Chorioretinal scars

H7_CHORSCAR

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.0 Hospital discharge: ICD-9 — 3633 Cause of death: ICD-10 — H31.0 Cause of death: ICD-9 — 3633 2 out of 7 registries used, show all original rules.	128
4. Check minimum number of events None	128
5. Include endpoints None	128
6. Filter based on genotype QC (FinnGen only)	120

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Cicatrices chorioretinales

NAME	H7_CHORSCAR
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H310
HD_ICD_9	3633
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H310
COD_ICD_9	3633
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chorioretinal scars based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	911	460	444
Only index persons	847	431	416
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	54.06	57.19	50.81
Only index persons	53.76	57.06	50.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	120	69	51
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	60.30	60.48	60.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
128: Matched controls
1280

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.0

ICD-10 Finland

Chorioretinal scars

+∞

181.7

127

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

7.3

16.3

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.7

15.0

XCK10

NOMESCO Finland

Photography of fundus of eye

4.8

10.4

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

59.6

9.8

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

59.6

9.8

H33.0

ICD-10 Finland

Retinal detachment with retinal break

+∞

9.5

Z96.1

ICD-10 Finland

Presence of intraocular lens

4.1

9.5

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

8.3

9.2

H33.3

ICD-10 Finland

Retinal breaks without detachment

+∞

7.4

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

73.4

6.5

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.1

6.3

126

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

217

2.31

4.35

2.7

2.1

0.95

1.32

mg/l

0.61

165

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.29

3.65

1.6

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

305

2.05

3.63

3.4

2.9

0.17

0.47

e6/l

1.12

218

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

182

2.18

3.44

2.5

2.6

1.36

1.01

e6/l

0.15

(3026493) Urate [Moles/volume] in Serum or Plasma

277

2.03

3.43

3.8

2.7

23537.73

11311.74

umol/l

0.42

241

(36304419) Bacteria [Presence] in Urine

293

1.95

3.14

3.4

2.9

—

(3002582) Erythrocytes [#/volume] in Urine

332

1.89

2.96

4.2

3.0

111.58

269.98

e6/l

0.32

244

(3014148) Varicella zoster virus Ab [Titer] in Serum

6.93

2.90

1.2

1.1

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

6.93

2.90

1.2

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.65

2.76

1.2

2.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

387

1.79

2.63

4.4

3.0

—

(3021589) Normoblasts [#/volume] in Blood

479

1.78

2.62

17.1

9.7

0.00

e9/l

0.71

388

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

789

1.87

2.41

4.2

4.1

14.94

14.78

pmol/l

0.29

723

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

167

1.95

2.37

2.7

3.59

2.03

e6/l

0.44

(3018095) Leukocytes [#/volume] in Urine

386

1.69

2.16

5.1

3.5

59.08

135.17

e6/l

0.71

260

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.21

2.05

7.1

5.0

4.05

3.57

g/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

735

1.69

1.98

5.6

4.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.09

1.97

1.6

1.5

—

(3023520) Reticulocytes [#/volume] in Blood

2.13

1.96

2.2

3.6

65.70

73.75

e9/l

0.67

(3027945) Reticulocytes/100 erythrocytes in Blood

124

1.93

1.91

4.5

3.4

1.74

1.81

0.21

112

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.35

1.80

1.5

1.6

—

(3002256) Pathology report gross observation

122

1.86

1.67

1.0

1.1

—

(4035726) Immunohistochemistry procedure

107

1.91

1.65

1.3

—

(3044889) 12 lead EKG panel

722

1.58

1.62

4.5

3.8

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.09

1.60

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

514

1.54

1.59

6.6

5.0

0.00

estimate

-0.00

102

(3011397) Hemoglobin [Presence] in Urine by Test strip

232

1.63

1.56

3.4

3.6

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

259

1.60

1.54

1.5

1.7

1.31

1.37

mmol/l

0.16

214

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.94

1.52

1.7

1.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.94

1.52

1.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.33

1.50

2.1

2.2

—

(3035350) Ketones [Presence] in Urine by Test strip

519

1.51

1.50

4.7

3.6

0.00

estimate

-0.00

111

(3009261) Glucose [Presence] in Urine by Test strip

519

1.51

1.50

4.7

3.7

0.00

estimate

-0.00

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.58

1.47

1.0

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

3.21

1.45

1.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

427

1.51

1.43

2.2

2.0

89.05

93.39

pmol/l

0.17

215

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

169

1.68

1.43

1.4

1.3

9.39

25.53

iu/ml

—

(40768804) Tissue Pathology biopsy report

418

1.50

1.43

2.4

2.0

—

(3026008) Bacteria identified in Urine by Culture

326

1.53

1.42

3.4

3.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

496

1.48

1.39

11.6

6.4

—

(1616796) Gas panel - Central venous blood

3.02

1.37

9.0

2.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

627

1.47

1.32

12.6

10.0

4.11

4.07

e9/l

0.05

545

(3013115) Eosinophils [#/volume] in Blood

539

1.46

1.31

10.3

6.4

0.19

e9/l

0.12

472

(3021901) Oxygen saturation in Capillary blood

2.85

1.29

2.0

2.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

2.85

1.29

1.2

1.1

—

(3019198) Lymphocytes [#/volume] in Blood

530

1.46

1.29

9.8

6.0

2.41

1.90

e9/l

0.42

469

(3006315) Basophils [#/volume] in Blood

521

1.46

1.28

9.8

6.0

0.04

e9/l

0.05

449

(3001604) Monocytes [#/volume] in Blood

521

1.46

1.28

9.8

6.0

0.58

0.57

e9/l

0.20

448

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

106

956

1.63

1.27

5.3

4.9

1.79

1.95

mu/l

0.83

869

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

112

1029

1.71

1.18

4.8

4.4

1.43

1.48

mmol/l

0.76

100

952

(3008898) HLA-B27 [Presence]

2.07

1.14

1.3

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

530

1.42

1.13

11.9

6.2

1.21

1.22

mmol/l

0.60

455

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.33

1.12

6.9

4.2

103.57

87.06

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

112

1034

1.67

1.09

5.1

4.4

4.58

4.63

mmol/l

0.24

100

960

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

109

1003

1.58

1.04

19.8

12.9

78.77

80.67

ml/min/173m2

0.36

810

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.00

0.98

1.3

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

2.00

0.98

1.9

2.4

0.00

0.54

g/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

396

1.38

0.96

5.1

3.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

111

1030

1.58

0.96

5.3

4.5

5.90

5.91

mmol/l

0.04

100

940

(3005322) IgE [Units/volume] in Serum or Plasma

1.82

0.93

1.2

1.1

100.52

179.94

u/ml

0.82

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.20

0.93

8.5

4.9

219.17

185.50

—

(40758558) Short blood count panel - Blood

289

1.39

0.88

6.4

7.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

118

1116

1.73

0.87

22.8

16.6

80.61

76.54

umol/l

0.46

118

1116

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

646

1.34

0.87

3.9

3.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

113

1059

1.57

0.86

5.5

4.9

2.72

2.74

mmol/l

0.08

104

979

(3028626) Oxygen [Partial pressure] in Capillary blood

1.98

0.85

2.8

2.1

9.03

8.15

kpa

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

165

1.48

0.85

1.4

1.3

1.11

8.21

u/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

291

1.38

0.85

4.9

3.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.79

0.84

1.9

2.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.79

0.82

2.6

2.3

—

(3019225) pH of Specimen

0.50

0.82

8.0

3.7

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.86

0.80

1.7

1.4

—

(3016879) Cocaine [Presence] in Urine

1.86

0.80

1.3

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.86

0.80

1.5

1.4

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.86

0.80

9.2

2.0

0.28

0.38

u/ml

—

(3000330) Specific gravity of Urine by Test strip

1.75

0.78

6.1

3.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

107

997

1.45

0.78

4.6

4.0

1.31

1.28

mmol/l

0.21

916

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.80

0.77

1.5

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.80

0.77

9.7

5.1

—

(3027008) Opiates [Presence] in Urine

1.80

0.77

1.5

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.80

0.77

1.5

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.80

0.77

1.5

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

187

1.42

0.76

3.2

2.8

0.75

0.74

ug/l

0.02

111

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.13

0.75

1.4

1.0

—

(3018418) pH of Serum or Plasma

334

1.33

0.75

8.1

3.7

7.39

7.40

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.04

0.73

2.6

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.75

0.71

1.9

2.2

—

(3011288) Drugs identified in Urine by Screen method

1.82

0.67

1.2

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

406

1.29

0.66

5.6

3.9

21.47

44.72

ng/l

1.16

281

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

1.50

0.66

5.7

3.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

484

1.28

0.65

20.9

13.5

1.17

1.28

inr

0.50

128

(3015377) Calcium [Moles/volume] in Serum or Plasma

369

1.29

0.65

4.3

3.2

2.37

2.36

mmol/l

0.15

319

(1002224) Polysomnography panel

1.61

0.62

1.0

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

115

1.45

0.60

2.8

1.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

124

1.43

0.59

15.9

5.3

1.06

1.03

mmol/l

0.15

117

(3014576) Chloride [Moles/volume] in Serum or Plasma

142

1.40

0.58

13.2

7.0

105.89

103.68

mmol/l

1.38

142

(3042936) Bacteria identified in Isolate by Culture

160

1.37

0.58

2.0

—

(3052851) Hemolysis interference index of Serum or Plasma

1.70

0.57

5.8

3.4

—

(3012516) Albumin [Mass/volume] in Urine

281

1.29

0.55

4.2

2.9

34.65

40.44

mg/l

0.13

185

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.61

0.55

1.3

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.52

0.52

1.3

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

246

1.29

0.52

5.0

4.2

24.56

21.28

0.60

114

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

3.0

2.2

—

(40768793) Breast Pathology biopsy report

1.58

0.42

1.2

1.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.38

0.42

18.8

8.3

92.46

93.99

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.54

0.42

2.0

2.4

—

(3029937) Albumin [Presence] in Urine by Test strip

272

1.24

0.42

5.3

4.1

0.00

estimate

-0.00

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

2.4

—

(40768797) Stomach Pathology biopsy report

142

1.31

0.41

1.5

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.44

0.40

1.4

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.44

0.40

1.7

1.8

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.33

0.40

2.1

3.9

0.75

0.69

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.40

0.0

5.1

—

(3019060) Gas panel - Arterial blood

1.33

0.38

3.8

3.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.33

0.38

2.4

1.4

—

(40761511) CBC panel - Blood by Automated count

115

1113

1.33

0.37

19.4

13.1

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.64

0.37

4.2

3.5

421.20

139.58

ng/l

—

(3023368) Bacteria identified in Blood by Culture

276

1.21

0.36

8.1

4.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

201

1.24

0.36

2.0

1.6

1039.50

1130.69

nmol/l

0.19

154

(3022145) Colonoscopy Study observation

118

1.31

0.35

1.3

—

(3000991) Gas panel - Venous blood

1.35

0.35

15.2

7.8

—

(40768443) Skin Pathology biopsy report

1.35

0.34

1.0

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

213

1.22

0.32

1.7

425.25

464.92

pmol/l

0.35

175

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

120

1.28

0.32

7.3

7.1

—

(21494755) Public health laboratory ask at order entry panel

106

0.74

0.30

1.9

1.3

—

(3000494) Fungus identified in Specimen by Culture

131

1.25

0.29

1.8

1.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.29

0.28

18.9

7.8

1.70

1.43

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.29

0.28

2.1

3.8

0.95

1.24

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.29

0.28

18.9

7.8

0.85

0.75

—

(3020682) Albumin/Creatinine [Ratio] in Urine

303

1.17

0.27

5.4

3.4

5.69

5.77

mg/mmol

0.01

194

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

143

1.22

0.25

1.3

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

115

1.24

0.24

2.6

1.8

—

(3007461) Platelets [#/volume] in Blood

120

1178

1.30

0.22

30.2

21.0

254.87

249.86

e9/l

0.33

115

1150

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.21

0.0

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.21

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

516

1.12

0.20

2.8

2.7

—

(3045414) Leukocytes [Presence] in Urine

1.26

0.20

1.2

1.7

—

(3013512) EKG study

301

1.13

0.19

5.4

4.1

—

(40761536) Microorganisms panel - Urine sediment

1.25

0.19

6.4

2.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

110

1075

1.17

0.19

21.8

14.2

18.39

22.50

mg/l

0.93

847

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

110

1.20

0.18

3.8

2.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.76

0.17

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.15

0.16

1.3

1.2

—

(3010813) Leukocytes [#/volume] in Blood

120

1180

1.27

0.14

30.1

21.1

7.19

6.69

e9/l

0.42

115

1149

(3026361) Erythrocytes [#/volume] in Blood

120

1180

1.27

0.14

30.1

21.0

4.43

4.48

e12/l

0.54

115

1149

(3044640) Blood type and Crossmatch panel - Blood

356

1.10

0.14

3.0

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

115

1.15

0.11

2.8

1.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

272

1.09

0.10

1.7

1.6

23.67

22.20

nmol/l

0.09

227

(3020891) Body temperature

1.14

0.10

2.8

3.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

165

1.11

0.09

2.8

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.15

0.09

3.1

1.9

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.12

0.09

1.3

3.4

4.43

4.45

pmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.79

0.08

1.8

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

245

0.93

0.08

1.4

1.2

1.81

1.29

u/ml

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.08

0.07

2.4

1.6

—

(36660697) Celiac disease serology panel - Serum

1.04

0.07

1.2

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

187

1.08

0.07

3.4

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

704

1.05

0.07

4.5

3.0

60.89

45.66

u/l

0.67

672

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

197

1.08

0.06

3.6

515.56

145.68

ng/l

0.45

147

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

102

0.87

0.06

3.2

2.6

4.53

8.23

ug/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

148

1.09

0.06

2.6

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

119

1.10

0.06

1.5

1.7

—

(3003694) ABO and Rh group [Type] in Blood

302

0.95

0.05

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

101

1.10

0.04

2.2

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

230

1.05

0.04

1.7

1.4

2.71

2.70

g/l

0.00

131

(1761868) Lipid panel - Serum or Plasma

360

1.04

0.03

4.1

2.9

—

(3000492) Spirometry study

114

1.06

0.01

2.7

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.01

0.00

1.3

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

272

0.99

0.00

3.1

2.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

202

0.99

0.00

2.1

1.6

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

0.0

2.0

—

60.20

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.4

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

2.8

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

2.2

—

128.40

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.2

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.84

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.91

-0.00

2.0

1.3

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

5.2

—

227.78

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.1

—

(40761535) Cells panel - Urine sediment

0.97

-0.00

5.1

3.5

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.8

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

25.5

—

823.33

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

31.8

—

1597.67

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(4200892) Spirometry reversibility

0.97

-0.00

1.9

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

8.7

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

1.3

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

36.58

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3022313) Gas panel - Capillary blood

0.96

-0.00

7.6

2.4

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

157.57

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

1.83

—

(3036603) Volume of Urine

0.00

-0.00

0.0

1.8

—

1990.83

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORSCAR and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORSCAR	1.083 [0.82, 1.43]	0.579
Birth year	0.995 [0.99, 1.0]	0.218

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 382 females with H7_CHORSCAR died.

Males

Parameter	HR [95% CI]	p-value
H7_CHORSCAR	0.918 [0.68, 1.23]	0.57
Birth year	0.992 [0.98, 1.0]	0.071

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 360 males with H7_CHORSCAR died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORSCAR.

N-year risk	Females	Males
1	0.086%	0.217%
5	0.547%	1.201%
10	1.513%	2.911%
15	2.959%	6.027%
20	5.279%	10.064%

Relationships between endpoints

↥

Index endpoint: H7_CHORSCAR – Chorioretinal scars

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chorioretinal scars

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints