No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
114 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Haemorrhagia chorioideae
Similar endpoints
↥List of similar endpoints to
Choroidal haemorrhage and rupture
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Bleeding
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1087 | 570 | 511 |
| Only index persons | 959 | 503 | 456 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 70.48 | 75.66 | 64.66 |
| Only index persons | 69.40 | 75.24 | 62.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 114 | 47 | 67 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 65.58 | 64.25 | 66.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1011
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
128.3
94
*
WX140
NOMESCO Finland
Parabulbar anesthesy
115.1
25.0
26
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
22.8
21
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
+∞
22.8
21
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
246.3
20.3
20
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.3
16.5
31
35
H43.1
ICD-10 Finland
Vitreous haemorrhage
46.2
16.0
19
5
XCK10
NOMESCO Finland
Photography of fundus of eye
12.2
15.6
29
32
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
5.7
15.3
65
242
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
+∞
15.0
14
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
15.0
14
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
13.9
13
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.2
13.5
36
72
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
58.0
13.2
15
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
12.8
12
*
S01ED51
ATC
timolol, combinations; ophthalmic
10.3
12.5
25
31
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.8
11.9
32
64
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
11.7
11
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
11.7
11.4
21
22
S01EC01
ATC
acetazolamide; systemic
18.7
10.8
16
10
CKC10
NOMESCO Finland
Local photocoagulation of retina
122.2
10.6
11
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
10.6
10
*
114
Kela drug reimbursment
Glaucoma
7.1
10.3
26
47
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
+∞
8.4
8
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
+∞
8.4
8
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.6
7.9
46
192
CKC12
NOMESCO Finland
Photocoagulation of retina
48.9
7.8
9
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
9.6
7.6
15
18
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
86.1
7.5
8
*
CKD60
NOMESCO Finland
Anterior vitrectomy
86.1
7.5
8
*
XCD20
NOMESCO Finland
Photoangiography of eye
86.1
7.5
8
*
S01EE05
ATC
tafluprost; ophthalmic
17.4
7.4
11
7
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
7.4
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.3
7.2
50
233
XCK00
NOMESCO Finland
Perimetry
7.8
6.8
15
22
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
74.3
6.5
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
6.4
50
246
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
6.3
6
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
+∞
6.3
6
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
+∞
6.3
6
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
6.3
6
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
6.3
6
*
H26.4
ICD-10 Finland
After-cataract
4.9
6.3
20
48
XCD10
NOMESCO Finland
Electrophysiological examination of eye
9.6
6.3
12
14
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.0
6.2
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
297
2.30
4.46
3.5
2.6
136.5
152.7
ug/l
0.15
46
262
38
197
2.39
4.31
2.4
2.1
3.0
3.4
mg/l
0.56
31
174
104
866
3.29
3.49
22.5
18.8
85.4
83.0
umol/l
0.31
104
866
105
908
2.98
3.16
27.5
23.4
130.7
134.8
g/l
1.91
105
886
60
412
1.96
3.11
4.3
4.0
0.0
0.0
estimate
0.00
17
84
60
417
1.93
2.96
4.6
4.0
0.0
0.0
estimate
0.00
16
80
94
765
2.30
2.95
6.9
6.2
43.2
41.0
mmol/mol
1.11
87
701
102
861
2.75
2.93
23.1
18.9
4.0
4.0
mmol/l
0.20
102
833
59
409
1.92
2.92
5.6
5.4
0.0
0.0
estimate
0.00
18
82
96
801
2.26
2.62
4.7
4.6
4.4
4.5
mmol/l
0.55
89
717
58
411
1.84
2.59
7.5
7.1
1.2
1.2
mmol/l
0.01
47
334
90
740
2.03
2.45
4.1
4.5
2.1
2.0
mu/l
0.16
82
647
95
798
2.14
2.41
4.6
4.6
1.4
1.4
mmol/l
0.09
88
714
38
242
1.86
2.35
3.4
3.0
0.2
0.4
e6/l
0.93
33
189
97
825
2.18
2.32
18.4
16.5
23.4
24.7
mg/l
0.17
78
661
76
597
1.82
2.32
3.5
3.7
15.0
15.1
pmol/l
0.13
69
527
92
771
2.00
2.25
16.8
14.3
72.6
75.8
ml/min/173m2
0.62
84
634
52
370
1.75
2.20
4.1
4.4
—
—
—
0
0
14
62
2.43
2.18
1.4
1.6
—
—
—
0
0
91
765
1.94
2.13
4.3
4.2
1.3
1.3
mmol/l
0.06
83
681
37
244
1.76
2.01
5.0
4.2
0.0
0.0
estimate
0.00
17
76
19
100
2.08
2.00
3.6
3.1
—
—
—
0
0
96
831
1.98
1.92
5.2
5.0
2.5
2.7
mmol/l
0.68
88
739
51
376
1.64
1.81
5.3
4.8
34.1
58.3
ng/l
0.94
41
279
92
791
1.85
1.80
4.8
5.0
6.4
6.0
mmol/l
1.70
86
707
13
62
2.24
1.73
3.0
3.3
57.2
65.4
ml/min/173m2
—
6
32
8
32
2.61
1.63
3.8
2.3
23.4
24.4
mmol/l
—
8
26
44
320
1.61
1.61
3.9
3.2
—
—
—
0
0
46
343
1.57
1.50
5.2
4.3
—
—
—
0
0
77
648
1.58
1.45
7.8
7.4
90.4
82.4
u/l
0.18
72
597
11
55
2.11
1.32
2.1
2.9
0.9
1.4
%
1.25
11
55
73
616
1.51
1.29
4.0
4.0
15.0
13.7
mm/h
0.20
66
556
28
196
1.57
1.17
1.9
2.6
—
—
—
0
0
40
306
1.47
1.11
3.5
3.5
2410.4
1739.4
ng/l
0.60
33
251
59
494
1.40
0.98
3.0
3.0
47.9
58.7
u/l
0.50
54
456
26
188
1.50
0.94
1.4
1.8
0.8
1.4
mg/l
1.33
17
148
29
215
1.47
0.93
2.1
1.8
436.9
451.3
pmol/l
0.09
21
181
8
42
1.97
0.91
4.1
6.0
26.8
24.3
mmol/l
—
8
42
27
200
1.46
0.87
2.6
2.9
1.9
0.8
ug/l
0.66
16
133
6
31
1.99
0.85
1.2
1.4
—
—
—
0
0
25
183
1.47
0.85
1.6
1.7
1.1
1.4
mmol/l
1.25
20
149
20
141
1.51
0.81
2.1
2.0
—
—
—
0
0
19
133
1.51
0.80
2.4
2.7
1.0
0.9
e6/l
0.11
14
82
5
26
1.96
0.71
1.2
1.5
—
—
—
0
0
5
26
1.96
0.71
1.2
1.5
—
—
—
0
0
41
339
1.33
0.69
1.9
2.0
91.1
92.8
pmol/l
0.09
23
169
5
28
1.82
0.67
2.0
1.6
—
—
—
0
0
8
51
1.61
0.62
2.4
3.0
0.3
0.1
e6/l
—
8
51
44
373
1.29
0.61
5.3
4.7
4.2
2.2
ug/l
0.76
39
321
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
16
115
1.46
0.60
2.6
2.9
2.3
2.7
e6/l
0.08
11
66
34
279
1.31
0.60
4.9
4.6
23.6
21.8
%
0.24
17
149
17
124
1.44
0.60
4.2
6.0
0.5
1.1
mmol/l
—
10
91
8
53
1.55
0.60
1.1
1.7
—
—
—
0
0
6
39
1.57
0.54
1.0
1.0
—
—
—
0
0
10
69
1.49
0.46
3.2
3.2
5.0
5.0
kpa
—
10
64
49
436
1.22
0.43
3.0
2.8
—
—
—
0
0
5
33
1.54
0.42
2.6
2.1
—
—
—
0
0
5
33
1.54
0.42
2.2
3.5
4.5
4.5
pmol/l
—
5
28
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
23
193
1.24
0.34
2.0
1.7
949.1
1311.3
nmol/l
1.29
18
142
42
386
1.14
0.23
4.7
4.4
33.7
34.7
g/l
0.44
36
360
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
12
100
1.22
0.19
1.8
1.9
—
—
—
0
0
12
100
1.22
0.19
1.8
2.0
—
—
—
0
0
17
155
1.11
0.09
1.5
1.1
0.8
2.2
u/ml
—
8
42
6
55
1.10
0.09
4.2
8.2
20.2
24.3
mmol/l
—
6
49
11
121
0.90
0.06
10.4
9.1
—
—
—
0
0
11
109
1.01
0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1776.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
323.8
—
0
8
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
0
5
0.00
0.00
0.0
6.0
—
47.4
—
0
5
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
8
84
0.95
0.00
3.1
1.8
400.4
378.4
nmol/l
—
8
75
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
247.3
—
0
6
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1196.2
—
0
6
5
58
0.86
0.00
3.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
76
0.92
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORHAEMORRHAGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.035 [0.83, 1.28] | 0.757 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 506 females with H7_CHORHAEMORRHAGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.019 [0.79, 1.31] | 0.884 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 419 males with H7_CHORHAEMORRHAGE died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORHAEMORRHAGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.219% |
| 5 | 0.534% | 1.415% |
| 10 | 1.286% | 3.496% |
| 15 | 2.713% | 6.676% |
| 20 | 4.845% | 11.232% |
Relationships between endpoints
↥Index endpoint: H7_CHORHAEMORRHAGE – Choroidal haemorrhage and rupture
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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