No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
119 |
4. Check minimum number of eventsNone |
119 |
5. Include endpointsNone |
119 |
6. Filter based on genotype QC (FinnGen only) |
117 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Haemorrhagia chorioideae
Similar endpoints
↥List of similar endpoints to
Choroidal haemorrhage and rupture
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Bleeding
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1087 | 570 | 511 |
| Only index persons | 959 | 503 | 456 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 70.48 | 75.66 | 64.66 |
| Only index persons | 69.40 | 75.24 | 62.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 117 | 47 | 70 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 65.94 | 64.19 | 67.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 119
- Matched controls
- 1190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
153.9
112
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
13.3
33.3
37
39
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
297.4
24.6
24
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
282.1
23.5
23
*
XCK10
NOMESCO Finland
Photography of fundus of eye
8.6
23.4
36
57
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.8
22.7
49
111
WX140
NOMESCO Finland
Parabulbar anesthesy
34.3
22.7
29
11
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
9.3
20.5
28
38
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
84.1
19.4
21
*
S01ED51
ATC
timolol, combinations; ophthalmic
8.0
19.0
30
48
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
18.2
17
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
50.3
18.0
21
5
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
16.0
15
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
33.9
15.8
20
7
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
41.9
14.9
18
5
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.5
14.7
74
318
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
14.1
40
111
114
Kela drug reimbursment
Glaucoma
5.3
12.9
31
74
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
12.7
12
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
12.7
12
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
11.6
11
*
S01EC01
ATC
acetazolamide; systemic
13.9
10.8
18
15
CKC10
NOMESCO Finland
Local photocoagulation of retina
120.2
10.6
11
*
S01EE01
ATC
latanoprost; ophthalmic
5.2
9.3
21
47
S01EA05
ATC
brimonidine; ophthalmic
10.2
8.9
17
19
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.5
8.8
24
63
H26.4
ICD-10 Finland
After-cataract
4.3
8.5
25
69
CKC12
NOMESCO Finland
Photocoagulation of retina
96.6
8.5
9
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
96.6
8.5
9
*
XCD20
NOMESCO Finland
Photoangiography of eye
48.2
7.8
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
7.8
66
353
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
85.2
7.5
8
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
7.4
7
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
7.4
7
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
7.4
7
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
7.4
7
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
+∞
7.4
7
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.1
7.2
13
13
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
42.5
6.8
8
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.6
6.8
15
22
S01EC03
ATC
dorzolamide; ophthalmic
15.4
6.5
10
7
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.7
6.5
61
336
XCK00
NOMESCO Finland
Perimetry
4.6
6.3
16
39
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
6.3
6
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
6.3
6
*
XCH00
NOMESCO Finland
Eye pressure measurement
8.0
6.1
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
217
2.36
4.42
2.4
2.0
3.08
3.40
mg/l
0.54
33
191
54
322
2.24
4.39
3.5
2.6
132.79
149.67
ug/l
0.17
48
285
109
909
3.37
3.65
22.4
19.3
85.56
82.82
umol/l
0.38
109
909
110
953
3.04
3.29
27.3
24.0
130.74
134.36
g/l
1.63
110
930
99
802
2.39
3.24
6.8
6.1
42.98
40.81
mmol/mol
1.07
90
731
107
904
2.82
3.09
23.0
19.4
4.01
3.99
mmol/l
0.16
107
876
7
13
5.64
2.91
3.6
1.5
59.00
60.31
%
—
7
13
44
276
1.94
2.90
4.3
3.6
8.82
6.49
mg/mmol
0.24
27
187
62
437
1.87
2.85
4.6
4.1
0.00
0.00
estimate
-0.00
19
92
81
625
1.93
2.78
3.4
3.7
15.07
15.13
pmol/l
0.08
72
552
62
440
1.85
2.77
4.8
4.1
0.00
0.00
estimate
-0.00
16
81
98
810
2.19
2.74
16.4
14.8
72.43
76.04
ml/min/173m2
0.78
88
669
61
432
1.85
2.73
5.7
5.5
0.00
0.00
estimate
-0.00
18
84
95
783
2.06
2.57
4.1
4.5
2.08
2.01
mu/l
0.24
86
685
67
495
1.81
2.56
7.6
9.3
4.43
4.30
e9/l
0.14
62
442
100
842
2.18
2.52
4.7
4.6
4.36
4.51
mmol/l
0.62
91
753
15
66
2.46
2.36
1.4
1.5
—
—
—
0
0
60
437
1.75
2.34
7.5
7.3
1.21
1.21
mmol/l
0.06
49
361
40
259
1.82
2.32
3.3
3.1
0.19
0.35
e6/l
0.82
34
203
99
840
2.06
2.30
4.6
4.6
1.41
1.43
mmol/l
0.18
90
751
39
253
1.81
2.24
5.3
4.3
0.00
0.00
estimate
-0.00
17
77
101
866
2.10
2.23
18.3
16.9
23.02
25.05
mg/l
0.30
82
696
55
395
1.73
2.23
2.3
2.8
—
—
—
0
0
95
805
1.89
2.07
4.3
4.2
1.28
1.27
mmol/l
0.06
85
716
97
836
1.87
1.88
4.8
4.9
6.40
6.02
mmol/l
1.80
90
747
19
103
2.01
1.85
3.6
3.0
—
—
—
0
0
100
874
1.90
1.80
5.2
5.0
2.51
2.66
mmol/l
0.76
91
778
86
726
1.67
1.69
22.0
19.2
14.93
15.37
%
0.35
86
712
13
65
2.12
1.55
2.9
3.2
57.17
65.41
ml/min/173m2
—
6
32
12
58
2.19
1.55
2.0
2.9
0.90
1.31
%
1.05
12
58
52
397
1.55
1.52
5.2
4.8
34.04
59.09
ng/l
1.04
42
293
78
652
1.57
1.51
4.1
4.0
14.37
13.53
mm/h
0.13
71
590
81
684
1.58
1.49
7.9
7.6
88.68
83.08
u/l
0.13
76
631
58
457
1.53
1.45
18.0
17.3
1.37
1.35
inr
0.08
21
141
46
346
1.54
1.42
3.8
3.2
—
—
—
0
0
7
29
2.50
1.41
1.7
1.8
—
—
—
0
0
47
360
1.51
1.31
5.4
4.3
—
—
—
0
0
23
149
1.67
1.29
2.0
2.1
—
—
—
0
0
11
56
2.06
1.26
2.1
2.9
0.59
0.74
%
0.76
11
56
43
330
1.47
1.17
3.4
3.5
2305.62
1742.36
ng/l
0.50
35
271
28
196
1.56
1.16
1.4
1.8
0.72
1.43
mg/l
1.77
19
156
13
73
1.88
1.16
5.0
6.3
16.88
10.03
mmol/l
1.77
13
68
30
215
1.53
1.13
1.8
2.5
—
—
—
0
0
7
34
2.12
1.05
2.1
2.2
—
—
—
0
0
29
212
1.49
0.99
3.0
3.0
1.90
0.80
ug/l
0.63
16
141
30
221
1.48
0.99
2.1
1.8
436.90
446.25
pmol/l
0.06
21
186
62
529
1.36
0.88
2.9
3.1
47.51
60.23
u/l
0.63
55
490
26
192
1.45
0.85
1.6
1.7
1.10
1.35
mmol/l
1.39
21
159
44
359
1.36
0.82
1.9
2.0
91.76
92.30
pmol/l
0.03
24
185
8
48
1.71
0.80
4.1
7.9
26.75
24.28
mmol/l
—
8
48
6
33
1.86
0.80
1.2
1.4
—
—
—
0
0
19
134
1.50
0.77
3.8
7.1
102.79
103.63
mmol/l
0.16
19
134
37
297
1.36
0.75
5.3
4.6
22.98
21.76
%
0.16
18
159
47
394
1.32
0.72
5.7
4.8
4.06
2.52
ug/l
0.56
41
339
20
146
1.44
0.69
2.3
2.8
1.20
0.94
e6/l
0.35
15
88
5
27
1.89
0.69
1.2
1.4
—
—
—
0
0
5
27
1.89
0.69
1.2
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
53
463
1.26
0.57
2.9
2.8
—
—
—
0
0
6
40
1.53
0.52
1.0
1.0
—
—
—
0
0
8
58
1.41
0.42
2.4
2.8
0.28
0.12
e6/l
—
8
58
8
59
1.38
0.42
1.1
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
17
133
1.32
0.41
4.2
6.8
0.51
1.00
mmol/l
—
10
99
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
5
34
1.49
0.41
1.4
2.1
32.28
80.51
u/ml
—
5
34
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
1.64
—
0
5
26
217
1.25
0.40
1.2
1.6
19.40
19.33
nmol/l
0.01
20
178
24
203
1.23
0.33
2.0
1.7
949.14
1267.02
nmol/l
1.08
18
151
16
129
1.28
0.32
2.6
3.0
2.33
2.53
e6/l
0.04
11
73
5
38
1.33
0.23
2.2
3.3
4.54
4.56
pmol/l
—
5
33
13
107
1.24
0.22
1.7
1.9
—
—
—
0
0
13
107
1.24
0.22
1.8
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
112.33
—
0
6
14
120
1.19
0.17
1.1
1.3
26.23
8.27
u/ml
—
9
54
13
115
1.15
0.11
1.7
1.5
—
—
—
0
0
43
411
1.07
0.09
4.6
4.4
33.89
34.78
g/l
0.37
37
384
7
80
0.87
0.07
1.6
1.4
—
—
—
0
0
8
92
0.86
0.07
3.1
1.7
400.38
384.72
nmol/l
—
8
83
17
163
1.05
0.01
1.5
1.1
0.77
2.18
u/ml
—
8
43
13
127
1.03
0.00
9.1
8.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
6.0
—
47.40
—
0
5
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
297.40
—
0
9
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.6
—
239.13
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
56
0.89
-0.00
3.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORHAEMORRHAGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.035 [0.83, 1.28] | 0.757 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 506 females with H7_CHORHAEMORRHAGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.019 [0.79, 1.31] | 0.884 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 419 males with H7_CHORHAEMORRHAGE died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORHAEMORRHAGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.219% |
| 5 | 0.534% | 1.415% |
| 10 | 1.286% | 3.496% |
| 15 | 2.713% | 6.676% |
| 20 | 4.845% | 11.232% |
Relationships between endpoints
↥Index endpoint: H7_CHORHAEMORRHAGE – Choroidal haemorrhage and rupture
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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