No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
507 |
6. Filter based on genotype QC (FinnGen only) |
507 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4103 | 2132 | 1941 |
| Only index persons | 3629 | 1908 | 1721 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 63.92 | 67.31 | 60.08 |
| Only index persons | 62.24 | 65.65 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 507 | 257 | 250 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 62.65 | 61.29 | 64.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 453
- Matched controls
- 4530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
120.3
110
*
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
102.0
94
*
H31.4
ICD-10 Finland
Choroidal detachment
+∞
81.8
76
*
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
63.0
59
*
XCK10
NOMESCO Finland
Photography of fundus of eye
9.8
59.6
131
180
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.7
59.4
112
114
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
221.0
57.5
58
*
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
51.0
48
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.2
50.3
113
157
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
507.4
47.2
46
*
WX140
NOMESCO Finland
Parabulbar anesthesy
21.2
44.3
66
36
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
43.4
41
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
41.9
135
308
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
410.2
38.6
38
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
130.0
34.2
36
*
S01EC01
ATC
acetazolamide; systemic
20.4
34.0
51
28
XCD10
NOMESCO Finland
Electrophysiological examination of eye
17.6
32.9
52
33
S01ED51
ATC
timolol, combinations; ophthalmic
6.5
32.8
92
171
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
32.7
31
*
H31.2
ICD-10 Finland
Hereditary choroidal dystrophy
+∞
32.7
31
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
37.4
32.4
41
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
32.3
131
372
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
13.2
30.3
54
46
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
28.5
211
969
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.3
28.4
65
89
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
35.4
28.2
36
11
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
27.4
26
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
26.4
217
1054
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
99.3
26.0
28
*
XCK00
NOMESCO Finland
Perimetry
6.2
25.7
73
136
H31.1
ICD-10 Finland
Choroidal degeneration
+∞
25.2
24
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
24.2
23
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.5
23.6
30
9
114
Kela drug reimbursment
Glaucoma
4.4
23.2
91
243
S01ED01
ATC
timolol; ophthalmic
8.6
22.7
50
64
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
19.9
19
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
26.0
19.8
27
11
S01EX03
ATC
NA
10.5
19.5
38
39
S01EC03
ATC
dorzolamide; ophthalmic
14.9
19.4
32
23
CKC10
NOMESCO Finland
Local photocoagulation of retina
104.4
18.7
20
*
CKC12
NOMESCO Finland
Photocoagulation of retina
46.0
18.4
22
5
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.7
18.0
42
59
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
17.6
164
810
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
17.1
220
1282
S01EC04
ATC
brinzolamide; ophthalmic
6.9
16.7
42
66
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
41.7
16.5
20
5
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
15.7
15
*
S01EA03
ATC
apraclonidine; ophthalmic
24.4
15.2
21
9
S01EE01
ATC
latanoprost; ophthalmic
4.3
14.1
54
139
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
14.0
63
188
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
77.5
13.7
15
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
23.3
13.0
18
8
H26.4
ICD-10 Finland
After-cataract
3.3
12.6
67
227
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
12.6
12
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
12.6
12
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.8
12.5
42
95
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.8
11.9
33
60
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
11.5
11
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
16.0
10.9
17
11
ZXA10
NOMESCO Finland
Bilateral
2.4
10.8
100
476
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
61.5
10.7
12
*
S01BC03
ATC
diclofenac; ophthalmic
7.1
10.5
25
37
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
112.5
10.5
11
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
10.5
10
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
10.5
10
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
10.5
10
*
ZXA05
NOMESCO Finland
Left side
2.1
10.3
135
752
H26.2
ICD-10 Finland
Complicated cataract
19.3
10.3
15
8
XCH00
NOMESCO Finland
Eye pressure measurement
5.4
10.2
30
59
CHD00
NOMESCO Finland
Laser trabeculoplasty
11.7
10.1
18
16
CHD99
NOMESCO Finland
Other filtering operation
41.0
10.0
12
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
41.0
10.0
12
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
13.8
9.7
16
12
H34.8
ICD-10 Finland
Other retinal vascular occlusions
56.2
9.7
11
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
56.2
9.7
11
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
56.2
9.7
11
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
30.7
9.4
12
*
H27.0
ICD-10 Finland
Aphakia
30.7
9.4
12
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
9.4
9
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
+∞
9.4
9
*
WX002
NOMESCO Finland
Sedation and analgesia
2.2
8.9
102
533
S01EE05
ATC
tafluprost; ophthalmic
4.2
8.6
32
81
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.9
8.6
15
13
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
28.1
8.5
11
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
8.4
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
8.4
8
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
8.4
8
*
H35.37
ICD-10 Finland
Macular holes
+∞
8.4
8
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.4
8.0
18
25
S01EE04
ATC
travoprost; ophthalmic
5.6
7.9
22
41
ZXA00
NOMESCO Finland
Right side
1.9
7.9
137
840
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
81.3
7.4
8
*
S01BC05
ATC
ketorolac; ophthalmic
3.6
7.4
32
94
S01EE03
ATC
bimatoprost; ophthalmic
5.1
7.4
22
45
CKD60
NOMESCO Finland
Anterior vitrectomy
9.6
7.3
14
15
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
7.3
7
*
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
30.5
7.2
9
*
S01FA01
ATC
atropine; ophthalmic
30.5
7.2
9
*
H33.5
ICD-10 Finland
Other retinal detachments
30.5
7.2
9
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
6.5
7.0
17
27
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
14.0
6.9
11
8
S01EC54
ATC
brinzolamide, combinations; ophthalmic
9.5
6.8
13
14
H27.1
ICD-10 Finland
Dislocation of lens
17.0
6.8
10
6
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
17.0
6.8
10
6
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
6.6
43
168
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
6.6
33
109
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
6.5
66
326
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
70.8
6.4
7
*
CHD10
NOMESCO Finland
Trabeculectomy
70.8
6.4
7
*
S01EA02
ATC
dipivefrine; ophthalmic
14.6
6.4
10
7
CHC05
NOMESCO Finland
Iridotomy
5.3
6.4
18
35
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
+∞
6.3
6
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
6.3
6
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
6.3
6
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
6.3
6
*
H3600, E113
ICD-10 Finland
NA
+∞
6.3
6
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
6.3
6
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
6.3
6
*
H3603, E103
ICD-10 Finland
NA
+∞
6.3
6
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
+∞
6.3
6
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
27.1
6.2
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
6.2
54
246
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
153
994
1.77
7.56
2.5
2.1
3.0
3.2
mg/l
0.52
130
843
95
567
1.83
6.11
3.4
2.3
2.2
2.3
g/l
1.21
90
515
212
1588
1.58
5.73
3.5
2.7
129.5
130.1
ug/l
0.01
198
1458
88
538
1.77
5.20
3.6
2.4
21.8
21.6
%
0.04
74
450
277
2238
1.52
5.13
11.4
8.8
4.1
4.1
e9/l
0.01
247
1958
340
2885
1.54
4.90
4.0
3.9
14.9
14.9
pmol/l
0.05
308
2598
165
1206
1.55
4.79
3.0
2.4
58.0
56.0
u/l
0.31
154
1116
258
2074
1.50
4.76
7.2
5.9
11.9
11.6
umol/l
0.12
247
1963
155
1121
1.55
4.71
3.6
3.1
0.2
0.5
e6/l
3.60
124
831
100
661
1.64
4.41
2.6
2.7
1.3
1.0
e6/l
0.41
55
371
119
823
1.58
4.36
2.5
1.7
1.1
1.3
mg/l
0.49
93
645
167
1245
1.51
4.36
4.5
3.1
30.4
33.5
u/l
0.75
159
1181
242
1948
1.46
4.28
5.0
3.8
0.0
0.0
estimate
0.00
52
369
12
32
3.82
4.10
1.0
1.1
—
—
—
0
0
243
1976
1.44
3.98
5.2
3.9
0.0
0.0
estimate
0.00
52
359
217
1728
1.45
3.98
6.5
4.4
35.1
35.4
g/l
0.27
200
1602
240
1953
1.43
3.89
7.0
5.1
0.0
0.0
estimate
0.00
54
363
189
1472
1.45
3.87
4.3
3.1
—
—
—
0
0
345
3013
1.45
3.72
10.6
7.2
85.4
78.4
u/l
0.70
328
2808
92
621
1.59
3.70
2.7
2.9
2.5
2.6
e6/l
0.06
47
337
392
3513
1.51
3.68
4.9
4.7
1.9
2.3
mu/l
0.54
356
3176
9
16
5.71
3.67
1.0
1.1
—
—
—
0
0
82
540
1.62
3.65
21.4
25.4
1.1
1.3
inr
—
8
69
139
1030
1.48
3.65
3.5
2.7
8022.8
8375.4
umol/l
0.03
124
892
244
2016
1.41
3.51
9.5
6.5
1.2
1.2
mmol/l
0.77
206
1687
11
31
3.60
3.50
1.7
1.5
—
—
—
0
0
277
2347
1.40
3.40
6.0
4.6
6.8
6.7
mmol/l
0.46
262
2187
437
4033
1.61
3.36
24.7
17.4
4.0
4.0
mmol/l
0.08
425
3915
361
3217
1.42
3.21
25.5
17.9
13.8
13.8
%
0.34
355
3150
435
4021
1.58
3.20
24.3
17.3
139.6
139.6
mmol/l
0.18
423
3907
156
1209
1.42
3.18
4.9
3.7
9.5
8.8
mg/mmol
0.09
101
759
17
69
2.51
2.99
3.5
3.1
4.0
4.3
e9/l
0.19
17
69
396
3608
1.45
2.95
7.0
5.7
41.5
39.9
mmol/mol
2.33
367
3333
193
1568
1.37
2.93
2.7
2.2
79.1
77.5
nmol/l
0.28
180
1395
17
70
2.48
2.91
3.5
3.3
60.1
58.9
%
0.14
17
70
197
1617
1.36
2.77
5.1
3.8
28.2
40.2
ng/l
1.63
150
1157
411
3785
1.45
2.76
4.7
4.3
4.5
4.6
mmol/l
0.95
374
3473
199
1639
1.35
2.73
2.0
2.0
101.2
95.2
pmol/l
0.72
102
854
28
148
1.94
2.66
1.7
3.3
3.4
3.2
g/l
0.26
19
118
70
481
1.53
2.61
7.3
6.9
1.5
1.2
mmol/l
0.29
47
367
12
44
2.77
2.56
1.2
1.3
2.8
6.1
u/ml
—
5
17
48
303
1.65
2.55
1.9
1.6
—
—
—
0
0
63
425
1.55
2.55
4.2
3.6
—
—
—
0
0
6
11
5.50
2.55
1.2
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
137
1.95
2.50
5.0
2.5
0.4
0.4
u/ml
0.04
17
83
107
810
1.41
2.44
1.9
1.8
1141.2
1180.8
nmol/l
0.16
77
604
406
3756
1.41
2.43
4.6
4.3
1.4
1.5
mmol/l
1.17
367
3424
72
506
1.49
2.42
6.8
6.4
104.3
104.0
mmol/l
0.20
72
495
58
389
1.55
2.42
4.9
3.7
1.7
2.0
mmol/l
0.28
45
307
439
4121
1.49
2.41
14.0
10.2
25.5
25.8
u/l
0.18
422
3963
6
12
5.05
2.41
1.0
1.0
1736.3
1412.8
miu/ml
—
6
12
184
1525
1.32
2.35
5.8
4.1
—
—
—
0
0
70
493
1.49
2.34
2.0
1.8
—
—
—
0
0
322
2887
1.32
2.30
5.3
4.1
15.4
13.0
mm/h
1.49
304
2647
392
3618
1.37
2.28
19.0
13.8
76.2
78.0
ml/min/173m2
0.78
330
2967
69
488
1.48
2.26
2.0
1.7
—
—
—
0
0
13
54
2.44
2.21
1.2
1.3
103.0
103.3
u/ml
—
6
13
15
67
2.28
2.19
2.6
2.5
3248.0
7054.0
u/l
—
7
24
52
349
1.55
2.18
2.4
1.9
355.3
377.7
nmol/l
0.32
46
313
27
152
1.82
2.16
1.7
3.3
11.7
10.3
g/l
0.50
19
131
12
49
2.48
2.12
1.4
1.6
30.5
32.8
pg
0.84
12
49
214
1832
1.29
2.10
4.5
4.0
—
—
—
0
0
8
25
3.23
2.10
2.0
1.3
—
—
—
0
0
18
89
2.06
2.08
1.6
1.7
227.8
308.2
mu/l
1.38
18
84
28
162
1.77
2.06
1.7
3.2
3.7
3.8
g/l
0.09
18
116
112
879
1.35
2.04
1.8
1.7
447.7
434.7
pmol/l
0.21
86
718
28
163
1.76
2.03
1.7
3.2
7.8
7.7
g/l
0.04
19
121
28
163
1.76
2.03
1.7
3.2
—
—
—
0
0
10
38
2.66
2.02
1.3
1.3
—
—
—
0
0
414
3883
1.36
1.95
5.3
4.9
2.7
2.7
mmol/l
0.60
377
3544
20
106
1.92
1.93
1.3
1.8
—
—
—
0
0
37
241
1.58
1.79
1.5
1.4
—
—
—
0
0
212
1841
1.26
1.79
8.9
5.7
1.2
1.2
mmol/l
1.12
196
1674
6
18
3.36
1.75
2.5
2.5
2014.8
1409.6
u/ml
—
6
18
89
691
1.35
1.74
2.1
1.8
—
—
—
0
0
401
3763
1.31
1.73
5.1
4.6
6.2
6.0
mmol/l
2.74
364
3408
388
3628
1.30
1.70
4.2
3.9
1.3
1.3
mmol/l
0.20
345
3297
49
346
1.46
1.65
5.3
3.8
1.2
1.2
mmol/l
0.37
44
304
17
91
1.90
1.62
1.6
1.7
11097.9
22654.3
e6/l
0.68
11
65
5
14
3.60
1.62
2.2
1.1
—
—
—
0
0
6
20
3.02
1.58
1.3
2.2
—
—
—
0
0
6
20
3.02
1.58
1.3
2.2
—
—
—
0
0
21
122
1.75
1.57
1.5
2.2
—
—
—
0
0
21
123
1.74
1.53
1.8
3.6
0.0
0.0
g/l
0.50
21
113
6
21
2.88
1.51
1.3
1.2
3.0
1.9
mmol/l
—
6
21
19
109
1.77
1.48
1.4
1.6
—
—
—
0
0
158
1351
1.25
1.48
4.3
3.2
2.3
2.4
mmol/l
0.07
141
1180
114
940
1.27
1.45
2.5
2.2
—
—
—
0
0
145
1232
1.25
1.43
2.7
2.1
163.5
220.8
u/l
0.55
139
1155
411
3910
1.27
1.31
22.3
14.8
23.9
24.1
mg/l
0.05
343
3131
57
435
1.35
1.27
2.9
2.5
10.4
9.3
umol/l
0.11
50
380
96
788
1.27
1.27
1.3
1.2
1.0
1.3
u/ml
0.32
38
208
127
1078
1.24
1.26
6.0
4.2
0.0
0.0
estimate
0.50
52
357
15
86
1.77
1.20
1.3
1.3
—
—
—
0
0
15
86
1.77
1.20
1.3
1.3
—
—
—
0
0
11
57
1.95
1.17
1.0
1.2
259.8
256.3
u/ml
—
6
32
11
57
1.95
1.17
1.0
1.2
—
—
—
0
0
18
110
1.66
1.17
1.2
1.3
—
—
—
0
0
15
87
1.75
1.16
1.1
1.2
—
—
—
0
0
13
72
1.83
1.16
1.5
1.6
—
—
—
0
0
5
23
2.19
0.98
1.0
1.0
—
—
—
0
0
5
23
2.19
0.98
2.6
3.3
—
—
—
0
0
7
37
1.90
0.94
1.0
1.3
—
—
—
0
0
12
70
1.73
0.93
1.4
1.5
—
—
—
0
0
10
55
1.83
0.92
1.1
1.7
—
—
—
0
0
26
185
1.43
0.91
10.2
4.1
24.5
24.1
mmol/l
0.24
21
169
11
63
1.76
0.90
1.3
1.7
—
—
—
0
0
8
42
1.92
0.89
1.0
1.0
1.5
1.4
g/l
—
8
36
17
111
1.55
0.88
1.8
2.1
—
—
—
0
0
10
56
1.80
0.88
1.2
1.1
—
—
—
0
0
265
2467
1.16
0.88
3.6
3.0
52.9
49.9
u/l
0.24
246
2279
20
136
1.49
0.88
3.4
2.9
—
—
—
0
0
8
43
1.87
0.87
1.4
1.3
223.9
262.5
pmol/l
—
8
35
8
43
1.87
0.87
1.9
2.2
—
—
—
0
0
8
43
1.87
0.87
1.1
1.1
—
—
—
0
0
8
44
1.83
0.86
1.1
1.3
—
—
—
0
0
366
3495
1.17
0.84
21.9
15.9
38.5
39.7
%
1.21
252
2431
91
782
1.20
0.81
3.4
3.0
2.5
2.5
mmol/l
0.04
77
688
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
43
341
1.29
0.79
2.1
3.0
67.0
66.2
g/l
0.26
38
310
13
82
1.60
0.78
1.2
1.7
1.8
8.2
iu/l
—
5
24
5
24
2.09
0.74
1.0
1.3
—
—
—
0
0
7
40
1.76
0.71
1.1
1.1
—
—
—
0
0
9
59
1.53
0.68
1.1
1.8
—
—
—
0
0
7
42
1.68
0.68
2.0
1.5
—
—
—
0
0
32
250
1.30
0.67
1.4
1.6
—
—
—
0
0
110
979
1.16
0.66
1.8
1.6
1.3
1.4
mmol/l
0.38
95
823
12
78
1.55
0.66
1.2
1.4
142.8
231.1
pmol/l
0.23
12
78
32
251
1.29
0.66
4.5
3.7
1.8
1.8
mmol/l
0.02
26
183
71
611
1.19
0.64
1.3
1.3
10.7
12.4
u/ml
0.12
35
219
20
266
0.74
0.61
2.6
2.0
—
—
—
0
0
42
347
1.23
0.58
2.9
2.3
28.0
31.8
u/l
0.54
35
298
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
14
98
1.44
0.57
1.9
1.6
—
—
—
0
0
38
312
1.24
0.56
3.0
2.8
51.0
64.0
ml/min/173m2
1.06
14
135
6
38
1.59
0.54
1.7
1.6
—
—
—
0
0
6
39
1.54
0.53
1.2
1.3
3175.2
305.1
u/l
—
6
39
6
39
1.54
0.53
1.0
1.1
—
—
—
0
0
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
14
100
1.41
0.52
1.9
1.4
—
—
—
0
0
6
40
1.51
0.51
2.0
1.6
—
—
—
0
0
87
777
1.14
0.51
4.5
3.9
286.2
289.2
ng/l
0.01
66
635
19
144
1.33
0.51
2.1
2.1
—
—
—
0
0
41
484
0.83
0.49
3.9
4.5
31.0
32.5
%
0.34
26
315
12
84
1.44
0.49
1.1
1.6
3.4
14.8
e6/l
—
7
69
120
1098
1.12
0.49
4.9
4.2
22.6
21.1
%
0.52
60
519
88
791
1.14
0.48
2.8
3.0
1.1
0.8
ug/l
0.48
52
511
7
47
1.50
0.47
1.4
1.5
—
—
—
0
0
7
48
1.46
0.47
1.3
1.5
—
—
—
0
0
7
48
1.46
0.47
1.3
1.5
—
—
—
0
0
136
1258
1.11
0.46
3.9
3.2
1984.5
1476.8
ng/l
1.02
122
1073
7
49
1.43
0.46
1.3
1.4
—
—
—
0
0
7
49
1.43
0.46
1.4
1.4
—
—
—
0
0
7
49
1.43
0.46
1.4
1.4
—
—
—
0
0
15
112
1.35
0.45
2.1
3.8
0.0
0.0
g/l
0.00
15
104
12
86
1.40
0.45
1.3
1.3
—
—
—
0
0
96
873
1.12
0.44
5.6
4.3
1.0
1.0
kg/l
1.00
13
121
18
139
1.31
0.44
4.7
2.2
951.1
319.9
ug/l
0.39
18
133
14
104
1.36
0.43
1.9
1.6
—
—
—
0
0
147
1372
1.10
0.42
5.2
4.9
2.5
2.6
ug/l
0.07
132
1227
5
32
1.57
0.42
1.6
1.8
—
—
—
0
0
70
627
1.14
0.41
1.3
1.3
53.9
38.6
iu/ml
0.48
23
199
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
15
114
1.33
0.41
2.1
3.8
0.0
0.0
g/l
0.00
15
105
0
17
0.00
0.40
0.0
1.9
—
—
—
0
0
24
196
1.24
0.40
9.0
9.4
23.7
24.5
mmol/l
0.37
24
181
8
61
1.32
0.39
2.1
1.9
—
—
—
0
0
22
178
1.25
0.39
2.6
3.0
66.7
38.6
u/ml
0.30
22
171
234
2239
1.08
0.38
3.1
2.9
—
—
—
0
0
25
300
0.82
0.38
2.9
2.1
—
—
—
0
0
26
217
1.21
0.36
1.2
1.2
91.8
121.7
iu/ml
—
8
87
5
79
0.63
0.35
1.2
1.3
—
—
—
0
0
48
426
1.14
0.34
3.6
4.0
34.0
17.6
ug/l
0.21
40
363
6
45
1.34
0.34
2.8
1.6
—
—
—
0
0
21
173
1.22
0.33
1.0
1.0
—
—
—
0
0
7
57
1.23
0.29
2.0
1.6
—
—
—
0
0
6
85
0.70
0.24
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
8.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
2.8
—
0
5
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
6
48
1.25
0.20
9.0
4.0
—
—
—
0
0
6
53
1.13
0.18
2.0
1.7
—
—
—
0
0
45
484
0.92
0.17
1.4
1.4
—
—
—
0
0
14
162
0.86
0.16
1.6
2.0
—
—
—
0
0
16
139
1.16
0.16
1.2
1.2
—
—
—
0
0
26
287
0.90
0.16
2.0
1.7
—
—
—
0
0
7
87
0.80
0.14
1.3
1.4
—
—
—
0
0
10
84
1.19
0.14
1.4
1.5
—
—
—
0
0
11
128
0.86
0.13
1.5
1.5
—
—
—
0
0
5
46
1.09
0.09
5.6
3.3
2.5
3.4
nmol/l
—
5
46
39
411
0.94
0.09
2.0
1.8
1.6
1.5
%
0.33
33
362
13
116
1.12
0.09
1.9
1.6
—
—
—
0
0
11
97
1.14
0.09
1.0
1.3
—
—
—
0
0
51
491
1.04
0.07
8.9
7.6
—
—
—
0
0
18
193
0.93
0.06
1.6
1.3
—
—
—
0
0
102
999
1.03
0.06
1.5
1.5
21.2
21.3
nmol/l
0.03
91
845
37
357
1.04
0.05
3.4
3.1
199.1
223.5
ng/l
0.15
31
326
60
587
1.03
0.04
1.7
1.5
—
—
—
0
0
12
112
1.07
0.03
1.5
1.5
—
—
—
0
0
38
373
1.02
0.01
2.9
2.4
12.9
7.3
ug/l
0.38
33
328
14
146
0.96
0.00
1.4
1.8
—
—
—
0
0
14
135
1.04
0.00
1.5
1.2
—
—
—
0
0
14
137
1.02
0.00
1.5
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
44.8
—
0
5
0
5
0.00
0.00
0.0
2.0
—
8.9
—
0
5
0
5
0.00
0.00
0.0
1.0
—
25.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
8.9
—
0
9
5
49
1.02
0.00
2.0
1.4
0.7
0.6
nmol/l
—
5
44
6
69
0.87
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
4.9
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
69
1.01
0.00
2.6
1.7
—
—
—
0
0
6
69
0.87
0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
7
78
0.90
0.00
1.3
1.5
—
—
—
0
0
6
69
0.87
0.00
1.2
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHOROIDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.061 [0.92, 1.22] | 0.4 |
| Birth year | 0.998 [0.99, 1.01] | 0.675 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 1781 females with H7_CHOROIDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.09 [0.93, 1.27] | 0.272 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 1549 males with H7_CHOROIDOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHOROIDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.209% |
| 5 | 0.689% | 1.294% |
| 10 | 1.593% | 3.192% |
| 15 | 3.182% | 5.938% |
| 20 | 5.824% | 10.166% |
Relationships between endpoints
↥Index endpoint: H7_CHOROIDOTH – Other disorders of choroid
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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