No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
124 |
4. Check minimum number of eventsNone |
124 |
5. Include endpointsNone |
124 |
6. Filter based on genotype QC (FinnGen only) |
124 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Cicatrices chorioretinales
Similar endpoints
↥List of similar endpoints to
Chorioretinal scars
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 911 | 460 | 444 |
| Only index persons | 847 | 431 | 416 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.06 | 57.19 | 50.81 |
| Only index persons | 53.76 | 57.06 | 50.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 124 | 70 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 59.66 | 59.80 | 59.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1111
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
157.1
110
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.8
12.0
23
26
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
120.9
10.6
11
*
XCK10
NOMESCO Finland
Photography of fundus of eye
8.0
10.5
24
37
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.2
9.8
24
41
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
108.8
9.6
10
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
9.5
9
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
+∞
7.4
7
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.1
6.1
14
22
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
6.0
28
95
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORSCAR | 1.083 [0.82, 1.43] | 0.579 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 382 females with H7_CHORSCAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORSCAR | 0.918 [0.68, 1.23] | 0.57 |
| Birth year | 0.992 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 360 males with H7_CHORSCAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | 0.217% |
| 5 | 0.547% | 1.201% |
| 10 | 1.513% | 2.911% |
| 15 | 2.959% | 6.027% |
| 20 | 5.279% | 10.064% |
Relationships between endpoints
↥Index endpoint: H7_CHORSCAR – Chorioretinal scars
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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