No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
83 |
4. Check minimum number of eventsNone |
83 |
5. Include endpointsNone |
83 |
6. Filter based on genotype QC (FinnGen only) |
83 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Ablatio chorioideae
Similar endpoints
↥List of similar endpoints to
Choroidal detachment
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 799 | 431 | 358 |
| Only index persons | 630 | 346 | 284 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 73.78 | 76.13 | 70.93 |
| Only index persons | 73.34 | 76.49 | 69.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 83 | 36 | 47 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 70.93 | 69.48 | 72.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 80
- Matched controls
- 799
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.4
ICD-10 Finland
Choroidal detachment
+∞
104.8
76
*
S01ED51
ATC
timolol, combinations; ophthalmic
29.7
33.8
49
40
S01EC01
ATC
acetazolamide; systemic
60.6
29.0
33
9
114
Kela drug reimbursment
Glaucoma
20.5
28.7
48
54
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
49.6
27.8
33
11
Z96.1
ICD-10 Finland
Presence of intraocular lens
14.8
24.4
48
73
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
23.0
21
*
S01EX03
ATC
NA
37.5
20.7
26
10
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
11.4
20.0
66
233
S01EC03
ATC
dorzolamide; ophthalmic
49.5
18.8
22
6
S01ED01
ATC
timolol; ophthalmic
20.8
18.6
28
20
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
20.8
18.6
28
20
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
18.4
17
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
18.0
17.6
28
23
S01EE01
ATC
latanoprost; ophthalmic
12.6
16.3
31
38
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
7.5
15.4
60
227
S01EC04
ATC
brinzolamide; ophthalmic
17.3
14.5
23
18
XCK00
NOMESCO Finland
Perimetry
13.2
13.4
24
25
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
11.7
11
*
CHC05
NOMESCO Finland
Iridotomy
41.6
11.7
14
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
50.9
11.3
13
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
14.2
11.3
19
17
S01EE05
ATC
tafluprost; ophthalmic
15.1
11.0
18
15
H57.1
ICD-10 Finland
Ocular pain
125.5
10.7
11
*
WX140
NOMESCO Finland
Parabulbar anesthesy
27.7
10.6
14
6
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
16.3
10.2
16
12
CHD99
NOMESCO Finland
Other filtering operation
112.5
9.6
10
*
H25.1
ICD-10 Finland
Senile nuclear cataract
4.5
9.4
47
190
S01EE03
ATC
bimatoprost; ophthalmic
15.0
9.3
15
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.2
8.8
48
208
S01EA03
ATC
apraclonidine; ophthalmic
31.3
8.7
11
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
+∞
8.5
8
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.6
8.4
22
43
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
37.5
8.3
10
*
S01BC05
ATC
ketorolac; ophthalmic
10.2
8.3
16
19
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
28.1
7.8
10
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
6.6
7.7
20
38
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
87.7
7.5
8
*
CHD35
NOMESCO Finland
Laser goniopuncture
87.7
7.5
8
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
7.4
7
*
S01EE04
ATC
travoprost; ophthalmic
11.6
7.3
13
13
S01EC54
ATC
brinzolamide, combinations; ophthalmic
33.3
7.3
9
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
7.1
19
38
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
43.8
6.9
8
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
43.8
6.9
8
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.8
6.6
23
62
CHD10
NOMESCO Finland
Trabeculectomy
75.4
6.5
7
*
S01FA04
ATC
cyclopentolate; ophthalmic
29.2
6.3
8
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
6.3
6
*
XCH00
NOMESCO Finland
Eye pressure measurement
11.3
6.2
11
11
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORDETACH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORDETACH | 0.994 [0.82, 1.21] | 0.953 |
| Birth year | 0.994 [0.99, 1.0] | 0.199 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 331 females with H7_CHORDETACH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORDETACH | 0.9 [0.7, 1.15] | 0.399 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 260 males with H7_CHORDETACH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORDETACH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.169% |
| 5 | 0.545% | 0.93% |
| 10 | 1.404% | 2.5% |
| 15 | 2.849% | 5.043% |
| 20 | 4.983% | 8.75% |
Relationships between endpoints
↥Index endpoint: H7_CHORDETACH – Choroidal detachment
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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