Chorioretinal scars

H7_CHORSCAR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.0 Hospital discharge: ICD-9 — 3633 Cause of death: ICD-10 — H31.0 Cause of death: ICD-9 — 3633 2 out of 7 registries used, show all original rules.	124
4. Check minimum number of events None	124
5. Include endpoints None	124
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Cicatrices chorioretinales

NAME	H7_CHORSCAR
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H310
HD_ICD_9	3633
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H310
COD_ICD_9	3633
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chorioretinal scars based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	911	460	444
Only index persons	847	431	416
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	54.06	57.19	50.81
Only index persons	53.76	57.06	50.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	70	54
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	59.66	59.80	59.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1111

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.0

ICD-10 Finland

Chorioretinal scars

+∞

157.1

110

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

10.8

12.0

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

120.9

10.6

XCK10

NOMESCO Finland

Photography of fundus of eye

8.0

10.5

XCW99

NOMESCO Finland

Other investigative procedure of eye

7.2

9.8

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

108.8

9.6

H33.0

ICD-10 Finland

Retinal detachment with retinal break

+∞

9.5

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

+∞

7.4

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

7.1

6.1

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.6

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

208

2.45

4.88

2.7

2.1

0.9

1.3

mg/l

0.64

159

(3030467) Casts [#/volume] in Urine by Automated count

293

2.11

3.81

3.3

2.9

0.2

0.5

e6/l

1.12

212

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.30

3.66

1.6

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

267

2.08

3.53

3.8

2.8

24724.9

11886.0

umol/l

0.42

229

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

175

2.21

3.43

2.4

2.6

1.4

1.0

e6/l

0.15

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.80

3.27

1.2

2.1

—

(36304419) Bacteria [Presence] in Urine

282

2.00

3.26

3.4

2.9

—

(3002582) Erythrocytes [#/volume] in Urine

318

1.96

3.18

4.2

3.1

114.3

279.5

e6/l

0.32

235

(42870588) Differential panel, method unspecified - Blood

332

1.91

2.99

7.9

6.5

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

6.24

2.73

1.2

1.1

—

(3021589) Normoblasts [#/volume] in Blood

468

1.82

2.71

17.4

9.8

0.0

e9/l

0.71

380

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

374

1.79

2.51

4.4

3.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

159

1.98

2.39

2.6

2.8

3.6

2.1

e6/l

0.41

(3018095) Leukocytes [#/volume] in Urine

373

1.74

2.29

5.1

3.5

60.5

138.4

e6/l

0.71

252

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.35

2.13

7.1

4.9

4.0

3.6

g/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

768

1.77

2.03

4.3

4.2

14.9

14.8

pmol/l

0.14

702

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.09

1.97

1.6

1.5

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.69

1.96

1.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.45

1.94

1.5

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

713

1.67

1.86

5.8

4.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

105

922

1.91

1.82

20.0

15.9

39.3

39.8

0.24

688

(3027945) Reticulocytes/100 erythrocytes in Blood

120

1.90

1.76

4.5

3.5

1.7

1.8

0.24

108

(4035726)

