No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
137 |
4. Check minimum number of eventsNone |
137 |
5. Include endpointsNone |
137 |
6. Filter based on genotype QC (FinnGen only) |
131 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 751 | 407 | 340 |
| Only index persons | 694 | 385 | 309 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 59.10 | 60.28 | 57.74 |
| Only index persons | 58.78 | 59.62 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 131 | 73 | 58 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 58.74 | 59.88 | 57.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 137
- Matched controls
- 1370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
84.3
72
*
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
71.2
62
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
24.9
67.0
55
36
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
31.0
63.9
46
22
XCK10
NOMESCO Finland
Photography of fundus of eye
14.3
45.4
50
53
XCW99
NOMESCO Finland
Other investigative procedure of eye
14.5
38.5
40
38
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
45.3
21.7
26
7
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
123.0
20.2
21
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.7
19.8
48
118
XCD10
NOMESCO Finland
Electrophysiological examination of eye
22.6
18.2
26
14
XCD20
NOMESCO Finland
Photoangiography of eye
83.3
13.9
15
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
13.8
13
*
WX140
NOMESCO Finland
Parabulbar anesthesy
17.0
11.7
18
12
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
9.5
9
*
H26.4
ICD-10 Finland
After-cataract
4.7
8.6
22
54
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
+∞
8.4
8
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.8
8.4
29
90
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.6
7.8
20
49
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
47.8
7.8
9
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
84.5
7.5
8
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
84.5
7.5
8
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
84.5
7.5
8
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
+∞
7.4
7
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
7.4
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.7
7.1
56
280
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
8.1
6.6
14
19
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
73.1
6.5
7
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
6.3
6
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
6.3
6
*
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
+∞
6.3
6
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
+∞
6.3
6
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
517
2.12
4.43
26.5
13.7
1.25
1.24
inr
0.06
19
153
28
126
2.54
4.19
5.8
4.6
246.68
245.92
u/l
0.01
28
119
11
24
4.89
3.84
1.5
1.3
—
1.81
—
0
7
13
34
4.11
3.81
1.3
1.9
—
—
—
0
0
40
227
2.08
3.45
3.1
1.8
1.25
1.17
mg/l
0.09
32
180
27
134
2.26
3.24
1.9
1.7
—
—
—
0
0
27
137
2.21
3.07
1.9
1.8
—
—
—
0
0
55
367
1.83
2.89
3.2
2.6
52.52
55.66
u/l
0.40
50
337
12
39
3.27
2.85
1.3
2.2
—
—
—
0
0
70
510
1.76
2.70
2.7
2.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
31
3.40
2.57
3.7
1.8
0.31
0.34
u/ml
—
5
19
62
441
1.74
2.56
2.3
2.4
77.37
76.32
nmol/l
0.10
56
388
101
827
1.84
2.53
4.4
4.0
14.89
14.85
pmol/l
0.05
93
746
25
135
2.04
2.42
3.2
2.2
21.54
20.47
%
0.14
20
118
32
189
1.90
2.41
1.8
1.9
—
—
—
0
0
29
166
1.95
2.39
8.5
1.9
30.73
29.65
s
0.28
29
159
5
8
6.43
2.39
1.0
1.3
—
—
—
0
0
48
323
1.75
2.38
5.4
3.5
8.43
10.92
mg/mmol
0.27
37
195
83
649
1.71
2.37
11.6
10.1
3.92
4.02
e9/l
0.21
75
576
41
268
1.76
2.23
2.2
2.1
—
—
—
0
0
60
440
1.65
2.12
2.2
1.9
103.78
96.29
pmol/l
0.44
38
200
10
37
2.83
2.12
1.3
2.4
—
—
—
0
0
77
602
1.64
2.11
8.9
6.4
12.35
11.01
umol/l
0.29
72
572
39
257
1.72
2.05
2.1
2.0
3.08
3.56
mg/l
0.38
32
220
8
27
3.08
1.97
1.0
1.1
4.88
3.93
mmol/l
—
8
22
102
865
1.70
1.95
12.9
7.6
88.04
77.38
u/l
0.57
96
801
31
199
1.72
1.77
1.9
1.7
1061.71
1220.13
nmol/l
0.42
24
146
7
24
3.02
1.74
1.6
1.7
—
—
—
0
0
51
374
1.58
1.74
6.3
3.2
2.36
2.36
mmol/l
0.04
46
328
21
121
1.87
1.70
3.3
3.4
—
—
—
0
0
8
31
2.68
1.69
1.0
1.3
—
—
—
0
0
5
14
3.66
1.63
1.0
2.1
—
—
—
0
0
7
28
2.58
1.47
1.1
1.3
—
—
—
0
0
57
443
1.49
1.45
4.5
4.0
20.77
38.24
ng/l
1.14
43
301
6
22
2.80
1.45
1.0
1.8
—
—
—
0
0
5
16
3.20
1.45
1.0
1.9
—
—
—
0
0
11
53
2.17
1.43
3.1
2.0
1.52
1.62
g/l
0.13
11
44
6
23
2.68
1.38
1.5
1.2
—
—
—
0
0
5
17
3.01
1.37
1.2
1.0
0.95
1.82
u/ml
—
5
11
27
180
1.62
1.34
1.3
1.3
1.09
8.56
u/ml
1.50
11
68
66
537
1.44
1.29
10.0
6.4
1.21
1.21
mmol/l
0.23
58
447
6
25
2.46
1.26
1.3
1.5
—
—
—
0
0
5
19
2.69
1.22
3.8
3.9
65.00
57.11
%
—
5
19
117
1073
1.62
1.17
7.2
5.5
41.80
39.60
mmol/mol
1.45
108
996
112
1019
1.54
1.14
5.7
4.8
1.96
1.92
mu/l
0.17
104
924
7
30
2.40
1.14
1.1
1.3
—
—
—
0
0
79
676
1.40
1.11
6.1
4.7
6.82
6.60
mmol/l
0.40
74
624
49
387
1.41
1.10
4.4
3.1
—
—
—
0
0
122
1136
1.68
1.07
22.6
14.0
26.04
22.97
mg/l
0.52
102
886
128
1209
1.89
1.06
25.1
16.2
80.85
76.29
umol/l
0.89
128
1209
27
191
1.52
1.05
5.3
3.7
405.25
109.69
ng/l
0.53
20
139
5
22
2.32
1.04
1.0
1.2
—
—
—
0
0
5
22
2.32
1.04
1.0
1.2
—
—
—
0
0
120
1117
1.60
1.00
4.3
4.5
1.44
1.47
mmol/l
0.40
110
1022
120
1119
1.58
0.97
4.4
4.5
4.67
4.68
mmol/l
0.03
111
1030
6
27
2.28
0.94
1.0
1.7
—
—
—
0
0
122
1145
1.60
0.91
5.3
5.0
2.78
2.76
mmol/l
0.10
113
1047
6
31
1.98
0.85
1.0
1.7
—
—
—
0
0
21
148
1.49
0.84
4.1
6.7
104.71
103.77
mmol/l
0.43
21
148
25
183
1.45
0.83
2.6
2.8
0.78
0.98
e6/l
0.23
13
102
6
32
1.91
0.83
1.2
2.5
0.00
0.00
g/l
—
6
32
23
166
1.46
0.82
2.3
3.1
2.56
3.14
e6/l
0.16
11
86
5
24
2.12
0.75
1.2
1.1
—
—
—
0
0
115
1078
1.42
0.74
19.5
13.2
78.67
81.28
ml/min/173m2
0.61
97
870
9
56
1.65
0.74
2.6
2.5
2.09
1.45
%
—
9
56
25
191
1.38
0.67
1.4
1.3
75.21
34.13
iu/ml
—
9
65
115
1083
1.39
0.67
3.9
4.1
1.36
1.31
mmol/l
0.33
104
984
106
987
1.33
0.66
26.5
16.8
15.65
15.21
%
0.24
106
971
37
302
1.31
0.65
4.0
3.0
0.13
0.35
e6/l
1.08
28
224
5
29
1.75
0.64
1.2
1.9
—
—
—
0
0
12
80
1.55
0.62
1.8
1.7
—
—
—
0
0
5
30
1.69
0.62
1.2
1.4
40.80
79.38
pmol/l
—
5
30
5
88
0.55
0.58
1.4
2.0
—
—
—
0
0
6
37
1.65
0.56
1.5
1.7
—
—
—
0
0
9
63
1.46
0.53
2.4
5.2
26.42
24.92
mmol/l
—
9
63
11
76
1.49
0.50
13.7
7.1
26.09
24.67
mmol/l
0.96
11
69
7
45
1.58
0.50
1.6
1.9
—
—
—
0
0
115
1096
1.31
0.49
5.1
4.6
6.21
5.96
mmol/l
0.79
103
1000
29
242
1.25
0.43
1.2
1.2
0.73
1.15
u/ml
—
8
67
5
31
1.64
0.43
1.2
2.5
0.00
0.00
g/l
—
5
31
5
31
1.64
0.43
1.2
2.5
0.00
0.00
g/l
—
5
31
5
35
1.44
0.39
1.4
1.9
—
—
—
0
0
10
135
0.72
0.38
1.2
1.8
1.63
1.52
%
—
10
121
9
69
1.33
0.38
1.6
1.7
—
—
—
0
0
61
561
1.16
0.33
5.3
3.7
0.00
0.00
estimate
-0.00
12
103
61
562
1.15
0.32
5.1
3.6
0.00
0.00
estimate
-0.00
13
115
60
553
1.15
0.31
7.0
4.7
0.00
0.00
estimate
-0.00
11
110
11
140
0.77
0.30
9.0
7.5
—
—
—
0
0
5
41
1.23
0.22
1.2
1.5
—
—
—
0
0
8
101
0.78
0.22
1.4
2.1
—
—
—
0
0
11
89
1.26
0.21
1.5
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
4.56
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
13.26
—
0
13
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
13
109
1.21
0.19
11.0
7.6
119.77
121.41
g/l
0.12
13
103
24
215
1.14
0.18
3.1
2.7
0.59
0.70
ug/l
0.36
16
130
28
304
0.90
0.14
6.8
4.0
0.00
0.00
estimate
-0.00
12
102
31
290
1.09
0.11
1.9
1.6
1.39
1.37
mmol/l
0.05
31
243
30
320
0.92
0.11
4.3
3.4
1552.74
1052.07
ng/l
0.51
30
260
5
43
1.17
0.10
1.6
1.1
—
—
—
0
0
71
730
0.94
0.09
2.6
3.0
—
—
—
0
0
6
54
1.12
0.09
1.3
1.2
—
—
—
0
0
5
61
0.81
0.08
2.2
1.3
—
—
—
0
0
12
131
0.91
0.06
11.9
6.7
10.97
12.35
kpa
0.70
12
122
45
436
1.05
0.05
5.7
3.7
—
—
—
0
0
16
149
1.08
0.05
4.6
4.4
31.30
31.72
%
—
10
94
15
161
0.92
0.05
1.4
1.4
—
—
—
0
0
30
291
1.04
0.02
5.6
4.3
20.10
21.00
%
0.13
14
122
21
203
1.04
0.01
1.3
1.5
—
—
—
0
0
10
94
1.07
0.01
6.1
4.0
1.22
1.23
mmol/l
—
10
86
13
131
0.99
0.00
11.1
6.7
5.23
5.13
kpa
0.23
13
121
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
76.19
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORNAS | 1.072 [0.76, 1.51] | 0.693 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 338 females with H7_CHORNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_CHORNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | No data |
| 5 | 0.555% | No data |
| 10 | 1.562% | No data |
| 15 | 3.141% | No data |
| 20 | 5.669% | No data |
Relationships between endpoints
↥Index endpoint: H7_CHORNAS – Other specified and unspecified disorders of choroid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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