Choroidal degeneration

H7_CHORDEGEN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.1 Hospital discharge: ICD-9 — 3634 Cause of death: ICD-10 — H31.1 Cause of death: ICD-9 — 3634 2 out of 7 registries used, show all original rules.	28
4. Check minimum number of events None	28
5. Include endpoints None	28
6. Filter based on genotype QC (FinnGen only)	28

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Degeneratio chorioideae

NAME	H7_CHORDEGEN
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H311
HD_ICD_9	3634
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H311
COD_ICD_9	3634
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Choroidal degeneration based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	276	162	113
Only index persons	247	149	98
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.01	0.00
Median age at first event (years)
Whole population	60.80	64.20	55.66
Only index persons	60.48	62.95	56.71

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	28	15	13
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	69.48	68.21	70.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36660697) Celiac disease serology panel - Serum

4.43

1.79

1.4

1.2

—

(3002256) Pathology report gross observation

3.52

1.68

1.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.81

1.20

1.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

168

2.44

1.18

7.3

8.0

65.7

78.3

u/l

1.43

154

(3019225) pH of Specimen

2.67

1.14

4.8

—

(40768797) Stomach Pathology biopsy report

2.18

0.90

1.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.98

0.90

1.4

2.1

102.9

88.7

pmol/l

—

(42870588) Differential panel, method unspecified - Blood

2.04

0.86

7.3

4.0

—

(3002385) Erythrocyte distribution width [Ratio]

159

1.90

0.79

18.0

19.9

13.8

13.9

0.05

152

(3042936) Bacteria identified in Isolate by Culture

1.97

0.64

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.97

0.64

2.2

2.1

—

(4010399)

0.00

0.63

0.0

1.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.74

0.60

2.5

2.2

73.8

83.2

nmol/l

0.84

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.61

0.52

2.6

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

1.47

0.44

2.7

2.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.42

0.0

6.4

—

92.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.42

0.0

2.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.00

0.42

0.0

3.5

—

64.8

—

(3044889) 12 lead EKG panel

133

1.47

0.36

3.8

4.1

—

(3019069) Monocytes/100 leukocytes in Blood

1.48

0.35

9.4

5.7

9.4

9.1

0.08

(3022096) Basophils/100 leukocytes in Blood

1.48

0.35

9.3

5.4

0.6

0.5

0.37

(3006504) Eosinophils/100 leukocytes in Blood

1.48

0.35

9.3

5.5

2.4

2.2

0.12

(36304419) Bacteria [Presence] in Urine

1.43

0.34

2.6

3.3

—

(3018010) Neutrophils/100 leukocytes in Blood

1.44

0.30

9.5

5.2

59.0

58.2

0.10

(3002030) Lymphocytes/100 leukocytes in Blood

1.44

0.30

9.5

5.6

26.5

27.1

0.09

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

126

1.41

0.30

4.3

2.7

48.7

49.3

u/l

0.01

113

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.41

0.29

3.3

4.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

137

1.39

0.28

7.1

4.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.7

—

0.8

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

2.5

—

0.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.7

—

1.1

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.22

0.0

1.7

—

45.6

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.22

0.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

3.6

—

24.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

(3020891) Body temperature

0.00

0.21

0.0

5.3

—

(3022621) pH of Urine by Test strip

0.00

0.21

0.0

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.30

0.19

2.5

3.5

—

(3023368) Bacteria identified in Blood by Culture

1.27

0.19

3.4

4.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

152

1.30

0.19

5.4

4.1

18.1

15.2

mm/h

0.30

132

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.71

0.18

11.3

4.7

—

(3013512) EKG study

1.18

0.18

7.1

5.6

—

(3015736) pH of Urine

1.23

0.18

5.7

3.9

—

(40768804) Tissue Pathology biopsy report

1.27

0.15

3.3

2.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.20

0.09

3.4

2.1

—

(1761868) Lipid panel - Serum or Plasma

0.80

0.09

4.3

3.3

—

(3026008) Bacteria identified in Urine by Culture

1.15

0.09

4.6

2.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

171

1.15

0.05

15.1

17.1

40.1

39.3

0.19

110

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

6.9

—

25.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

5.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

22.0

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

21.6

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

4.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.98

0.00

11.3

4.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

0.91

0.00

2.2

3.6

345.2

7680.3

umol/l

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(40758558) Short blood count panel - Blood

1.02

0.00

2.6

7.7

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

4.6

—

4.1

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

191.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

4.5

—

4.9

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

7.6

—

30.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

5.2

—

3.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

4.6

—

105.3

—

(1616796) Gas panel - Central venous blood

0.00

0.0

3.0

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

97.6

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

4.5

—

10.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORDEGEN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CHORDEGEN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_CHORDEGEN – Choroidal degeneration

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Choroidal degeneration

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints