2
14
20
G03DA04
ATC
progesterone; systemic, rectal, vaginal
2.3
6.2
56
254
P99
ICPC
Psychological disorders other
2.6
6.2
44
176
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.3
6.2
29
90
P73
ICPC
Affective psychosis
6.3
6.2
15
24
U02
ICPC
Urinary frequency/urgency
1.6
6.2
144
919
M79.6
ICD-10 Finland
Pain in limb
1.4
6.1
383
3018
F31.8
ICD-10 Finland
Other bipolar affective disorders
2.9
6.1
35
122
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.4
6.1
288
2156
N03AX12
ATC
gabapentin; oral
1.6
6.1
154
1007
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.537 [1.32, 1.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.271 |
During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 5615 females with E4_HYPERPRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.183 [1.0, 1.41] | 0.056 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 1157 males with E4_HYPERPRO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.213% |
| 5 | 0.784% | 1.263% |
| 10 | 2.184% | 3.222% |
| 15 | 4.019% | 6.2% |
| 20 | 7.392% | 10.984% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPRO – Hyperprolactinaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data