Risteys · M13_ATLOAXSUBLUX

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M43.3, M43.4 Cause of death: ICD-10 — M43.3, M43.4 2 out of 7 registries used, show all original rules.	239
4. Check minimum number of events None	239
5. Include endpoints None	239
6. Filter based on genotype QC (FinnGen only)	239

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1586	993	576
Only index persons	1308	813	495
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.03	0.03	0.02
Median age at first event (years)
Whole population	58.59	61.59	53.21
Only index persons	56.40	59.48	51.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	239	158	81
Unadjusted period prevalence (%)	0.05	0.05	0.04
Median age at first event (years)	53.82	52.76	55.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
211: Matched controls
2111

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M43.4

ICD-10 Finland

Other recurrent atlantoaxial subluxation

+∞

167.9

138

M43.3

ICD-10 Finland

Recurrent atlantoaxial subluxation with myelopathy

+∞

106.5

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

69.0

96.3

109

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

40.7

92.9

121

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

30.2

89.4

131

108

7140A

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]

110.3

82.2

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

25.3

64.5

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

193.7

57.1

P01BA02

ATC

hydroxychloroquine; oral

18.8

56.9

A07EC01

ATC

sulfasalazine; oral, rectal

21.1

56.3

NAG42

NOMESCO Finland

Posterior fusion of cervical spine with or without fixation

+∞

55.7

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

17.3

55.3

L04AA13

ATC

leflunomide; oral

45.0

54.0

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

39.5

53.9

M48.0

ICD-10 Finland

Spinal stenosis

123.5

46.0

71238

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita

74.0

45.8

L88

ICPC

Rheumatoid/seropositive arthritis

24.8

45.2

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

16.5

45.1

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

37.6

44.1

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

41.1

42.7

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

45.1

40.3

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

+∞

37.6

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

31.5

37.0

L04AA01

ATC

[U] ciclosporin; systemic

43.5

36.8

N02AX02

ATC

tramadol; systemic, rectal

6.5

35.1

141

500

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

22.8

34.9

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

29.6

32.1

71239

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD

83.3

32.0

L04AX01

ATC

azathioprine; systemic

21.2

31.5

M01CB01

ATC

sodium aurothiomalate; parenteral

45.9

31.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.7

30.6

130

465

H02AB06

ATC

prednisolone; systemic

5.8

30.4

153

662

NHG80

NOMESCO Finland

Fusion of first tarsometatarsal joint

21.9

29.9

NDG30

NOMESCO Finland

Fusion of wrist, total

93.9

29.7

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

22.5

28.9

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

25.6

28.7

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

13.8

27.7

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

18.4

26.9

N03AX16

ATC

pregabalin; oral

6.4

26.5

186

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

41.5

26.1

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

80.1

25.5

NA1BA

NOMESCO Finland

Cervical spine extensive X-ray examination without contrast

147.4

25.2

H02AB08

ATC

triamcinolone; systemic

147.4

25.2

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

8.8

24.9

N03AX12

ATC

gabapentin; oral

7.5

24.8

115

M05

ICD-10 Finland

Seropositive rheumatoid arthritis

61.5

23.7

M43.1

ICD-10 Finland

Spondylolisthesis

61.5

23.7

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

73.6

23.4

7140B

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]

73.6

23.4

9522

FHL

Synovectomy

94.1

23.2

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

8.2

23.0

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

6.6

22.7

134

H02AB04

ATC

methylprednisolone; systemic

6.2

22.4

151

ZZH31

NOMESCO Finland

Bone allograft, small pieces

244.2

22.0

NHG22

NOMESCO Finland

Fusion of subtalar joint

244.2

22.0

9284

FHL

Wrist ossification surgery

122.1

21.0

M54.2

ICD-10 Finland

Cervicalgia

13.3

21.0

NCB20

NOMESCO Finland

Primary total prosthetic replacement of elbow joint

231.8

21.0

9527

FHL

Alloarthroplasty, implant or endoprosthesis

231.8

21.0

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

9.2

20.8

NA1AD

NOMESCO Finland

Cervical spine CT examination

14.7

20.8

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

8.6

20.7

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

14.8

20.2

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

116.0

19.9

9531

FHL

Arthrodesis of the hand joint

219.7

19.9

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

14.8

19.7

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

7.3

19.3

TQW40

NOMESCO Finland

Remowal of suture of skin

7.7

19.2

7230B

ICD-9 Finland

Other disorders of cervical region, Spinal stenosis of cervical region[SUBLUXATIO ATLANTO-AXIALIS]