105

1.96

1.75

1.3

—

(3002256) Pathology report gross observation

113

1.92

1.73

1.1

—

(3026008) Bacteria identified in Urine by Culture

315

1.62

1.70

3.4

3.1

—

(40768804) Tissue Pathology biopsy report

401

1.56

1.60

2.5

2.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.10

1.60

1.0

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

249

1.63

1.58

1.6

1.7

1.2

1.4

mmol/l

0.84

206

(3013650) Neutrophils [#/volume] in Blood by Automated count

605

1.55

1.58

12.7

10.2

4.1

e9/l

0.12

526

(3021601) Nitrite [Presence] in Urine by Test strip

499

1.53

1.54

6.8

5.1

0.0

estimate

0.00

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

3.43

1.54

1.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.95

1.52

1.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.95

1.52

1.7

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.33

1.51

2.1

2.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.59

1.47

1.0

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

503

1.51

1.46

4.8

3.7

0.0

estimate

0.00

102

(3011397) Hemoglobin [Presence] in Urine by Test strip

228

1.61

1.45

3.5

3.7

—

(3009261) Glucose [Presence] in Urine by Test strip

504

1.51

1.44

4.8

3.7

0.0

estimate

0.00

(3013115) Eosinophils [#/volume] in Blood

524

1.51

1.43

10.4

6.5

0.2

e9/l

0.11

459

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.50

1.41

6.9

4.2

103.6

87.9

—

(3006315) Basophils [#/volume] in Blood

506

1.50

1.40

9.9

6.1

0.0

e9/l

0.10

435

(3001604) Monocytes [#/volume] in Blood

506

1.50

1.40

9.9

6.1

0.6

e9/l

0.19

432

(3019198) Lymphocytes [#/volume] in Blood

516

1.50

1.40

10.0

6.1

2.4

1.9

e9/l

0.41

453

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.02

1.37

1.2

1.1

—

(3021901) Oxygen saturation in Capillary blood

3.02

1.37

2.0

2.3

—

(3044889) 12 lead EKG panel

698

1.52

1.36

4.5

3.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

415

1.48

1.32

2.2

2.0

89.5

93.7

pmol/l

0.16

207

(1616796) Gas panel - Central venous blood

2.85

1.29

9.0

2.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

515

1.45

1.24

12.1

6.4

1.2

mmol/l

0.64

439

(3008898) HLA-B27 [Presence]

2.18

1.21

1.3

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.37

1.20

8.5

5.0

219.2

187.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

163

1.59

1.12

1.5

1.3

9.9

26.9

iu/ml

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

102

927

1.57

1.09

5.4

5.0

1.8

1.9

mu/l

0.54

841

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

108

995

1.66

1.08

4.9

4.4

1.4

1.5

mmol/l

0.96

917

(3012544) pH of Venous blood

107

1.68

1.06

4.6

4.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.32

1.04

1.4

1.0

—

(40758558) Short blood count panel - Blood

282

1.44

1.02

6.4

7.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.88

1.02

1.2

1.1

100.5

190.0

u/ml

0.96

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

2.06

1.02

1.9

2.4

0.0

0.6

g/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

385

1.40

1.00

5.1

3.9

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

108

1000

1.62

0.99

5.1

4.5

4.6

mmol/l

0.17

925

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.00

0.98

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

105

971

1.53

0.91

20.4

12.9

78.7

80.6

ml/min/173m2

0.34

786

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

2.12

0.90

9.2

2.0

0.3

0.4

u/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

280

1.40

0.88

5.0

3.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.05

0.88

1.5

—

(3032080) INR in Blood by Coagulation assay

412

1.36

0.87

15.8

8.5

1.2

inr

0.14

104

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

107

996

1.54

0.87

5.4

4.6

5.9

mmol/l

0.04

907

(3016879) Cocaine [Presence] in Urine

1.92

0.83

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.92

0.83

1.7

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.92

0.83

1.5

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.79

0.82

2.7

2.3

—

(3000330) Specific gravity of Urine by Test strip

1.79

0.82

6.1

3.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

621

1.34

0.82

4.0

3.2

—

(3042936) Bacteria identified in Isolate by Culture

150

1.48

0.80

2.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.86

0.80

9.7

5.2

—

(3000764) Benzodiazepines [Presence] in Urine

1.86

0.80

1.5

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.86

0.80

1.5

1.4

—

(3027008) Opiates [Presence] in Urine

1.86

0.80

1.5

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

109

1024

1.53

0.78

5.5

4.9

2.7

mmol/l

0.04

100

944

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

160

1.46

0.77

1.4

1.3

1.1

8.5

u/ml

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

1.57

0.77

5.8

3.1

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.89

0.75

1.9

2.3

3.0

3.2

g/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.04

0.73

2.6

1.5

—

(3018418) pH of Serum or Plasma

326

1.34

0.73

8.3

3.8

7.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

171

1.42

0.72

2.7

2.8

0.7

ug/l

0.00

105

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.75

0.71

1.9

2.2

7.2

7.8

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.75

0.71

1.9

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

111

1.51

0.70

2.8

1.7

—

(3019225) pH of Specimen

0.51

0.70

8.0

3.7

—

(3011288) Drugs identified in Urine by Screen method

1.89

0.69

1.2

1.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

964

1.40

0.68

4.7

4.0

1.3

mmol/l

0.23

883

(3001019) Free T4 and TSH panel - Serum or Plasma

1.63

0.66

2.0

2.3

—

(21494755) Public health laboratory ask at order entry panel

101

0.57

0.65

2.0

1.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

122

1.46

0.64

15.9

5.4

1.1

1.0

mmol/l

0.16

115

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.69

0.62

3.0

2.2

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.54

0.60

2.1

2.3

136.5

59.7

u/ml

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

1.75

0.58

2.0

2.3

39.3

37.3

g/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.70

0.57

1.3

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

396

1.26

0.55

5.8

4.0

21.5

45.2

ng/l

1.14

271

(3023368) Bacteria identified in Blood by Culture

264

1.29

0.53

8.2

4.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

227

1.30

0.53

4.8

4.3

25.1

21.1

0.75

108

(3015377) Calcium [Moles/volume] in Serum or Plasma

360

1.25

0.51

4.4

3.3

2.4

mmol/l

0.18

308

(3012516) Albumin [Mass/volume] in Urine

275

1.27

0.51

4.3

3.0

34.6

41.0

mg/l

0.14

181

(1002224) Polysomnography panel

1.49

0.47

1.0

1.1

—

(3029937) Albumin [Presence] in Urine by Test strip

268

1.26

0.47

5.3

4.1

0.0

estimate

0.00

(3004588) Protein electrophoresis panel - Serum or Plasma

1.49

0.46

1.7

1.8

—

(40768797) Stomach Pathology biopsy report

140

1.33

0.45

1.5

1.2

—

(3000991) Gas panel - Venous blood

1.42

0.44

15.2

8.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.46

0.43

18.8

8.5

92.5

94.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.46

0.43

2.1

4.1

0.8

0.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

196

1.28

0.43

2.0

1.6

1039.5

1152.2

nmol/l

0.24

151

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.47

0.43

1.4

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.59

0.42

2.0

2.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.41

0.42

2.1

4.1

1.0

1.2

—

(40768793) Breast Pathology biopsy report

1.54

0.42

1.2

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

2.4

—

(3017354) Segmented neutrophils/100 leukocytes in Blood

0.00

0.41

0.0

1.6

—

58.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.36

0.41

18.9

8.0

1.7

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.36

0.41

18.9

8.0

0.9

0.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

5.0

—

(3052851) Hemolysis interference index of Serum or Plasma

1.45

0.40

7.0

3.5

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

0.39

0.0

2.9

—

1.6

—

(3022145) Colonoscopy Study observation

116

1.33

0.39

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.37

0.39

2.4

1.4

—

(3019060) Gas panel - Arterial blood

1.35

0.38

3.8

3.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.40

0.38

1.4

1.6

—

(3000494) Fungus identified in Specimen by Culture

127

1.30

0.35

1.8

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

110

1.31

0.33

2.6

1.8

—

(3045414) Leukocytes [Presence] in Urine

1.29

0.33

1.2

1.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.25

0.28

5.6

2.1

5.1

5.0

kpa

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.23

0.27

1.3

1.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.69

0.27

4.2

3.7

421.2

146.1

ng/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

500

1.14

0.26

4.1

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

343

1.16

0.26

3.0

2.4

—

(40761511) CBC panel - Blood by Automated count

111

1083

1.24

0.24

20.1

13.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

297

1.15

0.23

5.9

3.7

5.7

5.8

mg/mmol

0.01

190

(40760892) CBC W Ordered Manual Differential panel - Blood

220

1.17

0.23

12.6

4.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

144

1.21

0.23

1.3

1.5

—

(3020891) Body temperature

1.23

0.22

2.8

3.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.21

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

108

1.23

0.21

3.8

2.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.21

0.0

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

213

1.16

0.20

1.7

1.8

432.5

463.5

pmol/l

0.25

174

(40761536) Microorganisms panel - Urine sediment

1.26

0.19

6.4

2.9

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.16

0.19

1.3

3.4

4.4

pmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

157

1.17

0.18

2.8

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.20

0.18

7.8

7.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

110

1.20

0.18

2.8

1.8

—

(3013512) EKG study

295

1.11

0.16

5.5

4.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.11

0.15

2.4

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

106

1039

1.14

0.14

22.5

14.3

18.0

22.0

mg/l

0.91

816

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

190

1.13

0.14

3.6

515.6

149.0

ng/l

0.44

143

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

675

1.09

0.13

4.5

3.0

62.2

46.0

u/l

0.69

643

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.17

0.12

3.1

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

144

1.13

0.11

2.6

1.7

—

(40768443) Skin Pathology biopsy report

1.17

0.10

1.0

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

223

1.09

0.10

1.7

1.5

2.7

g/l

0.01

125

(46235355) HIV 1 and 2 tests - Meaningful Use set

185

1.10

0.09

3.3

1.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.81

0.08

1.8

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.83

0.08

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.13

0.08

2.2

1.7

—

(3003694) ABO and Rh group [Type] in Blood

295

0.93

0.07

1.5

—

(36660697) Celiac disease serology panel - Serum

1.05

0.07

1.2

—

(1761868) Lipid panel - Serum or Plasma

347

1.05

0.05

4.2

2.9

—

(3021960) Folate [Moles/volume] in Serum or Plasma

268

1.06

0.05

1.7

1.6

24.0

22.0

nmol/l

0.12

224

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

239

0.95

0.03

1.4

1.3

1.8

1.3

u/ml

—

(3000492) Spirometry study

103

1.07

0.02

2.5

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

263

1.03

0.01

3.1

2.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.03

0.00

1.3

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

198

1.01

0.00

2.1

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

115

1.05

0.00

1.5

1.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.2

—

(4024509)

0.00

0.0

1.4

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.2

—

227.8

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.8

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(4027681)

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.93

0.00

3.2

2.6

4.5

8.5

ug/l

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

36.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

25.5

—

823.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.3

—

(3000012) Reticulocyte production index

0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

1.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

31.8

—

1597.7

—

(3022313) Gas panel - Capillary blood

1.02

0.00

7.6

2.1

—

(3025941) Bacteria identified in Stool by Culture

0.89

0.00

2.0

1.2

—

(40761535) Cells panel - Urine sediment

0.95

0.00

5.1

3.6

—

(4010399)

1.01

0.00

1.9

1.4

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.1

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

8.7

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(44806420)

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORSCAR and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORSCAR	1.083 [0.82, 1.43]	0.579
Birth year	0.995 [0.99, 1.0]	0.218

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 382 females with H7_CHORSCAR died.

Males

Parameter	HR [95% CI]	p-value
H7_CHORSCAR	0.918 [0.68, 1.23]	0.57
Birth year	0.992 [0.98, 1.0]	0.071

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 360 males with H7_CHORSCAR died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORSCAR.

N-year risk	Females	Males
1	0.086%	0.217%
5	0.547%	1.201%
10	1.513%	2.911%
15	2.959%	6.027%
20	5.279%	10.064%

Relationships between endpoints

↥

Index endpoint: H7_CHORSCAR – Chorioretinal scars

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chorioretinal scars

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints