Other specified and unspecified disorders of choroid

H7_CHORNAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.8, H31.9 Hospital discharge: ICD-9 — 363[8-9] Cause of death: ICD-10 — H31.8, H31.9 Cause of death: ICD-9 — 363[8-9] 2 out of 7 registries used, show all original rules.	125
4. Check minimum number of events None	125
5. Include endpoints None	125
6. Filter based on genotype QC (FinnGen only)	125

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_CHORNAS
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H31[8-9]
HD_ICD_9	363[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H31[8-9]
COD_ICD_9	363[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified and unspecified disorders of choroid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	751	407	340
Only index persons	694	385	309
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.10	60.28	57.74
Only index persons	58.78	59.62	57.73

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	125	69	56
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	58.02	58.59	57.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1111

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.9

ICD-10 Finland

Disorder of choroid, unspecified

+∞

69.2

H31.8

ICD-10 Finland

Other specified disorders of choroid

+∞

54.8

XCK10

NOMESCO Finland

Photography of fundus of eye

16.2

25.8

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

19.5

25.6

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

21.1

20.3

D31.3

ICD-10 Finland

Benign neoplasm: Choroid

48.1

17.0

XCD10

NOMESCO Finland

Electrophysiological examination of eye

36.5

16.8

XCW99

NOMESCO Finland

Other investigative procedure of eye

11.8

16.4

CK2L4

NOMESCO Finland

Wide-field/panoramic imaging of ocular fundus

171.7

14.8

XCD20

NOMESCO Finland

Photoangiography of eye

+∞

13.8

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

+∞

10.6

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.5

8.8

WX140

NOMESCO Finland

Parabulbar anesthesy

18.2

8.8

CK9F4

NOMESCO Finland

Fluorescein angiography (FAG) of choroid and retina

+∞

7.4

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

+∞

6.3

CKE65

NOMESCO Finland

Removal of brachytherapeutic plate from eye

+∞

6.3

CKE60

NOMESCO Finland

Brachytherapy of choroid and retina

+∞

6.3

C69.30

ICD-10 Finland

Malignant tumor of the chorioidea without histology

+∞

6.3

H35.7

ICD-10 Finland

Separation of retinal layers

+∞

6.3

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.72

5.44

1.5

1.7

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

4.64

4.17

1.5

1.4

—

1.8

—

(42870588) Differential panel, method unspecified - Blood

335

2.08

3.80

8.2

5.2

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.69

3.72

1.2

2.3

3.7

3.8

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.69

3.72

1.2

2.3

—

(3023368) Bacteria identified in Blood by Culture

267

2.07

3.52

5.0

4.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

121

2.33

3.20

3.2

2.3

21.5

19.9

0.23

106

(3032080) INR in Blood by Coagulation assay

405

1.93

3.20

19.4

9.2

1.3

1.2

inr

0.17

123

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

3.66

3.12

3.7

1.7

0.3

0.4

u/ml

—

(3012516) Albumin [Mass/volume] in Urine

286

1.96

3.10

4.6

2.9

2481.8

69.5

mg/l

0.77

179

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

116

2.32

3.08

6.3

4.6

252.5

242.8

u/l

0.14

109

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

127

2.21

2.86

1.9

1.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

213

1.97

2.76

3.3

1.8

1.3

1.2

mg/l

0.12

169

(3024928) Oxygen saturation in Venous blood

4.87

2.63

4.7

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

124

2.16

2.63

2.0

1.7

—

(3044889) 12 lead EKG panel

709

1.89

2.62

5.3

3.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.51

2.61

1.2

2.0

—

(3013115) Eosinophils [#/volume] in Blood

532

1.77

2.52

8.5

5.9

0.2

e9/l

0.14

475

(3044290) Cell count panel - Cerebral spinal fluid

4.57

2.51

1.0

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

245

1.86

2.48

2.3

2.0

—

(3006315) Basophils [#/volume] in Blood

516

1.75

2.44

8.2

5.6

0.0

e9/l

0.17

451

(3037522) Nuclear Ab [Titer] in Serum

121

2.10

2.40

1.4

403.6

533.8

titre

0.25

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

342

1.77

2.40

3.3

2.6

51.9

55.3

u/l

0.39

314

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

6.45

2.39

1.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

471

1.74

2.37

4.4

4.0

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

3.64

2.31

1.0

1.2

4.9

4.1

mmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

311

1.76

2.28

5.4

3.7

8.6

11.7

mg/mmol

0.34

186

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

401

1.72

2.26

2.1

1.9

102.6

97.2

pmol/l

0.28

185

(3007853) Bacteria identified in Skin by Aerobe culture

117

2.07

2.24

2.4

1.5

—

(3001604) Monocytes [#/volume] in Blood

515

1.70

2.23

8.3

5.6

0.6

e9/l

1.43

449

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

174

1.87

2.10

1.9

—

(3039000) Anion gap in Blood

3.64

2.09

16.0

5.8

10.1

10.3

mmol/l

—

(3018572) Chloride [Moles/volume] in Blood

3.64

2.09

16.0

5.8

105.1

103.9

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

600

1.68

2.08

11.9

10.1

4.0

4.1

e9/l

0.14

532

(3037467) Urinalysis macro (dipstick) panel - Urine

702

1.72

2.07

7.6

4.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

409

1.67

2.06

2.3

2.4

77.2

75.8

nmol/l

0.12

358

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

242

1.75

2.03

2.1

2.0

3.1

3.5

mg/l

0.30

208

(3012544) pH of Venous blood

2.12

2.02

3.9

3.6

—

(3019198) Lymphocytes [#/volume] in Blood

534

1.65

2.01

8.2

5.6

1.8

1.9

e9/l

0.39

476

(3019309) Folate [Moles/volume] in Red Blood Cells

185

1.82

1.99

1.9

1.7

1087.5

1193.2

nmol/l

0.24

136

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

2.58

1.99

3.1

2.2

1.5

1.7

g/l

0.24

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.31

1.91

1.6

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.69

1.84

1.3

2.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

757

1.67

1.80

4.2

3.9

14.9

pmol/l

0.05

680

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

3.45

1.77

1.3

1.2

—

(4062490)

3.96

1.73

1.8

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

137

1.83

1.70

1.3

1.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

795

1.66

1.68

13.3

7.5

89.8

77.4

u/l

0.61

732

(3018677) aPTT in Platelet poor plasma by Coagulation assay

154

1.78

1.66

9.6

2.0

31.4

29.6

0.46

147

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

553

1.55

1.62

9.3

6.2

12.8

10.9

umol/l

0.39

524

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.68

1.54

1.1

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.95

1.52

1.3

1.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.94

1.50

1.6

2.5

0.2

g/l

0.20

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

111

1.84

1.49

3.4

—

(3047181) Lactate [Moles/volume] in Blood

2.59

1.47

16.9

6.0

1.2

mmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

104

1.85

1.46

1.2

1.7

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.34

1.43

12.9

5.6

1.7

1.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.34

1.43

12.9

5.7

1.3

0.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.50

1.41

1.1

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.50

1.41

1.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

121

1.78

1.41

1.4

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

292

1.54

1.39

3.5

3.2

894.6

243.0

e6/l

0.34

222

(3002256) Pathology report gross observation

122

1.76

1.37

1.8

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

349

1.50

1.33

4.5

3.1

—

(3044640) Blood type and Crossmatch panel - Blood

322

1.51

1.32

2.7

2.2

—

(3034770) Mitochondria Ab [Titer] in Serum

2.57

1.32

1.0

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

222

1.53

1.16

5.2

3.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.04

1.15

1.7

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

171

1.58

1.14

5.2

3.4

405.3

110.1

ng/l

0.52

124

(3026008) Bacteria identified in Urine by Culture

322

1.46

1.13

4.2

3.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.44

1.10

1.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.44

1.10

1.0

1.2

—

(40761511) CBC panel - Blood by Automated count

116

1089

1.90

1.07

21.2

12.9

—

(3018095) Leukocytes [#/volume] in Urine

345

1.42

1.05

4.3

3.8

22.6

47.2

e6/l

0.83

245

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.32

1.04

1.0

1.8

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.32

1.04

1.6

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

498

1.39

1.03

10.4

6.2

1.2

mmol/l

0.30

405

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

159

1.55

1.00

2.7

0.9

1.0

e6/l

0.16

(3019832) Treponema pallidum Ab [Presence] in Serum

1.71

0.95

1.4

1.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

622

1.37

0.94

6.4

4.7

6.9

6.7

mmol/l

0.37

572

(3031040) Bacteria [#/volume] in Urine by Automated count

663

1.37

0.93

6.1

4.6

—

305.1

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

2.20

0.93

1.2

2.7

0.0

g/l

—

(40768443) Skin Pathology biopsy report

1.97

0.90

1.4

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

163

1.50

0.90

1.3

1.1

9.2

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

146

1.53

0.90

2.3

3.0

2.6

3.3

e6/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

109

1018

1.55

0.85

4.3

4.6

1.4

1.5

mmol/l

0.24

928

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

122

0.55

0.83

1.3

1.7

1.8

1.5

—

107

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

106

986

1.49

0.83

7.5

5.7

42.4

39.9

mmol/mol

1.50

911

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

109

1020

1.54

0.82

4.4

4.6

4.7

mmol/l

0.00

100

935

(3030467) Casts [#/volume] in Urine by Automated count

266

1.38

0.80

4.1

3.0

0.1

0.3

e6/l

0.75

199

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.5

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.79

0.0

1.6

—

273.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

101

934

1.42

0.79

5.5

4.8

2.0

1.9

mu/l

0.20

845

(36304419) Bacteria [Presence] in Urine

258

1.38

0.78

4.2

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

408

1.33

0.78

4.6

4.1

21.5

40.3

ng/l

1.13

279

(3017732) Neutrophils [#/volume] in Blood

1.66

0.78

1.3

2.3

3.8

3.6

e9/l

—

(3019225) pH of Specimen

100

1.57

0.77

5.2

3.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.22

0.77

1.2

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.22

0.77

1.0

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

116

1109

1.64

0.75

26.2

16.1

81.4

76.7

umol/l

0.83

116

1109

(3028026) IgM [Mass/volume] in Serum or Plasma

1.72

0.74

1.7

1.8

1.4

1.6

g/l

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.04

0.73

1.0

1.7

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.62

0.73

6.8

3.1

1.9

2.0

mmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.79

0.72

1.6

1.9

—

(3033658) Prothrombin time (PT) actual/Normal

243

1.37

0.72

4.9

3.6

93.5

90.1

0.27

238

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

110

1038

1.50

0.71

23.7

14.1

26.6

22.4

mg/l

0.75

815

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.71

0.69

1.3

1.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.89

0.69

1.2

2.7

0.0

g/l

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.89

0.69

1.2

1.4

40.8

82.9

pmol/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.89

0.69

1.2

1.9

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.89

0.69

1.2

2.7

0.0

g/l

—

(3019060) Gas panel - Arterial blood

1.60

0.64

11.9

4.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

1.0

1.7

—

(40758558) Short blood count panel - Blood

248

1.33

0.64

8.2

7.8

—

(40768797) Stomach Pathology biopsy report

150

0.64

0.63

1.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.69

0.62

1.2

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

110

1044

1.45

0.62

5.3

5.1

2.8

2.7

mmol/l

0.12

101

951

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.61

0.62

15.5

6.6

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.58

0.61

13.7

7.2

26.1

24.8

mmol/l

0.84

(3049717) Cytology report of Urine Cyto stain

1.75

0.58

1.3

2.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

169

1.37

0.58

1.2

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.56

0.58

1.9

1.5

—

(36660697) Celiac disease serology panel - Serum

1.51

0.57

1.3

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.65

0.56

1.5

1.7

—

(3013512) EKG study

328

1.27

0.56

4.6

4.0

—

(3042936) Bacteria identified in Isolate by Culture

153

1.37

0.54

3.5

1.8

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.49

0.54

6.9

3.0

5.3

5.0

kpa

—

(3009542) Hematocrit [Volume Fraction] of Blood

100

942

1.31

0.53

24.8

14.2

39.2

40.2

0.43

682

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

218

1.30

0.52

1.2

1.3

0.7

1.2

u/ml

—

(3018418) pH of Serum or Plasma

312

1.26

0.52

6.4

4.0

7.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

105

997

1.33

0.51

5.2

4.7

6.3

6.0

mmol/l

0.77

914

(3035350) Ketones [Presence] in Urine by Test strip

517

1.23

0.49

5.1

3.7

0.0

estimate

0.00

104

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

104

988

1.31

0.49

3.9

4.1

1.3

mmol/l

0.10

895

(4010399)

0.58

0.47

1.0

1.5

—

(1761868) Lipid panel - Serum or Plasma

387

0.80

0.47

2.2

3.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.42

0.46

2.9

2.6

1.1

1.4

—

(40768804) Tissue Pathology biopsy report

413

1.22

0.45

2.6

2.0

—

(3009261) Glucose [Presence] in Urine by Test strip

521

1.21

0.45

5.4

3.8

0.0

estimate

0.00

100

(3021601) Nitrite [Presence] in Urine by Test strip

512

1.21

0.44

7.0

4.9

0.0

estimate

0.00

105

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.62

0.44

1.5

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

1.4

1.9

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.38

0.41

11.0

7.6

119.8

120.6

g/l

0.06

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

2.8

—

60.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.36

0.41

1.6

1.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

2.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.40

0.38

4.8

3.0

—

(3021589) Normoblasts [#/volume] in Blood

468

1.19

0.38

13.9

10.1

0.0

e9/l

0.71

386

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

172

1.27

0.37

1.3

94.0

34.7

iu/ml

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.49

0.36

1.0

1.7

—

(40761535) Cells panel - Urine sediment

1.34

0.31

5.9

3.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

252

1.20

0.31

6.4

5.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.31

0.31

2.4

5.1

26.6

24.9

mmol/l

—

(3025941) Bacteria identified in Stool by Culture

1.27

0.28

1.8

1.3

—

(4035726)

113

1.27

0.28

1.7

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

198

1.20

0.27

3.2

2.8

0.6

0.7

ug/l

0.24

120

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

306

0.85

0.26

4.1

3.2

1633.4

1035.4

ng/l

0.56

247

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.31

0.25

1.0

1.5

—

(3016502) Oxygen saturation in Arterial blood

106

1.25

0.24

11.0

7.2

96.3

95.8

0.29

100

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

102

989

1.17

0.23

20.7

13.2

77.6

80.7

ml/min/173m2

0.72

800

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

656

0.89

0.22

2.6

2.9

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.23

0.22

1.2

1.5

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

4.6

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

13.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

154

0.83

0.20

1.3

1.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.20

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

409

1.12

0.19

5.6

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

131

0.82

0.18

9.1

7.4

—

(3000991) Gas panel - Venous blood

1.15

0.15

4.4

7.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

198

1.13

0.15

1.5

2.2

2.7

g/l

0.55

109

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

268

1.11

0.14

5.8

4.3

20.1

20.7

0.09

115

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

114

1.16

0.12

1.5

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

183

1.11

0.11

1.3

1.5

—

(3022313) Gas panel - Capillary blood

1.09

0.09

9.4

3.0

—

(3020891) Body temperature

1.07

0.09

5.0

4.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.09

1.7

2.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.14

0.09

1.3

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.04

0.08

1.2

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

264

1.08

0.08

2.0

1.7

1.4

mmol/l

0.01

219

(3005322) IgE [Units/volume] in Serum or Plasma

1.10

0.08

2.0

1.2

137.8

191.2

u/ml

—

(3022621) pH of Urine by Test strip

0.81

0.08

2.7

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.86

0.07

3.3

6.1

1.0

1.3

mmol/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

118

1.11

0.07

11.1

6.7

5.2

5.1

kpa

0.18

109

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.06

0.07

1.4

2.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.02

0.07

3.7

2.7

27.9

4.8

ug/l

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.11

0.04

6.1

4.0

1.2

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.08

0.02

1.4

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

143

1.06

0.01

3.7

4.5

33.9

31.8

—

(40761536) Microorganisms panel - Urine sediment

1.07

0.01

6.5

3.7

—

(21494755) Public health laboratory ask at order entry panel

1.05

0.00

1.5

1.4

—

(3022145) Colonoscopy Study observation

124

0.96

0.00

1.2

—

(3003694) ABO and Rh group [Type] in Blood

268

1.01

0.00

1.6

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

283

0.99

0.00

6.8

4.2

0.0

estimate

0.00

(3041096) Erythrocytes [Presence] in Urine by Automated

305

1.02

0.00

4.4

3.2

—

(3027801) Oxygen [Partial pressure] in Arterial blood

118

1.02

0.00

11.9

6.7

11.0

12.1

kpa

0.56

110

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

9.2

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.8

—

76.8

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.3

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.3

—

135.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

2.5

—

(3012565) Volume of 24 hour Urine

0.00

0.0

3.1

—

2063.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

13.6

—

939.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

10.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

6.3

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(44813793)

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(44806071)

0.00

0.0

1.2

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.4

—

14.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

11.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.9

—

0.7

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

7.2

—

40.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.6

—

(3000492) Spirometry study

0.93

0.00

1.9

1.5

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.2

—

6.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(44806420)

0.00

0.0

2.3

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

17.3

—

1788.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(4024509)

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORNAS	1.072 [0.76, 1.51]	0.693
Birth year	0.995 [0.99, 1.0]	0.211

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 338 females with H7_CHORNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CHORNAS.

N-year risk	Females	Males
1	0.093%	No data
5	0.555%	No data
10	1.562%	No data
15	3.141%	No data
20	5.669%	No data

Relationships between endpoints

↥

Index endpoint: H7_CHORNAS – Other specified and unspecified disorders of choroid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified and unspecified disorders of choroid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints