Choroidal detachment

H7_CHORDETACH

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.4 Hospital discharge: ICD-9 — 3637 Hospital discharge: ICD-8 — 3785 Cause of death: ICD-10 — H31.4 Cause of death: ICD-9 — 3637 Cause of death: ICD-8 — 3785 2 out of 7 registries used, show all original rules.	90
4. Check minimum number of events None	90
5. Include endpoints None	90
6. Filter based on genotype QC (FinnGen only)	87

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Ablatio chorioideae

NAME	H7_CHORDETACH
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H314
HD_ICD_9	3637
HD_ICD_8	3785
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H314
COD_ICD_9	3637
COD_ICD_8	3785
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Choroidal detachment based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	799	431	358
Only index persons	630	346	284
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	73.78	76.13	70.93
Only index persons	73.34	76.49	69.51

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	87	40	47
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	71.87	71.23	72.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
900

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.4

ICD-10 Finland

Choroidal detachment

+∞

119.2

S01ED51

ATC

timolol, combinations; ophthalmic

34.5

67.6

114

Kela drug reimbursment

Glaucoma

21.2

50.3

Z96.1

ICD-10 Finland

Presence of intraocular lens

15.3

39.1

109

S01ED01

ATC

timolol; ophthalmic

19.3

35.1

S01EE01

ATC

latanoprost; ophthalmic

15.4

34.0

S01EC01

ATC

acetazolamide; systemic

53.3

30.8

S01EA05

ATC

brimonidine; ophthalmic

47.1

30.8

XCK00

NOMESCO Finland

Perimetry

13.8

26.5

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

107.4

23.0

H40.10

ICD-10 Finland

Capsular glaucoma with pseudoexfoliation on the anterior lens capsule

29.2

22.3

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

19.9

20.2

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

11.3

20.1

310

S01EX03, ,

ATC

32.5

20.1

S01EC04

ATC

brinzolamide; ophthalmic

23.3

19.5

H33.0

ICD-10 Finland

Retinal detachment with retinal break

+∞

19.5

XCW99

NOMESCO Finland

Other investigative procedure of eye

10.4

19.3

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

7.6

18.2

259

S01EC03

ATC

dorzolamide; ophthalmic

33.7

18.0

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

9.2

17.5

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

+∞

15.0

WX140

NOMESCO Finland

Parabulbar anesthesy

22.3

14.7

XCK10

NOMESCO Finland

Photography of fundus of eye

7.3

14.3

S01EE03

ATC

bimatoprost; ophthalmic

47.9

13.7

CHD00

NOMESCO Finland

Laser trabeculoplasty

35.5

12.1

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

+∞

11.7

CHC05

NOMESCO Finland

Iridotomy

29.6

11.6

S01EE05

ATC

tafluprost; ophthalmic

13.2

11.5

S01EE04

ATC

travoprost; ophthalmic

25.3

11.1

S01EA03

ATC

apraclonidine; ophthalmic

32.7

11.1

S01EC54

ATC

brinzolamide, combinations; ophthalmic

32.7

11.1

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.2

11.0

TCW99

NOMESCO Finland

Other minor procedure in eye surgery

68.4

10.9

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

123.8

10.7

CHD99

NOMESCO Finland

Other filtering operation

61.9

9.9

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

14.7

9.8

CHD35

NOMESCO Finland

Laser goniopuncture

111.2

9.6

CHD15

NOMESCO Finland

Trabeculectomy and iridectomy

41.2

9.2

CJB10

NOMESCO Finland

Laser discission of secondary cataract

5.2

9.1

H25.1

ICD-10 Finland

Senile nuclear cataract

3.9

9.0

269

XCH00

NOMESCO Finland

Eye pressure measurement

10.2

8.8

H26.4

ICD-10 Finland

After-cataract

4.8

8.3

CHD05

NOMESCO Finland

Selective lasertrabeculoplasty

14.9

8.2

S01BA07

ATC

fluorometholone; ophthalmic

49.4

7.9

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

3.5

7.6

298

H57.1

ICD-10 Finland

Ocular pain

12.4

7.6

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

7.4

CHD10

NOMESCO Finland

Trabeculectomy

+∞

7.4

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

+∞

7.4

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

43.5

6.9

CHF05

NOMESCO Finland

Transscleral laser coagulation of ciliary body

43.5

6.9

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

24.7

6.8

H16.0

ICD-10 Finland

Corneal ulcer

11.3

6.8

S01EB01

ATC

pilocarpine; ophthalmic

28.9

6.3

3708

FHL

Trabeculectomy or equivalent

+∞

6.3

S01BC05

ATC

ketorolac; ophthalmic

6.2

S01ED02

ATC

betaxolol; ophthalmic

16.4

6.0

S01BC03

ATC

diclofenac; ophthalmic

16.4

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3035350) Ketones [Presence] in Urine by Test strip

283

2.28

3.60

4.8

4.3

0.00

estimate

-0.00

(3021601) Nitrite [Presence] in Urine by Test strip

286

2.24

3.48

6.3

5.7

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

290

2.20

3.32

4.9

4.3

0.00

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

396

2.10

2.86

4.5

4.8

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

323

2.04

2.78

5.8

6.9

1.20

1.22

mmol/l

0.89

276

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

212

2.07

2.68

5.8

4.7

—

(3026782) Osmolality of Urine

142

2.17

2.59

2.7

3.6

551.81

540.69

mosm/kgh2o

0.06

123

(3041096) Erythrocytes [Presence] in Urine by Automated

157

2.03

2.26

5.2

4.1

—

(3018095) Leukocytes [#/volume] in Urine

241

1.91

2.24

4.1

4.0

106.69

122.43

e6/l

0.08

169

(3027801) Oxygen [Partial pressure] in Arterial blood

2.25

2.19

2.6

6.4

11.07

11.29

kpa

0.10

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.25

2.19

2.6

6.4

4.87

5.02

kpa

0.23

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

244

1.88

2.14

3.8

3.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.83

2.08

3.0

0.11

0.08

e6/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

2.07

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

212

1.88

2.06

3.3

3.4

22.68

375.11

e6/l

0.59

159

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

163

1.94

2.02

2.4

2.1

3.14

3.22

mg/l

0.03

141

(3008898) HLA-B27 [Presence]

4.74

1.97

1.2

1.4

—

(3031040) Bacteria [#/volume] in Urine by Automated count

389

1.80

1.95

5.8

5.3

—

4229.79

—

(3049717) Cytology report of Urine Cyto stain

3.21

1.84

4.0

3.0

—

(3013512) EKG study

194

1.82

1.80

4.8

4.6

—

(3003396) Base excess in Arterial blood by calculation

2.10

1.80

2.7

6.5

0.82

0.96

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

113

1.99

1.79

2.8

2.9

0.73

2.59

e6/l

—

(3000330) Specific gravity of Urine by Test strip

2.49

1.65

1.4

4.3

—

(3015736) pH of Urine

225

1.74

1.64

3.2

4.1

—

5.73

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.08

1.61

1.3

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.05

1.56

1.3

1.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.46

1.54

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.46

1.54

1.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

220

1.71

1.53

4.2

3.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

419

1.64

1.47

4.0

15.10

15.25

pmol/l

0.17

369

(40768804) Tissue Pathology biopsy report

207

1.67

1.41

1.9

2.2

—

(3022621) pH of Urine by Test strip

2.21

1.35

8.3

2.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

254

1.62

1.34

2.6

2.2

—

(3013115) Eosinophils [#/volume] in Blood

283

1.59

1.31

7.1

5.5

0.17

0.19

e9/l

0.37

253

(3029937) Albumin [Presence] in Urine by Test strip

151

1.70

1.28

6.6

4.9

0.00

estimate

—

(3001604) Monocytes [#/volume] in Blood

277

1.57

1.23

7.2

5.3

0.59

0.62

e9/l

0.30

246

(3006315) Basophils [#/volume] in Blood

277

1.57

1.23

7.2

5.3

0.04

e9/l

0.01

246

(40760892) CBC W Ordered Manual Differential panel - Blood

250

1.58

1.22

7.8

6.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.21

1.22

1.9

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

197

1.61

1.20

3.0

3.3

0.08

0.39

e6/l

1.98

142

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.81

1.20

4.5

6.6

104.50

103.63

mmol/l

0.30

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.58

1.16

1.2

1.5

26.60

34.48

u/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.44

1.15

1.6

5.1

—

(3019060) Gas panel - Arterial blood

2.04

1.11

2.8

3.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.06

1.07

5.0

2.8

1.14

1.22

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.06

1.07

1.2

3.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.34

1.04

1.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

110

1.67

0.99

1.2

1.1

0.77

3.41

u/ml

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

153

1.58

0.98

2.1

1.8

506.07

458.35

pmol/l

0.21

125

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.92

0.96

2.1

1.5

—

(36304419) Bacteria [Presence] in Urine

180

1.54

0.96

3.8

3.4

—

(3025941) Bacteria identified in Stool by Culture

1.94

0.90

1.6

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.94

0.90

3.1

7.6

91.24

94.09

—

(3018418) pH of Serum or Plasma

210

1.48

0.89

3.5

4.7

7.36

7.40

—

(3020891) Body temperature

2.07

0.89

9.0

4.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.90

0.88

5.4

2.8

0.54

0.75

—

(3019309) Folate [Moles/volume] in Red Blood Cells

148

1.55

0.88

1.7

1.8

1092.92

1147.79

nmol/l

0.07

111

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

123

1.58

0.86

2.8

2.7

1.30

0.96

e6/l

—

(3044889) 12 lead EKG panel

412

1.42

0.84

4.4

4.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.94

0.83

2.8

7.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

134

1.53

0.80

4.3

3.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

280

1.41

0.79

2.1

2.2

98.49

92.67

pmol/l

0.25

139

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

527

1.42

0.78

5.0

4.9

1.71

2.03

mu/l

1.74

456

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.24

0.77

5.4

2.9

28.00

78.89

u/ml

—

(3022217) INR in Platelet poor plasma by Coagulation assay

329

1.39

0.76

15.3

19.7

1.10

1.38

inr

3.44

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

180

1.45

0.76

3.9

2.4

54.54

80.98

u/l

0.53

169

(3023368) Bacteria identified in Blood by Culture

199

1.43

0.74

4.8

4.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

173

1.44

0.71

5.2

4.4

20.05

22.84

0.46

(3021589) Normoblasts [#/volume] in Blood

256

1.39

0.71

16.3

9.9

0.00

e9/l

0.49

215

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

138

1.48

0.70

2.4

3.1

2.48

2.47

mmol/l

0.12

122

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

543

1.38

0.69

4.5

4.7

4.40

4.35

mmol/l

0.12

489

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.68

0.68

1.0

1.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

230

1.38

0.67

5.6

4.6

1.52

2.58

ug/l

0.98

198

(36660697) Celiac disease serology panel - Serum

1.83

0.67

1.6

1.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.83

0.67

1.0

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

535

1.36

0.65

7.1

6.5

42.44

41.50

mmol/mol

0.24

490

(3019150) Specific gravity of Urine by Refractometry

114

1.49

0.64

8.6

5.0

1.02

kg/l

—

(3044640) Blood type and Crossmatch panel - Blood

186

1.40

0.63

2.3

2.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.70

0.62

1.2

2.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

284

1.32

0.56

5.7

5.0

44.08

47.02

ng/l

0.07

219

(3007164) IgA [Mass/volume] in Serum or Plasma

100

1.47

0.56

1.4

1.3

2.06

2.57

g/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.62

0.55

3.0

4.3

25.12

25.04

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

109

1.45

0.55

1.5

2.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

102

1.44

0.51

2.9

2.5

10.51

10.68

umol/l

0.03

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.56

0.49

1.9

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

537

1.29

0.48

4.2

4.7

1.39

1.43

mmol/l

0.25

478

(3024928) Oxygen saturation in Venous blood

0.00

0.41

0.0

2.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

563

1.26

0.41

5.5

5.4

2.62

2.51

mmol/l

0.37

505

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.50

0.41

1.6

2.7

—

(40761511) CBC panel - Blood by Automated count

595

1.26

0.40

19.8

15.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.45

0.40

1.2

1.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

178

0.75

0.39

1.9

1.8

19.34

20.97

nmol/l

0.26

153

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

514

1.24

0.39

3.9

4.3

1.25

1.24

mmol/l

0.06

456

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.50

0.37

1.8

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.42

0.36

2.0

1.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

599

1.24

0.35

27.8

21.0

94.53

84.67

umol/l

0.58

599

(3018677) aPTT in Platelet poor plasma by Coagulation assay

108

0.72

0.31

1.0

1.8

30.38

30.02

—

103

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

582

1.21

0.31

22.9

17.0

26.41

26.05

mg/l

0.03

464

(40761535) Cells panel - Urine sediment

1.27

0.30

6.6

3.4

—

(40768797) Stomach Pathology biopsy report

1.36

0.29

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

543

1.19

0.29

22.4

16.8

70.44

71.01

ml/min/173m2

0.06

448

(3000991) Gas panel - Venous blood

1.30

0.29

6.8

7.7

—

(3000963) Hemoglobin [Mass/volume] in Blood

629

1.18

0.24

31.5

25.0

130.44

131.96

g/l

0.28

605

(3009542) Hematocrit [Volume Fraction] of Blood

629

1.18

0.24

31.1

24.8

38.56

39.25

0.25

575

(3020682) Albumin/Creatinine [Ratio] in Urine

202

1.19

0.23

3.1

3.6

21.72

6.09

mg/mmol

0.38

129

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.26

0.22

3.2

2.4

2.29

2.14

g/l

0.41

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.5

—

59.63

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.21

0.0

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

5.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

3.9

—

252.20

—

(40761536) Microorganisms panel - Urine sediment

1.24

0.20

6.3

4.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.24

0.20

2.2

1.6

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.20

0.0

4.4

—

(3022145) Colonoscopy Study observation

1.18

0.18

1.6

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.17

0.17

11.8

9.6

—

(1761868) Lipid panel - Serum or Plasma

169

1.16

0.16

2.1

3.3

—

(3012544) pH of Venous blood

1.14

0.16

4.9

4.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.17

0.10

7.9

5.1

1.26

1.04

mmol/l

—

(40758558) Short blood count panel - Blood

165

1.11

0.09

10.6

7.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

127

1.12

0.08

2.8

3.0

0.54

0.88

ug/l

—

(3012516) Albumin [Mass/volume] in Urine

186

1.10

0.08

2.8

2.9

117.07

33.65

mg/l

0.41

127

(3042936) Bacteria identified in Isolate by Culture

1.09

0.07

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

256

1.08

0.07

2.6

2.4

—

(3003694) ABO and Rh group [Type] in Blood

128

1.11

0.07

1.6

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

139

1.09

0.06

2.5

2.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

4.9

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

-0.00

0.0

4.3

—

57.00

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.2

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

1.2

—

40.82

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

28.28

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

3.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

11.35

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.86

-0.00

6.7

3.8

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.4

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.0

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

-0.00

0.0

5.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

0.33

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

23.50

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

262.33

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORDETACH and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORDETACH	0.994 [0.82, 1.21]	0.953
Birth year	0.994 [0.99, 1.0]	0.199

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 331 females with H7_CHORDETACH died.

Males

Parameter	HR [95% CI]	p-value
H7_CHORDETACH	0.9 [0.7, 1.15]	0.399
Birth year	0.987 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 260 males with H7_CHORDETACH died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORDETACH.

N-year risk	Females	Males
1	0.071%	0.169%
5	0.545%	0.93%
10	1.404%	2.5%
15	2.849%	5.043%
20	4.983%	8.75%

Relationships between endpoints

↥

Index endpoint: H7_CHORDETACH – Choroidal detachment

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Choroidal detachment

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints