Erythema in diseases classified elsewhere

L12_ERYTHINOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L54*
  • Cause of death: ICD-10 L54*

2 out of 7 registries used, show all original rules.

74

4. Check minimum number of events

None

74

5. Include endpoints

None

74

6. Filter based on genotype QC (FinnGen only)

74

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 461 302 158
Only index persons 439 286 153
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 56.68 58.12 53.91
Only index persons 56.26 57.79 53.42

-FinnGen-

Key figures

All Female Male
Number of individuals 74 49 25
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 54.10 51.01 60.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
68
Matched controls
681
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L548, A692
ICD-10 Finland
NA
+∞
43.5
37
*
A69.2
ICD-10 Finland
Lyme disease
27.0
20.1
28
17
L54.8
ICD-10 Finland
Erythema in other diseases classified elsewhere
+∞
17.4
16
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.1
8.6
22
43
L54.0*I00
ICD-10 Finland
Erythema marginatum in acute rheumatic fever
+∞
8.5
8
*

Mortality – FinRegistry

Association

Association between endpoint L12_ERYTHINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ERYTHINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ERYTHINOTH – Erythema in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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