Choroidal detachment

H7_CHORDETACH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.4 Hospital discharge: ICD-9 — 3637 Hospital discharge: ICD-8 — 3785 Cause of death: ICD-10 — H31.4 Cause of death: ICD-9 — 3637 Cause of death: ICD-8 — 3785 2 out of 7 registries used, show all original rules.	83
4. Check minimum number of events None	83
5. Include endpoints None	83
6. Filter based on genotype QC (FinnGen only)	83

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Ablatio chorioideae

NAME	H7_CHORDETACH
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H314
HD_ICD_9	3637
HD_ICD_8	3785
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H314
COD_ICD_9	3637
COD_ICD_8	3785
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Choroidal detachment based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	799	431	358
Only index persons	630	346	284
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	73.78	76.13	70.93
Only index persons	73.34	76.49	69.51

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	83	36	47
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	70.93	69.48	72.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
80: Matched controls
799

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.4

ICD-10 Finland

Choroidal detachment

+∞

104.8

S01ED51

ATC

timolol, combinations; ophthalmic

29.7

33.8

S01EC01

ATC

acetazolamide; systemic

60.6

29.0

114

Kela drug reimbursment

Glaucoma

20.5

28.7

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

49.6

27.8

Z96.1

ICD-10 Finland

Presence of intraocular lens

14.8

24.4

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

+∞

23.0

S01EX03

ATC

37.5

20.7

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

11.4

20.0

233

S01EC03

ATC

dorzolamide; ophthalmic

49.5

18.8

S01ED01

ATC

timolol; ophthalmic

20.8

18.6

H40.10

ICD-10 Finland

Capsular glaucoma with pseudoexfoliation on the anterior lens capsule

20.8

18.6

H33.0

ICD-10 Finland

Retinal detachment with retinal break

+∞

18.4

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

18.0

17.6

S01EE01

ATC

latanoprost; ophthalmic

12.6

16.3

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

7.5

15.4

227

S01EC04

ATC

brinzolamide; ophthalmic

17.3

14.5

XCK00

NOMESCO Finland

Perimetry

13.2

13.4

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

+∞

11.7

CHC05

NOMESCO Finland

Iridotomy

41.6

11.7

CHD00

NOMESCO Finland

Laser trabeculoplasty

50.9

11.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

14.2

11.3

S01EE05

ATC

tafluprost; ophthalmic

15.1

11.0

H57.1

ICD-10 Finland

Ocular pain

125.5

10.7

WX140

NOMESCO Finland

Parabulbar anesthesy

27.7

10.6

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

16.3

10.2

CHD99

NOMESCO Finland

Other filtering operation

112.5

9.6

H25.1

ICD-10 Finland

Senile nuclear cataract

4.5

9.4

190

S01EE03

ATC

bimatoprost; ophthalmic

15.0

9.3

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

4.2

8.8

208

S01EA03

ATC

apraclonidine; ophthalmic

31.3

8.7

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

+∞

8.5

XCK10

NOMESCO Finland

Photography of fundus of eye

6.6

8.4

CHD15

NOMESCO Finland

Trabeculectomy and iridectomy

37.5

8.3

S01BC05

ATC

ketorolac; ophthalmic

10.2

8.3

TCW99

NOMESCO Finland

Other minor procedure in eye surgery

28.1

7.8

CJB10

NOMESCO Finland

Laser discission of secondary cataract

6.6

7.7

CHD35

NOMESCO Finland

Laser goniopuncture

87.7

7.5

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

87.7

7.5

CHF05

NOMESCO Finland

Transscleral laser coagulation of ciliary body

+∞

7.4

S01EE04

ATC

travoprost; ophthalmic

11.6

7.3

S01EC54

ATC

brinzolamide, combinations; ophthalmic

33.3

7.3

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.2

7.1

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

43.8

6.9

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

43.8

6.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.8

6.6

CHD10

NOMESCO Finland

Trabeculectomy

75.4

6.5

S01FA04

ATC

cyclopentolate; ophthalmic

29.2

6.3

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

+∞

6.3

XCH00

NOMESCO Finland

Eye pressure measurement

11.3

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3035350) Ketones [Presence] in Urine by Test strip

256

2.30

3.39

4.9

4.1

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

259

2.26

3.27

6.7

5.4

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

264

2.20

3.07

5.2

4.1

0.0

estimate

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.63

2.93

2.6

6.9

4.9

5.0

kpa

0.25

(3027801) Oxygen [Partial pressure] in Arterial blood

2.63

2.93

2.6

6.9

11.1

11.4

kpa

0.13

(3037467) Urinalysis macro (dipstick) panel - Urine

356

2.12

2.75

4.7

4.8

—

(3003396) Base excess in Arterial blood by calculation

2.45

2.7

7.0

0.8

1.0

mmol/l

—

(3026782) Osmolality of Urine

131

2.17

2.41

2.8

3.2

541.7

553.4

mosm/kgh2o

0.05

112

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

198

2.00

2.30

6.1

4.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

289

1.92

2.20

6.4

7.0

1.2

mmol/l

1.17

241

(3007853) Bacteria identified in Skin by Aerobe culture

2.47

2.03

1.5

1.6

—

(3000330) Specific gravity of Urine by Test strip

2.78

2.00

1.4

4.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.31

1.89

1.4

1.8

—

(3022621) pH of Urine by Test strip

2.76

1.86

8.3

2.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.27

1.83

1.4

1.8

—

(3015736) pH of Urine

195

1.84

1.80

3.4

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

215

1.79

1.72

4.3

3.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

149

1.86

1.65

5.7

3.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

149

1.86

1.65

2.3

2.1

3.4

3.0

mg/l

0.16

130

(3003327) Ova and parasites identified in Stool by Light microscopy

3.73

1.64

1.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.57

1.58

1.9

1.4

—

(3031040) Bacteria [#/volume] in Urine by Automated count

350

1.71

1.56

6.2

5.2

—

4933.1

—

(3018095) Leukocytes [#/volume] in Urine

213

1.73

1.52

4.5

4.0

119.5

130.1

e6/l

0.04

152

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.95

1.49

3.0

0.8

2.2

e6/l

—

(3049717) Cytology report of Urine Cyto stain

2.86

1.46

4.5

2.6

—

(3013512) EKG study

180

1.74

1.46

5.1

4.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.40

1.45

5.0

2.8

1.1

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

189

1.73

1.45

3.6

3.4

24.4

416.4

e6/l

0.59

143

(1761482) Bacteria [#/volume] in Urine by Culture

2.54

1.42

1.6

5.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

376

1.66

1.41

4.1

3.7

15.1

15.3

pmol/l

0.13

329

(3019060) Gas panel - Arterial blood

2.23

1.34

2.8

3.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.49

1.33

3.5

2.9

0.0

0.1

e6/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

142

1.75

1.32

2.1

1.9

506.1

460.9

pmol/l

0.20

120

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.18

1.28

2.1

1.5

—

(3026008) Bacteria identified in Urine by Culture

195

1.66

1.28

4.3

3.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.22

1.22

5.4

2.8

0.5

0.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.22

1.22

3.1

8.1

91.2

93.9

—

(42870588) Differential panel, method unspecified - Blood

164

1.65

1.17

5.6

4.8

—

(3025941) Bacteria identified in Stool by Culture

2.10

1.15

1.6

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.05

1.12

1.3

3.3

—

(3029937) Albumin [Presence] in Urine by Test strip

141

1.66

1.09

7.0

4.6

0.0

estimate

—

(3013115) Eosinophils [#/volume] in Blood

258

1.54

1.07

7.5

5.6

0.2

e9/l

0.24

229

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.35

1.05

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

233

1.53

1.01

4.8

3.4

—

(3001604) Monocytes [#/volume] in Blood

252

1.51

0.99

7.7

5.4

0.6

e9/l

0.25

223

(3006315) Basophils [#/volume] in Blood

252

1.51

0.99

7.7

5.4

0.0

e9/l

0.04

223

(3020891) Body temperature

2.31

0.95

9.0

4.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.15

0.91

2.8

8.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

113

1.63

0.91

4.6

4.1

—

(3030467) Casts [#/volume] in Urine by Automated count

174

1.53

0.91

3.3

3.2

0.1

0.3

e6/l

1.84

126

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

105

1.65

0.90

2.9

2.7

1.3

1.0

e6/l

—

(36304419) Bacteria [Presence] in Urine

158

1.53

0.86

4.0

3.3

—

(40768804) Tissue Pathology biopsy report

186

1.49

0.83

2.0

2.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

261

1.44

0.81

5.6

4.6

44.9

48.3

ng/l

0.07

205

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.88

0.81

3.0

4.5

25.1

25.2

mmol/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.80

0.0

2.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

100

1.61

0.79

1.3

1.1

0.6

1.7

u/ml

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.82

0.78

1.8

1.4

—

(3018418) pH of Serum or Plasma

181

1.46

0.75

3.8

4.8

7.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

163

1.48

0.74

4.1

2.4

54.0

57.3

u/l

0.24

152

(3021960) Folate [Moles/volume] in Serum or Plasma

166

0.61

0.74

1.7

20.3

20.6

nmol/l

0.04

141

(3021589) Normoblasts [#/volume] in Blood

237

1.42

0.73

17.2

10.0

0.0

e9/l

0.48

201

(3019309) Folate [Moles/volume] in Red Blood Cells

137

1.50

0.73

1.9

1.8

1126.3

1133.5

nmol/l

0.01

102

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.77

0.72

1.9

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.98

0.72

1.0

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

121

1.51

0.69

2.3

3.0

2.5

mmol/l

0.20

108

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

486

1.39

0.67

4.5

4.8

4.4

4.3

mmol/l

0.06

436

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.55

0.67

1.6

1.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

177

1.41

0.64

3.2

3.7

21.7

6.5

mg/mmol

0.37

113

(3044889) 12 lead EKG panel

368

1.35

0.63

4.4

4.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.8

—

(3000991) Gas panel - Venous blood

1.56

0.60

6.9

8.6

—

(3023368) Bacteria identified in Blood by Culture

179

1.39

0.60

5.0

4.2

—

(3019150) Specific gravity of Urine by Refractometry

100

1.48

0.56

9.5

4.8

1.0

kg/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.58

0.54

1.0

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.58

0.54

2.0

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

102

1.45

0.51

8.6

5.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

467

1.30

0.50

5.1

4.7

1.7

2.0

mu/l

1.64

406

(40761535) Cells panel - Urine sediment

1.53

0.49

6.6

3.6

—

(40768797) Stomach Pathology biopsy report

1.51

0.47

1.2

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

168

1.33

0.46

2.5

2.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

168

1.33

0.46

5.1

4.5

20.0

22.8

0.45

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.60

0.43

1.6

2.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.60

0.43

1.2

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.43

0.43

1.4

1.3

2.1

2.6

g/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

483

1.27

0.42

4.2

4.8

1.4

mmol/l

0.36

428

(3012516) Albumin [Mass/volume] in Urine

161

1.32

0.42

2.8

2.9

117.1

37.7

mg/l

0.38

106

(3012544) pH of Venous blood

1.38

0.40

4.9

4.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.43

0.36

2.2

1.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

251

1.24

0.35

1.9

2.2

94.5

91.9

pmol/l

0.09

130

(40761511) CBC panel - Blood by Automated count

540

1.25

0.35

20.9

15.3

—

(3022145) Colonoscopy Study observation

1.41

0.32

1.6

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.38

0.32

7.9

5.5

1.3

1.0

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

462

1.21

0.31

4.0

4.3

1.2

mmol/l

0.02

408

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.32

0.29

11.8

9.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.31

0.28

3.3

2.5

10.5

10.8

umol/l

0.07

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

505

1.20

0.28

5.6

5.4

2.6

2.5

mmol/l

0.19

452

(3042936) Bacteria identified in Isolate by Culture

1.22

0.26

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

539

1.18

0.24

29.1

20.6

96.9

86.2

umol/l

0.56

539

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

3.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.21

0.0

1.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.30

0.21

6.3

3.9

—

(1761868) Lipid panel - Serum or Plasma

158

1.18

0.18

2.1

3.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

526

1.14

0.16

24.4

16.5

25.9

25.7

mg/l

0.01

424

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

488

1.12

0.14

23.2

16.5

69.3

70.7

ml/min/173m2

0.14

400

(3000963) Hemoglobin [Mass/volume] in Blood

569

1.13

0.14

33.1

24.3

130.0

132.4

g/l

0.43

547

(40758558) Short blood count panel - Blood

144

1.14

0.11

11.8

6.6

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

124

0.87

0.10

2.0

1.6

1.4

1.2

mmol/l

0.48

(3003694) ABO and Rh group [Type] in Blood

119

1.11

0.06

1.7

1.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.11

0.04

3.6

2.5

2.2

g/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

445

0.98

0.00

22.1

17.8

35.5

38.7

0.53

293

(3032080) INR in Blood by Coagulation assay

255

1.03

0.00

11.3

10.8

1.1

1.3

inr

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

125

0.95

0.00

2.4

3.0

0.5

0.9

ug/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

241

0.99

0.00

2.6

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

126

1.04

0.00

2.6

2.1

—

(44790049)

0.00

0.0

1.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.97

0.00

6.7

3.8

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

4.8

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.9

—

(44790047)

0.00

0.0

1.8

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

272.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

11.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

2.8

—

57.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.8

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

5.4

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

24.3

—

6.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.2

—

0.3

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(4146454)

0.00

0.0

1.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

28.3

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

23.5

—

(44806420)

0.00

0.0

2.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(44790048)

0.00

0.0

1.8

—

(44806118)

0.00

0.0

1.8

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

4.6

—

242.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORDETACH and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORDETACH	0.994 [0.82, 1.21]	0.953
Birth year	0.994 [0.99, 1.0]	0.199

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 331 females with H7_CHORDETACH died.

Males

Parameter	HR [95% CI]	p-value
H7_CHORDETACH	0.9 [0.7, 1.15]	0.399
Birth year	0.987 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 260 males with H7_CHORDETACH died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORDETACH.

N-year risk	Females	Males
1	0.071%	0.169%
5	0.545%	0.93%
10	1.404%	2.5%
15	2.849%	5.043%
20	4.983%	8.75%

Relationships between endpoints

↥

Index endpoint: H7_CHORDETACH – Choroidal detachment

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Choroidal detachment

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints