No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
537 |
6. Filter based on genotype QC (FinnGen only) |
512 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4103 | 2132 | 1941 |
| Only index persons | 3629 | 1908 | 1721 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 63.92 | 67.31 | 60.08 |
| Only index persons | 62.24 | 65.65 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 512 | 260 | 252 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.12 |
| Median age at first event (years) | 63.22 | 61.59 | 64.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 537
- Matched controls
- 5370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
138.7
127
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.8
133.0
148
155
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
122.7
113
*
XCK10
NOMESCO Finland
Photography of fundus of eye
10.0
113.9
154
208
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.3
108.7
140
177
WX140
NOMESCO Finland
Parabulbar anesthesy
20.4
102.8
82
47
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
13.9
96.4
96
83
H31.4
ICD-10 Finland
Choroidal detachment
+∞
92.4
86
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.9
77.9
184
436
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
77.0
72
*
S01EC01
ATC
acetazolamide; systemic
16.9
68.4
59
39
S01EA05
ATC
brimonidine; ophthalmic
14.4
66.8
63
49
XCD10
NOMESCO Finland
Electrophysiological examination of eye
15.2
66.6
61
45
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
66.0
62
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
155.3
65.6
68
5
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
19.7
65.4
52
29
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
27.2
64.7
45
18
S01ED51
ATC
timolol, combinations; ophthalmic
6.9
63.9
113
200
XCK00
NOMESCO Finland
Perimetry
7.6
56.6
88
135
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
53.5
164
469
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
199.6
53.0
54
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
475.3
44.9
44
*
S01ED01
ATC
timolol; ophthalmic
8.5
42.9
58
75
114
Kela drug reimbursment
Glaucoma
4.8
42.7
111
275
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
147.6
39.3
41
*
H31.2
ICD-10 Finland
Hereditary choroidal dystrophy
+∞
39.0
37
*
S01EC03
ATC
dorzolamide; ophthalmic
14.2
38.6
36
27
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
36.0
265
1290
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
55.3
35.0
41
8
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.0
34.1
263
1303
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
32.6
31
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.5
32.3
88
224
S01EX03, ,
ATC
9.5
31.9
39
44
XCD20
NOMESCO Finland
Photoangiography of eye
74.6
31.3
35
5
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
74.6
31.3
35
5
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.2
31.1
48
72
H31.1
ICD-10 Finland
Choroidal degeneration
+∞
30.5
29
*
XCH00
NOMESCO Finland
Eye pressure measurement
6.5
30.4
52
87
H26.4
ICD-10 Finland
After-cataract
4.0
29.2
93
265
S01EC04
ATC
brinzolamide; ophthalmic
6.0
28.8
54
99
H33.3
ICD-10 Finland
Retinal breaks without detachment
284.6
27.0
27
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
24.8
282
1627
S01BC03
ATC
diclofenac; ophthalmic
9.8
24.6
29
31
H43.1
ICD-10 Finland
Vitreous haemorrhage
22.6
23.7
34
16
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
23.1
22
*
S01EE01
ATC
latanoprost; ophthalmic
4.1
22.9
68
183
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
24.2
22.8
32
14
CKC10
NOMESCO Finland
Local photocoagulation of retina
228.9
21.8
22
*
CKC12
NOMESCO Finland
Photocoagulation of retina
38.9
21.0
26
7
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.7
20.7
40
75
S01EE04
ATC
travoprost; ophthalmic
7.8
20.5
29
39
H25.1
ICD-10 Finland
Senile nuclear cataract
2.4
19.3
205
1116
S01EE05
ATC
tafluprost; ophthalmic
5.2
19.3
41
84
ZXA10
NOMESCO Finland
Bilateral
2.6
19.0
132
591
S01EA03
ATC
apraclonidine; ophthalmic
26.1
18.4
25
10
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.3
18.0
49
123
Z3229
NOMESCO Finland
Other healthcare associate professional
3.3
17.8
74
249
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
16.8
16
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
16.8
16
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
175.2
16.6
17
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
24.0
16.6
23
10
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
14.6
14
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
14.6
14
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
154.0
14.5
15
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.6
14.5
93
396
S01EE03
ATC
bimatoprost; ophthalmic
5.9
14.3
26
46
H20.1
ICD-10 Finland
Chronic iridocyclitis
35.0
13.6
17
5
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
143.5
13.5
14
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
23.2
13.0
18
8
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
51.3
12.9
15
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
12.5
12
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
12.5
12
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
12.5
12
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
16.4
12.2
19
12
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
12.8
12.2
21
17
S01BA07
ATC
fluorometholone; ophthalmic
11.4
12.1
22
20
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
66.4
11.6
13
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
66.4
11.6
13
*
ZXA05
NOMESCO Finland
Left side
2.0
11.6
155
895
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
11.5
11
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
11.5
11
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
11.5
11
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
122.5
11.5
12
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
9.5
11.1
22
24
H26.2
ICD-10 Finland
Complicated cataract
18.3
10.8
16
9
WX002
NOMESCO Finland
Sedation and analgesia
2.1
10.7
120
646
CHD99
NOMESCO Finland
Other filtering operation
22.0
10.7
15
7
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
112.1
10.5
11
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
9.1
10.4
21
24
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.1
10.3
22
45
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
23.9
10.3
14
6
H40.0
ICD-10 Finland
Glaucoma suspect
2.8
10.1
52
197
H27.0
ICD-10 Finland
Aphakia
20.5
9.8
14
7
S01ED02
ATC
betaxolol; ophthalmic
9.3
9.6
19
21
H35.37
ICD-10 Finland
Macular holes
101.8
9.4
10
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
17.9
9.4
14
8
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
30.6
9.4
12
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
9.4
9
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
9.4
9
*
CHC05
NOMESCO Finland
Iridotomy
7.5
9.3
21
29
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
9.1
41
144
H35.9
ICD-10 Finland
Retinal disorder, unspecified
37.4
9.0
11
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
24.5
8.9
12
5
CKD60
NOMESCO Finland
Anterior vitrectomy
9.7
8.8
17
18
H57.1
ICD-10 Finland
Ocular pain
3.9
8.7
26
70
WX142
NOMESCO Finland
Sub-tenon anesthesy
50.8
8.7
10
*
ZXA00
NOMESCO Finland
Right side
1.8
8.5
156
985
H33.5
ICD-10 Finland
Other retinal detachments
28.0
8.5
11
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
91.4
8.4
9
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
91.4
8.4
9
*
H26.02
ICD-10 Finland
Presenil cataract
4.6
8.4
20
45
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.6
8.4
20
45
H25.8
ICD-10 Finland
Other senile cataract
2.2
8.4
71
341
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
8.4
8
*
H3600, E113,
ICD-10 Finland
+∞
8.4
8
*
H35.36
ICD-10 Finland
Macular cyst
+∞
8.4
8
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
33.9
8.1
10
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
33.9
8.1
10
*
S01BA04
ATC
prednisolone; ophthalmic
4.4
8.0
20
47
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.9
7.9
17
22
XCW10
NOMESCO Finland
Assessment of vision
9.0
7.6
15
17
Z3231
NOMESCO Finland
Registered nurse
1.8
7.5
152
984
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
3.5
7.5
25
73
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.4
7.4
50
217
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
7.4
72
365
H3603, E103,
ICD-10 Finland
+∞
7.3
7
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
7.3
7
*
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
7.3
7
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
7.3
7
*
H27.1
ICD-10 Finland
Dislocation of lens
16.0
7.3
11
7
S01BC05
ATC
ketorolac; ophthalmic
2.9
7.2
34
123
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.6
7.1
23
66
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
9.5
6.8
13
14
CHD35
NOMESCO Finland
Laser goniopuncture
12.4
6.6
11
9
ZXE00
NOMESCO Finland
One hour or less
1.6
6.6
201
1443
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.2
6.6
17
41
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
70.7
6.4
7
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
70.7
6.4
7
*
H36.01
ICD-10 Finland
Diabetic maculopathy
70.7
6.4
7
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
70.7
6.4
7
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
70.7
6.4
7
*
3708
FHL
Trabeculectomy or equivalent
70.7
6.4
7
*
L04AX01
ATC
azathioprine; systemic
3.1
6.4
26
86
CA1ME
NOMESCO Finland
Ultrasound oculometry
14.5
6.4
10
7
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.3
44
194
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
6.3
6
*
H3601, E113,
ICD-10 Finland
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
S01AX11
ATC
[U] ofloxacin
2.9
6.3
29
104
Z2221
NOMESCO Finland
Medical doctor
1.7
6.2
139
919
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.2
185
1318
S01EA02
ATC
dipivefrine; ophthalmic
12.7
6.1
10
8
H02AB06
ATC
prednisolone; systemic
1.6
6.1
246
1881
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
164
1069
1.77
7.99
2.5
2.1
2.92
3.24
mg/l
0.71
138
908
227
1684
1.60
6.48
3.4
2.7
131.31
131.08
ug/l
0.01
210
1545
100
599
1.82
6.33
3.3
2.3
2.22
2.33
g/l
1.23
94
546
367
3074
1.61
6.08
4.0
3.9
14.91
14.89
pmol/l
0.04
331
2776
182
1298
1.61
6.03
3.7
3.2
247.99
103.54
e6/l
0.35
141
1002
166
1178
1.59
5.53
3.5
3.2
0.16
0.50
e6/l
3.51
131
884
93
568
1.77
5.49
3.5
2.3
21.99
21.63
%
0.09
77
480
295
2382
1.53
5.48
11.1
8.7
4.12
4.13
e9/l
0.02
263
2082
257
2024
1.52
5.31
19.4
15.7
1.22
1.29
inr
0.66
76
585
177
1301
1.54
4.97
2.9
2.4
58.20
59.38
u/l
0.11
166
1205
180
1335
1.52
4.83
4.3
3.1
29.94
33.39
u/l
0.95
171
1266
274
2221
1.48
4.72
7.1
5.9
11.77
11.49
umol/l
0.10
263
2104
106
702
1.64
4.61
2.6
2.8
1.35
1.01
e6/l
0.43
57
401
422
3748
1.59
4.60
5.0
4.7
1.92
2.29
mu/l
0.57
384
3400
202
1549
1.49
4.56
4.2
3.1
—
—
—
0
0
150
1088
1.53
4.40
3.5
2.7
9254.64
8768.19
umol/l
0.04
136
949
125
871
1.57
4.39
2.4
1.7
1.07
1.30
mg/l
0.69
98
681
212
1661
1.46
4.22
2.7
2.2
79.33
77.37
nmol/l
0.39
196
1472
254
2063
1.44
4.15
5.0
3.8
0.00
0.00
estimate
0.50
58
419
127
899
1.54
4.14
3.5
2.6
4.61
5.26
e6/l
0.33
117
812
13
31
4.27
4.03
1.1
1.1
—
—
—
0
0
368
3211
1.46
4.02
10.4
7.2
84.86
78.17
u/l
0.72
351
3001
255
2085
1.42
3.96
5.1
3.8
0.00
0.00
estimate
-0.00
52
374
98
663
1.58
3.88
2.7
3.0
2.40
2.61
e6/l
0.12
49
366
252
2063
1.42
3.85
6.9
5.1
0.00
0.00
estimate
-0.00
54
382
260
2144
1.41
3.79
9.1
6.5
1.21
1.21
mmol/l
0.74
222
1819
466
4292
1.65
3.78
24.1
17.5
3.99
3.99
mmol/l
0.03
455
4168
229
1849
1.42
3.76
6.3
4.4
35.30
35.37
g/l
0.06
211
1719
9
16
5.70
3.67
1.0
1.1
—
—
—
0
0
464
4278
1.62
3.64
23.7
17.4
139.61
139.63
mmol/l
0.05
453
4158
424
3834
1.50
3.62
6.9
5.6
41.24
39.90
mmol/mol
1.96
392
3546
216
1740
1.40
3.54
2.0
2.0
101.83
95.02
pmol/l
0.93
108
895
97
670
1.55
3.51
4.4
3.2
0.82
0.81
mmol/l
0.02
92
629
234
1915
1.39
3.48
8.7
5.5
58.07
57.38
%
0.41
223
1802
293
2494
1.38
3.41
5.8
4.6
6.80
6.68
mmol/l
0.45
278
2334
236
1942
1.38
3.36
8.9
5.7
27.05
27.50
%
0.24
225
1823
12
33
3.70
3.31
1.7
1.5
—
—
—
0
0
424
3858
1.47
3.28
18.4
13.9
76.57
78.04
ml/min/173m2
0.63
357
3173
7
11
6.43
3.19
1.1
1.0
1693.43
1504.64
miu/ml
—
7
11
18
73
2.52
3.16
3.4
3.1
4.06
4.33
e9/l
0.20
18
73
18
74
2.48
3.08
3.4
3.3
60.28
58.72
%
0.22
18
74
210
1715
1.37
3.06
5.0
3.8
27.68
40.24
ng/l
1.88
159
1228
438
4033
1.47
2.98
4.7
4.4
4.51
4.61
mmol/l
1.02
399
3702
347
3076
1.36
2.92
5.3
4.0
15.09
13.02
mm/h
1.27
329
2817
37
208
1.84
2.91
1.9
1.9
1.60
1.60
g/l
0.00
32
183
469
4387
1.55
2.86
13.7
10.1
25.33
25.90
u/l
0.35
451
4218
485
4573
1.63
2.84
29.3
21.8
39.24
39.95
%
1.28
455
4254
485
4573
1.63
2.84
29.3
21.7
244.91
246.21
e9/l
0.16
473
4448
8
18
4.49
2.80
2.1
2.5
1600.88
1322.61
u/ml
—
8
18
485
4576
1.62
2.79
29.2
21.7
4.39
4.46
e12/l
2.06
471
4440
113
847
1.42
2.71
1.8
1.7
1118.05
1183.21
nmol/l
0.29
80
625
433
4001
1.42
2.68
4.5
4.3
1.42
1.46
mmol/l
1.06
392
3653
30
162
1.90
2.68
1.7
3.2
10.88
10.14
g/l
0.30
25
145
74
513
1.51
2.64
1.9
1.8
—
—
—
0
0
62
415
1.56
2.59
4.7
3.7
1.62
2.02
mmol/l
0.40
51
340
153
1216
1.36
2.58
4.0
3.0
1187.71
213.69
mg/l
0.83
102
773
161
1292
1.35
2.55
4.7
3.6
9.25
8.64
mg/mmol
0.08
104
813
74
517
1.50
2.54
2.0
1.8
—
—
—
0
0
56
368
1.58
2.53
2.4
1.8
353.31
380.96
nmol/l
0.44
49
332
159
1278
1.35
2.48
4.0
2.9
6.95
7.55
mmol/l
1.19
136
1069
31
174
1.83
2.47
1.7
3.0
—
—
—
0
0
39
236
1.70
2.43
4.1
3.2
23.42
25.29
mmol/l
2.39
39
229
6
12
5.04
2.41
1.2
1.3
—
—
—
0
0
50
324
1.60
2.40
1.9
1.6
—
—
—
0
0
9
27
3.37
2.40
2.2
1.3
—
—
—
0
0
443
4133
1.41
2.39
5.3
4.9
2.65
2.71
mmol/l
0.68
405
3771
12
46
2.65
2.37
1.2
1.3
2.80
6.06
u/ml
—
5
17
76
542
1.47
2.37
6.5
6.4
104.41
103.99
mmol/l
0.26
76
542
97
725
1.41
2.36
2.0
1.9
—
—
—
0
0
229
1951
1.30
2.35
2.8
2.5
—
—
—
0
0
14
59
2.41
2.31
1.1
1.3
103.00
103.31
u/ml
—
6
13
19
92
2.10
2.30
1.5
1.6
218.25
305.07
mu/l
1.58
19
87
65
452
1.50
2.30
4.2
3.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
142
1.87
2.27
5.0
2.5
0.38
0.36
u/ml
0.09
17
83
11
42
2.65
2.15
1.3
1.3
—
—
—
0
0
22
116
1.93
2.14
1.3
1.7
—
—
—
0
0
191
1606
1.29
2.12
5.8
4.1
—
—
—
0
0
15
69
2.21
2.06
2.6
2.5
3248.04
6771.81
u/l
—
7
25
12
50
2.43
2.04
1.4
1.6
30.50
32.70
pg
0.81
12
50
429
4015
1.34
1.99
5.0
4.6
6.22
5.96
mmol/l
2.72
391
3631
415
3867
1.32
1.98
4.2
3.9
1.31
1.29
mmol/l
0.21
370
3515
225
1950
1.26
1.92
8.6
5.7
1.20
1.21
mmol/l
1.05
210
1789
70
514
1.42
1.89
7.3
6.9
1.45
1.18
mmol/l
0.29
47
399
116
928
1.32
1.84
1.8
1.7
450.10
433.56
pmol/l
0.28
89
757
18
95
1.93
1.77
1.6
1.7
10176.08
22491.05
e6/l
0.77
12
66
17
88
1.96
1.76
1.3
1.7
1.70
7.91
iu/l
—
6
25
156
1305
1.28
1.76
2.6
2.0
158.83
220.49
u/l
0.67
150
1226
170
1438
1.27
1.75
4.1
3.2
2.35
2.35
mmol/l
0.29
152
1263
440
4156
1.33
1.74
21.7
14.8
23.93
24.09
mg/l
0.04
366
3334
22
127
1.76
1.66
1.4
2.1
—
—
—
0
0
5
14
3.59
1.62
2.2
1.1
—
—
—
0
0
14
71
2.00
1.55
1.4
1.6
—
—
—
0
0
50
361
1.42
1.51
5.2
3.8
1.22
1.23
mmol/l
0.41
45
318
124
1036
1.26
1.40
4.9
3.8
91.14
88.69
%
0.49
118
1011
6
23
2.63
1.37
1.3
2.2
—
—
—
0
0
6
23
2.63
1.37
1.3
2.2
—
—
—
0
0
120
1003
1.25
1.35
2.5
2.3
—
—
—
0
0
29
192
1.54
1.35
9.2
4.1
24.00
24.20
mmol/l
0.13
29
187
10
47
2.15
1.34
1.0
1.0
1.68
1.42
g/l
—
10
41
101
831
1.27
1.30
1.3
1.2
1.01
1.25
u/ml
0.26
39
226
37
261
1.45
1.29
1.5
1.4
—
—
—
0
0
5
18
2.79
1.28
1.0
1.1
72.40
95.12
u/l
—
5
18
12
62
1.96
1.28
1.2
1.2
—
—
—
0
0
80
641
1.29
1.27
1.3
1.3
10.22
12.85
u/ml
0.20
37
231
6
25
2.42
1.24
1.0
1.3
—
—
—
0
0
61
472
1.33
1.24
3.1
2.5
9.87
9.42
umol/l
0.05
54
413
12
63
1.93
1.23
1.2
1.7
—
—
—
0
0
11
56
1.98
1.23
1.1
1.7
—
—
—
0
0
5
19
2.65
1.22
1.0
1.3
5.68
7.21
mmol/l
—
5
19
287
2640
1.19
1.19
3.6
3.0
52.00
49.83
u/l
0.18
266
2443
10
50
2.02
1.17
1.2
1.3
—
—
—
0
0
19
118
1.63
1.16
1.2
1.3
—
—
—
0
0
22
144
1.55
1.10
3.2
2.9
—
—
—
0
0
131
1135
1.20
1.05
6.0
4.1
0.00
0.00
estimate
0.50
52
373
80
658
1.25
1.05
1.4
1.3
47.21
40.16
iu/ml
0.21
27
209
19
122
1.58
1.04
1.4
1.6
—
—
—
0
0
13
75
1.75
1.03
1.4
1.6
—
—
—
0
0
15
91
1.67
1.01
1.3
1.4
—
—
—
0
0
15
91
1.67
1.01
1.3
1.4
—
—
—
0
0
11
61
1.82
0.99
1.2
1.2
272.50
269.49
u/ml
—
6
35
47
364
1.32
0.98
2.0
3.1
67.05
66.15
g/l
0.33
41
330
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
5
23
2.18
0.98
1.2
1.5
1.12
0.94
g/l
—
5
23
36
268
1.37
0.97
1.4
1.7
—
—
—
0
0
9
51
1.78
0.95
2.1
1.4
—
—
—
0
0
9
51
1.78
0.95
2.1
1.4
—
—
—
0
0
98
837
1.21
0.92
3.3
3.0
2.45
2.45
mmol/l
0.14
83
734
15
95
1.60
0.88
1.1
1.2
—
—
—
0
0
8
44
1.83
0.86
1.9
2.2
—
—
—
0
0
6
31
1.95
0.84
2.3
2.5
—
—
—
0
0
8
45
1.79
0.84
1.1
1.1
—
—
—
0
0
120
1053
1.18
0.84
1.7
1.6
1.35
1.39
mmol/l
0.21
103
889
254
2364
1.14
0.80
3.1
2.9
—
—
—
0
0
17
114
1.51
0.80
1.8
2.1
—
—
—
0
0
6
33
1.83
0.79
1.2
1.1
—
—
—
0
0
6
33
1.83
0.79
1.5
1.8
—
—
—
0
0
6
33
1.83
0.79
1.2
1.1
—
—
—
0
0
6
33
1.83
0.79
1.2
1.1
—
—
—
0
0
6
34
1.77
0.76
1.0
1.1
—
—
—
0
0
9
53
1.71
0.75
2.7
2.0
3.56
74.48
u/ml
—
9
53
13
83
1.58
0.75
1.2
1.4
134.42
164.44
pmol/l
0.10
13
83
15
100
1.51
0.73
1.9
1.6
—
—
—
0
0
5
25
2.01
0.73
2.6
3.4
—
—
—
0
0
7
40
1.76
0.71
1.1
1.1
—
—
—
0
0
7
40
1.76
0.71
1.0
1.3
—
—
—
0
0
95
831
1.17
0.70
4.4
3.9
269.15
275.86
ng/l
0.02
71
678
10
61
1.65
0.69
1.2
1.1
—
—
—
0
0
147
1333
1.14
0.67
3.9
3.1
1914.45
1452.17
ng/l
0.98
132
1136
25
188
1.35
0.67
2.4
3.0
59.84
70.19
u/ml
0.09
25
181
21
281
0.74
0.66
2.5
1.9
—
—
—
0
0
7
44
1.60
0.65
2.0
1.5
—
—
—
0
0
96
847
1.16
0.64
3.1
3.0
1.04
0.80
ug/l
0.43
57
554
33
262
1.28
0.62
4.5
3.7
1.81
1.82
mmol/l
0.01
26
193
45
373
1.23
0.60
3.1
2.3
31.95
33.61
u/l
0.11
38
320
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
15
106
1.43
0.58
1.9
1.6
—
—
—
0
0
5
86
0.58
0.56
1.2
1.3
—
—
—
0
0
29
230
1.28
0.56
1.1
1.2
130.70
118.17
iu/ml
—
9
92
6
37
1.63
0.55
1.5
1.7
—
—
—
0
0
9
61
1.48
0.54
1.1
1.8
—
—
—
0
0
129
1178
1.13
0.54
5.1
4.3
22.27
21.39
%
0.29
63
563
13
91
1.44
0.53
1.1
1.5
3.38
13.96
e6/l
—
8
74
9
62
1.46
0.53
2.0
1.9
—
—
—
0
0
6
39
1.54
0.53
2.0
1.5
—
—
—
0
0
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
6
40
1.51
0.51
1.0
1.1
—
—
—
0
0
39
327
1.21
0.49
2.9
2.8
51.00
63.45
ml/min/173m2
0.99
14
140
7
47
1.50
0.47
2.6
1.6
—
—
—
0
0
16
120
1.34
0.46
2.1
3.6
0.00
0.00
g/l
-0.00
16
111
158
1473
1.10
0.46
5.4
4.9
2.51
2.59
ug/l
0.06
141
1318
7
50
1.41
0.45
1.9
1.8
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
81.83
—
0
6
19
149
1.29
0.42
2.1
2.1
—
—
—
0
0
5
32
1.57
0.42
1.4
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.1
—
—
—
0
0
5
32
1.57
0.42
1.2
1.1
—
—
—
0
0
101
924
1.11
0.42
5.7
4.2
1.01
1.02
kg/l
1.09
15
125
5
33
1.52
0.41
1.2
2.2
13.00
13.17
%
—
5
33
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
8
59
1.36
0.41
1.9
1.6
—
—
—
0
0
5
37
1.35
0.37
1.2
1.2
9.80
11.09
u/l
—
5
32
14
108
1.30
0.35
1.9
1.4
—
—
—
0
0
6
90
0.66
0.33
1.0
1.1
—
—
—
0
0
19
155
1.23
0.33
4.5
2.2
901.97
307.51
ug/l
0.39
19
148
7
52
1.35
0.31
1.3
1.4
—
—
—
0
0
7
52
1.35
0.31
1.4
1.4
—
—
—
0
0
7
52
1.35
0.31
1.3
1.4
—
—
—
0
0
7
53
1.32
0.31
1.3
1.4
—
—
—
0
0
7
53
1.32
0.31
8.1
4.4
—
—
—
0
0
27
314
0.85
0.30
2.8
2.0
—
—
—
0
0
7
54
1.30
0.30
1.4
1.4
—
—
—
0
0
7
54
1.30
0.30
1.4
1.4
—
—
—
0
0
12
94
1.28
0.28
1.3
1.4
—
—
—
0
0
46
508
0.90
0.26
4.2
4.4
31.24
32.38
%
0.24
29
334
113
1068
1.07
0.25
1.6
1.5
21.15
21.13
nmol/l
0.00
99
905
9
74
1.22
0.25
2.1
1.4
—
—
—
0
0
9
74
1.22
0.25
2.1
1.4
—
—
—
0
0
43
390
1.11
0.23
2.7
2.4
12.61
7.11
ug/l
0.42
37
340
22
190
1.16
0.23
1.0
1.0
—
—
—
0
0
7
92
0.76
0.22
1.3
1.3
—
—
—
0
0
5
41
1.22
0.22
8.0
2.3
—
—
—
0
0
49
450
1.10
0.21
3.5
4.0
33.22
16.72
ug/l
0.22
41
385
0
10
0.00
0.21
0.0
1.1
—
8.78
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
2.84
—
0
5
6
51
1.18
0.19
1.0
1.0
—
—
—
0
0
12
100
1.20
0.18
1.0
1.3
—
—
—
0
0
24
214
1.13
0.18
9.0
9.4
23.71
24.52
mmol/l
0.40
24
207
8
70
1.14
0.16
2.4
1.6
—
—
—
0
0
55
517
1.07
0.15
8.4
7.6
—
—
—
0
0
18
159
1.14
0.15
1.3
1.8
—
—
—
0
0
11
93
1.19
0.14
1.5
1.5
—
—
—
0
0
28
305
0.91
0.14
2.0
1.7
—
—
—
0
0
14
124
1.13
0.11
1.9
1.6
—
—
—
0
0
11
125
0.88
0.10
1.5
1.5
—
—
—
0
0
16
145
1.11
0.09
1.2
1.2
—
—
—
0
0
5
48
1.04
0.09
5.6
3.4
2.50
3.32
nmol/l
—
5
48
19
205
0.92
0.08
1.6
1.3
—
—
—
0
0
45
434
1.04
0.06
1.9
1.8
1.56
1.49
%
0.25
38
384
49
505
0.97
0.05
1.4
1.4
—
—
—
0
0
63
622
1.01
0.01
1.7
1.5
—
—
—
0
0
18
175
1.03
0.00
1.5
1.9
—
—
—
0
0
12
116
1.04
0.00
1.5
1.5
—
—
—
0
0
14
144
0.97
0.00
1.5
1.2
—
—
—
0
0
15
146
1.03
0.00
1.5
1.2
—
—
—
0
0
39
387
1.01
0.00
3.3
3.1
206.85
219.05
ng/l
0.07
33
354
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
8.86
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
25.82
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
44.80
—
0
5
6
69
0.87
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
4.86
—
0
8
6
69
0.87
-0.00
1.2
1.4
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.5
—
—
—
0
0
5
51
0.98
-0.00
2.0
1.4
0.72
0.59
nmol/l
—
5
46
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHOROIDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.061 [0.92, 1.22] | 0.4 |
| Birth year | 0.998 [0.99, 1.01] | 0.675 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 1781 females with H7_CHOROIDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.09 [0.93, 1.27] | 0.272 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 1549 males with H7_CHOROIDOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHOROIDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.209% |
| 5 | 0.689% | 1.294% |
| 10 | 1.593% | 3.192% |
| 15 | 3.182% | 5.938% |
| 20 | 5.824% | 10.166% |
Relationships between endpoints
↥Index endpoint: H7_CHOROIDOTH – Other disorders of choroid
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data