+∞

19.0

9503

FHL

Tendon or tendon sheath cleansing surgery (tenosynovectomy)

42.7

19.0

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

109.9

18.9

9283

FHL

Subtalar joint ossification surgery (or triple)

207.6

18.8

NDG76

NOMESCO Finland

Fusion of DIP joint

48.8

18.6

NC1AA

NOMESCO Finland

Elbow X-ray examination without contrast

15.1

17.6

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

9.6

17.4

M05BA04

ATC

alendronic acid; oral

6.2

17.1

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

15.2

17.0

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

16.9

NHG20

NOMESCO Finland

Fusion of talocrural joint

97.9

16.8

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

18.7

16.5

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

13.8

16.4

M06.8

ICD-10 Finland

Other specified rheumatoid arthritis

51.9

16.3

M01AX01

ATC

nabumetone; oral

9.8

16.2

H02AB07

ATC

prednisone; oral

4.9

16.0

147

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

172.2

15.7

NDU20

NOMESCO Finland

Removal of internal fixation device from wrist or hand

14.7

15.1

M05BA07

ATC

risedronic acid; oral

10.1

15.1

NHG24

NOMESCO Finland

Fusion of subtalar joint and between bones of ankle

61.2

15.0

M01AH01

ATC

celecoxib; oral (coxibs)

4.2

14.9

203

M01AB55

ATC

diclofenac, combinations; oral

6.9

14.8

N02AA05

ATC

oxycodone; systemic

4.8

14.8

142

NDG77

NOMESCO Finland

Other excision, reconstruction or fusion of joint of first finger

+∞

14.8

L04AB01

ATC

etanercept; parenteral

21.0

14.6

NF1AA

NOMESCO Finland

Hip X-ray examination

5.8

14.5

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

6.7

14.5

L28

ICPC

Limited function/disability (L)

4.4

14.1

159

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.1

14.0

117

601

M43.0

ICD-10 Finland

Spondylolysis

57.3

14.0

M05BX04

ATC

denosumab; parenteral

8.1

13.7

L01BB01

ATC

149.1

13.6

TNX32

NOMESCO Finland

Custom moulded splint, unspecified region

8.1

13.3

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

10.1

13.2

M01CB03

ATC

auranofin; oral

30.6

13.2

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

15.4

13.1

NDG74

NOMESCO Finland

Fusion of first IP joint

53.5

13.0

M01CC01

ATC

penicillamine; oral

53.5

13.0

9272

FHL

Metatarsophalangeal joint resection

53.5

13.0

A02BC01

ATC

omeprazole; systemic

3.3

13.0

355

J01FF01

ATC

clindamycin; systemic

3.3

12.8

350

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

34.4

12.8

L04AA11

ATC

[U] etanercept; parenteral

34.4

12.8

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

74.4

12.7

L04AA17

ATC

[U] adalimumab; parenteral

74.4

12.7

9289

FHL

Other measure in this category

74.4

12.7

9260

FHL

Alloarthroplasty, endoprosthesis or implant

+∞

12.6

M05.3

ICD-10 Finland

Rheumatoid arthritis with involvement of other organs and systems

+∞

12.6

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

+∞

12.6

NDC40

NOMESCO Finland

Secondary prosthetic replacement in of joint of finger or metacarpal

137.8

12.6

NH1AD

NOMESCO Finland

Ankle and foot CT

17.2

12.4

WX204

NOMESCO Finland

Axillary plexus blockaced

11.1

12.3

NHG82

NOMESCO Finland

Fusion of other tarsal joint

28.6

12.2

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

22.9

12.2

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

5.7

11.9

M01AH02

ATC

rofecoxib; oral

4.4

11.9

121

9294

FHL

Endoprosthesis replacement of the entire hip joint (eg Charnley)

32.1

11.8

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

24.6

11.8

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

4.6

11.7

112

A02BC03

ATC

lansoprazole; oral

3.1

11.5

336

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

8.9

11.4

NH3EA

NOMESCO Finland

Feet X-ray examination with load

18.3

11.4

WZA10

NOMESCO Finland

Long statement of health and health related matters

21.5

11.3

M54.4

ICD-10 Finland

Lumbago with sciatica

4.9

11.1

9256

FHL

Synovectomy (knee 9311)

45.9

11.0

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

5.0

11.0

9165

FHL

Removal of osteosynthesis material

13.9

10.9

M01AE03

ATC

ketoprofen; systemic, rectal

2.8

10.8

480

SPAT1229

SPAT

Assessment of need for aid

5.0

10.8

NDB78

NOMESCO Finland

Prosthetic replacement of several of finger or metacarpal

63.3

10.7

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.4

10.7

212

A02BC02

ATC

pantoprazole; systemic

2.8

10.5

152

1019

NCF10

NOMESCO Finland

Synovectomy of elbow joint, open

115.5

10.5

M53.2

ICD-10 Finland

Spinal instabilities

+∞

10.5

M47.1

ICD-10 Finland

Other spondylosis with myelopathy

+∞

10.5

NDL52

NOMESCO Finland

Tenosynovectomy of hand

20.0

10.4

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

24.8

10.4

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

4.4

10.2

100

NDB60

NOMESCO Finland

Prosthetic replacement of MCP joint of finger

42.2

10.1

X59

ICD-10 Finland

Exposure to unspecified factor

3.3

10.0

220

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

17.8

10.0

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

7.0

9.9

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

7.0

9.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.6

9.9

112

642

3006

Kela drug reimbursment

Baricitinib

57.7

9.7

M54.9

ICD-10 Finland

Dorsalgia, unspecified

6.4

9.7

TNG10

NOMESCO Finland

Puncture of knee

16.0

9.7

B01AB05

ATC

enoxaparin; parenteral

2.7

9.6

421

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

7.5

9.6

TPH04

NOMESCO Finland

Cathetrisation of vein

3.1

9.6

241

S97

ICPC

Chronic ulcer skin

6.3

9.6

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

18.6

9.5

M05BA01

ATC

etidronic acid; systemic

31.6

9.5

ZXM20

NOMESCO Finland

Intraoperative use of computerised tomography

104.5

9.5

9477

FHL

Cleansing or splitting of a tendon or tendon sheath (eg tenosynovectomy, tenolysis)

+∞

9.4

M45

ICD-10 Finland

Ankylosing spondylitis

+∞

9.4

L01AA02

ATC

chlorambucil; oral

+∞

9.4

M81.9

ICD-10 Finland

Osteoporosis, unspecified

7.3

9.4

NE1AA

NOMESCO Finland

Pelvis X-ray examination

5.3

9.3

X58

ICD-10 Finland

Exposure to other specified factors

3.7

9.3

138

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.7

9.2

370

NDF60

NOMESCO Finland

Operation for osteochondritis of a joint of hand,v

38.5

9.1

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.5

9.1

101

567

NBB10

NOMESCO Finland

Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified

25.3

9.0

M47.9

ICD-10 Finland

Spondylosis, unspecified

25.3

9.0

WX203

NOMESCO Finland

Infraclavicular plexus blockade

10.2

9.0

M01AB01

ATC

indometacin; systemic, rectal

5.3

8.9

SPAT1148

SPAT

Treatment of chronic ulcer or burn

3.4

8.8

156

M03BC01

ATC

orphenadrine (citrate); systemic

3.1

8.8

207

293

Kela drug reimbursment

Baricitinib

52.2

8.7

L04AA37

ATC

baricitinib; oral

52.2

8.7

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

9.6

8.7

NBB20

NOMESCO Finland

Primary total prosthetic replacement of humero-scapular joint

17.2

8.7

P01BA01

ATC

chloroquine; systemic

28.8

8.6

9473

FHL

Local soft tissue removal or exploration (eg Bursa)

28.8

8.6

XX9XE

NOMESCO Finland

Other ultrasound examination

28.8

8.6

R52.2

ICD-10 Finland

Other chronic pain

13.5

8.5

M50.3

ICD-10 Finland

Other cervical disc degeneration

93.6

8.5

NDF10

NOMESCO Finland

Synovectomy of wrist

93.6

8.5

NDL66

NOMESCO Finland

Transposition of tendon of wrist or hand, other tendon

93.6

8.5

ZXA05

NOMESCO Finland

Left side

2.6

8.5

353

ABC16

NOMESCO Finland

Microsurgical excision of lumbar intervertebral disc displacement

+∞

8.4

ABC60

NOMESCO Finland

Decompression of cervical spinal cord

+∞

8.4

ZXE20

NOMESCO Finland

More than three and less than five hours

3.3

8.4

160

ZX120

NOMESCO Finland

Intravenous

3.9

8.3

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.7

8.2

292

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.6

8.2

351

A02BB01

ATC

misoprostol; oral

34.8

8.1

ZX140

NOMESCO Finland

Intra articular

23.1

8.1

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.3

8.1

108

653

9273

FHL

Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe

13.7

8.0

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

13.7

8.0

SPAT1215

SPAT

Assessment of need for medical rehabilitation

7.5

8.0

L04AB04

ATC

adalimumab; parenteral

10.0

7.9

R06.0

ICD-10 Finland

Dyspnoea

2.6

7.9

299

ZXA00

NOMESCO Finland

Right side

2.5

7.9

374

N02AJ06

ATC

codeine and paracetamol; systemic

2.4

7.8

447

WX002

NOMESCO Finland

Sedation and analgesia

2.8

7.8

254

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

7.2

7.8

WX320

NOMESCO Finland

Spinalanesthesy

2.6

7.8

292

WX707

NOMESCO Finland

Fiberoscopic intubation

46.7

7.8

RT271

NOMESCO Finland

46.7

7.8

NH1AE

NOMESCO Finland

Ankle joint ultrasound examination

46.7

7.8

M54.5

ICD-10 Finland

Low back pain

2.7

7.8

279

NGC30

NOMESCO Finland

Secondary implantation of prosthesis in knee joint, special prosthesis

19.2

7.7

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

19.2

7.7

L04AA24

ATC

abatacept; parenteral

19.2

7.7

N02AC04

ATC

dextropropoxyphene; oral

9.4

7.7

M05BA06

ATC

ibandronic acid; systemic

9.4

7.7

9314

FHL

Total knee endoprosthesis (also includes patellar part)

