No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
239 |
4. Check minimum number of eventsNone |
239 |
5. Include endpointsNone |
239 |
6. Filter based on genotype QC (FinnGen only) |
239 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Precocious central puberty
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2852 | 1930 | 912 |
| Only index persons | 2430 | 1642 | 788 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.59 | 8.54 | 11.31 |
| Only index persons | 9.31 | 8.52 | 10.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 239 | 165 | 74 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 10.10 | 8.90 | 12.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 223
- Matched controls
- 2228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.80
ICD-10 Finland
Central precocious puberty
+∞
102.1
90
*
L02AE02
ATC
leuprorelin; implant, parenteral
62.3
52.4
60
13
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
46.5
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
36.5
34
*
H01AC01
ATC
somatropin; parenteral
+∞
33.1
31
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
32.0
30
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
32.0
30
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
21.5
27.8
41
23
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
20.1
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
15.8
15
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
15.8
15
*
L02AE04
ATC
triptorelin; parenteral
+∞
14.7
14
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
160.0
14.6
15
*
H02AB09
ATC
hydrocortisone; systemic
11.1
12.8
24
24
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
74.2
12.7
14
*
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
12.6
12
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.6
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
11.7
81
349
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
11.6
11
*
E34.35
ICD-10 Finland
Abnormal growth retardation
+∞
10.5
10
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.5
10
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.7
10.3
35
84
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
57.5
9.7
11
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
+∞
9.4
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
8.4
32
86
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
8.4
8
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
8.4
8
*
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
34.7
8.1
10
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
11.4
7.9
14
13
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
7.1
7.8
18
27
H03AA01
ATC
levothyroxine sodium; systemic
3.0
7.7
46
175
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
7.6
67
322
H47.2
ICD-10 Finland
Optic atrophy
26.0
7.6
10
*
301
Kela drug reimbursment
Growth hormone
+∞
7.3
7
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
7.3
7
*
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
7.3
7
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
7.3
7
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.4
7.2
15
19
L04AA01
ATC
[U] ciclosporin; systemic
31.1
7.2
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
6.9
39
144
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.8
6.9
22
50
602
Kela drug reimbursment
Children's severe malnutrition
23.3
6.7
9
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
6.1
42
176
Mortality – FinRegistry
↥Association
Association between endpoint E4_PRECOXCENTPUB and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PRECOXCENTPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PRECOXCENTPUB – Precocious central puberty
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data