No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
125 |
4. Check minimum number of eventsNone |
125 |
5. Include endpointsNone |
125 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 751 | 407 | 340 |
| Only index persons | 694 | 385 | 309 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 59.10 | 60.28 | 57.74 |
| Only index persons | 58.78 | 59.62 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 69 | 56 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 58.02 | 58.59 | 57.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1111
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
69.2
59
*
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
54.8
48
*
XCK10
NOMESCO Finland
Photography of fundus of eye
16.2
25.8
44
43
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
19.5
25.6
40
31
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
21.1
20.3
30
19
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
48.1
17.0
20
5
XCD10
NOMESCO Finland
Electrophysiological examination of eye
36.5
16.8
21
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.8
16.4
31
35
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
171.7
14.8
15
*
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
13.8
13
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
10.6
10
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
8.8
34
99
WX140
NOMESCO Finland
Parabulbar anesthesy
18.2
8.8
13
8
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
7.4
7
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
6.3
6
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
+∞
6.3
6
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
+∞
6.3
6
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
+∞
6.3
6
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
+∞
6.3
6
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORNAS | 1.072 [0.76, 1.51] | 0.693 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 338 females with H7_CHORNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_CHORNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | No data |
| 5 | 0.555% | No data |
| 10 | 1.562% | No data |
| 15 | 3.141% | No data |
| 20 | 5.669% | No data |
Relationships between endpoints
↥Index endpoint: H7_CHORNAS – Other specified and unspecified disorders of choroid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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