26.1

7.6

TNX50

NOMESCO Finland

Removal of cutom molded cast and internal stretch

5.3

7.5

R4120

NOMESCO Finland

Occupational therapy

4.5

7.5

M01AH05

ATC

etoricoxib; oral

2.2

7.5

128

860

NHB10

NOMESCO Finland

Primary partial prosthetic replacement of ankle joint

82.8

7.5

TNC11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in elbow joint

82.8

7.5

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

7.3

7.5

M54.3

ICD-10 Finland

Sciatica

8.9

7.5

J01MA12

ATC

levofloxacin; systemic

2.8

7.4

222

Z50.1

ICD-10 Finland

Other physical therapy

5.2

7.4

M01AC06

ATC

meloxicam; systemic, rectal

2.3

7.3

475

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

+∞

7.3

9252

FHL

Plaster bandage placement or replacement (no fracture) in the operating room

+∞

7.3

NAG63

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, more than 3 vertebraea

+∞

7.3

0103

NOMESCO Finland

+∞

7.3

A28

ICPC

Limited function/disability NOS

3.1

7.3

151

J01DB01

ATC

cefalexin; oral

2.6

7.3

176

1387

M19.0

ICD-10 Finland

Primary arthrosis of other joints

3.9

7.3

WZA90

NOMESCO Finland

Other doctors statement

2.6

7.2

294

L04AB06

ATC

golimumab; parenteral

31.2

7.2

ZZH40

NOMESCO Finland

Substitute of bone

31.2

7.2

NB2AT

NOMESCO Finland

Intra artrial injection of shoulder with ultrasound guidance

20.9

7.2

J01DA01

ATC

[U] cefalexin; systemic

2.2

7.2

140

986

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

9.3

7.2

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

7.4

7.1

9271

FHL

Hallux surgery

6.7

7.1

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.8

7.1

205

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.4

7.0

369

M03BX01

ATC

baclofen; systemic

14.4

7.0

J01MA02

ATC

ciprofloxacin; systemic

2.2

6.9

551

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.9

6.9

182

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.4

6.9

NFC40

NOMESCO Finland

Repair of hip prosthesis by bone transplant to acetabulum

41.4

6.8

ZZH20

NOMESCO Finland

Graft of patients own bone

41.4

6.8

NDG71

NOMESCO Finland

Arthrodes of first MP joint

41.4

6.8

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.9

6.7

166

NG1DA

NOMESCO Finland

X-ray of knees

8.2

6.7

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

12.8

6.7

NB1AD

NOMESCO Finland

Shoulder CT examination

9.1

6.7

NDG60

NOMESCO Finland

Arthroplasty of first CMC joint

10.5

6.6

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

10.5

6.6

R13

ICD-10 Finland

Dysphagia

4.7

6.6

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.2

6.5

R50.9

ICD-10 Finland

Fever, unspecified

3.0

6.5

145

M01AE02

ATC

naproxen; oral, rectal

2.1

6.5

123

840

A02BC05

ATC

esomeprazole; systemic

2.2

6.5

537

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

71.9

6.5

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

71.9

6.5

M17.4

ICD-10 Finland

Other secondary gonarthrosis, bilateral

71.9

6.5

L04AD01

ATC

ciclosporin; systemic

11.5

6.4

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

11.5

6.4

A06AD11

ATC

lactulose; oral

3.0

6.4

140

H04.10

ICD-10 Finland

Dry eye syndrome

3.2

6.3

116

M05BB03

ATC

alendronic acid and colecalciferol; oral

7.4

6.3

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.7

6.3

200

TNB11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in shoulder joint

18.7

6.3

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

18.7

6.3

KFD20

NOMESCO Finland

Excision of hydrocele of testis

18.7

6.3

M01AX17

ATC

nimesulide; oral

2.4

6.3

323

ZXE10

NOMESCO Finland

More than one and less than three hours

2.2

6.3

508

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

6.3

M96.1

ICD-10 Finland

Postlaminectomy syndrome, not elsewhere classified

+∞

6.3

L01AA01

ATC

cyclophosphamide; systemic

27.6

6.3

H05AA02

ATC

teriparatide; parenteral

27.6

6.3

ZXC95

NOMESCO Finland

Use of surgical navigator

27.6

6.3

318

Kela drug reimbursment

Teriparatide

27.6

6.3

J01MA14

ATC

moxifloxacin; systemic

3.6

6.2

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.3

6.2

387

Mortality – FinRegistry

↥

Association

Association between endpoint M13_ATLOAXSUBLUX and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_ATLOAXSUBLUX	2.573 [2.2, 3.01]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.099

During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 797 females with M13_ATLOAXSUBLUX died.

Males

Parameter	HR [95% CI]	p-value
M13_ATLOAXSUBLUX	1.478 [1.18, 1.85]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 500 males with M13_ATLOAXSUBLUX died.

Mortality risk

Mortality risk for people of age

years, who have M13_ATLOAXSUBLUX.

N-year risk	Females	Males
1	0.211%	0.239%
5	1.353%	1.353%
10	3.347%	3.58%
15	6.752%	6.956%
20	11.712%	11.871%

NAME	M13_ATLOAXSUBLUX
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M43[3-4]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M43[3-4]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Atlantoaxial subluxation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints